Blood Conservation in Cardiac Surgery
Transfusion Reactions, Post Cardiac Surgery
About this trial
This is an interventional prevention trial for Transfusion Reactions focused on measuring Blood conservation, Transfusion, Hemoglobin trigger, Transfusion trigger, Cardiac surgery, Transfusion triggers post cardiac surgery
Eligibility Criteria
Inclusion Criteria:
Subjects who meet all of the following criteria will be considered for inclusion in this study:
Subjects scheduled to undergo any of the following cardiac surgeries as part of their routine medical care:
- CABG
- AVR
- MVR
- MV Repair
- CABG/AVR
- CABG/MVR
- CABG/MV Repair
- Thoracic Aneurysm Repair ± any concomitant cardiac procedure (valve, CABG, etc.)
- Subjects must be > 18 years of age
- No prior history of cardiac surgery.
- Able and willing to give informed consent
Exclusion Criteria:
Subjects who meet any of the following criteria will be excluded from participation in this study:
- Prior history of cardiac surgery
- Patients who do not have sufficient time prior to surgery to give proper informed consent (i.e.: immediate, emergency surgery)
- Patients who are younger than 18 years of age
Prior history of
- bleeding disorders
- symptomatic anemia (i.e. persistent tachycardia, orthostatic hypotension, persistent pressor requirement)
- hereditary/acquired coagulopathy
- platelet defects (e.g.: disseminated intravascular coagulation (DIC), hemophilia, Henoch-Schönlein purpura, hereditary hemorrhagic telangiectasia, thrombocytopenia (ITP, TTP), thrombophilia, Von Willebrand's disease)
- History of leukemia or any other blood related malignancy
- History of liver failure
- Current, or history of, pre-existing medical condition other than current cardiac condition, which in the opinion of the investigator, would place the subject at risk or have the potential to confound interpretation of the study results
- Participation in another clinical trial
- Lack of capacity to give informed consent.
Sites / Locations
- Hackensack University Medical Center
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Conservative Transfusion Arm
Liberal Transfusion Arm
Subjects in the conservative transfusion arm will receive transfusion only when their hemoglobin levels reach 7.5 g/dl.
Subjects in the liberal transfusion arm will receive transfusion only when their hemoglobin levels reach 9.0 g/dl.