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Circadian Sleep-wake Cycles and Light Therapy in Borderline Personality Disorder

Primary Purpose

Borderline Personality Disorder, Sleep Disturbances, Depression

Status
Completed
Phase
Not Applicable
Locations
Switzerland
Study Type
Interventional
Intervention
light therapy
Sponsored by
University Hospital, Basel, Switzerland
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional trial for Borderline Personality Disorder focused on measuring Circadian rhythms, Sleep-wake cycles, Melatonin, Borderline Personality Disorder, Light therapy

Eligibility Criteria

20 Years - 45 Years (Adult)Female

Inclusion Criteria:

  • Borderline Personality Disorder (DSM IV-criteria)
  • German-speaking
  • normal ocular function

Exclusion Criteria:

  • lack of compliance

Sites / Locations

  • Centre for Chronobiology, Psychiatric Hospital, University of Basel

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

light therapy

Arm Description

Morning bright light treatment (at 8000 lux for 40min, daily during 3 weeks)

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
March 3, 2011
Last Updated
March 7, 2011
Sponsor
University Hospital, Basel, Switzerland
Collaborators
Velux Fonden, Lumie UK
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1. Study Identification

Unique Protocol Identification Number
NCT01311193
Brief Title
Circadian Sleep-wake Cycles and Light Therapy in Borderline Personality Disorder
Official Title
Circadian Sleep-wake Cycles, Well-being and Light Therapy in Borderline Personality Disorder
Study Type
Interventional

2. Study Status

Record Verification Date
March 2011
Overall Recruitment Status
Completed
Study Start Date
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Primary Completion Date
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Study Completion Date
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3. Sponsor/Collaborators

Name of the Sponsor
University Hospital, Basel, Switzerland
Collaborators
Velux Fonden, Lumie UK

4. Oversight

5. Study Description

Brief Summary
Individuals with borderline personality disorder (BPD) frequently suffer from emotional instability, daytime fatigue and sleep disturbances. The investigators examined circadian rhythms, sleep and well-being in women with BPD under their habitual life conditions with and without light treatment. Treated women diagnosed with BPD were investigated during 3 weeks without and 3 weeks with morning LT. Rest-activity cycles were continuously measured using wrist actigraphy, together with proximal skin temperature. Saliva samples were collected weekly to determine the diurnal melatonin rhythm. A range of self-ratings and questionnaires were used to assess depression and clinical state throughout the 6-week protocol. Ten matched healthy women followed the same 6-week protocol without light treatment.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Borderline Personality Disorder, Sleep Disturbances, Depression
Keywords
Circadian rhythms, Sleep-wake cycles, Melatonin, Borderline Personality Disorder, Light therapy

7. Study Design

Study Phase
Not Applicable

8. Arms, Groups, and Interventions

Arm Title
light therapy
Arm Type
Experimental
Arm Description
Morning bright light treatment (at 8000 lux for 40min, daily during 3 weeks)
Intervention Type
Other
Intervention Name(s)
light therapy
Intervention Description
early morning exposures to bright light, 8000lux for 40min, daily during 3 weeks

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
45 Years
Eligibility Criteria
Inclusion Criteria: Borderline Personality Disorder (DSM IV-criteria) German-speaking normal ocular function Exclusion Criteria: lack of compliance
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Christian Cajochen, PhD
Organizational Affiliation
Centre for Chronobiology, Psychiatric Hospital, University of Basel
Official's Role
Principal Investigator
Facility Information:
Facility Name
Centre for Chronobiology, Psychiatric Hospital, University of Basel
City
Basel
State/Province
BS
ZIP/Postal Code
4012
Country
Switzerland

12. IPD Sharing Statement

Links:
URL
http://www.chronobiology.ch
Description
Related Info

Learn more about this trial

Circadian Sleep-wake Cycles and Light Therapy in Borderline Personality Disorder

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