Effects of Transfusion of Older Stored Red Cells
Sickle Cell Disease, Thalassemia
About this trial
This is an interventional treatment trial for Sickle Cell Disease focused on measuring iron, transfusion, red blood cells, sickle cell disease, thalassemia, blood donors
Eligibility Criteria
Inclusion Criteria (Recipient):
- specific, well-characterized hemoglobinopathy
- chronic simple transfusion therapy (transfusion episodes < 6 weeks apart in frequency)
- chronic iron chelation therapy
- not pregnant by self-report and not planning pregnancy
- age > 1 year old
Exclusion Criteria (Recipient):
- clinically unstable
- treatment for mental illness
- imprisonment
- institutionalization
Inclusion Criteria (Donor):
- 21-65 years of age
- male weight > 130 lbs, female weight > 150 lbs
- male height > 5'1", female height > 5'5"
- hemoglobin > 15.0 g/dL
- reasonably certain of intention to stay in New York City metropolitan area for study duration
- previously tolerated red blood cell donation
Exclusion Criteria (Donor):
- ineligible for donation based on New York Blood Center blood donor screening questionnaire
- systolic blood pressure < 90 or > 180 mm Hg, diastolic blood pressure < 50 or > 100 mm Hg
- heart rate < 50 or > 100
- temperature > 99.5 F prior to donation
- positive by standard infectious disease testing performed on blood donors
Sites / Locations
- Columbia University Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Experimental
Active Comparator
Active Comparator
Transfusion of Fresh blood
Transfusion of Stored blood
Transfusion of Cryopreserved Blood
Transfusion of Washed Blood
The recipient will receive one or two units of fresh blood <14 days old, as per their chronic transfusion schedule - on or off chelation therapy.
The recipient will receive one or two units of old blood >28 days old, as per their chronic transfusion schedule - on or off chelation therapy.
The recipient will receive one or two units of cryopreserved (fresh/old) blood, as per their chronic transfusion schedule - off chelation therapy.
The recipient will receive one or two units of washed (fresh/old) stored blood >28 days old, as per their chronic transfusion schedule - off chelation therapy.