Treatment Development Targeting Severe and Persistent Negative Symptoms (MOVE)
Schizophrenia
About this trial
This is an interventional supportive care trial for Schizophrenia focused on measuring negative symptoms
Eligibility Criteria
Inclusion Criteria:
- Male or female between the 18-60 who meet DSM-IV criteria for schizophrenia confirmed by the Structured Clinical Interview Diagnosis (SCID-P version). Outpatient status.
- Receiving treatment with antipsychotic medication
- Clinically stable for a minimum of 5 months prior to screening (no significant changes in schizophrenia symptomatology, depressive symptoms, or community functioning, no hospitalizations, emergency visits or incarceration due to symptoms of schizophrenia or depression, no medication increases due to symptom exacerbation)
- Has clinically meaningful negative symptoms as indicted by a score of 4 or higher on at least 2 of 6 of the following symptom domains as rated by the NSA-16; restricted affect, diminished emotional range, poverty of speech, curbing of interest, diminished sense of purpose, and diminished social drive
- No more than moderate positive symptoms as indicated by a score of 5 or lower on BPRS-E items measuring delusions and hallucinations and no more than a 4 or higher on conceptual disorganization
- No more than mild depression as indicated by a score of 3 or lower on the BPRS
- No significant movement disorder as indicated by a score of 3 or lower on the ESRS-A
- Able to provide evidence of a stable living environment (individual apartment, family home, board and care facility with no plans to move in the next year)
Exclusion Criteria:
- History of significant head trauma
- History of a seizure disorder
- Mental Retardation
- Alcohol or drug abuse or dependence within the past 3 months
- History of violence in the past one year
Sites / Locations
- The Center for Health Care Services
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
MOVE
Treatment As Usual
MOVE Program group: MOVE consists of medication follow-up at the CHCS or ATCMHMR and meeting once a week for 9 months with a MOVE trainer in your home. You and your trainer will work on interviews for the first three visits that will talk about negative symptoms, thoughts, attitudes, and social skills that will help each of you develop goals together. Activities will be developed around improving initiation, enjoyment, success and outcome. These activities will be customized to you and will change based on your needs weekly throughout the 9 months
Participants of this group will continue to receive medication follow up at the Center for Health Care Services. They will not be required to do anything additional except to complete assessment visits.