Evaluation of the Effectiveness of Daily Pulse Lavage Therapy in Chronic Wounds (PLI2)
Chronic Wounds
About this trial
This is an interventional treatment trial for Chronic Wounds focused on measuring chronic wound treatment, pulse lavage, serial pulse lavage, wounds, bacterial colonization of wounds
Eligibility Criteria
Inclusion Criteria:
- Patients must have a chronic wound (as defined by the wound being present for >30 days) located on any part of their body
- The wound must be smaller than 10cm in greatest diameter.
- Patients must have an expected remaining hospital duration of 4 days
- Patients must be willing and able to comply with all study procedures
Exclusion Criteria:
- Patients must not have undergone any surgical excisions or debridements of the wound in the past 30 days
- The wound may not undergo any surgical procedures or other treatments other than the study treatments during the course of the study.
- The wound may not require any immediate surgical intervention or debridement
- Patients may not start any new antibiotic therapy during the course of the study
- Must not have an allergy to skin adhesives.
- Patients must not be taking any immunosuppressive medications.
- Subjects who, in the opinion of the investigator, may not complete the study for any reason.
Sites / Locations
- Northwestern Memorial Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Lavage arm
Moist dressings
This group will serve as the experimental arm. They will undergo twice daily pulse lavage of their wounds for 4 days. In between the lavage treatments, their wounds will be dressed with moist gauze.
This group will serve as the control group. They will undergo twice daily dressing changes with moist gauze dressings for a total of 4 days (8 dressing changes). Bacterial counts and gene expression analysis will be performed prior to the first dressing change and after the last dressing change.