Aneurysm Wall Histology Registry

Albany Medical College, Northwestern University, Stony Brook University, Royal University Hospital Foundation, Indiana University, Providence Health & Services, University of Illinois at Chicago, Vanderbilt University, Methodist Health System

The purpose of this prospective registry is to determine if patients harboring intracranial aneurysms have any predictive markers between aneurysm wall tissue, cerebrospinal fluid and blood plasma.

To design a registry to evaluate the wall of intracranial aneurysms during open surgical clipping by direct photographic appearance, wall biopsy samples, CSF and blood plasma fluid collection (Interleukins; IL-8/ Matrix Metalloproteinase; MMP-9) for complete evaluation and comparison. The focus of the registry will be to determine the presence of aneurysmal wall defects, mural clot, atherosclerotic and atheroma, wall permeability and delamination. These findings will then be correlated to the collected CSF and blood values to determine if there is any direct features of the aneurysm wall that would predict any of the reported post embolic syndromes. The collected data can also be correlated to the peroperative imaging, (MRI, CT and Angiogram).

To determine the relative and absolute differences in histological changes as seen in the tissue samples comparing this to the CSF and blood plasma samples. To also determine if there is any gene expressions that can be utilized as predictive markers in this cohort of patients.

an average of 1 day after aneurysm treatment an analysis of the histological sample, CSF sample, and plasma samples will occur

clinical outcome at approximately 6 months after surgical clipping at routine follow up visit and approximately 12 months after clipping at routine follow up visit if indicated

approximately clinical outcome at 6 months after surgical clipping at routine follow up visit and approximately 12 months after clipping at routine follow up visit if indicated

Inclusion Criteria: Patient > 18 years but < 80 years of age Patient with an unruptured Intracranial aneurysm 8mm or larger Patient that surgical exposure and clipping will be the primary treatment option Exclusion Criteria: Any patient that has a ruptured intracranial aneurysm Any Pediatric patients Any patient presenting with any pre-treatment intracranial lesions Vascular malformations Hemorrhage Normal Pressure Hydrocephalus Obstructive Hydrocephalus White matter disease Tumors Trauma Other vascular type lesions Any meningitis type symptoms Medical or surgical co-morbidities such that the patient's life expectancy is less than 1 year Inability to obtain consent

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