To Compare the Safety, Tolerability, and Pharmacokinetics of QBX258 in Patients With Asthma

This is an interventional other trial for Asthma focused on measuring Asthma, VAK694, QAX576, QBX258, pharmacokinetics Read More

Inclusion Criteria:

• Male and female subjects age 18-60 years (inclusive)
• Well controlled mild to moderate atopic asthma
• Female subjects must be post-menopausal or surgically sterile
• Male subjects must be using two methods of contraception
• Subjects must have a positive skin prick test to one or more common airborne allergen

Exclusion Criteria:

• Participation in any clinical investigation or use of other investigational drugs at time of enrollment
• A history of clinically significant ECG abnormalities
• History of malignancy of any organ system
• Smokers (use of tobacco products in the previous 3 months)
• Use of prescription drugs other than those required for control and relief of asthma
• Use of oral steroids within 12 weeks prior to dosing
• FEVI < 80% predicted at screening or baseline
• Use of albuterol more than twice a week for relief of asthma
• Patients suffering from active hay fever at baseline or likely to require treatment during the study
• History of chronic respiratory disease other than asthma or chronic allergic rhinitis
• Emergency room visit within 6 weeks of screening due to asthma
• Hospitalization for asthma in the last year
• History of intubation/assisted ventilation for asthma in the last 5 years
• Administration of live vaccines within the preceding month

Other protocol-defined inclusion/exclusion criteria may apply.