Humoral Response to Tick-borne Encephalitis Vaccine in Elderly
Tick-borne Encephalitis
About this trial
This is an interventional prevention trial for Tick-borne Encephalitis focused on measuring immune response, TBE-vaccine, elderly, additional doses
Eligibility Criteria
Inclusion Criteria:
- Age 50 years or more
- generally healthy
- no immunosuppressive condition
- fertile women must use contraceptives
Exclusion Criteria:
- Previous TBE infection
- Previously immunized with TBE vaccine
- Anaphylactic reaction to egg protein
- Any disease or therapy which might suppress the immune response
- Vaccination should be delayed if a participant has fever
Sites / Locations
- Dept infectious diseases
- Dept infectious diseases
- Dept infectious diseases
- Department of infectious diseases
- Dept infectious diseases
- Department of infectious diseases
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Active Comparator
Active Comparator
TBE vaccine at 0+30 days
TBE vaccine at 0+7+21 days
TBE vaccinte at 0+30+90 days
younger participants
This group of 50 participants will follow the standard recommendation and will be given TBE vaccine 0.5 ml FSME immune at 0 + 30 days during the first year and an additional dose one year later
This group of 50 participants will will be given TBE vaccine 0.5 ml FSME immune at 0 + 7 +21 days during the first year and an additional dose one year later
This group of 50 participants will will be given TBE vaccine 0.5 ml FSME immune at 0 + 30 + 90 days during the first year and an additional dose one year later
This group of 50 participants in the age group 18-49 years will be given TBE vaccine 0.5 ml FSME immune at 0 +30 days during the first year and an additional dose one year later