Radioactive Iodide Therapy for Pediatric Graves' Disease
Graves' Disease
About this trial
This is an interventional treatment trial for Graves' Disease focused on measuring Hyperthyroidism, Antithyroid drugs, Cancer, Dosimetry, Children
Eligibility Criteria
Inclusion Criteria:
- A diagnosis of GD based on initial laboratory studies showing a suppressed TSH (i.e. <0.01); high total T3, high total T4 and/or free T4 level; an elevated thyroid stimulating immunoglobulin (TSI) titer; increased and diffuse uptake of 123I, 131I, or 99Tc in the thyroid gland.
- Age <18 years at the time of GD disease diagnosis.
- Non-smoking parents.
Exclusion Criteria:
- > 18 years.
- Smoking parents.
Sites / Locations
- University of Florida
- Texas Childrens Hospital
Arms of the Study
Arm 1
Arm 2
Other
Other
RAI treatment
ATD Group
Characteristics of study population. We will recruit a total of 150 patients diagnosed with GD younger than 18 years of age. All subjects are to be treated with 131I. In this trial, children will not be randomized to treatment, but will be treated per physician prescribed care. To ensure an equal distribution of age and gender between the two groups of children, we stratify enrollment by gender (male vs. female) and age (5-10 yrs, 10-15 yrs, 15-18 yrs).
Characteristics of study population. We will recruit a total of 150 patients diagnosed with GD younger than 18 years of age. All subjects are to be treated with antithyroid drugs (ATDs). In this trial, children will not be randomized to treatment, but will be treated per physician prescribed care. To ensure an equal distribution of age and gender between the two groups of children, we stratify enrollment by gender (male vs. female) and age (5-10 yrs, 10-15 yrs, 15-18 yrs).