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Efficacy and Safety Study of NeuVax™ (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence (PRESENT)

Primary Purpose

Breast Cancer With Low to Intermediate HER2 Expression

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
NeuVax™ vaccine
Leukine® (sargramostim, GM-CSF) and water for injection
Sponsored by
Galena Biopharma, Inc.
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Breast Cancer With Low to Intermediate HER2 Expression focused on measuring HER2, low or intermediate, breast cancer, node-positive tumors

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)FemaleDoes not accept healthy volunteers

Key Inclusion Criteria:

  • Pathological diagnosis of invasive adenocarcinoma of the breast
  • Breast cancer completely excised, or patient receiving neoadjuvant therapy prior to surgery

  • One of these 2 surgical treatments and axillary staging with sentinel lymph node dissection or axillary dissection level I/II:

    1. Total mastectomy-patients with a positive sentinel lymph node must have undergone a completion axillary dissection level I/II
    2. BCS (lumpectomy)-patients with a positive sentinel lymph node must have undergone a completion axillary dissection level I/II unless they had clinically node negative T1-T2 tumors and fewer than 3 involved lymph nodes
  • Node-positive disease
  • Primary tumor stage T1-3 at initial diagnosis
  • HER2 negative (HER2 1+ by IHC or HER2 2+ by IHC/FISH)
  • HLA-A2 or HLA-A3 haplotype
  • Completed NCCN approved neo-adjuvant/adjuvant chemotherapy or both
  • Completed radiation therapy
  • No evidence of disease
  • Able and willing (or have legal representative) to understand the study and provide consent

Key Exclusion Criteria:

  • Bilateral breast malignancy or suspicious mass in opposite breast
  • Inflammatory breast malignancy
  • History of prior breast cancer, ductal carcinoma in situ
  • Prior trastuzumab therapy
  • New York Heart Association Stage 3 or 4 cardiac disease
  • Sensory/motor neuropathy ≥ Grade 2
  • Autoimmune diseases or immune deficiency disease
  • Subjects on chronic steroid therapy, other immunosuppressive therapy

Sites / Locations

  • Alabama Oncology
  • Physicians Pain Specialists of Alabama, P.C.
  • Pain Centers Nationwide
  • Valley Pain Consultants
  • East Valley Hematology and Oncology Medical Group
  • Coastal Pain Research
  • Navajo Road Pain Management Center
  • California Cancer Associates for Research and Excellence, Inc.
  • California Cancer Associates For Research and Excellence
  • St. Jude Medical Center, Virginia K. Crosson Cancer Center
  • Interventional Pain Management
  • South Orange County Surgical Medical Group
  • University of Southern California/Norris Cancer Hospital
  • Alexander Ford, MD
  • Cancer Care Institute
  • Pete J. Ruane, MD, Inc.
  • Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute
  • Moores UC San Diego Cancer Center (UCSD)
  • University of California, San Francisco (UCSF), Hellen Diller Family Comprehensive Cancer Center
  • Pain Institute of Santa Monica
  • Randy Scharlach, MD
  • University of Colorado Cancer Center, Anschutz Medical Campus
  • Red Rocks Center for Rehabilitation
  • Western Connecticut Health Network, Danbury Hospital
  • Stamford Hospital, Bennett Cancer Center
  • Pain Management Associates of CT, PC
  • Innovative Medical Research of South Florida, Inc.
  • Holy Cross Hospital-Michael & Dianne Bienes Comprehensive Cancer Center
  • Cancer Specialists of North Florida (ICON)
  • MD Anderson Center-Orlando Health
  • Florida Cancer Research Institute (Florida Cancer Care)
  • Florida Cancer Care
  • H.Lee Moffitt Cancer Center and Research Institute
  • Northeast Georgia Cancer Care
  • Interventional Spine and Pain Management
  • Central Georgia Cancer Care
  • Cancer Treatment Centers of America
  • Northwestern University Feinberg School of Medicine, Lynn Sage Comprehensive Breast Center
  • Pain Management Institute
  • Cancer Center of Kansas
  • James Graham Brown Cancer Center, University of Louisville
  • Mary Bird Perkins Cancer Center
  • Center of Cancer and Blood Disorders (VEEDA network)
  • Beth Israel Deaconess Medical Center
  • Lahey Clinic Department of Hematology and Oncology
  • Physiatry Consultants
  • Michigan Interventional Pain Center
  • William Beaumont Hospital Cancer Center
  • Glenn Saperstein, D.O., LLC
  • Advanced Physical Medicine
  • Eastchester Cancer Care Center
  • Fountain Medical Group
  • Weill Cornell Medical College
  • Upper East Side Pain Medicine, P.C.
  • Comprehensive Pain Management
  • APWI
  • Wake Forest Baptist Health
  • St. Alexius Medical Center, Mid Dakota Clinic, PC
  • Akron General Medical Center
  • Cancer Treatment Centers of America
  • OHSU Knight Cancer Institute
  • Gettysburg Cancer Center
  • Conemaugh Memorial Hospital-Memorial Medical Center
  • J. Fred Stoner, MD
  • University of Pittsburgh Medical Center (UPMC) Cancer Center
  • Progressive Pain Solutions
  • Jerrold Rosenberg, MD
  • The West Clinic Comprehensive Breast Center
  • The West Clinic
  • PRIDE
  • UT Southwestern Medical Center / Simmons Comprehensive Cancer Center
  • Brooke Army Medical Center (now SAMMC)
  • Baylor College of Medicine
  • The University of Texas MD Anderson Cancer Center
  • University of Texas MD Anderson Cancer Center
  • Cancer Care Centers of South Texas
  • Clinical Trials of Texas, Inc
  • Virginia Cancer Specialists
  • Swedish Cancer Institute Research
  • Multicare Health System-Research Institute
  • Medical College of Wisconsin Department of Surgery Froedtert Hospital and Cancer Center
  • Central Onco Hospital
  • Serdika
  • Tsaritsa Yoanna - ISUL
  • Complex Oncology Center, Veliko Tarnovo
  • Sveta Marina
  • Cross Cancer Institute
  • Ottawa Hospital Cancer Centre
  • Health Sciences North Cancer Centre
  • Sunnybrook Research Institute
  • Hospital Charles LeMorne
  • Masaryk Memorial Cancer Institute, Comprehensive Cancer Care Clinic
  • University Hospital Hradec Kralove, Clinic of Oncology and Radiotherapy
  • University Hospital Olomouc, Clinic of Oncology
  • General University Hospital in Prague, Clinic of Oncology
  • Institut de Cancérologie de l'Ouest Siet Paul Papin
  • Centre Oscar Lambret
  • Institut de Cancérologie de l'Ouest/René Gauducheau
  • Centre Antoine Lacassagne
  • Charité Campus Mitte Universitaetsmedizin-Berlin Brustzentrum/Studienzentrum
  • Brustzentrum Klinikum Bremen-Mitte gGmbH
  • Universitätsklinikum Erlangen, Frauenklinik
  • Kliniken Essen Mitte, Evang. Huyssens Stiftung/Knappschaft GmbH, Klinik für Senologie/Brustzentrum
  • Universitätsklinikum Frankfurt, Klinik für Frauenheilkunde und Geburtshilfe
  • Nationales Centrum für Tumorerkrankungen (NCT), Gynäkologische Onkologie
  • Universitätsklinikum Schleswig-Holstein, Campus Kiel
  • Universität Marburg
  • Rotkreuzklinikum München gGmbH, Frauenklinik
  • Universitätsklinikum Münster, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
  • Klinikum Stuttgart, Krankenhaus Bad Cannstatt, Frauenklinik
  • Klinikum Mutterhaus der Borromaeerinnen
  • Gemeinschaftspraxis für Innere Medizin, Haematologie und internistische Onkologie Dr. R Schlag/Dr. Schoettker
  • Hetenyi Geza Hospital, Department of Oncology
  • Szent Margit Hospital, V. Department of Internal Medicine, Oncology
  • Semmelweis University, Department of Diagnostic Radiology and Oncotherapy
  • Petz Aladar County Teaching Hospital, Center for Oncoradiology
  • Kaposi Mor County Teaching Hospital, Center for Clinical Oncology
  • Borsod-Abauj-Zemplen County Hospital and University Educational Hospital, Center for Clinical Oncology and Radiology
  • Sheba Medical Centre
  • Rambam Health Care Campus
  • Rabin Medical Centre
  • Kaplan Medical Centre
  • Provincial Specialist Hospital in Wroclaw, Department of Chemotherapy
  • Polish Red Cross Marine Hospital, Department of Chemotherapy
  • Nicolaus Copernicus Memorial Provincial Specialist Hospital in Lodz, Department of Chemotheraphy
  • Greater Poland Cancer Center, Department of Chemotherapy
  • Magodent
  • Non-Public Health Care Facility MAGODENT
  • "Gavril Curteanu" Municipal Clinical Hospital
  • Medisprof SRL, Department of Medical Oncology
  • Oncology Center "Sf. Nectarie", Department of Medical Oncology
  • Dr. Constantin Opris County Emergency Hospital, Department of Oncology
  • Filantropia Clinical Hospital, Obstetrics and Gynaecology Department
  • Coltea Clinical Hospital, Oncology Department
  • Bucharest Universtiy Emergency Hosptial, Oncology Department
  • "Prof. Dr. Ion Chiricuta" Institute of Oncology
  • Iasi Regional Oncology Institute, Department of Medical Oncology
  • Oncomed SRL, Department of Medical Oncology
  • Oncology Center #2, Department of Healthcare of Krasnodar Territory Administration
  • Republican Oncology Center
  • Republican Clinical Oncoogy Center
  • Pyatigorsk Oncology Center
  • Arkhangelsk Clinical Oncology Center
  • Sverdlovsk Regional Oncology Center
  • Regional Oncology Center
  • Ivanovo Regional Oncology Center
  • Clinical Oncology Center #1, Department of Healthcare of Krasnodar Territory Administration
  • Krasnoyarsk Kryzhanovsky Regional Oncology Center
  • Kursk Regional Clinical Oncology Center
  • N.N. Blokhin Russian Cancer Research Center
  • N.N. Blokhin Russian Cancer Reserach Center
  • Clinical Diagnostics Center
  • Nizhny Novgorod Regional Oncology Center
  • Orel Oncology Center
  • Orenburg Regional Clinical Oncology Center
  • Medical Institution of Ryazan Region
  • Samara Regional Clinical Oncology Center
  • Petrov Research Institute of Oncology
  • Leningrad Regional Oncology Center
  • St. Petersburg Clinical Hospital
  • Mechnikov North-Western State Medical University
  • Municipal Clinical Oncology Center
  • Tambov Regional Clinical Oncology Center
  • Research Institute of Oncology
  • Bashkir State Medical University
  • Regional Clinical Oncology Center
  • Volgograd Regional Oncology Center #3
  • Yaroslavl Regional Oncology Center
  • Clinical Diagnostics Center
  • Kryvyi Rih Oncology Center/Dnipropetrovsk Regional Council, Department of Chemotherapy
  • Mariupol City Interdistrict Oncology Center, Surgery Department #2
  • Kharkiv Regional Clinical Oncology Center, Day Care Unit
  • Chernivtsi Regional Clinical Oncology Center, Day Care Unit
  • Dnipropetrovsk City Multispecialty Clinical Hospital #4/Dnipropetrovsk Regional Council, Department of Chemotherapy
  • Donetsk City Oncology Center
  • Donetsk Regional Antitumor Center, Oncosurgery Department #2
  • State Institution: S.P. Grigoriev Institute of Medical Radiology Under the Academy of Medical Sciences of Ukraine
  • Public Institution: Kiev Regional Oncology Hospital within Kyiv Regional Council
  • Kirovohrad Regional Oncology Center, Department of Mammology
  • Kyiv City Clinical Oncology Center, Department of Chemotherapy
  • Lviv State Regional Treatment and Diagnostics Oncology Center, Department of Chemotherapy
  • Odesa Regional Clinical Hospital, Center for Mastology
  • Zakarpattia Regional Clinical Oncology Center, Department of Chemotherapy
  • Vinnytsia Regional Clinical Oncology Center
  • Public Institution Zaporizhia Regional Clinical Oncology Center within Zaporizhia Regional Council
  • Macclesfield District General Hospital
  • The Christie NHS Foundation Trust
  • The Royal Marsden NHS Foundation Trust
  • Leeds Teaching Hospitals Trust, St. James University Hospital
  • Leicester Royal Infirmary
  • The Royal Marsden NHS Foundation Trust
  • James Cook University Hospital
  • Academic Unit of Oncology, Nottingham University Hospital-City Campus
  • Plymouth Oncology Centre, Derriford Hospital
  • Weston Park Hospital
  • Southampton General Hospital
  • University Hospital of North Staffordshire

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

NeuVax™

Leukine®

Arm Description

NeuVax™ in WFI solution with Leukine®

Leukine® with WFI

Outcomes

Primary Outcome Measures

Comparison of DFS in vaccine treated patients and control patients
The primary objective is to compare the DFS in subjects with operable early-stage, node-positive breast cancer who receive standard of care multimodality therapy plus NeuVax™ as the treatment group or standard of care multimodality therapy plus the vaccine adjuvant, Leukine® as the control group.

Secondary Outcome Measures

Assessment of DFS and OS at 3, 5 and 10 years in vaccine and control groups, respectively; assessment of safety
The secondary objectives are to evaluate the 2 groups of subjects for: 5- and 10-year DFS 3-year OS 5- and 10-year OS Time to recurrence (TTR), time to local recurrence (TTLR), time to distant recurrence (TTDR), time to bone metastases (TTBM) Overall safety profile and adverse events (AEs)

Full Information

First Posted
November 20, 2011
Last Updated
February 23, 2017
Sponsor
Galena Biopharma, Inc.
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1. Study Identification

Unique Protocol Identification Number
NCT01479244
Brief Title
Efficacy and Safety Study of NeuVax™ (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence
Acronym
PRESENT
Official Title
PRESENT: Prevention of Recurrence in Early-Stage, Node-Positive Breast Cancer With Low to Intermediate HER2 Expressions With NeuVax™Treatment
Study Type
Interventional

2. Study Status

Record Verification Date
February 2017
Overall Recruitment Status
Completed
Study Start Date
November 2011 (undefined)
Primary Completion Date
September 21, 2016 (Actual)
Study Completion Date
September 21, 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Galena Biopharma, Inc.

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Purpose of this trial: To assess the efficacy and safety of NeuVax™ administered with adjuvant Leukine® (sargramostim, GM-CSF). To evaluate and compare the disease free survival (DFS) in the vaccinated and control subjects.
Detailed Description
This is a multicenter, multinational, prospective, randomized, double-blind, controlled Phase 3 study. The subjects eligible for this trial have an early stage node-positive breast cancer. Their tumors express low or intermediate levels of the HER2 protein. NeuVax™ will be administered after completion of front-line, standard of care therapy (surgery, radiation therapy, and chemotherapy) and can be given concomitantly with physician prescribed endocrine treatment. NeuVax™ is the immmunodominant nonapeptide derived from the extracellular domain of the HER2 protein, a well-established target for therapeutic intervention in breast carcinoma. The nelipepimut sequence stimulates specific CD8+ cytotoxic T lymphocytes (CTL) following binding to HLA-A2/A3 molecules on antigen presenting cells (APC). These activated specific CTLs recognize, neutralize and destroy through cell lysis HER2 expressing cancer cells, including occult cancer cells and micrometastatic foci. The nelipepimut immune response can also generate CTLs to other immunogenic peptides through inter- and intra-antigenic epitope spreading. Based on a successful Phase 2 trial, which achieved its primary endpoint of DFS, the Food and Drug Administration (FDA) granted NeuVax a Special Protocol Assessment (SPA) for its Phase 3 PRESENT (Prevention of Recurrence in Early-Stage, Node-Positive Breast Cancer with Low to Intermediate HER2 Expression with NeuVax Treatment) study. The active portion of the study will last three years (36 months). The follow-up will last from 5 to 10 years. Endpoints: Primary efficacy endpoint: 3-year DFS Secondary efficacy endpoints: 5- and 10-year DFS 3-year OS 5- and 10-year OS Safety profile, and adverse events (AEs) Patterns of recurrence to include Time to recurrence (TTR), time to local recurrence (TTLR), time to distant recurrence (TTDR), time to bone metastases (TTBM) Safety Assessments: Subjects will be assessed at every study visit for the safety endpoints, AEs,vital signs, physical examinations and laboratory data; yearly follow-up of survival will include imaging studies, ECGs, MUGA or ECHO scans and concomitant medications.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Breast Cancer With Low to Intermediate HER2 Expression
Keywords
HER2, low or intermediate, breast cancer, node-positive tumors

7. Study Design

Primary Purpose
Prevention
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
758 (Actual)

8. Arms, Groups, and Interventions

Arm Title
NeuVax™
Arm Type
Experimental
Arm Description
NeuVax™ in WFI solution with Leukine®
Arm Title
Leukine®
Arm Type
Active Comparator
Arm Description
Leukine® with WFI
Intervention Type
Biological
Intervention Name(s)
NeuVax™ vaccine
Other Intervention Name(s)
E75 peptide acetate , WFI, sargramostim, GM-CSF
Intervention Description
E75 peptide acetate (HER2/neu p366-379) in WFI (1.5 mg/mL) mixed with 250 micrograms Leukine® (sargramostim, GM-CSF), will be administered in intradermal injections, in four divided doses (4 sites on upper thigh) once a month, for six consecutive months. At the end of the six months, NeuVax™ vaccine boosters will be given the same way once every six months for the next five times (totaling 36 months).
Intervention Type
Biological
Intervention Name(s)
Leukine® (sargramostim, GM-CSF) and water for injection
Other Intervention Name(s)
Leukine®
Intervention Description
Leukine® 250 micrograms in water for injection, will be administered in intradermal injections, in four divided doses (4 sites on upper thigh) once a month, for six consecutive months. At the end of the six months, boosters inoculations will be given the same way once every six months for the next five times (totaling 36 months).
Primary Outcome Measure Information:
Title
Comparison of DFS in vaccine treated patients and control patients
Description
The primary objective is to compare the DFS in subjects with operable early-stage, node-positive breast cancer who receive standard of care multimodality therapy plus NeuVax™ as the treatment group or standard of care multimodality therapy plus the vaccine adjuvant, Leukine® as the control group.
Time Frame
36 months
Secondary Outcome Measure Information:
Title
Assessment of DFS and OS at 3, 5 and 10 years in vaccine and control groups, respectively; assessment of safety
Description
The secondary objectives are to evaluate the 2 groups of subjects for: 5- and 10-year DFS 3-year OS 5- and 10-year OS Time to recurrence (TTR), time to local recurrence (TTLR), time to distant recurrence (TTDR), time to bone metastases (TTBM) Overall safety profile and adverse events (AEs)
Time Frame
3 through 10 years

10. Eligibility

Sex
Female
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Key Inclusion Criteria: Pathological diagnosis of invasive adenocarcinoma of the breast Breast cancer completely excised, or patient receiving neoadjuvant therapy prior to surgery One of these 2 surgical treatments and axillary staging with sentinel lymph node dissection or axillary dissection level I/II: Total mastectomy-patients with a positive sentinel lymph node must have undergone a completion axillary dissection level I/II BCS (lumpectomy)-patients with a positive sentinel lymph node must have undergone a completion axillary dissection level I/II unless they had clinically node negative T1-T2 tumors and fewer than 3 involved lymph nodes Node-positive disease Primary tumor stage T1-3 at initial diagnosis HER2 negative (HER2 1+ by IHC or HER2 2+ by IHC/FISH) HLA-A2 or HLA-A3 haplotype Completed NCCN approved neo-adjuvant/adjuvant chemotherapy or both Completed radiation therapy No evidence of disease Able and willing (or have legal representative) to understand the study and provide consent Key Exclusion Criteria: Bilateral breast malignancy or suspicious mass in opposite breast Inflammatory breast malignancy History of prior breast cancer, ductal carcinoma in situ Prior trastuzumab therapy New York Heart Association Stage 3 or 4 cardiac disease Sensory/motor neuropathy ≥ Grade 2 Autoimmune diseases or immune deficiency disease Subjects on chronic steroid therapy, other immunosuppressive therapy
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Elizabeth A Mittendorf, MD,FACS
Organizational Affiliation
M.D. Anderson Cancer Center
Official's Role
Principal Investigator
Facility Information:
Facility Name
Alabama Oncology
City
Bessemer
State/Province
Alabama
ZIP/Postal Code
35022
Country
United States
Facility Name
Physicians Pain Specialists of Alabama, P.C.
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36606
Country
United States
Facility Name
Pain Centers Nationwide
City
Peoria
State/Province
Arizona
ZIP/Postal Code
83582
Country
United States
Facility Name
Valley Pain Consultants
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85254
Country
United States
Facility Name
East Valley Hematology and Oncology Medical Group
City
Burbank
State/Province
California
ZIP/Postal Code
91505
Country
United States
Facility Name
Coastal Pain Research
City
Carlsbad
State/Province
California
ZIP/Postal Code
92009
Country
United States
Facility Name
Navajo Road Pain Management Center
City
El Cajon
State/Province
California
ZIP/Postal Code
92020
Country
United States
Facility Name
California Cancer Associates for Research and Excellence, Inc.
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Facility Name
California Cancer Associates For Research and Excellence
City
Fresno
State/Province
California
ZIP/Postal Code
93720
Country
United States
Facility Name
St. Jude Medical Center, Virginia K. Crosson Cancer Center
City
Fullerton
State/Province
California
ZIP/Postal Code
92801
Country
United States
Facility Name
Interventional Pain Management
City
Irvine
State/Province
California
ZIP/Postal Code
92618
Country
United States
Facility Name
South Orange County Surgical Medical Group
City
Laguna Hills
State/Province
California
ZIP/Postal Code
92653
Country
United States
Facility Name
University of Southern California/Norris Cancer Hospital
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Alexander Ford, MD
City
Los Angeles
State/Province
California
ZIP/Postal Code
90035
Country
United States
Facility Name
Cancer Care Institute
City
Los Angeles
State/Province
California
ZIP/Postal Code
90036
Country
United States
Facility Name
Pete J. Ruane, MD, Inc.
City
Los Angeles
State/Province
California
ZIP/Postal Code
90036
Country
United States
Facility Name
Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
Moores UC San Diego Cancer Center (UCSD)
City
San Diego
State/Province
California
ZIP/Postal Code
92093
Country
United States
Facility Name
University of California, San Francisco (UCSF), Hellen Diller Family Comprehensive Cancer Center
City
San Francisco
State/Province
California
ZIP/Postal Code
94115
Country
United States
Facility Name
Pain Institute of Santa Monica
City
Santa Monica
State/Province
California
ZIP/Postal Code
90404
Country
United States
Facility Name
Randy Scharlach, MD
City
Woodland Hills
State/Province
California
ZIP/Postal Code
91367
Country
United States
Facility Name
University of Colorado Cancer Center, Anschutz Medical Campus
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Red Rocks Center for Rehabilitation
City
Golden
State/Province
Colorado
ZIP/Postal Code
80401
Country
United States
Facility Name
Western Connecticut Health Network, Danbury Hospital
City
Danbury
State/Province
Connecticut
ZIP/Postal Code
06810
Country
United States
Facility Name
Stamford Hospital, Bennett Cancer Center
City
Stamford
State/Province
Connecticut
ZIP/Postal Code
06904
Country
United States
Facility Name
Pain Management Associates of CT, PC
City
Stamford
State/Province
Connecticut
ZIP/Postal Code
06905
Country
United States
Facility Name
Innovative Medical Research of South Florida, Inc.
City
Aventura
State/Province
Florida
ZIP/Postal Code
33180
Country
United States
Facility Name
Holy Cross Hospital-Michael & Dianne Bienes Comprehensive Cancer Center
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33308
Country
United States
Facility Name
Cancer Specialists of North Florida (ICON)
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32256
Country
United States
Facility Name
MD Anderson Center-Orlando Health
City
Orlando
State/Province
Florida
ZIP/Postal Code
32806
Country
United States
Facility Name
Florida Cancer Research Institute (Florida Cancer Care)
City
Plantation
State/Province
Florida
ZIP/Postal Code
33317
Country
United States
Facility Name
Florida Cancer Care
City
Plantation
State/Province
Florida
ZIP/Postal Code
33324
Country
United States
Facility Name
H.Lee Moffitt Cancer Center and Research Institute
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Facility Name
Northeast Georgia Cancer Care
City
Athens
State/Province
Georgia
ZIP/Postal Code
30607
Country
United States
Facility Name
Interventional Spine and Pain Management
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30309
Country
United States
Facility Name
Central Georgia Cancer Care
City
Macon
State/Province
Georgia
ZIP/Postal Code
31201
Country
United States
Facility Name
Cancer Treatment Centers of America
City
Newnan
State/Province
Georgia
ZIP/Postal Code
30265
Country
United States
Facility Name
Northwestern University Feinberg School of Medicine, Lynn Sage Comprehensive Breast Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
Facility Name
Pain Management Institute
City
Overland Park
State/Province
Kansas
ZIP/Postal Code
66210
Country
United States
Facility Name
Cancer Center of Kansas
City
Wichita
State/Province
Kansas
ZIP/Postal Code
67214
Country
United States
Facility Name
James Graham Brown Cancer Center, University of Louisville
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
Mary Bird Perkins Cancer Center
City
Baton Rouge
State/Province
Louisiana
ZIP/Postal Code
70809
Country
United States
Facility Name
Center of Cancer and Blood Disorders (VEEDA network)
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20817
Country
United States
Facility Name
Beth Israel Deaconess Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Lahey Clinic Department of Hematology and Oncology
City
Burlington
State/Province
Massachusetts
ZIP/Postal Code
01805
Country
United States
Facility Name
Physiatry Consultants
City
Bay City
State/Province
Michigan
ZIP/Postal Code
48796
Country
United States
Facility Name
Michigan Interventional Pain Center
City
Brownstown
State/Province
Michigan
ZIP/Postal Code
48183
Country
United States
Facility Name
William Beaumont Hospital Cancer Center
City
Royal Oak
State/Province
Michigan
ZIP/Postal Code
48071
Country
United States
Facility Name
Glenn Saperstein, D.O., LLC
City
Saginaw
State/Province
Michigan
ZIP/Postal Code
48604
Country
United States
Facility Name
Advanced Physical Medicine
City
St. Clair Shores
State/Province
Michigan
ZIP/Postal Code
48080
Country
United States
Facility Name
Eastchester Cancer Care Center
City
Bronx
State/Province
New York
ZIP/Postal Code
10469
Country
United States
Facility Name
Fountain Medical Group
City
New York
State/Province
New York
ZIP/Postal Code
10021
Country
United States
Facility Name
Weill Cornell Medical College
City
New York
State/Province
New York
ZIP/Postal Code
100665
Country
United States
Facility Name
Upper East Side Pain Medicine, P.C.
City
New York
State/Province
New York
ZIP/Postal Code
36607
Country
United States
Facility Name
Comprehensive Pain Management
City
Syosset
State/Province
New York
ZIP/Postal Code
11791
Country
United States
Facility Name
APWI
City
Williamsville
State/Province
New York
ZIP/Postal Code
14221
Country
United States
Facility Name
Wake Forest Baptist Health
City
Winston-Salem
State/Province
North Carolina
ZIP/Postal Code
27157
Country
United States
Facility Name
St. Alexius Medical Center, Mid Dakota Clinic, PC
City
Bismarck
State/Province
North Dakota
ZIP/Postal Code
58501
Country
United States
Facility Name
Akron General Medical Center
City
Akron
State/Province
Ohio
ZIP/Postal Code
44302
Country
United States
Facility Name
Cancer Treatment Centers of America
City
Tulsa
State/Province
Oklahoma
ZIP/Postal Code
74133
Country
United States
Facility Name
OHSU Knight Cancer Institute
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Gettysburg Cancer Center
City
Gettysburgh
State/Province
Pennsylvania
ZIP/Postal Code
17325
Country
United States
Facility Name
Conemaugh Memorial Hospital-Memorial Medical Center
City
Johnstown
State/Province
Pennsylvania
ZIP/Postal Code
15905
Country
United States
Facility Name
J. Fred Stoner, MD
City
New Castle
State/Province
Pennsylvania
ZIP/Postal Code
16101
Country
United States
Facility Name
University of Pittsburgh Medical Center (UPMC) Cancer Center
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15232
Country
United States
Facility Name
Progressive Pain Solutions
City
Wind Gap
State/Province
Pennsylvania
ZIP/Postal Code
18091
Country
United States
Facility Name
Jerrold Rosenberg, MD
City
Providence
State/Province
Rhode Island
ZIP/Postal Code
02904
Country
United States
Facility Name
The West Clinic Comprehensive Breast Center
City
Germantown
State/Province
Tennessee
ZIP/Postal Code
38138
Country
United States
Facility Name
The West Clinic
City
Memphis
State/Province
Tennessee
ZIP/Postal Code
38120
Country
United States
Facility Name
PRIDE
City
Dallas
State/Province
Texas
ZIP/Postal Code
75235
Country
United States
Facility Name
UT Southwestern Medical Center / Simmons Comprehensive Cancer Center
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Brooke Army Medical Center (now SAMMC)
City
Ft. Sam Houston
State/Province
Texas
ZIP/Postal Code
78234
Country
United States
Facility Name
Baylor College of Medicine
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
The University of Texas MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
University of Texas MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
Cancer Care Centers of South Texas
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Clinical Trials of Texas, Inc
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Facility Name
Virginia Cancer Specialists
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22031
Country
United States
Facility Name
Swedish Cancer Institute Research
City
Seattle
State/Province
Washington
ZIP/Postal Code
98104
Country
United States
Facility Name
Multicare Health System-Research Institute
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Medical College of Wisconsin Department of Surgery Froedtert Hospital and Cancer Center
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
52336
Country
United States
Facility Name
Central Onco Hospital
City
Plovdiv
ZIP/Postal Code
4002
Country
Bulgaria
Facility Name
Serdika
City
Sofia
ZIP/Postal Code
1303
Country
Bulgaria
Facility Name
Tsaritsa Yoanna - ISUL
City
Sofia
ZIP/Postal Code
1527
Country
Bulgaria
Facility Name
Complex Oncology Center, Veliko Tarnovo
City
Tarnovo
ZIP/Postal Code
5000
Country
Bulgaria
Facility Name
Sveta Marina
City
Varna
ZIP/Postal Code
9010
Country
Bulgaria
Facility Name
Cross Cancer Institute
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G1Z2
Country
Canada
Facility Name
Ottawa Hospital Cancer Centre
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Facility Name
Health Sciences North Cancer Centre
City
Sudbury
State/Province
Ontario
ZIP/Postal Code
P3E 5J1
Country
Canada
Facility Name
Sunnybrook Research Institute
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Facility Name
Hospital Charles LeMorne
City
Greenfield Park
State/Province
Quebec
ZIP/Postal Code
J4V 2H1
Country
Canada
Facility Name
Masaryk Memorial Cancer Institute, Comprehensive Cancer Care Clinic
City
Brno
ZIP/Postal Code
656 53
Country
Czech Republic
Facility Name
University Hospital Hradec Kralove, Clinic of Oncology and Radiotherapy
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czech Republic
Facility Name
University Hospital Olomouc, Clinic of Oncology
City
Olomouc
ZIP/Postal Code
775 20
Country
Czech Republic
Facility Name
General University Hospital in Prague, Clinic of Oncology
City
Prague 2
ZIP/Postal Code
128 08
Country
Czech Republic
Facility Name
Institut de Cancérologie de l'Ouest Siet Paul Papin
City
Angers
State/Province
Cedex 9
ZIP/Postal Code
49933
Country
France
Facility Name
Centre Oscar Lambret
City
Cédex
State/Province
Lille
ZIP/Postal Code
59020
Country
France
Facility Name
Institut de Cancérologie de l'Ouest/René Gauducheau
City
St Herblain, Nantes Cedex
State/Province
Loire-Atlantique
ZIP/Postal Code
44805
Country
France
Facility Name
Centre Antoine Lacassagne
City
Nice
ZIP/Postal Code
06189
Country
France
Facility Name
Charité Campus Mitte Universitaetsmedizin-Berlin Brustzentrum/Studienzentrum
City
Berlin
ZIP/Postal Code
10117
Country
Germany
Facility Name
Brustzentrum Klinikum Bremen-Mitte gGmbH
City
Bremen
ZIP/Postal Code
28177
Country
Germany
Facility Name
Universitätsklinikum Erlangen, Frauenklinik
City
Erlangen
ZIP/Postal Code
D-91054
Country
Germany
Facility Name
Kliniken Essen Mitte, Evang. Huyssens Stiftung/Knappschaft GmbH, Klinik für Senologie/Brustzentrum
City
Essen
ZIP/Postal Code
D-45136
Country
Germany
Facility Name
Universitätsklinikum Frankfurt, Klinik für Frauenheilkunde und Geburtshilfe
City
Frankfurt
ZIP/Postal Code
60590
Country
Germany
Facility Name
Nationales Centrum für Tumorerkrankungen (NCT), Gynäkologische Onkologie
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
Facility Name
Universitätsklinikum Schleswig-Holstein, Campus Kiel
City
Kiel
ZIP/Postal Code
24105
Country
Germany
Facility Name
Universität Marburg
City
Marburg
ZIP/Postal Code
35043
Country
Germany
Facility Name
Rotkreuzklinikum München gGmbH, Frauenklinik
City
Muenchen
ZIP/Postal Code
80637
Country
Germany
Facility Name
Universitätsklinikum Münster, Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe
City
Münster
ZIP/Postal Code
48149
Country
Germany
Facility Name
Klinikum Stuttgart, Krankenhaus Bad Cannstatt, Frauenklinik
City
Stuttgart
ZIP/Postal Code
70374
Country
Germany
Facility Name
Klinikum Mutterhaus der Borromaeerinnen
City
Trier
ZIP/Postal Code
54290
Country
Germany
Facility Name
Gemeinschaftspraxis für Innere Medizin, Haematologie und internistische Onkologie Dr. R Schlag/Dr. Schoettker
City
Wuerzburg
ZIP/Postal Code
D-97080
Country
Germany
Facility Name
Hetenyi Geza Hospital, Department of Oncology
City
Szolnok
State/Province
Jasz-Nagykun-Szolnok
ZIP/Postal Code
H-5000
Country
Hungary
Facility Name
Szent Margit Hospital, V. Department of Internal Medicine, Oncology
City
Budapest
ZIP/Postal Code
H-1032
Country
Hungary
Facility Name
Semmelweis University, Department of Diagnostic Radiology and Oncotherapy
City
Budapest
ZIP/Postal Code
H-1083
Country
Hungary
Facility Name
Petz Aladar County Teaching Hospital, Center for Oncoradiology
City
Gyor
ZIP/Postal Code
H-9024
Country
Hungary
Facility Name
Kaposi Mor County Teaching Hospital, Center for Clinical Oncology
City
Kaposvar
ZIP/Postal Code
7400
Country
Hungary
Facility Name
Borsod-Abauj-Zemplen County Hospital and University Educational Hospital, Center for Clinical Oncology and Radiology
City
Miskolc
ZIP/Postal Code
3526
Country
Hungary
Facility Name
Sheba Medical Centre
City
Tel Hasomer
State/Province
Ramat Gan
ZIP/Postal Code
52621
Country
Israel
Facility Name
Rambam Health Care Campus
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Facility Name
Rabin Medical Centre
City
Petach Tikva
ZIP/Postal Code
49100
Country
Israel
Facility Name
Kaplan Medical Centre
City
Rehovot
ZIP/Postal Code
76100
Country
Israel
Facility Name
Provincial Specialist Hospital in Wroclaw, Department of Chemotherapy
City
Kamienskiego
State/Province
Wroclaw
ZIP/Postal Code
51-124
Country
Poland
Facility Name
Polish Red Cross Marine Hospital, Department of Chemotherapy
City
Gdynia
ZIP/Postal Code
81-519
Country
Poland
Facility Name
Nicolaus Copernicus Memorial Provincial Specialist Hospital in Lodz, Department of Chemotheraphy
City
Lodz
ZIP/Postal Code
93-513
Country
Poland
Facility Name
Greater Poland Cancer Center, Department of Chemotherapy
City
Poznan
ZIP/Postal Code
61-866
Country
Poland
Facility Name
Magodent
City
Warsaw
ZIP/Postal Code
04-125
Country
Poland
Facility Name
Non-Public Health Care Facility MAGODENT
City
Warsaw
ZIP/Postal Code
04-125
Country
Poland
Facility Name
"Gavril Curteanu" Municipal Clinical Hospital
City
Oradea
State/Province
Bihor
ZIP/Postal Code
410469
Country
Romania
Facility Name
Medisprof SRL, Department of Medical Oncology
City
Cluj-Napoca
State/Province
Cluj
ZIP/Postal Code
400058
Country
Romania
Facility Name
Oncology Center "Sf. Nectarie", Department of Medical Oncology
City
Craiova
State/Province
Dolj County
ZIP/Postal Code
200347
Country
Romania
Facility Name
Dr. Constantin Opris County Emergency Hospital, Department of Oncology
City
Baia Mare, Maramures
ZIP/Postal Code
430031
Country
Romania
Facility Name
Filantropia Clinical Hospital, Obstetrics and Gynaecology Department
City
Bucharest
ZIP/Postal Code
011171
Country
Romania
Facility Name
Coltea Clinical Hospital, Oncology Department
City
Bucharest
ZIP/Postal Code
030171
Country
Romania
Facility Name
Bucharest Universtiy Emergency Hosptial, Oncology Department
City
Bucharest
ZIP/Postal Code
050098
Country
Romania
Facility Name
"Prof. Dr. Ion Chiricuta" Institute of Oncology
City
Cluj-Napoca
ZIP/Postal Code
400015
Country
Romania
Facility Name
Iasi Regional Oncology Institute, Department of Medical Oncology
City
Iasi
ZIP/Postal Code
700483
Country
Romania
Facility Name
Oncomed SRL, Department of Medical Oncology
City
Timisoara
ZIP/Postal Code
300239
Country
Romania
Facility Name
Oncology Center #2, Department of Healthcare of Krasnodar Territory Administration
City
Sochi
State/Province
Krasnodar
ZIP/Postal Code
354057
Country
Russian Federation
Facility Name
Republican Oncology Center
City
Saransk
State/Province
Republic of Mordovia
ZIP/Postal Code
430032
Country
Russian Federation
Facility Name
Republican Clinical Oncoogy Center
City
Kazan
State/Province
Republic of Tatarstan
ZIP/Postal Code
420029
Country
Russian Federation
Facility Name
Pyatigorsk Oncology Center
City
Pyatigorsk
State/Province
Stavropol Region
ZIP/Postal Code
357502
Country
Russian Federation
Facility Name
Arkhangelsk Clinical Oncology Center
City
Arkhangelsk
ZIP/Postal Code
163045
Country
Russian Federation
Facility Name
Sverdlovsk Regional Oncology Center
City
Ekaterinburg
ZIP/Postal Code
620036
Country
Russian Federation
Facility Name
Regional Oncology Center
City
Irkutsk
ZIP/Postal Code
664035
Country
Russian Federation
Facility Name
Ivanovo Regional Oncology Center
City
Ivanovo
ZIP/Postal Code
153040
Country
Russian Federation
Facility Name
Clinical Oncology Center #1, Department of Healthcare of Krasnodar Territory Administration
City
Krasnodar
ZIP/Postal Code
350040
Country
Russian Federation
Facility Name
Krasnoyarsk Kryzhanovsky Regional Oncology Center
City
Krasnoyarsk
ZIP/Postal Code
660133
Country
Russian Federation
Facility Name
Kursk Regional Clinical Oncology Center
City
Kursk
ZIP/Postal Code
305035
Country
Russian Federation
Facility Name
N.N. Blokhin Russian Cancer Research Center
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
N.N. Blokhin Russian Cancer Reserach Center
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
Clinical Diagnostics Center
City
Nizhny Novgorod
ZIP/Postal Code
603006
Country
Russian Federation
Facility Name
Nizhny Novgorod Regional Oncology Center
City
Nizhny Novgorod
ZIP/Postal Code
603081
Country
Russian Federation
Facility Name
Orel Oncology Center
City
Orel
ZIP/Postal Code
302020
Country
Russian Federation
Facility Name
Orenburg Regional Clinical Oncology Center
City
Orenburg
ZIP/Postal Code
460051
Country
Russian Federation
Facility Name
Medical Institution of Ryazan Region
City
Ryazan
ZIP/Postal Code
390011
Country
Russian Federation
Facility Name
Samara Regional Clinical Oncology Center
City
Samara
ZIP/Postal Code
443031
Country
Russian Federation
Facility Name
Petrov Research Institute of Oncology
City
St Petersburg
ZIP/Postal Code
197758
Country
Russian Federation
Facility Name
Leningrad Regional Oncology Center
City
St. Petersburg
ZIP/Postal Code
191104
Country
Russian Federation
Facility Name
St. Petersburg Clinical Hospital
City
St. Petersburg
ZIP/Postal Code
194017
Country
Russian Federation
Facility Name
Mechnikov North-Western State Medical University
City
St. Petersburg
ZIP/Postal Code
195067
Country
Russian Federation
Facility Name
Municipal Clinical Oncology Center
City
St. Petersburg
ZIP/Postal Code
198255
Country
Russian Federation
Facility Name
Tambov Regional Clinical Oncology Center
City
Tambov
ZIP/Postal Code
392013
Country
Russian Federation
Facility Name
Research Institute of Oncology
City
Tomsk
ZIP/Postal Code
634028
Country
Russian Federation
Facility Name
Bashkir State Medical University
City
Ufa
ZIP/Postal Code
450000
Country
Russian Federation
Facility Name
Regional Clinical Oncology Center
City
Veliky Novgorod
ZIP/Postal Code
173016
Country
Russian Federation
Facility Name
Volgograd Regional Oncology Center #3
City
Volzhskiy
ZIP/Postal Code
404130
Country
Russian Federation
Facility Name
Yaroslavl Regional Oncology Center
City
Yaroslavl
ZIP/Postal Code
150054
Country
Russian Federation
Facility Name
Clinical Diagnostics Center
City
Simferopol
State/Province
Autonomous Republic of Crimea
ZIP/Postal Code
95000
Country
Ukraine
Facility Name
Kryvyi Rih Oncology Center/Dnipropetrovsk Regional Council, Department of Chemotherapy
City
Kryvyi Rih
State/Province
Dnipropetrovsk Region
ZIP/Postal Code
50000
Country
Ukraine
Facility Name
Mariupol City Interdistrict Oncology Center, Surgery Department #2
City
Mariupol
State/Province
Donetsk Region
ZIP/Postal Code
87500
Country
Ukraine
Facility Name
Kharkiv Regional Clinical Oncology Center, Day Care Unit
City
Kharkiv
State/Province
Kyivskyi District
ZIP/Postal Code
61070
Country
Ukraine
Facility Name
Chernivtsi Regional Clinical Oncology Center, Day Care Unit
City
Chernivtsi
ZIP/Postal Code
58013
Country
Ukraine
Facility Name
Dnipropetrovsk City Multispecialty Clinical Hospital #4/Dnipropetrovsk Regional Council, Department of Chemotherapy
City
Dnipropetrovsk
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
Donetsk City Oncology Center
City
Donetsk
ZIP/Postal Code
83087
Country
Ukraine
Facility Name
Donetsk Regional Antitumor Center, Oncosurgery Department #2
City
Donetsk
ZIP/Postal Code
83092
Country
Ukraine
Facility Name
State Institution: S.P. Grigoriev Institute of Medical Radiology Under the Academy of Medical Sciences of Ukraine
City
Kharkiv
ZIP/Postal Code
61024
Country
Ukraine
Facility Name
Public Institution: Kiev Regional Oncology Hospital within Kyiv Regional Council
City
Kiev
ZIP/Postal Code
04107
Country
Ukraine
Facility Name
Kirovohrad Regional Oncology Center, Department of Mammology
City
Kirovohrad
ZIP/Postal Code
25011
Country
Ukraine
Facility Name
Kyiv City Clinical Oncology Center, Department of Chemotherapy
City
Kyiv
ZIP/Postal Code
03115
Country
Ukraine
Facility Name
Lviv State Regional Treatment and Diagnostics Oncology Center, Department of Chemotherapy
City
Lviv
ZIP/Postal Code
79031
Country
Ukraine
Facility Name
Odesa Regional Clinical Hospital, Center for Mastology
City
Odesa
ZIP/Postal Code
65000
Country
Ukraine
Facility Name
Zakarpattia Regional Clinical Oncology Center, Department of Chemotherapy
City
Uzhhorod
ZIP/Postal Code
88014
Country
Ukraine
Facility Name
Vinnytsia Regional Clinical Oncology Center
City
Vinnytsia
ZIP/Postal Code
21029
Country
Ukraine
Facility Name
Public Institution Zaporizhia Regional Clinical Oncology Center within Zaporizhia Regional Council
City
Zaporizhia
ZIP/Postal Code
69040
Country
Ukraine
Facility Name
Macclesfield District General Hospital
City
Macclesfield
State/Province
Cheshire
ZIP/Postal Code
SK10 3BL
Country
United Kingdom
Facility Name
The Christie NHS Foundation Trust
City
Withington
State/Province
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
Facility Name
The Royal Marsden NHS Foundation Trust
City
Sutton
State/Province
Surrey
ZIP/Postal Code
SM2 5PT
Country
United Kingdom
Facility Name
Leeds Teaching Hospitals Trust, St. James University Hospital
City
Leeds
State/Province
West Yorkshire
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Facility Name
Leicester Royal Infirmary
City
Leicester
ZIP/Postal Code
LE1 5WW
Country
United Kingdom
Facility Name
The Royal Marsden NHS Foundation Trust
City
London
ZIP/Postal Code
SW3 6JJ
Country
United Kingdom
Facility Name
James Cook University Hospital
City
Middlesborough
ZIP/Postal Code
TS4 3BW
Country
United Kingdom
Facility Name
Academic Unit of Oncology, Nottingham University Hospital-City Campus
City
Nottingham
ZIP/Postal Code
NG7 2UH
Country
United Kingdom
Facility Name
Plymouth Oncology Centre, Derriford Hospital
City
Plymouth
ZIP/Postal Code
PL6 8DH
Country
United Kingdom
Facility Name
Weston Park Hospital
City
Sheffield
ZIP/Postal Code
S10 2SJ
Country
United Kingdom
Facility Name
Southampton General Hospital
City
Southampton
ZIP/Postal Code
SO16 6YD
Country
United Kingdom
Facility Name
University Hospital of North Staffordshire
City
Stoke on Trent
ZIP/Postal Code
ST4 6QG
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
18392824
Citation
Amin A, Benavides LC, Holmes JP, Gates JD, Carmichael MG, Hueman MT, Mittendorf EA, Storrer CE, Jama YH, Craig D, Stojadinovic A, Ponniah S, Peoples GE. Assessment of immunologic response and recurrence patterns among patients with clinical recurrence after vaccination with a preventive HER2/neu peptide vaccine: from US Military Cancer Institute Clinical Trials Group Study I-01 and I-02. Cancer Immunol Immunother. 2008 Dec;57(12):1817-25. doi: 10.1007/s00262-008-0509-2. Epub 2008 Apr 8.
Results Reference
background
PubMed Identifier
21989902
Citation
Mittendorf EA, Clifton GT, Holmes JP, Clive KS, Patil R, Benavides LC, Gates JD, Sears AK, Stojadinovic A, Ponniah S, Peoples GE. Clinical trial results of the HER-2/neu (E75) vaccine to prevent breast cancer recurrence in high-risk patients: from US Military Cancer Institute Clinical Trials Group Study I-01 and I-02. Cancer. 2012 May 15;118(10):2594-602. doi: 10.1002/cncr.26574. Epub 2011 Oct 11.
Results Reference
background
PubMed Identifier
31036542
Citation
Mittendorf EA, Lu B, Melisko M, Price Hiller J, Bondarenko I, Brunt AM, Sergii G, Petrakova K, Peoples GE. Efficacy and Safety Analysis of Nelipepimut-S Vaccine to Prevent Breast Cancer Recurrence: A Randomized, Multicenter, Phase III Clinical Trial. Clin Cancer Res. 2019 Jul 15;25(14):4248-4254. doi: 10.1158/1078-0432.CCR-18-2867. Epub 2019 Apr 29.
Results Reference
derived
Links:
URL
http://www.galenabiopharma.com
Description
Sponsor website
URL
http://NeuVax.com
Description
Vaccine site

Learn more about this trial

Efficacy and Safety Study of NeuVax™ (Nelipepimut-S or E75) Vaccine to Prevent Breast Cancer Recurrence

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