Left Atrial Distensibility Guiding Management in Advanced Chronic Heart Failure
Chronic Heart Failure
About this trial
This is an interventional treatment trial for Chronic Heart Failure focused on measuring left atrial distensibility, advanced chronic heart failure, decompensation, rehospitalization, prognosis, all-cause mortality, heart failure with hospitalization, the duration of hospitalization
Eligibility Criteria
Inclusion Criteria:
- Advanced chronic heart failure (HF) will be defined as left ventricular ejection fraction less than 35%, creatinine less than 2 mg/dL, and CHF NY functional class III-IV for more than 3 months. Enrolled patients should be admitted to hospital due to heart failure requiring adjustment of inotropic agents or diuretics within recent 6 months.
Exclusion Criteria:
- presence of mitral stenosis or prosthetic mitral valve
- any abnormality of atrial septum (e.g., atrial septal defect or aneurysm)
- inadequate image quality
- lack of informed consent
Sites / Locations
- Kaohsiung Veterans General Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
Patients under LA distensibility-guiding management
patients under conservative monitor and management
The management of guide group will be adjusted by LA distensibility, including the adjustments of inotropic agents, diuretics, beta-blocker, ACEI, and AIIB.
This group will be treated by conventional management and traditional echocardiography can be performed as in-charge doctor request. Renal function will be checked 1 time per 3 months.