A Research Study to Evaluate the Effects of Repeated Intravitreal Injections on Bacteria Around the Eye
Central Retinal Vein Occlusion, Choroidal Neovascularization, Age-related Macular Degeneration
About this trial
This is an interventional supportive care trial for Central Retinal Vein Occlusion focused on measuring Conjunctival bacterial flora, prophylactic topical antibiotic, injection, intravitreal injection, bacterial resistance, serial injection, serial intravitreal injections, CNV, CRVO, AMD, BRVO
Eligibility Criteria
Inclusion Criteria: Subjects will be eligible if the following criteria are met:
- Ability to provide written informed consent and comply with study assessments for the full duration of the study.
- Have been diagnosed with neovascular AMD, CRVO or BRVO.
- Have been determined by the investigator to require intravitreal injections of bevacizumab or ranibizumab.
Exclusion Criteria: Subjects meeting any of the following criteria are ineligible for study entry:
- Prior intraocular injection in either eye.
- Chronic use of opthalmic medication.
- Contact lens wear.
- Ocular surgery within the past 6 months.
- Use of ophthalmic medications in either eye or ocular infection within the past 6 months.
- Use of systemic antibiotics within 6 months.
- Known allergy or contraindication to povidone iodine or fluoroquinolones.
Sites / Locations
- Wills Eye InstituteRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Other
Topical antibiotic
No Antibiotic Arm
Patients will be randomized in a 1:1 fashion to receive a drop of topical antibiotic before and after the intravitreal injection in the +ABX arm (in addition to the typical prep with betadine).
No topical antibiotics in the -ABX arm (only the typical prep with betadine)