Efficacy of Buffered Hypertonic Saline(BHS)Nasal Irrigation in Allergic Rhinitis (AR) Children

Efficacy of Buffered Hypertonic Saline Nasal Irrigation in Children With Symptomatic Allergic Rhinitis : A Randomized Double-blind Study.

The purpose of this study is to investigate whether buffered hypertonic saline (BHS) is superior to normal saline (NSS) for improving mucociliary function and relief nasal symptoms in children with allergic rhinitis.

BHS is superior to NSS for improving mucociliary function that by measure saccharine clearance time(SCT)at 10 minute after nasal irrigation compare to baseline. BHS is superior to NSS for clinical effectiveness at short period and 1 month follow up at short period: compare the following results at baseline and 10 minute after nasal irrigation total nasal symptom score(TNSS) satisfaction to nasal irrigation side effect at 2 and 4 weeks follow up : compare the following results at baseline and 10 minute after nasal irrigation quality of life(by specific questionnaire for Thai allergic rhinoconjunctivitis patient) medication use to relieve AR symptom(from diary record) compliance for nasal irrigation (from diary record) side effect (from diary record) overall satisfaction to nasal irrigation

SCT method : subjects seated with their head upright. A rhinoprobe was used to place a small piece of saccharine on the medial aspect of the inferior turbinate approximately 1 cm, posterior to the nasal vestibule. The SCT was recorded as the subject's first perception of a sweet taste.

evaluate total nasal symptom score, side effect, satisfaction for nasal irrigation, quality of life at 1st visit, 2nd week and 4 week follow up

Inclusion Criteria: age 6-15 years diagnosed AR obtained by history, physical examination and positive skin prick test or nasal cytology TNSS ≥ 4 at the first visit of this study Exclusion Criteria: Patients with a history of nasal anatomical defects Abnormal nasal ciliary function or an upper respiratory tract infection in the preceding 2 weeks