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The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes (HITPET)

Primary Purpose

Type 2 Diabetes Mellitus, Healthy Volunteers

Status
Unknown status
Phase
Not Applicable
Locations
Finland
Study Type
Interventional
Intervention
HIT exercise intervention
Aerobic exercise intervention
Sponsored by
Turku University Hospital
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional trial for Type 2 Diabetes Mellitus

Eligibility Criteria

40 Years - 55 Years (Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

The healthy patients

  1. Age 40-55
  2. BMI 18.5-30
  3. Fasting plasma glucose less than 6.1 mmol/l
  4. Normal glucose tolerance test (OGTT)

The type 2 diabetic patients:

  1. Age-, sex-, and BMI-matched with the study subjects in the phase 1
  2. In a good treatment balance
  3. Glycated haemoglobin (HbA1c) less than 7.5 mmol/l
  4. Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l

Exclusion Criteria:

The healthy patients

  1. Blood pressure > 140/90 mmHg
  2. Any chronic disease
  3. Any chronic medical defect or injury which hinder/interfere everyday life
  4. History of anorexia nervosa or bulimia
  5. History of rest or exercise-induced asthma
  6. Previous use of anabolic steroids, additives or any other substrates
  7. Smoking of tobacco, taking of snuffs, or use of narcotics.
  8. Significant use of alcohol
  9. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  10. Presence of any ferromagnetic objects that would make MR imaging contraindicated
  11. Current or history of regular and systematic exercise training
  12. VO2max >40 ml/min/kg

The type 2 diabetic patients:

  1. Any other chronic disease than diabetes
  2. Blood pressure > 140/90 mmHg
  3. Any chronic medical defect or injury which hinder/interfere everyday life
  4. History of anorexia nervosa or bulimia
  5. History of rest or exercise-induced asthma
  6. Smoking of tobacco, taking of snuffs, or use of narcotics.
  7. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  8. Presence of any ferromagnetic objects that would make MRI imaging contraindicated
  9. Current or history of regular and systematic exercise training
  10. VO2max >40 ml/ min/kg

Sites / Locations

  • Turku PET CentreRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

HIT training

Aerobic exercise training

Arm Description

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
April 28, 2011
Last Updated
April 28, 2011
Sponsor
Turku University Hospital
Collaborators
European Foundation for the Study of Diabetes, Ministry of Education and Culture, Finland, Orion Farmos Research Foundation, Academy of Finland, Turku PET Centre, University of Turku, Verve Research, Oulu, Finland, University of Helsinki
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1. Study Identification

Unique Protocol Identification Number
NCT01344928
Brief Title
The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes
Acronym
HITPET
Study Type
Interventional

2. Study Status

Record Verification Date
April 2011
Overall Recruitment Status
Unknown status
Study Start Date
undefined (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor
Turku University Hospital
Collaborators
European Foundation for the Study of Diabetes, Ministry of Education and Culture, Finland, Orion Farmos Research Foundation, Academy of Finland, Turku PET Centre, University of Turku, Verve Research, Oulu, Finland, University of Helsinki

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The objectives of this study are to investigate the effects of short-time high-intensity interval training on tissue glucose and fat metabolism in healthy lean subjects and type 2 diabetic patients using modern and noninvasive imaging methods positron emission tomography (PET), magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Type 2 Diabetes Mellitus, Healthy Volunteers

7. Study Design

Study Phase
Not Applicable

8. Arms, Groups, and Interventions

Arm Title
HIT training
Arm Type
Experimental
Arm Title
Aerobic exercise training
Arm Type
Active Comparator
Intervention Type
Behavioral
Intervention Name(s)
HIT exercise intervention
Intervention Type
Behavioral
Intervention Name(s)
Aerobic exercise intervention

10. Eligibility

Sex
Male
Minimum Age & Unit of Time
40 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: The healthy patients Age 40-55 BMI 18.5-30 Fasting plasma glucose less than 6.1 mmol/l Normal glucose tolerance test (OGTT) The type 2 diabetic patients: Age-, sex-, and BMI-matched with the study subjects in the phase 1 In a good treatment balance Glycated haemoglobin (HbA1c) less than 7.5 mmol/l Two hours glucose value in oral glucose tolerance test (OGTT) less than 10.0 mmol/l Exclusion Criteria: The healthy patients Blood pressure > 140/90 mmHg Any chronic disease Any chronic medical defect or injury which hinder/interfere everyday life History of anorexia nervosa or bulimia History of rest or exercise-induced asthma Previous use of anabolic steroids, additives or any other substrates Smoking of tobacco, taking of snuffs, or use of narcotics. Significant use of alcohol Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results Presence of any ferromagnetic objects that would make MR imaging contraindicated Current or history of regular and systematic exercise training VO2max >40 ml/min/kg The type 2 diabetic patients: Any other chronic disease than diabetes Blood pressure > 140/90 mmHg Any chronic medical defect or injury which hinder/interfere everyday life History of anorexia nervosa or bulimia History of rest or exercise-induced asthma Smoking of tobacco, taking of snuffs, or use of narcotics. Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results Presence of any ferromagnetic objects that would make MRI imaging contraindicated Current or history of regular and systematic exercise training VO2max >40 ml/ min/kg
Facility Information:
Facility Name
Turku PET Centre
City
Turku
ZIP/Postal Code
20521
Country
Finland
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jarna C Hannukainen, PhD
Phone
+358-2-3131878
Email
jarna.hannukainen@tyks.fi
First Name & Middle Initial & Last Name & Degree
Jarna C Hannukainen, PhD
First Name & Middle Initial & Last Name & Degree
Kari K Kalliokoski, PhD
First Name & Middle Initial & Last Name & Degree
Joonas J Eskelinen, BM
First Name & Middle Initial & Last Name & Degree
Anna Savolainen, BM
First Name & Middle Initial & Last Name & Degree
Ilkka Heinonen, PhD
First Name & Middle Initial & Last Name & Degree
Kirsi A Virtanen, PhD
First Name & Middle Initial & Last Name & Degree
Jukka Kemppainen, PhD
First Name & Middle Initial & Last Name & Degree
Juhani Knuuti, Professor
First Name & Middle Initial & Last Name & Degree
Pirjo Nuutila, Professor
First Name & Middle Initial & Last Name & Degree
Jussi Pärkkä, MD
First Name & Middle Initial & Last Name & Degree
Virva Lepomäki, MSc
First Name & Middle Initial & Last Name & Degree
Riitta Parkkola, MD, PhD

12. IPD Sharing Statement

Citations:
PubMed Identifier
32785654
Citation
Ojala R, Motiani KK, Ivaska KK, Arponen M, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Heiskanen MA, U-Din M, Nuutila P, Kalliokoski KK, Hannukainen JC. Bone Marrow Metabolism Is Impaired in Insulin Resistance and Improves After Exercise Training. J Clin Endocrinol Metab. 2020 Dec 1;105(12):e4290-303. doi: 10.1210/clinem/dgaa516.
Results Reference
derived
PubMed Identifier
31425383
Citation
Motiani KK, Collado MC, Eskelinen JJ, Virtanen KA, Loyttyniemi E, Salminen S, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia. Med Sci Sports Exerc. 2020 Jan;52(1):94-104. doi: 10.1249/MSS.0000000000002112.
Results Reference
derived
PubMed Identifier
29717337
Citation
Heiskanen MA, Motiani KK, Mari A, Saunavaara V, Eskelinen JJ, Virtanen KA, Koivumaki M, Loyttyniemi E, Nuutila P, Kalliokoski KK, Hannukainen JC. Exercise training decreases pancreatic fat content and improves beta cell function regardless of baseline glucose tolerance: a randomised controlled trial. Diabetologia. 2018 Aug;61(8):1817-1828. doi: 10.1007/s00125-018-4627-x. Epub 2018 May 2.
Results Reference
derived

Learn more about this trial

The Effects of Short-time High-intensity Interval Training on Tissue Glucose and Fat Metabolism in Healthy Subjects and Patients With Type 2 Diabetes

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