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Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients

Primary Purpose

Coronary Artery Disease, Exercise Addiction, Complication, Cardio-respiratory

Status
Completed
Phase
Phase 2
Locations
Study Type
Interventional
Intervention
aerobic exercise training
Sponsored by
Hospital TotalCor
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Coronary Artery Disease focused on measuring Coronary artery disease, Exercise, Ventilatory efficiency

Eligibility Criteria

40 Years - 79 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • was stable coronary artery disease diagnosed by coronary angiography

Exclusion Criteria:

  • unstable angina pectoris,
  • complex ventricular arrhythmias,
  • pulmonary congestion and
  • orthopaedic or neurological limitations to exercise

Sites / Locations

    Arms of the Study

    Arm 1

    Arm 2

    Arm Type

    Experimental

    Experimental

    Arm Label

    Continuous exercise training

    interval exercise training

    Arm Description

    The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.

    The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes

    Outcomes

    Primary Outcome Measures

    PetCO2 response during graded exercise test
    End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation

    Secondary Outcome Measures

    Full Information

    First Posted
    January 18, 2012
    Last Updated
    January 20, 2012
    Sponsor
    Hospital TotalCor
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    1. Study Identification

    Unique Protocol Identification Number
    NCT01515033
    Brief Title
    Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients
    Official Title
    Effect of Continuous and Interval Exercise Training on PETCO2 Response During Graded Exercise Test in Patients With Coronary Artery Disease
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    January 2012
    Overall Recruitment Status
    Completed
    Study Start Date
    September 2010 (undefined)
    Primary Completion Date
    June 2011 (Actual)
    Study Completion Date
    August 2011 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Principal Investigator
    Name of the Sponsor
    Hospital TotalCor

    4. Oversight

    Data Monitoring Committee
    Yes

    5. Study Description

    Brief Summary
    The purpose of the present study was to evaluate: 1) the effects of continuous exercise training and interval exercise training on end-tidal carbon dioxide pressure (PETCO2) response during graded exercise test in patients with coronary artery disease; and 2) examine the effects of exercise training modalities on the association among PETCO2 at ventilatory anaerobic threshold (VAT) and indicators of ventilatory efficiency and cardiorespiratory fitness in patients with coronary artery disease.
    Detailed Description
    End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions. Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation. In this regard, it has been shown that patients with cardiac disease have an abnormally low PETCO2 during exercise, especially those with an impaired response of cardiac output during exercise

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Coronary Artery Disease, Exercise Addiction, Complication, Cardio-respiratory
    Keywords
    Coronary artery disease, Exercise, Ventilatory efficiency

    7. Study Design

    Primary Purpose
    Treatment
    Study Phase
    Phase 2
    Interventional Study Model
    Parallel Assignment
    Masking
    None (Open Label)
    Allocation
    Randomized
    Enrollment
    37 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    Continuous exercise training
    Arm Type
    Experimental
    Arm Description
    The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold.
    Arm Title
    interval exercise training
    Arm Type
    Experimental
    Arm Description
    The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
    Intervention Type
    Other
    Intervention Name(s)
    aerobic exercise training
    Other Intervention Name(s)
    continuous training, interval training
    Intervention Description
    The continuous exercise training was performed on a treadmill with a 50-minutes duration and intensity at ventilatory anaerobic threshold. The interval exercise training consisted of 7 sets of 3 minutes at respiratory compensation point and 7 sets of 3 minutes of exercise at moderate intensity corresponding to the ventilatory anaerobic threshold totaling 42 minutes
    Primary Outcome Measure Information:
    Title
    PetCO2 response during graded exercise test
    Description
    End-tidal carbon dioxide pressure (PETCO2) is a noninvasive index considered to be a good indicator in evaluating the ventilation/perfusion relationship in patients over a wide range conditions (1,2). Variations in PETCO2 have been shown to reflect changes in both cardiac output and pulmonary blood flow in animals and humans under constant ventilation
    Time Frame
    before and after 3 months of the interventions

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    40 Years
    Maximum Age & Unit of Time
    79 Years
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: was stable coronary artery disease diagnosed by coronary angiography Exclusion Criteria: unstable angina pectoris, complex ventricular arrhythmias, pulmonary congestion and orthopaedic or neurological limitations to exercise
    Overall Study Officials:
    First Name & Middle Initial & Last Name & Degree
    Danilo ML Prado, Prof.MS
    Organizational Affiliation
    Hospital TotalCor
    Official's Role
    Principal Investigator

    12. IPD Sharing Statement

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    Aerobic Exercise on PETCO2 Response in Coronary Artery Disease Patients

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