Back to resultsSleep Duration Required to Restore Performance During Chronic Sleep Restriction
Primary Purpose
Sleep, Sleep Deprivation, Insufficient Sleep Syndrome
Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Sleep:wake 1
Sleep:wake 2
Sponsored by
About this trial
This is an interventional basic science trial for Sleep focused on measuring Inpatients, Health Normalcy, circadian rhythm
Eligibility Criteria
Inclusion Criteria:
- Healthy
Exclusion Criteria:
- Prescription medications
Sites / Locations
- Brigham and Women's Hospital
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
Sleep:wake 2
Sleep:wake 1
Arm Description
Sleep and wake durations for arm 2 for inpatient portion of protocol. .There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 1.
Sleep and wake durations for arm 1 of the inpatient portion of the protocol. There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 2.
Outcomes
Primary Outcome Measures
Psychomotor Vigilance Task (PVT) performance
PVT metrics are reaction time. It is measured when the participants are awake during the inpatient portion of the protocol.
Secondary Outcome Measures
Full Information
NCT ID
NCT01581125
First Posted
March 22, 2012
Last Updated
July 15, 2016
Sponsor
Brigham and Women's Hospital
1. Study Identification
Unique Protocol Identification Number
NCT01581125
Brief Title
Sleep Duration Required to Restore Performance During Chronic Sleep Restriction
Official Title
Sleep Duration Required to Restore Performance During Chronic Sleep Restriction
Study Type
Interventional
2. Study Status
Record Verification Date
July 2016
Overall Recruitment Status
Completed
Study Start Date
April 2012 (undefined)
Primary Completion Date
June 2016 (Actual)
Study Completion Date
June 2016 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Brigham and Women's Hospital
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase.
Detailed Description
The purpose of this study is to test the hypothesis that sleep and performance depend on length of time awake, length of time asleep, the amount of sleep over several sleep episodes, and circadian phase. Inpatient sleep and performance data will be collected from healthy volunteers.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Sleep, Sleep Deprivation, Insufficient Sleep Syndrome
Keywords
Inpatients, Health Normalcy, circadian rhythm
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
19 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Sleep:wake 2
Arm Type
Experimental
Arm Description
Sleep and wake durations for arm 2 for inpatient portion of protocol. .There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 1.
Arm Title
Sleep:wake 1
Arm Type
Experimental
Arm Description
Sleep and wake durations for arm 1 of the inpatient portion of the protocol. There are a variety of sleep and wake durations during the protocol; some of these are longer and some are shorter and some are the same as in arm 2.
Intervention Type
Behavioral
Intervention Name(s)
Sleep:wake 1
Intervention Description
Sleep and Wake durations for arm 1
Intervention Type
Behavioral
Intervention Name(s)
Sleep:wake 2
Intervention Description
Sleep and Wake durations for arm2
Primary Outcome Measure Information:
Title
Psychomotor Vigilance Task (PVT) performance
Description
PVT metrics are reaction time. It is measured when the participants are awake during the inpatient portion of the protocol.
Time Frame
PVT during waking for arms 1 and 2 during the 32-day inpatient portion of the protocol
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
35 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Healthy
Exclusion Criteria:
Prescription medications
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Elizabeth B Klerman, MD PhD
Organizational Affiliation
Brigham and Women's Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Brigham and Women's Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
12. IPD Sharing Statement
Citations:
PubMed Identifier
30722039
Citation
McHill AW, Hull JT, Cohen DA, Wang W, Czeisler CA, Klerman EB. Chronic sleep restriction greatly magnifies performance decrements immediately after awakening. Sleep. 2019 May 1;42(5):zsz032. doi: 10.1093/sleep/zsz032.
Results Reference
derived
PubMed Identifier
29946297
Citation
McHill AW, Hull JT, McMullan CJ, Klerman EB. Chronic Insufficient Sleep Has a Limited Impact on Circadian Rhythmicity of Subjective Hunger and Awakening Fasted Metabolic Hormones. Front Endocrinol (Lausanne). 2018 Jun 12;9:319. doi: 10.3389/fendo.2018.00319. eCollection 2018.
Results Reference
derived
Learn more about this trial
Sleep Duration Required to Restore Performance During Chronic Sleep Restriction
We'll reach out to this number within 24 hrs