Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia
Primary Purpose
Bradyarrhythmia
Status
Unknown status
Phase
Locations
Taiwan
Study Type
Observational
Intervention
Sponsored by
About this trial
This is an observational trial for Bradyarrhythmia
Eligibility Criteria
Inclusion Criteria:
- The patients with non-familial bradyarrhythmia
Exclusion Criteria:
- Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases
Sites / Locations
- China Medical University HospitalRecruiting
- China Medical University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Arm Label
sinus node dysfunction
Atrioventricular block
control
Arm Description
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT01310907
First Posted
March 6, 2011
Last Updated
March 6, 2011
Sponsor
China Medical University Hospital
Collaborators
China Medical University, China
1. Study Identification
Unique Protocol Identification Number
NCT01310907
Brief Title
Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia
Study Type
Observational
2. Study Status
Record Verification Date
March 2011
Overall Recruitment Status
Unknown status
Study Start Date
February 2011 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)
3. Sponsor/Collaborators
Name of the Sponsor
China Medical University Hospital
Collaborators
China Medical University, China
4. Oversight
5. Study Description
Brief Summary
Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia.
Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Bradyarrhythmia
7. Study Design
Enrollment
400 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
sinus node dysfunction
Arm Title
Atrioventricular block
Arm Title
control
10. Eligibility
Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
The patients with non-familial bradyarrhythmia
Exclusion Criteria:
Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases
Study Population Description
The case group include 200 patients and the control group include 200 patients.
Sampling Method
Probability Sample
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Jan-Yow Chen, MD
Phone
+422052121
Ext
2311
Email
janyow@ms77.hinet.net
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Organizational Affiliation
China Medical University Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
404
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Phone
+88622052121
Ext
2311
Email
janyow@ms77.hinet.net
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
404
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Phone
+886-4-22052121
Ext
2311
Email
janyow@ms77.hinet.net
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
12. IPD Sharing Statement
Citations:
PubMed Identifier
10706901
Citation
Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. doi: 10.1056/NEJM200003093421006. No abstract available.
Results Reference
background
Links:
URL
http://www.hrsonline.org/
Description
Heart Rhythm Society
Learn more about this trial
Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia
We'll reach out to this number within 24 hrs