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Perception and Multisensory Integration in Neurological Patients Using fMRI

Primary Purpose

Acute Inflammatory Demyelinating Polyradiculoneuropathy, Myasthenia Gravis, Stroke

Status
Unknown status
Phase
Not Applicable
Locations
Israel
Study Type
Interventional
Intervention
Siemens magnetom avanto1.5 Tesla, Siemens magnetom trio A Tim system 3 Tesla
Sponsored by
Hadassah Medical Organization
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Acute Inflammatory Demyelinating Polyradiculoneuropathy

Eligibility Criteria

18 Years - 80 Years (Adult, Older Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • diagnosis of the investigated neuronal disease

Exclusion Criteria:

  • contraindication for MRI scan
  • pregnancy
  • refusal to participate in the study

Sites / Locations

  • Hadassah Medical Organization

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

study group

Arm Description

fMRI

Outcomes

Primary Outcome Measures

assessing hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD)signal
Distinct maps of sensory and multisensory representations related to certain disorders will be assed by measurement of the Blood-oxygen-level dependence(BOLD)signal.

Secondary Outcome Measures

Full Information

First Posted
November 1, 2011
Last Updated
November 8, 2011
Sponsor
Hadassah Medical Organization
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1. Study Identification

Unique Protocol Identification Number
NCT01469858
Brief Title
Perception and Multisensory Integration in Neurological Patients Using fMRI
Official Title
Perception and Multisensory Integration in Neurological Patients Using fMRI
Study Type
Interventional

2. Study Status

Record Verification Date
September 2011
Overall Recruitment Status
Unknown status
Study Start Date
November 2011 (undefined)
Primary Completion Date
November 2013 (Anticipated)
Study Completion Date
November 2015 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hadassah Medical Organization

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The main objective of the study is to explore and map brain areas involved in sensory perception and multisensory integration in patients with central or peripheral neurological damage. The investigators hypothesize for example, that a change (compare to healthy subjects) in the perceptual maps and body representation could be detected and characterize in patients suffering from impairments of peripheral nerve conduction.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acute Inflammatory Demyelinating Polyradiculoneuropathy, Myasthenia Gravis, Stroke, Anosognosia, Asomatognosia

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
30 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
study group
Arm Type
Experimental
Arm Description
fMRI
Intervention Type
Device
Intervention Name(s)
Siemens magnetom avanto1.5 Tesla, Siemens magnetom trio A Tim system 3 Tesla
Intervention Description
functional magnetic resonance imaging
Primary Outcome Measure Information:
Title
assessing hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD)signal
Description
Distinct maps of sensory and multisensory representations related to certain disorders will be assed by measurement of the Blood-oxygen-level dependence(BOLD)signal.
Time Frame
1 year

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: diagnosis of the investigated neuronal disease Exclusion Criteria: contraindication for MRI scan pregnancy refusal to participate in the study
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Shahar Arzi, MD PhD
Phone
97226777741
Email
shahar.arzy@gmail.com
Facility Information:
Facility Name
Hadassah Medical Organization
City
Jerusalem
Country
Israel
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Arik Tzukert, DMD
Phone
00 972 2 6776095
Email
arik@hadassah.org.il
First Name & Middle Initial & Last Name & Degree
Hadas Lemberg, PhD
Phone
00 972 2 6777572
Email
lhadas@hadassah.org.il
First Name & Middle Initial & Last Name & Degree
Shahar Arzy, MD PhD

12. IPD Sharing Statement

Citations:
PubMed Identifier
16831974
Citation
Arzy S, Overney LS, Landis T, Blanke O. Neural mechanisms of embodiment: asomatognosia due to premotor cortex damage. Arch Neurol. 2006 Jul;63(7):1022-5. doi: 10.1001/archneur.63.7.1022.
Results Reference
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Perception and Multisensory Integration in Neurological Patients Using fMRI

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