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Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

Primary Purpose

Bradyarrhythmia

Status
Unknown status
Phase
Locations
Taiwan
Study Type
Observational
Intervention
Sponsored by
China Medical University Hospital
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an observational trial for Bradyarrhythmia

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • The patients with non-familial bradyarrhythmia

Exclusion Criteria:

  • Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases

Sites / Locations

  • China Medical University HospitalRecruiting
  • China Medical University HospitalRecruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Arm Label

sinus node dysfunction

Atrioventricular block

control

Arm Description

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
March 6, 2011
Last Updated
March 6, 2011
Sponsor
China Medical University Hospital
Collaborators
China Medical University, China
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1. Study Identification

Unique Protocol Identification Number
NCT01310907
Brief Title
Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia
Study Type
Observational

2. Study Status

Record Verification Date
March 2011
Overall Recruitment Status
Unknown status
Study Start Date
February 2011 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
China Medical University Hospital
Collaborators
China Medical University, China

4. Oversight

5. Study Description

Brief Summary
Bradyarrhythmia, including sinus node dysfunction and atrioventricular block, is a major cause necessitating pacemaker implantation. In contrast to familial bradyarrhythmia known as by mutations at particular ion channels, limited information is available for the mechanistic study in non-familial bradyarrhythmia. Possible gene polymorphisms related to non-familial bradyarrhythmia were studied. Comparison of multi-locus analysis and single-locus analysis will be analyzed between the cases and controls. Functional studies will perform to clarify the results of association study.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Bradyarrhythmia

7. Study Design

Enrollment
400 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
sinus node dysfunction
Arm Title
Atrioventricular block
Arm Title
control

10. Eligibility

Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: The patients with non-familial bradyarrhythmia Exclusion Criteria: Familial bradyarrhythmia Reversible bradyarrhythmia Bradyarrhythmia after open heart surgery and severe organic heart diseases
Study Population Description
The case group include 200 patients and the control group include 200 patients.
Sampling Method
Probability Sample
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Jan-Yow Chen, MD
Phone
+422052121
Ext
2311
Email
janyow@ms77.hinet.net
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Organizational Affiliation
China Medical University Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
404
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Phone
+88622052121
Ext
2311
Email
janyow@ms77.hinet.net
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
404
Country
Taiwan
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD
Phone
+886-4-22052121
Ext
2311
Email
janyow@ms77.hinet.net
First Name & Middle Initial & Last Name & Degree
Jan-Yow Chen, MD

12. IPD Sharing Statement

Citations:
PubMed Identifier
10706901
Citation
Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. doi: 10.1056/NEJM200003093421006. No abstract available.
Results Reference
background
Links:
URL
http://www.hrsonline.org/
Description
Heart Rhythm Society

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Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia

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