Premenstrual Symptoms Treatment Comparing Between Oral Contraceptives Containing Desogestrel and Drospirenone
Premenstrual Syndrome
About this trial
This is an interventional treatment trial for Premenstrual Syndrome focused on measuring PMS, Low-dose combine contraceptives pills, COC
Eligibility Criteria
Inclusion Criteria:
- age 18-35years
- Regular menses, I:21-35 days
- Willingness to take COC for 6 months
- No history of COC in last 6 months
- No history of injected contraception in last 6 months
- History of implant contraception need to have regular menses 3 cycles
- History of miscarriage need to have regular menses 3 cycles
Exclusion Criteria:
- Pregnant or suspected pregnant
- Breast feeding
- Smoking
- Contraindication of WHO 2,3 and 4
- PMDD
Sites / Locations
- Family Unit, King Chulalongkorn Memorial Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
DSG
DRSP
The low-dose oral contraceptive pill which one consists of 20 microgram ethinyl estradiol and 150 mg desogestrel were taken orally by participants every day beginning Day1 to Day 3 of the first menstrual cycle until complete 24 days and continued with free-hormone pills for 4 days. The next cycle has to continue in the same way until complete 6 cycles.
The other low-dose oral contraceptive pill which consists of 20 microgram ethinyl estradiol and 3 mg drospirenone were taken orally by participants every day beginning Day1 to Day 3 of the first menstrual cycle until complete 24 days and continued with free-hormone pills for 4 days. The next cycle has to continue in the same way until complete 6 cycles.