Quality Study of Anesthetic Technique on Breast Cancer Surgery (PQSAT)
Postoperative Pain, Quality of Recovery, Satisfaction
About this trial
This is an interventional treatment trial for Postoperative Pain
Eligibility Criteria
Inclusion Criteria:
- Patient has a physical status between ASA I and III
- Female
- 18 - 70 years of age
- Patients able to read a newspaper in Chinese.
- Elective unilateral wide excision/simple mastectomy and SLNB/ALND
- Patient has signed an informed consent
- Without contraindication of GA or PVB
- Body mass index (BMI) less than 24 kg/m2
Exclusion Criteria:
- ASA > III
- inability to provide informed consent
- Bleeding disorders
- Contraindications to nonsteroidal anti-inflammatory drugs (NSAIDs)
- Allergy to amide-type local anesthetics or NSAIDs
- Infection at the thoracic paravertebral injection site
- Pregnancy or breast-feeding
- Severe spine or chest wall deformity
- body mass index equal to or more than 24 kg/m2
- patients with major psychosis or drug and alcohol abuse
- patients with a history of significant neurological, psychiatric, neuromuscular, cardiovascular, pulmonary, renal or hepatic disease
- Patients with significant visual impairment or other physical disability that precludes complete cooperation
Sites / Locations
- Koo Foundation Sun Yat-Sen Cancer Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
general anesthesia and PVB
sedation and PVB
general anesthesia
general anesthetics consisting of propofol, cisatracurium and fentanyl for endotracheal intubation and deaflurane for maintenance will be given. After intubation, paravertebral injections will be performed under ultrasound guidance.
After sedation with midazolam and fentanyl, the patients in sedation and PVB group will receive PVB. paravertebral injections will be performed under ultrasound guidance.Intraoperative sedation will be provided with propofol titrated to moderate sedation.
general anesthetics consisting of propofol, cisatracurium and fentanyl for endotracheal intubation and deaflurane for maintenance will be given.