Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation

This is an interventional basic science trial for Cystic Fibrosis focused on measuring broccoli sprouts, sulforaphane, triterpenoid, Nrf2 activation, cystic fibrosis, healthy volunteers, anti-inflammatory Read More

Inclusion Criteria:

• Healthy volunteers and patients with cystic fibrosis ≥ 18 < 50 years of age
• Healthy volunteers must be in general good health as determined by a medical history
• CF subjects must have a documented diagnosis of CF (positive sweat chloride ≥ 60 mEq/liter, by pilocarpine iontophoresis) and/or a genotype with two identifiable mutations consistent with CF accompanied by one or more clinical features with the CF) phenotype
• CF subjects must have a baseline FEV1 percent predicted > 50% (in the last year, obtained from medical record)
• CF subjects must be clinically stable: free of any acute illness for > 14 days CF subjects must not have been prescribed any new systemic antibiotics for the 14 days prior to enrollment
• Ability to provide written informed consent
• Ability to adhere to the protocol

Exclusion Criteria:

• Use of NSAIDS (e.g., ibuprofen) or corticosteroids including inhaled steroids for the 4 weeks prior to enrollment
• Active gingival disease (active tooth or gum disease)
• History of nephrolithiasis or cholelithiasis
• Allergy to broccoli
• Any chronic condition that compromises the participant as determined by medical history
• Pregnancy
• Inability to tolerate the study procedures
• CF subjects: Infected with B. cepacia