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Molecular Profiling of Metastatic Cancer in Pleural Effusion and Ascites

Primary Purpose

Metastatic Cancer

Status
Unknown status
Phase
Locations
Taiwan
Study Type
Observational
Intervention
Sponsored by
Taipei Medical University WanFang Hospital
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for Metastatic Cancer focused on measuring Metastatic Cancer

Eligibility Criteria

20 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • cancer patients
  • pleural effusion or peritoneal effusion

Exclusion Criteria:

  • infected and fever patients
  • anticoagulant treatment patients
  • patients don't attend this study

Sites / Locations

  • Taipei Medical University - WanFang Hospital

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
June 8, 2011
Last Updated
June 8, 2011
Sponsor
Taipei Medical University WanFang Hospital
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1. Study Identification

Unique Protocol Identification Number
NCT01369992
Brief Title
Molecular Profiling of Metastatic Cancer in Pleural Effusion and Ascites
Official Title
Molecular Profiling of Metastatic Cancer in Pleural Effusion and Ascites
Study Type
Observational

2. Study Status

Record Verification Date
June 2011
Overall Recruitment Status
Unknown status
Study Start Date
May 2011 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
May 2013 (Anticipated)

3. Sponsor/Collaborators

Name of the Sponsor
Taipei Medical University WanFang Hospital

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Cancers are among the most frequent leading causes of death in Taiwan, and many of them show their respective unique epidemiological and pathophysiological features in Taiwanese population. One of the distinguishing features of cancers includes their potential to metastasize outside the primary tumor. Pleural cavity and peritoneum are two of the most frequent sites of metastases when serosal surfaces are involved. The prognoses of such patients are extremely poor with a median survival of months. The understandings of cancer biology of tumor metastasis demand more in-depth studies at the molecular and cell levels. Studies based on cell culture are excellent approaches for this purpose as the cell culture provides a relevant and renewable model for studying the pathological and molecular changes underlying human malignant tumors.
Detailed Description
Due to their easy accessibility, pleural effusions and ascites are two important clinical sources of metastatic cancer cells, which upon isolation, permit comparative studies between the biology nature of primary tumor and metastatic ones. In this study, we will try to isolate cancer cells from human malignant effusions, said to be pleural effusions and/or ascites. We will establish phenotypic alterations along the progression of malignant tumors with serosal metastasis, with special emphasis on expression of some proteases, laminin receptors and transcription factors involved in the process of invasion and metastasis. We would also perform clinical correlations, including tumor type, staging, status of lymph node metastasis and histopathological differentiation and grading, etc.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Metastatic Cancer
Keywords
Metastatic Cancer

7. Study Design

Enrollment
20 (Anticipated)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
20 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: cancer patients pleural effusion or peritoneal effusion Exclusion Criteria: infected and fever patients anticoagulant treatment patients patients don't attend this study
Study Population Description
cancer patients
Sampling Method
Non-Probability Sample
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Tze-Sian Chan
Organizational Affiliation
Taipei Medical University WanFang Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Taipei Medical University - WanFang Hospital
City
Taipei
Country
Taiwan

12. IPD Sharing Statement

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Molecular Profiling of Metastatic Cancer in Pleural Effusion and Ascites

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