Back to resultsA Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors
Primary Purpose
Rheumatoid Arthritis
Status
Completed
Phase
Phase 4
Locations
International
Study Type
Interventional
Intervention
Etanercept
Tocilizumab
Sponsored by
About this trial
This is an interventional treatment trial for Rheumatoid Arthritis
Eligibility Criteria
Inclusion Criteria:
- Participants with moderate to severe RA of greater than or equal to (>=6) months duration
- Inadequate response to at least one non-biologic DMARD
- Positive for Rheumatoid Factor (RF) and/or anti-cyclic citrullinated peptide (CCP) antibodies at screening
- Have C-reactive protein (CRP) greater than (>) 0.3 milligrams per deciliter (mg/dL) at screening or at the baseline visit
- Swollen joint count (SJC) >=8 (66 joint count) and tender joint count (TJC) >= 8 (68 joint count) during screening or at the baseline visit
- History of Coronary Heart Disease (CHD) or presence of one or more additional CHD risk factors, including current cigarette smoking, hypertension, low High Density Lipoprotein (HDL) cholesterol, family history of premature CHD, diabetes, presence of extra-articular disease associated with rheumatoid arthritis
- At the time of randomization, will have discontinued infliximab, adalimumab, golimumab, or certolizumab for >= 4 weeks
Exclusion Criteria:
- Major surgery (including joint surgery or coronary revascularization) within 8 weeks prior to screening or planned major surgery within 1 year of study start
- Rheumatic autoimmune disease other than RA
- History of or current inflammatory joint disease other than RA
- Current or recent (within past 3 months) evidence of serious uncontrolled concomitant cardiovascular or cerebrovascular disease (myocardial infarction, revascularization, stroke, transient ischemic attack, or acute coronary syndrome)
- Current or previous (within the past 2 years) evidence of serious uncontrolled concomitant pulmonary (including obstructive pulmonary disease), renal, hepatic, endocrine (including uncontrolled diabetes mellitus) or gastrointestinal disease
- Uncontrolled disease states, such as asthma or inflammatory bowel disease where flares are commonly treated with oral or parenteral corticosteroids
- Pre-existing central nervous system demyelinating or seizure disorders
- History of diverticulitis, diverticulosis requiring treatment or other lower gastrointestinal tract conditions that might predispose to perforations
- Current liver disease as determined by the investigator; a history of asymptomatic elevations in liver function tests (LFTs) is not considered an exclusion
- Active current infection or history of recurrent bacterial, viral, fungal, mycobacterial or other infections, including but not limited to tuberculosis and atypical mycobacterial disease, hepatitis B and C, and herpes zoster, but excluding fungal infections of nail beds
- Any major episode of infection requiring hospitalization or treatment with IV antibiotics within four weeks of screening or oral antibiotics within two weeks prior to screening visit
- Active tuberculosis (TB) requiring treatment within 3 years prior to baseline
- Latent TB diagnosed during screening that has not been appropriately treated
- Primary or secondary immunodeficiency (history of or currently active)
- Moderate to severe heart failure
- Evidence of active malignant disease, malignancies diagnosed within the previous 10 years (including hematologic malignancies and solid tumors, except basal cell carcinoma of the skin that has been excised and cured), or breast cancer diagnosed within the previous 20 years
- Breast feeding mothers
- History of alcohol, drug or chemical abuse within the 6 months prior to screening
- Participants with lack of peripheral venous access
- Participants with a history of allergic reactions to latex
- Previous treatment with non-tumor necrosis factor (non-TNF)-inhibitor biologic therapy
- Treatment with any investigational agent within 4 weeks of screening visit
- Treatment with any cell depleting therapies within 1 year of baseline
- Treatment with IV gamma globulin, plasmapheresis or Prosorba column within 6 months of baseline visit
- Immunization with a live/attenuated vaccine within 4 weeks prior to baseline visit
- Any previous treatment with alkylating agents, such as cyclophosphamide or chlorambucil, or with total lymphoid irradiation
Sites / Locations
- Uni Of Alabama,Birmingham; Medicine - Rheumatology
- Rheumatology Associates of North Alabama
- Clinical and Translational Research Center of Alabama, PC
- Arizona Arthritis & Rheumatology Associates, P.C.
- Arizona Arthritis & Rheumatology Research, Pllc
- Sun Valley Arthritis Center
- Valley Arthritis Care
- Advanced Arthritis Care & Research
- Camp Lowell Medical Specialists
- The University of Arizona
- NEA Baptist Clinic
- OrthoArkansas; Orthopedics & Sports Medicine
- Samy Metyas, MD, Inc
- Talbert Medical Group
- Allergy & Rheumatology Medical Clinic, Inc
- Valerius Medical Group
- Clinical Interventions Research Institute
- Dr. Brigid Freyne, MD
- Sharp Rees-Stealy Medical Group
- San Diego Arthritis Med Clnc
- Purushotham & Akther Kotha Inc
- C Michael Neuwelt MD Inc
- Pacific Arthritis Ctr Med Grp
- Orrin M. Troum, Md
- Harbor UCLA Medical Center
- Inland Rheumatology; Clinical Trials, Inc.
- Medvin Clinical Research
- Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs
- Joao Nascimento
- University of Connecticut Health Center
- Arthritis & Osteoporosis Center Pc
- ZASA Clinical Research
- DC Health Clinic
- Tsai, Yong
- Jacksonville Center For Clinical Research
- Pharmax Research Clinic Inc.
- Arthritis/Osteoporosis Treatment Center
- Arthritis Rsrch of Florida, Inc.
- Baptist Hospital Clinical Research
- Pinellas Medical Research, LLC
- Lovelace Scientific Resources
- Centre for Arthritis and Rheumatic Diseases
- SW Florida Clinical Research
- Healthpoint Medical group, Inc
- Emory Uni ; Division of Rheumatology
- Arthritis & Rheumatology of Georgia
- North Georgia Rheumatology
- Harbin Clinic
- St. Joseph'S/Candler Health System, Inc.; Office of Research
- Sonora Clinical Research
- St. Luke's Intermountain Research Center
- Selah Medical Ctr
- Coeur D'Alene Arthritis Clinic
- Idaho Arthritis Center
- University of Illinois at Chicago
- Apex Medical Research, AMR, Inc.
- Methodist Medical Center of Ilinois
- Northern Indiana Research Alliance
- Diagnostic Rheumatology & Research
- Memorial Medical Group Clinical Research
- Graves Gilbert Clinic
- Research Integrity
- Arthritis & Diabetes Clinic, Inc
- Ochsner Health System
- Rheumatology Associates of Baltimore
- Osteoporosis & Clinical Trials Center
- Center For Rheumatology & Bone Research
- Phase Iii Clinical Research
- UMass Memorial Medical Center
- Clinical Pharmacology Study Group
- Hurley Research Center
- Rheumatology, P.C.; Medical Arts Building
- Advanced Rheumatology, PC
- Northern Michigan Regional Hospital
- St. Paul Rheumatology
- Va Medical Center
- Mayo Clinic Rochester
- Jackson Arthritis Clinic
- North Mississippi Med Clinics, Inc.
- Glacier View Research Institute
- Univ of Nebraska Medical Ctr
- Advanced Biomedical Research of America
- Innovative Health Research
- Dartmouth-Hitchcock Medical Center, Rheumatology 5C
- Nashua Rheumatology - Foundation Medical Partners
- Summit Medical Group
- Rheumatology Associates Of New Jersey
- Arthritis Rheumatic & Back Disease Associates
- Albuquerque Center For Rheumatology
- Arthritis and Osteoporosis Associates of New Mexico
- Arthritis & Osteoporosis Medical Associates, Pllc
- SUNY Downstate Medical Center.
- DiGiovanna Inst for Med Ed&Res
- Southern Tier Arthritis & Rheumatism
- Arthritis Health Associates; Clinical Research
- Asheville Arthritis & Osteoporosis Center, PA
- Joint & Muscle Research Institute
- Carolina Bone & Joint P.A.
- Durham Rheumatology
- PMG Research of Hickory LLC
- Shanahan Rheumatology & Immunology, PLLC
- Specialty Medical Clinic and Research Center
- Carolina Arthritis Associates, Pa
- Trinity Health Center
- Cincinnati Rheumatic Disease Study Group
- University Hospitals Case Medical Center
- Ohio State Univ Med Center
- Columbus Arthritis Center
- Clinical Research Source, Inc.
- Toledo Clinic
- Lynn Health Science Institute
- Altoona Center For Clinical Research
- Penn State Milton S. Hershey Medical Center
- Ilumina Clinical Associates
- PMA Medical Specialists
- Pivotal Clinical Research, Llc
- Arthritis Group
- University of Pittsburgh Medical Center Health System; Infectious Disease
- Allegheny Rheumatology
- Clinical Research Center of Reading
- Pennsylvania Regional Center for Arthritis and Osteoporosis Research
- Columbia Arthritis Center (Partnership Practice)
- South Carolina Research Center
- Brown Clinic
- Ramesh Gupta - PP
- Amarillo Center For Clinical Research
- Adriana Pop-Moody MD Clinic PA
- Metroplex Clinical Research
- Leading Edge Research, PA; Office of Dr. Burbano
- Rheumatic Disease Clin Res Ctr
- Houston Inst. For Clinical Research
- Southwest Rheumatology
- Leading Edge Research, PA; Office of Dr. Burbano
- Texas Arthritis Research Center
- Arthritis & Osteoporosis Clinic
- Arthritis and Rheumatic Disease Associates
- Sentara Medical Group
- Apex Clinical Research
- Seattle Rheumatology Associates
- Office of George Krick, Md
- Rheum & Pulmonary Clinic
- Mountain State Clinical Research
- Arthritis Centre; Suite 103
- Organizacion Medica de Investigacion
- CEIM Consultorios Especializados en Investigaciones Médicas
- APRILLUS
- Instituto centenario
- Fundación CIDEA
- Atencion Integral En Reumatologia Buenos Aires
- CEMIC
- Hospital General de Agudos Dr. J. M. Ramos Mejia
- Hospital Britanico de Buenos Aires
- Centro de Investigaciones Reumatologicas y Osteologicas
- Hospital Privado Cordoba
- Instituto Reumatológico Strusberg
- Hospital Italiano de Cordoba
- Centro de Investigaciones Médicas - CIM
- Hospital Municipal Nuestra Sra. de Lujan
- Centro de Investigacion Pergamino SA
- Instituto Centralizado de Asistencia e Investigaci
- Sanatorio Parque de Rosario
- CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica
- Centro Médico Privado de Reumatología
- Centro de Investigaciones Reumatologicas Tucuman
- Lkh-Univ. Klinikum Graz
- Landesklinikum Weinviertel Stockerau; Rheumatologie
- Medizinische Universität Wien
- Rheuma-Zentrum Favoriten Wien
- Krankenhaus Hietzing; 2.Med.Abteilung, Pav.3A
- CHU St Pierre (St Pierre)
- Cliniques Universitaires St-Luc
- AZ Groeninge (Vercruysselaan)
- CHU Sart-Tilman
- ZNA Jan Palfijn
- University Clinical Center of the Republic of Srpska
- University Clinic Ctr Sarajevo
- General Hospital Prim.dr.Abdulah Nakas
- Uni Hospital Center Tuzla
- Royal Alexandra Hospital
- The Medical Arts Health Research Group
- Baker, Milton F.
- Nexus Clinical Research Centre
- St. Clare'S Mercy Hospital
- Arthur Karasik, MD
- Charlton Medical Center
- K-W Musculoskeletal Research
- St. Joseph's Hospital
- Credit Valley, Rheumatology
- Niagara Peninsula Arthritis Centre
- Mount Sinai Hospital
- Institut de Rhumatologie de Montreal
- Groupe de Recherche En Rhumatologie Et Maladies Osseuses
- Chus Hopital Fleurimont
- Centre de Recherche Musculo-Squelettique
- Centre Re Recherche Saint-Louis
- Hospital San Juan de Dios La Serena
- Centro Medico Prosalud
- Interin
- Centro de Estudios Reumatológicos
- Hospital Clinico Pontificia Universidad Catolica de Chile
- Centro de Investigacion Clinica del Sur
- Clinica Alemana de Temuco
- Hospital Clinico Viña del Mar- Oncovida
- Centro de Estudios Clinicos V Region Limitada
- General Hospital Karlovac
- Special Hospital for Medical Rehabilitation
- Clinical Hospital Centre Rijeka; Department of Rheumatology and Clinical Immunology
- Clinical Hospital Centre Zagreb
- Universtiy Hospital Dubrava
- Fakultni nemocnice u sv. Anny v Brne
- Revmatologicka ambulance
- Revmatologicka Ambulance
- Interni a revmatologicka ordinace
- Revmatologicka a-interni ambulance
- Revmatologie MUDr. Klara Sirova s.r.o.
- Revmatologicka ambulance
- Revmatologicky Ustav
- Fakultni Thomayerova nemocnice s poliklinikou
- Artroscan s.r.o.
- Revmatologicka Ambulance-Terezin
- PV - Medical, s.r.o.
- Hospital Clínica Santa Inés
- Centro de Reumatología y Rehabilitación
- OMNI Hospital
- Centro Medico Alcivar 4
- Centro Medico Picasso
- Novaclinica Santa Cecilia; Reumatology
- CHU d'Amiens Hôpital Nord; Pharmacie Clinique
- Groupe Hospitalier Pellegrin
- CHU Hopital Gabriel Montpied
- Centre Hospitalier Sud Francilien
- CHU Grenoble Sud
- Hôpital Edouard Herriot; Service de Rhumatologie
- CHR Orleans, Hopital Madeleine
- Hôpital Saint-Antoine; Service de Psychiatrie
- Groupe Hospitalier Pitie-Salpetriere
- Hopital Cochin; Gastro Enterologie
- Hôpital Sud - CHU de Rennes
- Hôpital Victor Provo
- CHU de Rouen, Hopital de Bois Guillaume; Service de Rhumatologie
- CHU Saint-Etienne, Hopital Bellevue
- Hôpital General - CHRU de Dijon
- Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O)
- Charité Universitaetsmedizin Berlin, Campus Charité Mitte
- Schlosspark-Klinik
- Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden
- Universitätsklinikum Erlangen; Augenklinik
- Praxisgemeinschaft Rheumatologie-Nephrologie Erlangen PGRN
- Universitaetsklinikum Frankfurt
- Universitaetsklinikum Hamburg-Eppendorf; Medizinische Klinik Nephrologie/Rheumatologie
- Schön Klinik Hamburg-Eilbek Klinik für Rheumatologie
- Rheumazentrum Ruhrgebiet; St. Josefs-Krankenhaus
- Gemeinschaftspraxis Dr. Von Hinueber/Dr. Demary; Rheumatologie
- Universitätsklinikum Köln, Klinik I für Innere Medizin
- Universitaetsklinikum Leipzig
- Praxiszentrum St. Bonifatius
- Ludwig Maximilians; Universitaet
- Rheumatologische Gemeinschaftspraxis
- Evangelisches Fachkrankenhaus
- Laiko General Hospital Athen
- Euroclinic of Athens; Internal Medicine & Immunology Dept.
- University General Hospital of Heraklion
- University General Hospital of Larissa; Rheumatology Unit
- General Hospital of Thessaloniki Hippokration
- Euromedica Kyanous Stavros General Hospital
- 424 Military Training Hospital-Egnatia
- Országos Fizioterápiás És Reumatológiai Intézet; I. Reumatológiai És Metabolikus Osteológiai Osztály
- Clinexpert Egeszsegugyi Szolgaltato es Kereskedelmi Kft
- Obudai Egeszsegugyi Centrum Kft.
- Synexus Magyarorszag Kft
- Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika
- Markhot Ferenc Eu. Szolg. Nonprofit Kiem. Kozh. Kft.
- Bekes Megyei Kepviselotestulet Pandy Kalman Korhaza
- Varosi Korhaz-Rendelointezet
- Fejer Megyei Szent Gyorgy Korhaz
- Clinfan Szolgaltato Kft.
- Zala Megyei Korhaz; Reumatologia
- Shalby Hospital Limited
- Vedanta Institute; Medical Sciences
- Manipal Hospital
- St.John's Medical College Hospital
- Arthritis Super Speciality Centre
- Care Institute of Medical Sciences
- Jasleen Hospital
- Barzilai Medical Center
- Assaf Harofeh Medical Center
- The Lady Davis Carmel Medical Center
- Chaim Sheba Medical Center; Rheumatology
- Tel-Aviv Sourasky Medical Center
- Azienda Ospedaliera A. Cardarelli
- Ospedale San Giovanni Bosco; Divisione di Reumatologia
- Fondazione Salvatore Maugeri IRCCS; Istituto Scientifico di Riabilitazione di Telese
- Ospedale La Colletta
- Azienda Ospedaliero Universitaria San Martino
- Ospedali Riuniti di Bergamo
- Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia
- Ospedale Di Circolo E Fondazione Macchi
- Presidio Ospedaliero Vittorio Emanuele
- Azienda Ospedaliera Universitaria Careggi
- Ospedale Misericordia e Dolce
- L.Krumina GP practice
- Daugavpils Regional Hospital
- D.Saulite-Kandevica Private Practice
- Clinic ORTO
- Private Practice EHOKG
- Riga East Clinical University Hospital; Clinic Gailezers
- P. Stradins Clinical University Hospital
- Alytus Regional S. Kudirkos Hospital, Public Institution
- Klaipeda Seamen's Hospital, Public Institution
- Klaipeda University Hospital; Public Institution
- Siauliai Republican Hospital Public Institution
- Vilnius District Central Outpatient Clinic, Public Institution
- Hospital Raja Permaisuri Bainun
- Hospital Selayang
- Hospital Umum Sarawak
- Hospital Pulau Pinang
- Sunway Medical Centre
- Sime Darby Medical Centre
- Centro de Investigacion del Noroeste SC
- Centro de Investigación de Tratamientos Innovadores de Sinaloa (CITI)
- Unidad de Atencion Medica e Investigacion en Salud S.C.
- Hospital Christus Muguerza del Parque; Reumatologia
- Hospital CIMA Chihuahua; Reumatologia
- Hospital Privado San Jose de Ciudad Obregon SA de CV
- Private Practice Dr. Cortes
- RM pharma specialist SA de CV
- Mentrials S.A. de C.V
- Centro de Investigacion y Atencion Integral Durango CIAID
- Mundo Fisico
- Clinica Hospital Angeles Chapalita
- Centro de Investigacion en Enfermedades Reumaticas y Osteoporosis
- Inst. Mexicano de Investigacion Clinica
- Instituto Nacional de Cardiologia Ignacio Chavez
- Hospital Mocel
- Mexico Centre for Clinical Research
- Comite Mexicano Para la Prevencion de Osteoporosis AC
- Cliditer SA de CV
- Hospital Universitario de Saltillo
- Hospital Central Dr. Ignacio Morones Prieto
- Centro de Alta Especialidad en Reumatología e Investigación del Potosí, S.C.
- Unidad de Enfermedades Reumaticas y Cronicodegenerativas
- Jan Van Breemen Instituut
- Albert Schweitzer Ziekenhuis ; Dordwijk
- Franciscus Ziekenhuis
- Vlietland Hospital
- Cebu Doctors' University Hospital- North General Hospital
- Chong Hua Hospital, Cebu City
- St. Paul Hospital; Arthritis Center
- Mary Mediatrix Medical Center
- Makati Medical Center
- Szpital Uniwersytecki; nr 2 im. Dr J. Biziela
- Wojewodzki Szpital Zespolony w Elblagu
- Szpital Specjalistyczny Im J. Dietla Malopolskie Centrum Reumat; Oddzial Rumatologii
- Szpital Specjalistyczny im. J. Dietla
- NZOZ REUMED Sp. z o.o.
- Lecznica MAK-MED NZOZ
- SP Szpital Kliniczny nr 1 Pomorskiej Akademii Medycznej im. prof. Tadeusza Sokolowskiego
- Slaski Szpital Reumatologiczno; Rehabilitacyjny; Iii Oddzial Reumatologiczny
- Rheuma Medicus Zaklad Opieki Zdrowotnej
- ARS Rheumatica Sp.z o. o
- Akademicki Szpital Kliniczny im. Jana Mikulicza Radeckiego
- Spitalul Clinic Judetean de Urgenta Brasov
- Spitalul Clinic Dr. I Cantacuzino
- Spitalul Clinic Sf. Maria; Dept Interna si Reumatologie
- Centrul de Boli Reumatismale Dr. Ioan Stoia
- Medex SRL
- Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Clinica de Medicina Muncii
- CMI Dr.Ciornohuz Adriana
- Spitalul Clinic de Recuperare Iasi
- Spitalul Municipal Ploiesti
- Spitalul Clinic Colentina
- Spitalul Judetean de Urgenta Targoviste
- Mediab SRL
- Spitalul Clinic Municipal de Urgenta Timisoara
- State institution of health care - Territorial Clinical Hospital
- SEI of HPE "Altay State Medical University of Roszdrav"
- Scientific and research medical complex Your Health
- SIH Kemerovo Regional Clinical Hospital
- City Hospital No.4
- Scient Res Inst Rheumat RAMS
- Moscow State Medical Stomatological University
- Head Clinical Hospital of Internal Affair Ministry of Russia
- MHI City Clinical Hospital#19
- FSBI Scientific Research Institute of Clinical Immunology of SB of RAMS
- Ryazan Regional Clinincal Cardiology Dispensary
- State institution of healthcare "Regional hospital for war veterans"
- Leningradskaya Regional Clinical Hospital; Rheumatology Dept
- Stavropol State Medical Academy
- Tomsk Regional Clinical Hospital
- Voronezh Regional Clinical Hospital #1
- MCHI Medical Sanitary Unit of Yaroslavl Diesel Apparatus Plant
- Institute of Rheumatology
- Military Medical Academy
- Clinical Center Bezanijska Kosa
- Institute of Rheumatology and Cardiovascular Diseases; Rheumatology
- Groote Schuur Hospital; Rheumatology Unit
- Chris Hani Baragwanath Hospital; Rheumatology Department
- Charlotte Maxeke Academic Hospital
- University of Pretoria; Clinical Trial Unit
- Hospital de Merida ;Servicio de Reumatologia
- Corporacio Sanitaria Parc Tauli
- Hospital Sierrallana
- Hospital Clinico Universitario de Santiago
- Hospital Infanta Sofia; Servicio de Reumatologia
- Hospital Regional Universitario Carlos Haya
- Hospital Universitario Virgen Macarena
- Hospital Universitario de Canarias
- Hospital de Cruces; Servicio de Reumatologia
- Hospital Universitario Basurto
- Hospital General de Castellon; Servicio de Reumatologia
- Hospital Gregorio Marañon
- Akdeniz Univesity Medical Faculty
- Trakya University Medical Faculty
- Ataturk University Med Faculty
- Karadeniz Tecnical Uni. Med. Fac.
- Selly Oak Hospital; Rheumatology Dept
- Addenbrooke's NHS Trust
- Cannock Chase Hospital; Rheumatology
- Russells Hall Hospital; Rheumatology Department
- Leicester Royal Infirmary NHS Trust
- Royal London Hospital Outpatients Department
- Whipps Cross Hospital; Rheumatology Dept
- King'S College Hospital
- Royal Victoria Infirmary
- Salford Royal NHS Foundation Trust
- Southampton General Hospital; Rheumatology
- Southend Hospital; Rheumatology Department
- Wrightington Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
Etanercept
Tocilizumab
Arm Description
Outcomes
Primary Outcome Measures
Time to First Cardiovascular (CV) Events Adjudication Committee (EAC) (CV-EAC) Adjudicated Event
Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke.
Percentage of Patients Reporting a Cardiovascular (CV) Events Adjudication Committee (EAC) (CV-EAC) Adjudicated Event
Percentage of patients reporting any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke
Time to First CV-EAC Adjudicated Event - Sensitivity Analysis
Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analysis
Percentage of Patients With a CV-EAC Adjudicated Event - Sensitivity Analysis
Percentage of patients with any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analysis
Time to First CV-EAC Adjudicated Event Excluding Undetermined Cause of Death - Sensitivity Analysis
Prospective comparison of time to first occurrence of any component of the composite of CV death (excluding events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analyses
Percentage of Patients With a CV-EAC Adjudicated Event Excluding Undetermined Cause of Death - Sensitivity Analysis
Percentage of patients with any component of the composite of CV death (excluding events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analyses
Time to First CV-EAC Adjudicated Event Before Last Direct Contact Date
Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke before last direct contact date (i.e., latest date of visit, IVRS call, or site call).
Percentage of Participants With a CV-EAC Adjudicated Event Before Last Direct Contact Date
Percentage of participants with any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke before last direct contact date (i.e., latest date of visit, IVRS call, or site call).
Secondary Outcome Measures
The Time to First Occurrence of an Expanded CV Composite Endpoint
Prospective comparison of the time to first ccurrence of the expanded composite endpoint. The expanded composite endpoint is defined as the CV composite of the primary endpoint with the addition of non-elective coronary revascularization procedures and hospitalization for unstable angina.
Percentages of Participants With an Expanded CV Composite Endpoint
Percentages of participants with the expanded CV composite endpoint. The expanded composite endpoint is defined as the CV composite of the primary endpoint with the addition of non-elective coronary revascularization procedures and hospitalization for unstable angina.
Time to First Occurrence of Individual Component of Primary Endpoint: Non-fatal Myocardial Infarction
Prospective comparison of time to first occurrence of Individual component of primary endpoint: non-fatal Myocardial Infarction
Percentage of Patients With Individual Component of Primary Endpoint: Non-fatal Myocardial Infarction
Percentage of patients reporting Individual component of primary endpoint: non-fatal Myocardial Infarction
Time to First Occurrence of Individual Component of Primary Endpoint: Cardiovascular Death
Prospective comparison of time to first occurrence of Individual component of primary endpoint: cardiovascular death
Percentage of Patients With Individual Component of Primary Endpoint: Cardiovascular Death
Percentage of patients reporting Individual component of primary endpoint: cardiovascular death
Time to First Occurrence of Individual Component of Primary Endpoint: Non-fatal Stroke
Prospective comparison of time to first occurrence of Individual component of primary endpoint: non-fatal stroke
Percentage of Patients With Individual Component of Primary Endpoint: Non-fatal Stroke
Time to First Occurrence of Individual Component of Primary Endpoint: All-cause Mortality
Prospective comparison of time to first occurrence of Individual component of primary endpoint: All-cause mortality
Percentage of Patients With Individual Component of Primary Endpoint: All-cause Mortality
Percentage of patients reporting Individual component of primary endpoint: All-cause mortality
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT01331837
Brief Title
A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors
Official Title
A Clinical Outcomes Study to Evaluate the Effects of IL-6 Receptor Blockade With Tocilizumab (TCZ) in Comparison With Etanercept (ETA) on the Rate of Cardiovascular Events in Patients With Moderate to Severe Rheumatoid Arthritis (RA)
Study Type
Interventional
2. Study Status
Record Verification Date
June 2017
Overall Recruitment Status
Completed
Study Start Date
August 2, 2011 (Actual)
Primary Completion Date
March 25, 2016 (Actual)
Study Completion Date
March 25, 2016 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hoffmann-La Roche
4. Oversight
5. Study Description
Brief Summary
This randomized, open-label, parallel-group, multicenter study will evaluate the rate of cardiovascular events with tocilizumab in comparison to etanercept in participants with rheumatoid arthritis (RA). Participants will be randomized to receive intravenous (IV) 8 milligrams per kilogram (mg/kg) tocilizumab every 4 weeks or subcutaneous 50 milligrams (mg) etanercept weekly, with or without non-biologic disease-modifying anti-rheumatic drug (DMARD).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Rheumatoid Arthritis
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
3080 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Etanercept
Arm Type
Active Comparator
Arm Title
Tocilizumab
Arm Type
Experimental
Intervention Type
Drug
Intervention Name(s)
Etanercept
Intervention Description
Participants will receive 50 mg etanercept subcutaneously weekly until switch to another RA therapy or up to 4.9 years.
Intervention Type
Drug
Intervention Name(s)
Tocilizumab
Other Intervention Name(s)
Actemra
Intervention Description
Participants will receive 8 mg/kg tocilizumab IV every 4 weeks until switch to another RA therapy or up to 4.9 years.
Primary Outcome Measure Information:
Title
Time to First Cardiovascular (CV) Events Adjudication Committee (EAC) (CV-EAC) Adjudicated Event
Description
Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke.
Time Frame
From baseline up to 4.9 years
Title
Percentage of Patients Reporting a Cardiovascular (CV) Events Adjudication Committee (EAC) (CV-EAC) Adjudicated Event
Description
Percentage of patients reporting any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke
Time Frame
From baseline up to 4.9 years
Title
Time to First CV-EAC Adjudicated Event - Sensitivity Analysis
Description
Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analysis
Time Frame
From Baseline up to 4.9 years
Title
Percentage of Patients With a CV-EAC Adjudicated Event - Sensitivity Analysis
Description
Percentage of patients with any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analysis
Time Frame
From Baseline up to 4.9 years
Title
Time to First CV-EAC Adjudicated Event Excluding Undetermined Cause of Death - Sensitivity Analysis
Description
Prospective comparison of time to first occurrence of any component of the composite of CV death (excluding events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analyses
Time Frame
From baseline up to 4.9 years
Title
Percentage of Patients With a CV-EAC Adjudicated Event Excluding Undetermined Cause of Death - Sensitivity Analysis
Description
Percentage of patients with any component of the composite of CV death (excluding events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke - Sensitivity Analyses
Time Frame
From baseline up to 4.9 years
Title
Time to First CV-EAC Adjudicated Event Before Last Direct Contact Date
Description
Prospective comparison of time to first occurrence of any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke before last direct contact date (i.e., latest date of visit, IVRS call, or site call).
Time Frame
From Baseline up to 4.9 years
Title
Percentage of Participants With a CV-EAC Adjudicated Event Before Last Direct Contact Date
Description
Percentage of participants with any component of the composite of CV death (including events adjudicated as 'Undetermined Cause of Death'), non-fatal myocardial infarction, or non-fatal stroke before last direct contact date (i.e., latest date of visit, IVRS call, or site call).
Time Frame
From Baseline up to 4.9 years
Secondary Outcome Measure Information:
Title
The Time to First Occurrence of an Expanded CV Composite Endpoint
Description
Prospective comparison of the time to first ccurrence of the expanded composite endpoint. The expanded composite endpoint is defined as the CV composite of the primary endpoint with the addition of non-elective coronary revascularization procedures and hospitalization for unstable angina.
Time Frame
From baseline up to 4.9 years
Title
Percentages of Participants With an Expanded CV Composite Endpoint
Description
Percentages of participants with the expanded CV composite endpoint. The expanded composite endpoint is defined as the CV composite of the primary endpoint with the addition of non-elective coronary revascularization procedures and hospitalization for unstable angina.
Time Frame
From baseline up to 4.9 years
Title
Time to First Occurrence of Individual Component of Primary Endpoint: Non-fatal Myocardial Infarction
Description
Prospective comparison of time to first occurrence of Individual component of primary endpoint: non-fatal Myocardial Infarction
Time Frame
From baseline up to 4.9 years
Title
Percentage of Patients With Individual Component of Primary Endpoint: Non-fatal Myocardial Infarction
Description
Percentage of patients reporting Individual component of primary endpoint: non-fatal Myocardial Infarction
Time Frame
From baseline up to 4.9 years
Title
Time to First Occurrence of Individual Component of Primary Endpoint: Cardiovascular Death
Description
Prospective comparison of time to first occurrence of Individual component of primary endpoint: cardiovascular death
Time Frame
From baseline up to 4.9 years
Title
Percentage of Patients With Individual Component of Primary Endpoint: Cardiovascular Death
Description
Percentage of patients reporting Individual component of primary endpoint: cardiovascular death
Time Frame
From baseline up to 4.9 years
Title
Time to First Occurrence of Individual Component of Primary Endpoint: Non-fatal Stroke
Description
Prospective comparison of time to first occurrence of Individual component of primary endpoint: non-fatal stroke
Time Frame
From baseline up to 4.9 years
Title
Percentage of Patients With Individual Component of Primary Endpoint: Non-fatal Stroke
Time Frame
From baseline up to 4.9 years
Title
Time to First Occurrence of Individual Component of Primary Endpoint: All-cause Mortality
Description
Prospective comparison of time to first occurrence of Individual component of primary endpoint: All-cause mortality
Time Frame
From baseline up to 4.9 years
Title
Percentage of Patients With Individual Component of Primary Endpoint: All-cause Mortality
Description
Percentage of patients reporting Individual component of primary endpoint: All-cause mortality
Time Frame
From baseline up to 4.9 years
10. Eligibility
Sex
All
Minimum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Participants with moderate to severe RA of greater than or equal to (>=6) months duration
Inadequate response to at least one non-biologic DMARD
Positive for Rheumatoid Factor (RF) and/or anti-cyclic citrullinated peptide (CCP) antibodies at screening
Have C-reactive protein (CRP) greater than (>) 0.3 milligrams per deciliter (mg/dL) at screening or at the baseline visit
Swollen joint count (SJC) >=8 (66 joint count) and tender joint count (TJC) >= 8 (68 joint count) during screening or at the baseline visit
History of Coronary Heart Disease (CHD) or presence of one or more additional CHD risk factors, including current cigarette smoking, hypertension, low High Density Lipoprotein (HDL) cholesterol, family history of premature CHD, diabetes, presence of extra-articular disease associated with rheumatoid arthritis
At the time of randomization, will have discontinued infliximab, adalimumab, golimumab, or certolizumab for >= 4 weeks
Exclusion Criteria:
Major surgery (including joint surgery or coronary revascularization) within 8 weeks prior to screening or planned major surgery within 1 year of study start
Rheumatic autoimmune disease other than RA
History of or current inflammatory joint disease other than RA
Current or recent (within past 3 months) evidence of serious uncontrolled concomitant cardiovascular or cerebrovascular disease (myocardial infarction, revascularization, stroke, transient ischemic attack, or acute coronary syndrome)
Current or previous (within the past 2 years) evidence of serious uncontrolled concomitant pulmonary (including obstructive pulmonary disease), renal, hepatic, endocrine (including uncontrolled diabetes mellitus) or gastrointestinal disease
Uncontrolled disease states, such as asthma or inflammatory bowel disease where flares are commonly treated with oral or parenteral corticosteroids
Pre-existing central nervous system demyelinating or seizure disorders
History of diverticulitis, diverticulosis requiring treatment or other lower gastrointestinal tract conditions that might predispose to perforations
Current liver disease as determined by the investigator; a history of asymptomatic elevations in liver function tests (LFTs) is not considered an exclusion
Active current infection or history of recurrent bacterial, viral, fungal, mycobacterial or other infections, including but not limited to tuberculosis and atypical mycobacterial disease, hepatitis B and C, and herpes zoster, but excluding fungal infections of nail beds
Any major episode of infection requiring hospitalization or treatment with IV antibiotics within four weeks of screening or oral antibiotics within two weeks prior to screening visit
Active tuberculosis (TB) requiring treatment within 3 years prior to baseline
Latent TB diagnosed during screening that has not been appropriately treated
Primary or secondary immunodeficiency (history of or currently active)
Moderate to severe heart failure
Evidence of active malignant disease, malignancies diagnosed within the previous 10 years (including hematologic malignancies and solid tumors, except basal cell carcinoma of the skin that has been excised and cured), or breast cancer diagnosed within the previous 20 years
Breast feeding mothers
History of alcohol, drug or chemical abuse within the 6 months prior to screening
Participants with lack of peripheral venous access
Participants with a history of allergic reactions to latex
Previous treatment with non-tumor necrosis factor (non-TNF)-inhibitor biologic therapy
Treatment with any investigational agent within 4 weeks of screening visit
Treatment with any cell depleting therapies within 1 year of baseline
Treatment with IV gamma globulin, plasmapheresis or Prosorba column within 6 months of baseline visit
Immunization with a live/attenuated vaccine within 4 weeks prior to baseline visit
Any previous treatment with alkylating agents, such as cyclophosphamide or chlorambucil, or with total lymphoid irradiation
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Trials
Organizational Affiliation
Hoffmann-La Roche
Official's Role
Study Director
Facility Information:
Facility Name
Uni Of Alabama,Birmingham; Medicine - Rheumatology
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
Rheumatology Associates of North Alabama
City
Huntsville
State/Province
Alabama
ZIP/Postal Code
35801
Country
United States
Facility Name
Clinical and Translational Research Center of Alabama, PC
City
Tuscaloosa
State/Province
Alabama
ZIP/Postal Code
35406
Country
United States
Facility Name
Arizona Arthritis & Rheumatology Associates, P.C.
City
Glendale
State/Province
Arizona
ZIP/Postal Code
85306
Country
United States
Facility Name
Arizona Arthritis & Rheumatology Research, Pllc
City
Paradise Valley
State/Province
Arizona
ZIP/Postal Code
85253
Country
United States
Facility Name
Sun Valley Arthritis Center
City
Peoria
State/Province
Arizona
ZIP/Postal Code
85381
Country
United States
Facility Name
Valley Arthritis Care
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85027
Country
United States
Facility Name
Advanced Arthritis Care & Research
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85258
Country
United States
Facility Name
Camp Lowell Medical Specialists
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85715
Country
United States
Facility Name
The University of Arizona
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85724
Country
United States
Facility Name
NEA Baptist Clinic
City
Jonesboro
State/Province
Arkansas
ZIP/Postal Code
72401
Country
United States
Facility Name
OrthoArkansas; Orthopedics & Sports Medicine
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72205
Country
United States
Facility Name
Samy Metyas, MD, Inc
City
Covina
State/Province
California
ZIP/Postal Code
91723
Country
United States
Facility Name
Talbert Medical Group
City
Huntington Beach
State/Province
California
ZIP/Postal Code
92646
Country
United States
Facility Name
Allergy & Rheumatology Medical Clinic, Inc
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Valerius Medical Group
City
Los Alamitos
State/Province
California
ZIP/Postal Code
90720
Country
United States
Facility Name
Clinical Interventions Research Institute
City
Mission Viejo
State/Province
California
ZIP/Postal Code
92692
Country
United States
Facility Name
Dr. Brigid Freyne, MD
City
Murrieta
State/Province
California
ZIP/Postal Code
92563
Country
United States
Facility Name
Sharp Rees-Stealy Medical Group
City
Poway
State/Province
California
ZIP/Postal Code
92064
Country
United States
Facility Name
San Diego Arthritis Med Clnc
City
San Diego
State/Province
California
ZIP/Postal Code
92108
Country
United States
Facility Name
Purushotham & Akther Kotha Inc
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
Facility Name
C Michael Neuwelt MD Inc
City
San Leandro
State/Province
California
ZIP/Postal Code
94578
Country
United States
Facility Name
Pacific Arthritis Ctr Med Grp
City
Santa Maria
State/Province
California
ZIP/Postal Code
93454
Country
United States
Facility Name
Orrin M. Troum, Md
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Facility Name
Harbor UCLA Medical Center
City
Torrance
State/Province
California
ZIP/Postal Code
90509
Country
United States
Facility Name
Inland Rheumatology; Clinical Trials, Inc.
City
Upland
State/Province
California
ZIP/Postal Code
91786
Country
United States
Facility Name
Medvin Clinical Research
City
Whittier
State/Province
California
ZIP/Postal Code
90606
Country
United States
Facility Name
Arthritis Assoc & Osteoporosis; Ctr of Colorado Springs
City
Colorado Springs
State/Province
Colorado
ZIP/Postal Code
80920
Country
United States
Facility Name
Joao Nascimento
City
Bridgeport
State/Province
Connecticut
ZIP/Postal Code
06606
Country
United States
Facility Name
University of Connecticut Health Center
City
Farmington
State/Province
Connecticut
ZIP/Postal Code
06030
Country
United States
Facility Name
Arthritis & Osteoporosis Center Pc
City
Hamden
State/Province
Connecticut
ZIP/Postal Code
06518
Country
United States
Facility Name
ZASA Clinical Research
City
Boynton Beach
State/Province
Florida
ZIP/Postal Code
33472
Country
United States
Facility Name
DC Health Clinic
City
Coral Gables
State/Province
Florida
ZIP/Postal Code
33134
Country
United States
Facility Name
Tsai, Yong
City
Daytona Beach
State/Province
Florida
ZIP/Postal Code
32117
Country
United States
Facility Name
Jacksonville Center For Clinical Research
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Pharmax Research Clinic Inc.
City
Miami
State/Province
Florida
ZIP/Postal Code
33126
Country
United States
Facility Name
Arthritis/Osteoporosis Treatment Center
City
Orange Park
State/Province
Florida
ZIP/Postal Code
32073
Country
United States
Facility Name
Arthritis Rsrch of Florida, Inc.
City
Palm Harbor
State/Province
Florida
ZIP/Postal Code
34684
Country
United States
Facility Name
Baptist Hospital Clinical Research
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32501
Country
United States
Facility Name
Pinellas Medical Research, LLC
City
Saint Petersburg
State/Province
Florida
ZIP/Postal Code
33708
Country
United States
Facility Name
Lovelace Scientific Resources
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34292
Country
United States
Facility Name
Centre for Arthritis and Rheumatic Diseases
City
South Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
Facility Name
SW Florida Clinical Research
City
Tampa
State/Province
Florida
ZIP/Postal Code
33609
Country
United States
Facility Name
Healthpoint Medical group, Inc
City
Tampa
State/Province
Florida
ZIP/Postal Code
33614
Country
United States
Facility Name
Emory Uni ; Division of Rheumatology
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30303
Country
United States
Facility Name
Arthritis & Rheumatology of Georgia
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30342
Country
United States
Facility Name
North Georgia Rheumatology
City
Duluth
State/Province
Georgia
ZIP/Postal Code
30096
Country
United States
Facility Name
Harbin Clinic
City
Rome
State/Province
Georgia
ZIP/Postal Code
30165
Country
United States
Facility Name
St. Joseph'S/Candler Health System, Inc.; Office of Research
City
Savannah
State/Province
Georgia
ZIP/Postal Code
31405
Country
United States
Facility Name
Sonora Clinical Research
City
Boise
State/Province
Idaho
ZIP/Postal Code
83702
Country
United States
Facility Name
St. Luke's Intermountain Research Center
City
Boise
State/Province
Idaho
ZIP/Postal Code
83702
Country
United States
Facility Name
Selah Medical Ctr
City
Boise
State/Province
Idaho
ZIP/Postal Code
83704
Country
United States
Facility Name
Coeur D'Alene Arthritis Clinic
City
Coeur d'Alene
State/Province
Idaho
ZIP/Postal Code
83814
Country
United States
Facility Name
Idaho Arthritis Center
City
Meridian
State/Province
Idaho
ZIP/Postal Code
83642
Country
United States
Facility Name
University of Illinois at Chicago
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Apex Medical Research, AMR, Inc.
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60616
Country
United States
Facility Name
Methodist Medical Center of Ilinois
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61602
Country
United States
Facility Name
Northern Indiana Research Alliance
City
Fort Wayne
State/Province
Indiana
ZIP/Postal Code
46804
Country
United States
Facility Name
Diagnostic Rheumatology & Research
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46227
Country
United States
Facility Name
Memorial Medical Group Clinical Research
City
South Bend
State/Province
Indiana
ZIP/Postal Code
46601
Country
United States
Facility Name
Graves Gilbert Clinic
City
Bowling Green
State/Province
Kentucky
ZIP/Postal Code
42101
Country
United States
Facility Name
Research Integrity
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Arthritis & Diabetes Clinic, Inc
City
Monroe
State/Province
Louisiana
ZIP/Postal Code
71203
Country
United States
Facility Name
Ochsner Health System
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Rheumatology Associates of Baltimore
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21286
Country
United States
Facility Name
Osteoporosis & Clinical Trials Center
City
Hagerstown
State/Province
Maryland
ZIP/Postal Code
21740
Country
United States
Facility Name
Center For Rheumatology & Bone Research
City
Wheaton
State/Province
Maryland
ZIP/Postal Code
20902
Country
United States
Facility Name
Phase Iii Clinical Research
City
Fall River
State/Province
Massachusetts
ZIP/Postal Code
02720
Country
United States
Facility Name
UMass Memorial Medical Center
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01605
Country
United States
Facility Name
Clinical Pharmacology Study Group
City
Worcester
State/Province
Massachusetts
ZIP/Postal Code
01610
Country
United States
Facility Name
Hurley Research Center
City
Flint
State/Province
Michigan
ZIP/Postal Code
48503
Country
United States
Facility Name
Rheumatology, P.C.; Medical Arts Building
City
Kalamazoo
State/Province
Michigan
ZIP/Postal Code
49009
Country
United States
Facility Name
Advanced Rheumatology, PC
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48910
Country
United States
Facility Name
Northern Michigan Regional Hospital
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
St. Paul Rheumatology
City
Eagan
State/Province
Minnesota
ZIP/Postal Code
55121
Country
United States
Facility Name
Va Medical Center
City
Minneapolis
State/Province
Minnesota
ZIP/Postal Code
55417
Country
United States
Facility Name
Mayo Clinic Rochester
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Jackson Arthritis Clinic
City
Flowood
State/Province
Mississippi
ZIP/Postal Code
39232
Country
United States
Facility Name
North Mississippi Med Clinics, Inc.
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
Facility Name
Glacier View Research Institute
City
Kalispell
State/Province
Montana
ZIP/Postal Code
59901
Country
United States
Facility Name
Univ of Nebraska Medical Ctr
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68198
Country
United States
Facility Name
Advanced Biomedical Research of America
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89123
Country
United States
Facility Name
Innovative Health Research
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89128
Country
United States
Facility Name
Dartmouth-Hitchcock Medical Center, Rheumatology 5C
City
Lebanon
State/Province
New Hampshire
ZIP/Postal Code
03756
Country
United States
Facility Name
Nashua Rheumatology - Foundation Medical Partners
City
Nashua
State/Province
New Hampshire
ZIP/Postal Code
03060
Country
United States
Facility Name
Summit Medical Group
City
Berkeley Heights
State/Province
New Jersey
ZIP/Postal Code
07922
Country
United States
Facility Name
Rheumatology Associates Of New Jersey
City
Teaneck
State/Province
New Jersey
ZIP/Postal Code
07666
Country
United States
Facility Name
Arthritis Rheumatic & Back Disease Associates
City
Voorhees
State/Province
New Jersey
ZIP/Postal Code
08043
Country
United States
Facility Name
Albuquerque Center For Rheumatology
City
Albuquerque
State/Province
New Mexico
ZIP/Postal Code
87102
Country
United States
Facility Name
Arthritis and Osteoporosis Associates of New Mexico
City
Las Cruces
State/Province
New Mexico
ZIP/Postal Code
88011
Country
United States
Facility Name
Arthritis & Osteoporosis Medical Associates, Pllc
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11201
Country
United States
Facility Name
SUNY Downstate Medical Center.
City
Brooklyn
State/Province
New York
ZIP/Postal Code
11203
Country
United States
Facility Name
DiGiovanna Inst for Med Ed&Res
City
North Massapequa
State/Province
New York
ZIP/Postal Code
11758
Country
United States
Facility Name
Southern Tier Arthritis & Rheumatism
City
Olean
State/Province
New York
ZIP/Postal Code
14760
Country
United States
Facility Name
Arthritis Health Associates; Clinical Research
City
Syracuse
State/Province
New York
ZIP/Postal Code
13210
Country
United States
Facility Name
Asheville Arthritis & Osteoporosis Center, PA
City
Asheville
State/Province
North Carolina
ZIP/Postal Code
28803
Country
United States
Facility Name
Joint & Muscle Research Institute
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28204
Country
United States
Facility Name
Carolina Bone & Joint P.A.
City
Charlotte
State/Province
North Carolina
ZIP/Postal Code
28210
Country
United States
Facility Name
Durham Rheumatology
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27704
Country
United States
Facility Name
PMG Research of Hickory LLC
City
Hickory
State/Province
North Carolina
ZIP/Postal Code
28602
Country
United States
Facility Name
Shanahan Rheumatology & Immunology, PLLC
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27617
Country
United States
Facility Name
Specialty Medical Clinic and Research Center
City
Sanford
State/Province
North Carolina
ZIP/Postal Code
27330
Country
United States
Facility Name
Carolina Arthritis Associates, Pa
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28401
Country
United States
Facility Name
Trinity Health Center
City
Minot
State/Province
North Dakota
ZIP/Postal Code
58701
Country
United States
Facility Name
Cincinnati Rheumatic Disease Study Group
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219
Country
United States
Facility Name
University Hospitals Case Medical Center
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44109
Country
United States
Facility Name
Ohio State Univ Med Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Columbus Arthritis Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43215
Country
United States
Facility Name
Clinical Research Source, Inc.
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43606
Country
United States
Facility Name
Toledo Clinic
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43623
Country
United States
Facility Name
Lynn Health Science Institute
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Altoona Center For Clinical Research
City
Duncansville
State/Province
Pennsylvania
ZIP/Postal Code
16635
Country
United States
Facility Name
Penn State Milton S. Hershey Medical Center
City
Hershey
State/Province
Pennsylvania
ZIP/Postal Code
17033
Country
United States
Facility Name
Ilumina Clinical Associates
City
Indiana
State/Province
Pennsylvania
ZIP/Postal Code
15701
Country
United States
Facility Name
PMA Medical Specialists
City
Limerick
State/Province
Pennsylvania
ZIP/Postal Code
19468
Country
United States
Facility Name
Pivotal Clinical Research, Llc
City
Perkasie
State/Province
Pennsylvania
ZIP/Postal Code
18944
Country
United States
Facility Name
Arthritis Group
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19152
Country
United States
Facility Name
University of Pittsburgh Medical Center Health System; Infectious Disease
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213-2582
Country
United States
Facility Name
Allegheny Rheumatology
City
Wexford
State/Province
Pennsylvania
ZIP/Postal Code
15090
Country
United States
Facility Name
Clinical Research Center of Reading
City
Wyomissing
State/Province
Pennsylvania
ZIP/Postal Code
19610
Country
United States
Facility Name
Pennsylvania Regional Center for Arthritis and Osteoporosis Research
City
Wyomissing
State/Province
Pennsylvania
ZIP/Postal Code
19610
Country
United States
Facility Name
Columbia Arthritis Center (Partnership Practice)
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29204
Country
United States
Facility Name
South Carolina Research Center
City
Myrtle Beach
State/Province
South Carolina
ZIP/Postal Code
29572
Country
United States
Facility Name
Brown Clinic
City
Watertown
State/Province
South Dakota
ZIP/Postal Code
57201
Country
United States
Facility Name
Ramesh Gupta - PP
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38119
Country
United States
Facility Name
Amarillo Center For Clinical Research
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79124
Country
United States
Facility Name
Adriana Pop-Moody MD Clinic PA
City
Corpus Christi
State/Province
Texas
ZIP/Postal Code
78404
Country
United States
Facility Name
Metroplex Clinical Research
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Leading Edge Research, PA; Office of Dr. Burbano
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76109
Country
United States
Facility Name
Rheumatic Disease Clin Res Ctr
City
Houston
State/Province
Texas
ZIP/Postal Code
77004
Country
United States
Facility Name
Houston Inst. For Clinical Research
City
Houston
State/Province
Texas
ZIP/Postal Code
77074
Country
United States
Facility Name
Southwest Rheumatology
City
Mesquite
State/Province
Texas
ZIP/Postal Code
75150
Country
United States
Facility Name
Leading Edge Research, PA; Office of Dr. Burbano
City
Richardson
State/Province
Texas
ZIP/Postal Code
75080
Country
United States
Facility Name
Texas Arthritis Research Center
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78217
Country
United States
Facility Name
Arthritis & Osteoporosis Clinic
City
Waco
State/Province
Texas
ZIP/Postal Code
76710
Country
United States
Facility Name
Arthritis and Rheumatic Disease Associates
City
Burke
State/Province
Virginia
ZIP/Postal Code
22015
Country
United States
Facility Name
Sentara Medical Group
City
Norfolk
State/Province
Virginia
ZIP/Postal Code
23510
Country
United States
Facility Name
Apex Clinical Research
City
Kennewick
State/Province
Washington
ZIP/Postal Code
99336
Country
United States
Facility Name
Seattle Rheumatology Associates
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
Office of George Krick, Md
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Rheum & Pulmonary Clinic
City
Beckley
State/Province
West Virginia
ZIP/Postal Code
25801
Country
United States
Facility Name
Mountain State Clinical Research
City
Clarksburg
State/Province
West Virginia
ZIP/Postal Code
26301
Country
United States
Facility Name
Arthritis Centre; Suite 103
City
Racine
State/Province
Wisconsin
ZIP/Postal Code
53406
Country
United States
Facility Name
Organizacion Medica de Investigacion
City
Buenos Aires
ZIP/Postal Code
C1015ABO
Country
Argentina
Facility Name
CEIM Consultorios Especializados en Investigaciones Médicas
City
Buenos Aires
ZIP/Postal Code
C1117ABK
Country
Argentina
Facility Name
APRILLUS
City
Buenos Aires
ZIP/Postal Code
C1194AAO
Country
Argentina
Facility Name
Instituto centenario
City
Buenos Aires
ZIP/Postal Code
C1204AAD
Country
Argentina
Facility Name
Fundación CIDEA
City
Buenos Aires
ZIP/Postal Code
C1425DTG
Country
Argentina
Facility Name
Atencion Integral En Reumatologia Buenos Aires
City
Buenos Aires
ZIP/Postal Code
C1426AAL
Country
Argentina
Facility Name
CEMIC
City
Buenos Aires
ZIP/Postal Code
C1431FWO
Country
Argentina
Facility Name
Hospital General de Agudos Dr. J. M. Ramos Mejia
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1221ADC
Country
Argentina
Facility Name
Hospital Britanico de Buenos Aires
City
Ciudad Autonoma Buenos Aires
ZIP/Postal Code
C1284AEB
Country
Argentina
Facility Name
Centro de Investigaciones Reumatologicas y Osteologicas
City
Ciudad Autonoma de Buenos Aires
ZIP/Postal Code
1111
Country
Argentina
Facility Name
Hospital Privado Cordoba
City
Cordoba Pcia
ZIP/Postal Code
5016
Country
Argentina
Facility Name
Instituto Reumatológico Strusberg
City
Cordoba
ZIP/Postal Code
5000
Country
Argentina
Facility Name
Hospital Italiano de Cordoba
City
Cordoba
ZIP/Postal Code
X5004BAL
Country
Argentina
Facility Name
Centro de Investigaciones Médicas - CIM
City
Florencio Varela
ZIP/Postal Code
1888
Country
Argentina
Facility Name
Hospital Municipal Nuestra Sra. de Lujan
City
Lujan
ZIP/Postal Code
6700
Country
Argentina
Facility Name
Centro de Investigacion Pergamino SA
City
Pergamino
ZIP/Postal Code
B2700CPM
Country
Argentina
Facility Name
Instituto Centralizado de Asistencia e Investigaci
City
Rosario, Santa Fe
ZIP/Postal Code
S2000PBJ
Country
Argentina
Facility Name
Sanatorio Parque de Rosario
City
Rosario
ZIP/Postal Code
S2000DSV
Country
Argentina
Facility Name
CER San Juan Centro Polivalente de Asistencia e Investigacion Clinica
City
San Juan
ZIP/Postal Code
5400
Country
Argentina
Facility Name
Centro Médico Privado de Reumatología
City
San Miguel de Tucuman
ZIP/Postal Code
T4000AXL
Country
Argentina
Facility Name
Centro de Investigaciones Reumatologicas Tucuman
City
Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Lkh-Univ. Klinikum Graz
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Landesklinikum Weinviertel Stockerau; Rheumatologie
City
Stockerau
ZIP/Postal Code
2000
Country
Austria
Facility Name
Medizinische Universität Wien
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Rheuma-Zentrum Favoriten Wien
City
Wien
ZIP/Postal Code
1100
Country
Austria
Facility Name
Krankenhaus Hietzing; 2.Med.Abteilung, Pav.3A
City
Wien
ZIP/Postal Code
1130
Country
Austria
Facility Name
CHU St Pierre (St Pierre)
City
Brussels
ZIP/Postal Code
1000
Country
Belgium
Facility Name
Cliniques Universitaires St-Luc
City
Bruxelles
ZIP/Postal Code
1200
Country
Belgium
Facility Name
AZ Groeninge (Vercruysselaan)
City
Kortrijk
ZIP/Postal Code
8500
Country
Belgium
Facility Name
CHU Sart-Tilman
City
Liège
ZIP/Postal Code
4000
Country
Belgium
Facility Name
ZNA Jan Palfijn
City
Merksem
ZIP/Postal Code
2170
Country
Belgium
Facility Name
University Clinical Center of the Republic of Srpska
City
Banja Luka
ZIP/Postal Code
78000
Country
Bosnia and Herzegovina
Facility Name
University Clinic Ctr Sarajevo
City
Sarajevo
ZIP/Postal Code
71 000
Country
Bosnia and Herzegovina
Facility Name
General Hospital Prim.dr.Abdulah Nakas
City
Sarajevo
ZIP/Postal Code
71000
Country
Bosnia and Herzegovina
Facility Name
Uni Hospital Center Tuzla
City
Tuzla
ZIP/Postal Code
75000
Country
Bosnia and Herzegovina
Facility Name
Royal Alexandra Hospital
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T5H 3V9
Country
Canada
Facility Name
The Medical Arts Health Research Group
City
Powell River
State/Province
British Columbia
ZIP/Postal Code
V8A 3B6
Country
Canada
Facility Name
Baker, Milton F.
City
Victoria
State/Province
British Columbia
ZIP/Postal Code
V8P 5P6
Country
Canada
Facility Name
Nexus Clinical Research Centre
City
St John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1A 5E8
Country
Canada
Facility Name
St. Clare'S Mercy Hospital
City
St John's
State/Province
Newfoundland and Labrador
ZIP/Postal Code
A1C 5B8
Country
Canada
Facility Name
Arthur Karasik, MD
City
Etobicoke
State/Province
Ontario
ZIP/Postal Code
M9C 5N2
Country
Canada
Facility Name
Charlton Medical Center
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8N 1Y2
Country
Canada
Facility Name
K-W Musculoskeletal Research
City
Kitchener
State/Province
Ontario
ZIP/Postal Code
N2M 5N6
Country
Canada
Facility Name
St. Joseph's Hospital
City
London
State/Province
Ontario
ZIP/Postal Code
N6A 4V2
Country
Canada
Facility Name
Credit Valley, Rheumatology
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5M 2V8
Country
Canada
Facility Name
Niagara Peninsula Arthritis Centre
City
St. Catharines
State/Province
Ontario
ZIP/Postal Code
L2N 7E4
Country
Canada
Facility Name
Mount Sinai Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 1Z5
Country
Canada
Facility Name
Institut de Rhumatologie de Montreal
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H2L 1S6
Country
Canada
Facility Name
Groupe de Recherche En Rhumatologie Et Maladies Osseuses
City
Quebec City
State/Province
Quebec
ZIP/Postal Code
G1V 3M7
Country
Canada
Facility Name
Chus Hopital Fleurimont
City
Sherbrooke
State/Province
Quebec
ZIP/Postal Code
J1H 5N4
Country
Canada
Facility Name
Centre de Recherche Musculo-Squelettique
City
Trois-rivieres
State/Province
Quebec
ZIP/Postal Code
G8Z 1Y2
Country
Canada
Facility Name
Centre Re Recherche Saint-Louis
City
Quebec
ZIP/Postal Code
G1W 4R4
Country
Canada
Facility Name
Hospital San Juan de Dios La Serena
City
La Serena
ZIP/Postal Code
1700000
Country
Chile
Facility Name
Centro Medico Prosalud
City
Santiago
ZIP/Postal Code
7500000
Country
Chile
Facility Name
Interin
City
Santiago
ZIP/Postal Code
7500035
Country
Chile
Facility Name
Centro de Estudios Reumatológicos
City
Santiago
ZIP/Postal Code
7501126
Country
Chile
Facility Name
Hospital Clinico Pontificia Universidad Catolica de Chile
City
Santiago
ZIP/Postal Code
8320112
Country
Chile
Facility Name
Centro de Investigacion Clinica del Sur
City
Temuco
ZIP/Postal Code
4780000
Country
Chile
Facility Name
Clinica Alemana de Temuco
City
Temuco
ZIP/Postal Code
4780000
Country
Chile
Facility Name
Hospital Clinico Viña del Mar- Oncovida
City
Viña del Mar
ZIP/Postal Code
2520612
Country
Chile
Facility Name
Centro de Estudios Clinicos V Region Limitada
City
Viña del Mar
Country
Chile
Facility Name
General Hospital Karlovac
City
Karlovac
ZIP/Postal Code
47000
Country
Croatia
Facility Name
Special Hospital for Medical Rehabilitation
City
Krapinske Toplice
ZIP/Postal Code
49217
Country
Croatia
Facility Name
Clinical Hospital Centre Rijeka; Department of Rheumatology and Clinical Immunology
City
Rijeka
ZIP/Postal Code
51000
Country
Croatia
Facility Name
Clinical Hospital Centre Zagreb
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Universtiy Hospital Dubrava
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
Facility Name
Fakultni nemocnice u sv. Anny v Brne
City
Brno
ZIP/Postal Code
656 91
Country
Czechia
Facility Name
Revmatologicka ambulance
City
Bruntal
ZIP/Postal Code
792 01
Country
Czechia
Facility Name
Revmatologicka Ambulance
City
Hlucin
ZIP/Postal Code
748 01
Country
Czechia
Facility Name
Interni a revmatologicka ordinace
City
Hostivice
ZIP/Postal Code
253 01
Country
Czechia
Facility Name
Revmatologicka a-interni ambulance
City
Kladno
ZIP/Postal Code
272 01
Country
Czechia
Facility Name
Revmatologie MUDr. Klara Sirova s.r.o.
City
Ostrava - Moravska Ostrava
ZIP/Postal Code
702 00
Country
Czechia
Facility Name
Revmatologicka ambulance
City
Praha 4
ZIP/Postal Code
140 00
Country
Czechia
Facility Name
Revmatologicky Ustav
City
Praha
ZIP/Postal Code
128 50
Country
Czechia
Facility Name
Fakultni Thomayerova nemocnice s poliklinikou
City
Praha
ZIP/Postal Code
140 59
Country
Czechia
Facility Name
Artroscan s.r.o.
City
Sokolov
ZIP/Postal Code
356 01
Country
Czechia
Facility Name
Revmatologicka Ambulance-Terezin
City
Terezin
ZIP/Postal Code
411 55
Country
Czechia
Facility Name
PV - Medical, s.r.o.
City
Zlin
ZIP/Postal Code
748 01
Country
Czechia
Facility Name
Hospital Clínica Santa Inés
City
Cuenca
ZIP/Postal Code
101168
Country
Ecuador
Facility Name
Centro de Reumatología y Rehabilitación
City
Guayaquil
ZIP/Postal Code
593
Country
Ecuador
Facility Name
OMNI Hospital
City
Guayaquil
ZIP/Postal Code
593
Country
Ecuador
Facility Name
Centro Medico Alcivar 4
City
Guayaquil
ZIP/Postal Code
EC090114
Country
Ecuador
Facility Name
Centro Medico Picasso
City
Quito
ZIP/Postal Code
005932
Country
Ecuador
Facility Name
Novaclinica Santa Cecilia; Reumatology
City
Quito
ZIP/Postal Code
EC170517
Country
Ecuador
Facility Name
CHU d'Amiens Hôpital Nord; Pharmacie Clinique
City
Amiens
ZIP/Postal Code
80054
Country
France
Facility Name
Groupe Hospitalier Pellegrin
City
Bordeaux
ZIP/Postal Code
33000
Country
France
Facility Name
CHU Hopital Gabriel Montpied
City
Clermont Ferrand
ZIP/Postal Code
63003
Country
France
Facility Name
Centre Hospitalier Sud Francilien
City
Corbeil Essonnes
ZIP/Postal Code
91106
Country
France
Facility Name
CHU Grenoble Sud
City
Echirolles
ZIP/Postal Code
38434
Country
France
Facility Name
Hôpital Edouard Herriot; Service de Rhumatologie
City
Lyon
ZIP/Postal Code
69003
Country
France
Facility Name
CHR Orleans, Hopital Madeleine
City
Orléans
ZIP/Postal Code
45067
Country
France
Facility Name
Hôpital Saint-Antoine; Service de Psychiatrie
City
Paris
ZIP/Postal Code
75571
Country
France
Facility Name
Groupe Hospitalier Pitie-Salpetriere
City
Paris
ZIP/Postal Code
75651
Country
France
Facility Name
Hopital Cochin; Gastro Enterologie
City
Paris
ZIP/Postal Code
75679
Country
France
Facility Name
Hôpital Sud - CHU de Rennes
City
Rennes
ZIP/Postal Code
35033
Country
France
Facility Name
Hôpital Victor Provo
City
Roubaix
ZIP/Postal Code
59056
Country
France
Facility Name
CHU de Rouen, Hopital de Bois Guillaume; Service de Rhumatologie
City
Rouen
ZIP/Postal Code
76031
Country
France
Facility Name
CHU Saint-Etienne, Hopital Bellevue
City
Saint-Etienne
ZIP/Postal Code
42055
Country
France
Facility Name
Hôpital General - CHRU de Dijon
City
Strasbourg
ZIP/Postal Code
67098
Country
France
Facility Name
Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O)
City
Toulouse
ZIP/Postal Code
31059
Country
France
Facility Name
Charité Universitaetsmedizin Berlin, Campus Charité Mitte
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Facility Name
Schlosspark-Klinik
City
Berlin
ZIP/Postal Code
14059
Country
Germany
Facility Name
Universitätsklinikum "Carl Gustav Carus" der Technischen Universität Dresden
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Universitätsklinikum Erlangen; Augenklinik
City
Erlangen
ZIP/Postal Code
91054
Country
Germany
Facility Name
Praxisgemeinschaft Rheumatologie-Nephrologie Erlangen PGRN
City
Erlangen
ZIP/Postal Code
91056
Country
Germany
Facility Name
Universitaetsklinikum Frankfurt
City
Frankfurt
ZIP/Postal Code
60528
Country
Germany
Facility Name
Universitaetsklinikum Hamburg-Eppendorf; Medizinische Klinik Nephrologie/Rheumatologie
City
Hamburg
ZIP/Postal Code
20251
Country
Germany
Facility Name
Schön Klinik Hamburg-Eilbek Klinik für Rheumatologie
City
Hamburg
ZIP/Postal Code
22081
Country
Germany
Facility Name
Rheumazentrum Ruhrgebiet; St. Josefs-Krankenhaus
City
Herne
ZIP/Postal Code
44649
Country
Germany
Facility Name
Gemeinschaftspraxis Dr. Von Hinueber/Dr. Demary; Rheumatologie
City
Hildesheim
ZIP/Postal Code
31134
Country
Germany
Facility Name
Universitätsklinikum Köln, Klinik I für Innere Medizin
City
Koeln
ZIP/Postal Code
50937
Country
Germany
Facility Name
Universitaetsklinikum Leipzig
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Facility Name
Praxiszentrum St. Bonifatius
City
Muenchen
ZIP/Postal Code
81541
Country
Germany
Facility Name
Ludwig Maximilians; Universitaet
City
München
ZIP/Postal Code
80337
Country
Germany
Facility Name
Rheumatologische Gemeinschaftspraxis
City
Osnabrueck
ZIP/Postal Code
49074
Country
Germany
Facility Name
Evangelisches Fachkrankenhaus
City
Ratingen
ZIP/Postal Code
40882
Country
Germany
Facility Name
Laiko General Hospital Athen
City
Athens
ZIP/Postal Code
115 27
Country
Greece
Facility Name
Euroclinic of Athens; Internal Medicine & Immunology Dept.
City
Athens
ZIP/Postal Code
15121
Country
Greece
Facility Name
University General Hospital of Heraklion
City
Crete
ZIP/Postal Code
71110
Country
Greece
Facility Name
University General Hospital of Larissa; Rheumatology Unit
City
Larissa
ZIP/Postal Code
411 10
Country
Greece
Facility Name
General Hospital of Thessaloniki Hippokration
City
Thessaloniki
ZIP/Postal Code
54 642
Country
Greece
Facility Name
Euromedica Kyanous Stavros General Hospital
City
Thessaloniki
ZIP/Postal Code
546 36
Country
Greece
Facility Name
424 Military Training Hospital-Egnatia
City
Thessaloniki
Country
Greece
Facility Name
Országos Fizioterápiás És Reumatológiai Intézet; I. Reumatológiai És Metabolikus Osteológiai Osztály
City
Budapest
ZIP/Postal Code
1027
Country
Hungary
Facility Name
Clinexpert Egeszsegugyi Szolgaltato es Kereskedelmi Kft
City
Budapest
ZIP/Postal Code
1033
Country
Hungary
Facility Name
Obudai Egeszsegugyi Centrum Kft.
City
Budapest
ZIP/Postal Code
1036
Country
Hungary
Facility Name
Synexus Magyarorszag Kft
City
Budapest
ZIP/Postal Code
1036
Country
Hungary
Facility Name
Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Markhot Ferenc Eu. Szolg. Nonprofit Kiem. Kozh. Kft.
City
Eger
ZIP/Postal Code
3300
Country
Hungary
Facility Name
Bekes Megyei Kepviselotestulet Pandy Kalman Korhaza
City
Gyula
ZIP/Postal Code
5700
Country
Hungary
Facility Name
Varosi Korhaz-Rendelointezet
City
Mor
ZIP/Postal Code
8060
Country
Hungary
Facility Name
Fejer Megyei Szent Gyorgy Korhaz
City
Szekesfehervar
ZIP/Postal Code
8000
Country
Hungary
Facility Name
Clinfan Szolgaltato Kft.
City
Szekszard
ZIP/Postal Code
7100
Country
Hungary
Facility Name
Zala Megyei Korhaz; Reumatologia
City
Zalaegerszeg
ZIP/Postal Code
8901
Country
Hungary
Facility Name
Shalby Hospital Limited
City
Ahmedabad
State/Province
Gujarat
ZIP/Postal Code
380015
Country
India
Facility Name
Vedanta Institute; Medical Sciences
City
Ahmedabad
ZIP/Postal Code
380009
Country
India
Facility Name
Manipal Hospital
City
Bangalore
ZIP/Postal Code
560017
Country
India
Facility Name
St.John's Medical College Hospital
City
Banglore
ZIP/Postal Code
560034
Country
India
Facility Name
Arthritis Super Speciality Centre
City
Hubli
ZIP/Postal Code
580020
Country
India
Facility Name
Care Institute of Medical Sciences
City
Hyderabad
ZIP/Postal Code
500034
Country
India
Facility Name
Jasleen Hospital
City
Nagpur
ZIP/Postal Code
440010
Country
India
Facility Name
Barzilai Medical Center
City
Ashkelon
ZIP/Postal Code
78278
Country
Israel
Facility Name
Assaf Harofeh Medical Center
City
Beer Yaacov
ZIP/Postal Code
6093000
Country
Israel
Facility Name
The Lady Davis Carmel Medical Center
City
Haifa
ZIP/Postal Code
34362
Country
Israel
Facility Name
Chaim Sheba Medical Center; Rheumatology
City
Ramat Gan
ZIP/Postal Code
5262000
Country
Israel
Facility Name
Tel-Aviv Sourasky Medical Center
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
Azienda Ospedaliera A. Cardarelli
City
Napoli
State/Province
Campania
ZIP/Postal Code
80131
Country
Italy
Facility Name
Ospedale San Giovanni Bosco; Divisione di Reumatologia
City
Napoli
State/Province
Campania
ZIP/Postal Code
80144
Country
Italy
Facility Name
Fondazione Salvatore Maugeri IRCCS; Istituto Scientifico di Riabilitazione di Telese
City
Telese Terme
State/Province
Campania
ZIP/Postal Code
82037
Country
Italy
Facility Name
Ospedale La Colletta
City
Arenzano
State/Province
Liguria
ZIP/Postal Code
16011
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria San Martino
City
Genova
State/Province
Liguria
ZIP/Postal Code
16132
Country
Italy
Facility Name
Ospedali Riuniti di Bergamo
City
Bergamo
State/Province
Lombardia
ZIP/Postal Code
24128
Country
Italy
Facility Name
Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia
City
Milano
State/Province
Lombardia
ZIP/Postal Code
20162
Country
Italy
Facility Name
Ospedale Di Circolo E Fondazione Macchi
City
Varese
State/Province
Lombardia
ZIP/Postal Code
21100
Country
Italy
Facility Name
Presidio Ospedaliero Vittorio Emanuele
City
Catania
State/Province
Sicilia
ZIP/Postal Code
95124
Country
Italy
Facility Name
Azienda Ospedaliera Universitaria Careggi
City
Firenze
State/Province
Toscana
ZIP/Postal Code
50141
Country
Italy
Facility Name
Ospedale Misericordia e Dolce
City
Prato
State/Province
Toscana
ZIP/Postal Code
59100
Country
Italy
Facility Name
L.Krumina GP practice
City
Bauska
ZIP/Postal Code
3901
Country
Latvia
Facility Name
Daugavpils Regional Hospital
City
Daugavpils
ZIP/Postal Code
5417
Country
Latvia
Facility Name
D.Saulite-Kandevica Private Practice
City
Liepaja
ZIP/Postal Code
3400
Country
Latvia
Facility Name
Clinic ORTO
City
Riga
ZIP/Postal Code
1005
Country
Latvia
Facility Name
Private Practice EHOKG
City
Riga
ZIP/Postal Code
1021
Country
Latvia
Facility Name
Riga East Clinical University Hospital; Clinic Gailezers
City
Riga
ZIP/Postal Code
LV 1002
Country
Latvia
Facility Name
P. Stradins Clinical University Hospital
City
Riga
ZIP/Postal Code
LV-1002
Country
Latvia
Facility Name
Alytus Regional S. Kudirkos Hospital, Public Institution
City
Alytus
ZIP/Postal Code
62114
Country
Lithuania
Facility Name
Klaipeda Seamen's Hospital, Public Institution
City
Klaipeda
ZIP/Postal Code
92288
Country
Lithuania
Facility Name
Klaipeda University Hospital; Public Institution
City
Klaipeda
ZIP/Postal Code
92288
Country
Lithuania
Facility Name
Siauliai Republican Hospital Public Institution
City
Siauliai
ZIP/Postal Code
76231
Country
Lithuania
Facility Name
Vilnius District Central Outpatient Clinic, Public Institution
City
Vilnius
ZIP/Postal Code
06122
Country
Lithuania
Facility Name
Hospital Raja Permaisuri Bainun
City
Ipoh
State/Province
Perak
ZIP/Postal Code
30990
Country
Malaysia
Facility Name
Hospital Selayang
City
Kuala Lumpur
ZIP/Postal Code
68100
Country
Malaysia
Facility Name
Hospital Umum Sarawak
City
Kuching
ZIP/Postal Code
93586
Country
Malaysia
Facility Name
Hospital Pulau Pinang
City
Penang
ZIP/Postal Code
10990
Country
Malaysia
Facility Name
Sunway Medical Centre
City
Selangor
ZIP/Postal Code
46150
Country
Malaysia
Facility Name
Sime Darby Medical Centre
City
Selangor
ZIP/Postal Code
47500
Country
Malaysia
Facility Name
Centro de Investigacion del Noroeste SC
City
Tijuana
State/Province
Baja California
ZIP/Postal Code
22010
Country
Mexico
Facility Name
Centro de Investigación de Tratamientos Innovadores de Sinaloa (CITI)
City
Culiacán Rosales
State/Province
Sinaloa
ZIP/Postal Code
80000
Country
Mexico
Facility Name
Unidad de Atencion Medica e Investigacion en Salud S.C.
City
Mérida
State/Province
Yucatan
ZIP/Postal Code
97000
Country
Mexico
Facility Name
Hospital Christus Muguerza del Parque; Reumatologia
City
Chihuahua
ZIP/Postal Code
31000
Country
Mexico
Facility Name
Hospital CIMA Chihuahua; Reumatologia
City
Chihuahua
ZIP/Postal Code
31238
Country
Mexico
Facility Name
Hospital Privado San Jose de Ciudad Obregon SA de CV
City
Ciudad Obregon
ZIP/Postal Code
85000
Country
Mexico
Facility Name
Private Practice Dr. Cortes
City
Cuernavaca
ZIP/Postal Code
62270
Country
Mexico
Facility Name
RM pharma specialist SA de CV
City
Delegacion Benito Juarez
ZIP/Postal Code
03100
Country
Mexico
Facility Name
Mentrials S.A. de C.V
City
Distrito Federal
ZIP/Postal Code
06600
Country
Mexico
Facility Name
Centro de Investigacion y Atencion Integral Durango CIAID
City
Durango
ZIP/Postal Code
34080
Country
Mexico
Facility Name
Mundo Fisico
City
Guadalajara
ZIP/Postal Code
44500
Country
Mexico
Facility Name
Clinica Hospital Angeles Chapalita
City
Guadalajara
ZIP/Postal Code
45040
Country
Mexico
Facility Name
Centro de Investigacion en Enfermedades Reumaticas y Osteoporosis
City
Mexicali
ZIP/Postal Code
21100
Country
Mexico
Facility Name
Inst. Mexicano de Investigacion Clinica
City
Mexico City
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Instituto Nacional de Cardiologia Ignacio Chavez
City
Mexico City
ZIP/Postal Code
14080
Country
Mexico
Facility Name
Hospital Mocel
City
Mexico Df
ZIP/Postal Code
11850
Country
Mexico
Facility Name
Mexico Centre for Clinical Research
City
Mexico
ZIP/Postal Code
03100
Country
Mexico
Facility Name
Comite Mexicano Para la Prevencion de Osteoporosis AC
City
Mexico
ZIP/Postal Code
06100
Country
Mexico
Facility Name
Cliditer SA de CV
City
Miexico City
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Hospital Universitario de Saltillo
City
Saltillo
ZIP/Postal Code
25000
Country
Mexico
Facility Name
Hospital Central Dr. Ignacio Morones Prieto
City
San Luis Potosi S.L.P.
ZIP/Postal Code
78240
Country
Mexico
Facility Name
Centro de Alta Especialidad en Reumatología e Investigación del Potosí, S.C.
City
San Luis Potosí
ZIP/Postal Code
78200
Country
Mexico
Facility Name
Unidad de Enfermedades Reumaticas y Cronicodegenerativas
City
Torreon
ZIP/Postal Code
27000
Country
Mexico
Facility Name
Jan Van Breemen Instituut
City
Amsterdam
ZIP/Postal Code
1056 AB
Country
Netherlands
Facility Name
Albert Schweitzer Ziekenhuis ; Dordwijk
City
Dordrecht
ZIP/Postal Code
3318AT
Country
Netherlands
Facility Name
Franciscus Ziekenhuis
City
Roosendaal
ZIP/Postal Code
4708 AE
Country
Netherlands
Facility Name
Vlietland Hospital
City
Schiedam
ZIP/Postal Code
3118 JH
Country
Netherlands
Facility Name
Cebu Doctors' University Hospital- North General Hospital
City
Cebu City
ZIP/Postal Code
6000
Country
Philippines
Facility Name
Chong Hua Hospital, Cebu City
City
Cebu City
ZIP/Postal Code
6000
Country
Philippines
Facility Name
St. Paul Hospital; Arthritis Center
City
Iloilo City
ZIP/Postal Code
5000
Country
Philippines
Facility Name
Mary Mediatrix Medical Center
City
Lipa City
ZIP/Postal Code
4217
Country
Philippines
Facility Name
Makati Medical Center
City
Makati City
ZIP/Postal Code
1229
Country
Philippines
Facility Name
Szpital Uniwersytecki; nr 2 im. Dr J. Biziela
City
Bydgoszcz
ZIP/Postal Code
85-168
Country
Poland
Facility Name
Wojewodzki Szpital Zespolony w Elblagu
City
Elblag
ZIP/Postal Code
82-300
Country
Poland
Facility Name
Szpital Specjalistyczny Im J. Dietla Malopolskie Centrum Reumat; Oddzial Rumatologii
City
Krakow
ZIP/Postal Code
30-119
Country
Poland
Facility Name
Szpital Specjalistyczny im. J. Dietla
City
Krakow
ZIP/Postal Code
31-121
Country
Poland
Facility Name
NZOZ REUMED Sp. z o.o.
City
Lublin
ZIP/Postal Code
20-607
Country
Poland
Facility Name
Lecznica MAK-MED NZOZ
City
Nadarzyn
ZIP/Postal Code
05-830
Country
Poland
Facility Name
SP Szpital Kliniczny nr 1 Pomorskiej Akademii Medycznej im. prof. Tadeusza Sokolowskiego
City
Szczecin
ZIP/Postal Code
71-252
Country
Poland
Facility Name
Slaski Szpital Reumatologiczno; Rehabilitacyjny; Iii Oddzial Reumatologiczny
City
Ustron
ZIP/Postal Code
43-450
Country
Poland
Facility Name
Rheuma Medicus Zaklad Opieki Zdrowotnej
City
Warszawa
ZIP/Postal Code
02-118
Country
Poland
Facility Name
ARS Rheumatica Sp.z o. o
City
Warszawa
ZIP/Postal Code
02-653
Country
Poland
Facility Name
Akademicki Szpital Kliniczny im. Jana Mikulicza Radeckiego
City
Wroclaw
ZIP/Postal Code
50-556
Country
Poland
Facility Name
Spitalul Clinic Judetean de Urgenta Brasov
City
Brasov
ZIP/Postal Code
500365
Country
Romania
Facility Name
Spitalul Clinic Dr. I Cantacuzino
City
Bucharest
ZIP/Postal Code
020475
Country
Romania
Facility Name
Spitalul Clinic Sf. Maria; Dept Interna si Reumatologie
City
Bucuresti
ZIP/Postal Code
011172
Country
Romania
Facility Name
Centrul de Boli Reumatismale Dr. Ioan Stoia
City
Bucuresti
ZIP/Postal Code
020983
Country
Romania
Facility Name
Medex SRL
City
Cluj-Napoca
ZIP/Postal Code
400130
Country
Romania
Facility Name
Spitalul Clinic Judetean de Urgenta Cluj-Napoca, Clinica de Medicina Muncii
City
Cluj-Napoca
ZIP/Postal Code
400349
Country
Romania
Facility Name
CMI Dr.Ciornohuz Adriana
City
Iasi
ZIP/Postal Code
700127
Country
Romania
Facility Name
Spitalul Clinic de Recuperare Iasi
City
Iasi
ZIP/Postal Code
700656
Country
Romania
Facility Name
Spitalul Municipal Ploiesti
City
Ploiesti
ZIP/Postal Code
100337
Country
Romania
Facility Name
Spitalul Clinic Colentina
City
Sector 2
ZIP/Postal Code
020125
Country
Romania
Facility Name
Spitalul Judetean de Urgenta Targoviste
City
Targoviste
ZIP/Postal Code
130083
Country
Romania
Facility Name
Mediab SRL
City
Targu Mures
ZIP/Postal Code
540142
Country
Romania
Facility Name
Spitalul Clinic Municipal de Urgenta Timisoara
City
Timisoara
ZIP/Postal Code
300194
Country
Romania
Facility Name
State institution of health care - Territorial Clinical Hospital
City
Barnaul
ZIP/Postal Code
656024
Country
Russian Federation
Facility Name
SEI of HPE "Altay State Medical University of Roszdrav"
City
Barnaul
ZIP/Postal Code
656038
Country
Russian Federation
Facility Name
Scientific and research medical complex Your Health
City
Kazan
ZIP/Postal Code
420097
Country
Russian Federation
Facility Name
SIH Kemerovo Regional Clinical Hospital
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
Facility Name
City Hospital No.4
City
Moscow
ZIP/Postal Code
115093
Country
Russian Federation
Facility Name
Scient Res Inst Rheumat RAMS
City
Moscow
ZIP/Postal Code
115522
Country
Russian Federation
Facility Name
Moscow State Medical Stomatological University
City
Moscow
ZIP/Postal Code
121374
Country
Russian Federation
Facility Name
Head Clinical Hospital of Internal Affair Ministry of Russia
City
Moscow
ZIP/Postal Code
123060
Country
Russian Federation
Facility Name
MHI City Clinical Hospital#19
City
Novosibirsk
ZIP/Postal Code
630068
Country
Russian Federation
Facility Name
FSBI Scientific Research Institute of Clinical Immunology of SB of RAMS
City
Novosibirsk
ZIP/Postal Code
630099
Country
Russian Federation
Facility Name
Ryazan Regional Clinincal Cardiology Dispensary
City
Ryazan
ZIP/Postal Code
390026
Country
Russian Federation
Facility Name
State institution of healthcare "Regional hospital for war veterans"
City
Saratov
ZIP/Postal Code
410002
Country
Russian Federation
Facility Name
Leningradskaya Regional Clinical Hospital; Rheumatology Dept
City
St Petersburg
ZIP/Postal Code
194291
Country
Russian Federation
Facility Name
Stavropol State Medical Academy
City
Stavropol
ZIP/Postal Code
355017
Country
Russian Federation
Facility Name
Tomsk Regional Clinical Hospital
City
Tomsk
ZIP/Postal Code
634063
Country
Russian Federation
Facility Name
Voronezh Regional Clinical Hospital #1
City
Voronezh
ZIP/Postal Code
394066
Country
Russian Federation
Facility Name
MCHI Medical Sanitary Unit of Yaroslavl Diesel Apparatus Plant
City
Yaroslavl
ZIP/Postal Code
150007
Country
Russian Federation
Facility Name
Institute of Rheumatology
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Military Medical Academy
City
Belgrade
ZIP/Postal Code
11040
Country
Serbia
Facility Name
Clinical Center Bezanijska Kosa
City
Belgrade
ZIP/Postal Code
11070
Country
Serbia
Facility Name
Institute of Rheumatology and Cardiovascular Diseases; Rheumatology
City
Niska Banja
ZIP/Postal Code
18205
Country
Serbia
Facility Name
Groote Schuur Hospital; Rheumatology Unit
City
Cape Town
ZIP/Postal Code
7925
Country
South Africa
Facility Name
Chris Hani Baragwanath Hospital; Rheumatology Department
City
Diepkloof
ZIP/Postal Code
1862
Country
South Africa
Facility Name
Charlotte Maxeke Academic Hospital
City
Johannesburg
ZIP/Postal Code
2193
Country
South Africa
Facility Name
University of Pretoria; Clinical Trial Unit
City
Pretoria
ZIP/Postal Code
0002
Country
South Africa
Facility Name
Hospital de Merida ;Servicio de Reumatologia
City
Merida
State/Province
Badajoz
ZIP/Postal Code
06800
Country
Spain
Facility Name
Corporacio Sanitaria Parc Tauli
City
Sabadell
State/Province
Barcelona
ZIP/Postal Code
08208
Country
Spain
Facility Name
Hospital Sierrallana
City
Torrelavega
State/Province
Cantabria
ZIP/Postal Code
39300
Country
Spain
Facility Name
Hospital Clinico Universitario de Santiago
City
Santiago de Compostela
State/Province
La Coruña
ZIP/Postal Code
15706
Country
Spain
Facility Name
Hospital Infanta Sofia; Servicio de Reumatologia
City
San Sebastian de los Reyes
State/Province
Madrid
ZIP/Postal Code
28702
Country
Spain
Facility Name
Hospital Regional Universitario Carlos Haya
City
Málaga
State/Province
Malaga
ZIP/Postal Code
29009
Country
Spain
Facility Name
Hospital Universitario Virgen Macarena
City
Seville
State/Province
Sevilla
ZIP/Postal Code
41071
Country
Spain
Facility Name
Hospital Universitario de Canarias
City
S. Cristobal de la Laguna
State/Province
Tenerife
ZIP/Postal Code
38320
Country
Spain
Facility Name
Hospital de Cruces; Servicio de Reumatologia
City
Barakaldo
State/Province
Vizcaya
ZIP/Postal Code
48903
Country
Spain
Facility Name
Hospital Universitario Basurto
City
Bilbao
State/Province
Vizcaya
ZIP/Postal Code
48013
Country
Spain
Facility Name
Hospital General de Castellon; Servicio de Reumatologia
City
Castellon
ZIP/Postal Code
12004
Country
Spain
Facility Name
Hospital Gregorio Marañon
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Akdeniz Univesity Medical Faculty
City
Antalya
ZIP/Postal Code
07058
Country
Turkey
Facility Name
Trakya University Medical Faculty
City
Edirne
ZIP/Postal Code
22030
Country
Turkey
Facility Name
Ataturk University Med Faculty
City
Erzurum
ZIP/Postal Code
25050
Country
Turkey
Facility Name
Karadeniz Tecnical Uni. Med. Fac.
City
Trabzon
ZIP/Postal Code
61100
Country
Turkey
Facility Name
Selly Oak Hospital; Rheumatology Dept
City
Birmingham
ZIP/Postal Code
B29 6JD
Country
United Kingdom
Facility Name
Addenbrooke's NHS Trust
City
Cambridge
ZIP/Postal Code
CB2 0QQ
Country
United Kingdom
Facility Name
Cannock Chase Hospital; Rheumatology
City
Cannock
ZIP/Postal Code
WS11 5XY
Country
United Kingdom
Facility Name
Russells Hall Hospital; Rheumatology Department
City
Dudley
ZIP/Postal Code
DY1 2HQ
Country
United Kingdom
Facility Name
Leicester Royal Infirmary NHS Trust
City
Leicester
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Facility Name
Royal London Hospital Outpatients Department
City
London
ZIP/Postal Code
E1 1BB
Country
United Kingdom
Facility Name
Whipps Cross Hospital; Rheumatology Dept
City
London
ZIP/Postal Code
E11 1NR
Country
United Kingdom
Facility Name
King'S College Hospital
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
Facility Name
Royal Victoria Infirmary
City
Newcastle upon Tyne
ZIP/Postal Code
NE1 4LP
Country
United Kingdom
Facility Name
Salford Royal NHS Foundation Trust
City
Salford
ZIP/Postal Code
M6 8HD
Country
United Kingdom
Facility Name
Southampton General Hospital; Rheumatology
City
Southampton
ZIP/Postal Code
SO16 6YD
Country
United Kingdom
Facility Name
Southend Hospital; Rheumatology Department
City
Westcliffe-on-sea
ZIP/Postal Code
SS0 0RY
Country
United Kingdom
Facility Name
Wrightington Hospital
City
Wrightington
ZIP/Postal Code
WN6 9EP
Country
United Kingdom
12. IPD Sharing Statement
Citations:
PubMed Identifier
31469238
Citation
Giles JT, Sattar N, Gabriel S, Ridker PM, Gay S, Warne C, Musselman D, Brockwell L, Shittu E, Klearman M, Fleming TR. Cardiovascular Safety of Tocilizumab Versus Etanercept in Rheumatoid Arthritis: A Randomized Controlled Trial. Arthritis Rheumatol. 2020 Jan;72(1):31-40. doi: 10.1002/art.41095.
Results Reference
derived
Learn more about this trial
A Study of Tocilizumab in Comparison to Etanercept in Participants With Rheumatoid Arthritis and Cardiovascular Disease Risk Factors
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