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Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study) (APEX)

Primary Purpose

Venous Thromboembolism (VTE)

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Betrixaban
Enoxaparin
Sponsored by
Portola Pharmaceuticals
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional prevention trial for Venous Thromboembolism (VTE) focused on measuring Phase III

Eligibility Criteria

40 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • men and non-pregnant, non-breastfeeding women
  • anticipated to be severely immobilized for at least 24 hours after randomization

  • hospitalized with one of the following

    • congestive heart failure
    • acute respiratory failure,
    • acute infection without septic shock,
    • acute rheumatic disorders
    • acute ischemic stroke with lower extremity hemiparesis or hemi paralysis

Exclusion Criteria:

  • a condition requiring prolonged anticoagulation or anti-platelets
  • active bleeding or at high risk of bleeding
  • contraindication to anticoagulant therapy
  • general conditions in which subjects are not suitable to participate in the study

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Betrixaban

Enoxaparin

Arm Description

Daily oral (PO) betrixaban capsules for 35 to 42 days and subcutaneous (SQ) injections of enoxaparin placebo for 10 ± 4 days

Daily subcutaneous (SQ) injections of enoxaparin for 10 ± 4 days and oral (PO) betrixaban placebo capsules for 35 to 42 days

Outcomes

Primary Outcome Measures

Modified Intent-to-Treat (mITT) Cohort 1: Percentage of Participants Experiencing the Composite Event of Symptomatic Deep Vein Thrombosis (DVT), Non-fatal Pulmonary Emboli (PE), VTE-related Death, or Asymptomatic Proximal DVT, Through Visit 3
mITT Cohort 1: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, venous thromboembolism (VTE) related death adjudicated by a blinded independent Clinical Events Committee (CEC) between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3, or a blinded ultrasound core laboratory measuring of asymptomatic proximal DVT between randomization and Day 47. Visit 3 is between day 35-42 after randomization (day 1).
mITT Cohort 2: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, VTE-related Death, or Asymptomatic Proximal DVT, Through Visit 3
mITT Cohort 2: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3, or a blinded ultrasound core laboratory measuring of asymptomatic proximal DVT between randomization and Day 47. Visit 3 is between day 35-42 after randomization (day 1).
mITT: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, VTE-related Death, or Asymptomatic Proximal DVT, Through Visit 3
mITT: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3, or a blinded ultrasound core laboratory measuring of asymptomatic proximal DVT between randomization and Day 47. Visit 3 is between day 35-42 after randomization (day 1).
Percentage of Participants Experiencing Major Bleeding Through Seven Days After Discontinuation of All Study Medication
Percentage of participants experiencing at least one major bleeding adjudicated by a blinded independent CEC between randomization (day 1) and up to seven days after discontinuation of all study medication.

Secondary Outcome Measures

mITT Cohort 1: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, or VTE-related Death, Through Visit 3
mITT Cohort 1: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, or VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3. Visit 3 is between day 35-42 after randomization (day 1).
mITT Cohort 2: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, or VTE-related Death, Through Visit 3
mITT Cohort 2: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, or VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3. Visit 3 is between day 35-42 after randomization (day 1).
mITT: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, or VTE-related Death, Through Visit 3
mITT: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, or VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3. Visit 3 is between day 35-42 after randomization (day 1).

Full Information

First Posted
April 16, 2012
Last Updated
August 3, 2023
Sponsor
Portola Pharmaceuticals
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1. Study Identification

Unique Protocol Identification Number
NCT01583218
Brief Title
Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)
Acronym
APEX
Official Title
(Apex) Multicenter, Randomized, Active-Controlled Efficacy And Safety Study Comparing Extended Duration Betrixaban With Standard Of Care Enoxaparin For The Prevention Of Venous Thromboembolism In Acute Medically Ill Patients
Study Type
Interventional

2. Study Status

Record Verification Date
August 2023
Overall Recruitment Status
Completed
Study Start Date
March 2012 (undefined)
Primary Completion Date
December 2015 (Actual)
Study Completion Date
January 2016 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Portola Pharmaceuticals

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The purpose of this study is to evaluate whether extended prophylaxis with oral betrixaban can prevent blood clots in the leg and lung that sometime occur in patients hospitalized for an acute medical illness and to compare these results with standard of care enoxaparin. The safety of betrixaban will also be studied.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Venous Thromboembolism (VTE)
Keywords
Phase III

7. Study Design

Primary Purpose
Prevention
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
7513 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Betrixaban
Arm Type
Experimental
Arm Description
Daily oral (PO) betrixaban capsules for 35 to 42 days and subcutaneous (SQ) injections of enoxaparin placebo for 10 ± 4 days
Arm Title
Enoxaparin
Arm Type
Active Comparator
Arm Description
Daily subcutaneous (SQ) injections of enoxaparin for 10 ± 4 days and oral (PO) betrixaban placebo capsules for 35 to 42 days
Intervention Type
Drug
Intervention Name(s)
Betrixaban
Intervention Description
Betrixaban 80 mg PO once daily (QD) for 35 day + 7 days. Enoxaparin Placebo: Once daily, 6-14 days
Intervention Type
Drug
Intervention Name(s)
Enoxaparin
Intervention Description
Enoxaparin 40 mg subcutaneous (SC) QD for 10 ± 4 days. Betrixaban Placebo: once daily, 35 days
Primary Outcome Measure Information:
Title
Modified Intent-to-Treat (mITT) Cohort 1: Percentage of Participants Experiencing the Composite Event of Symptomatic Deep Vein Thrombosis (DVT), Non-fatal Pulmonary Emboli (PE), VTE-related Death, or Asymptomatic Proximal DVT, Through Visit 3
Description
mITT Cohort 1: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, venous thromboembolism (VTE) related death adjudicated by a blinded independent Clinical Events Committee (CEC) between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3, or a blinded ultrasound core laboratory measuring of asymptomatic proximal DVT between randomization and Day 47. Visit 3 is between day 35-42 after randomization (day 1).
Time Frame
mITT Cohort 1: Between randomization and Day 47 (max)
Title
mITT Cohort 2: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, VTE-related Death, or Asymptomatic Proximal DVT, Through Visit 3
Description
mITT Cohort 2: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3, or a blinded ultrasound core laboratory measuring of asymptomatic proximal DVT between randomization and Day 47. Visit 3 is between day 35-42 after randomization (day 1).
Time Frame
mITT Cohort 2: Between randomization and Day 47 (max)
Title
mITT: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, VTE-related Death, or Asymptomatic Proximal DVT, Through Visit 3
Description
mITT: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3, or a blinded ultrasound core laboratory measuring of asymptomatic proximal DVT between randomization and Day 47. Visit 3 is between day 35-42 after randomization (day 1).
Time Frame
mITT: Between randomization and Day 47 (max)
Title
Percentage of Participants Experiencing Major Bleeding Through Seven Days After Discontinuation of All Study Medication
Description
Percentage of participants experiencing at least one major bleeding adjudicated by a blinded independent CEC between randomization (day 1) and up to seven days after discontinuation of all study medication.
Time Frame
Between randomization and Day 49 (max)
Secondary Outcome Measure Information:
Title
mITT Cohort 1: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, or VTE-related Death, Through Visit 3
Description
mITT Cohort 1: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, or VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3. Visit 3 is between day 35-42 after randomization (day 1).
Time Frame
mITT Cohort 1: Between randomization and Day 42 (max)
Title
mITT Cohort 2: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, or VTE-related Death, Through Visit 3
Description
mITT Cohort 2: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, or VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3. Visit 3 is between day 35-42 after randomization (day 1).
Time Frame
mITT Cohort 2: Between randomization and Day 42 (max)
Title
mITT: Percentage of Participants Experiencing the Composite Event of Symptomatic DVT, Non-fatal PE, or VTE-related Death, Through Visit 3
Description
mITT: Percentage of participants experiencing either symptomatic DVT, non-fatal PE, or VTE related death adjudicated by a blinded independent CEC between randomization and on or before Visit 3 or Day 42 if patient did not have a Visit 3. Visit 3 is between day 35-42 after randomization (day 1).
Time Frame
mITT: Between randomization and Day 42 (max)

10. Eligibility

Sex
All
Minimum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: men and non-pregnant, non-breastfeeding women anticipated to be severely immobilized for at least 24 hours after randomization hospitalized with one of the following congestive heart failure acute respiratory failure, acute infection without septic shock, acute rheumatic disorders acute ischemic stroke with lower extremity hemiparesis or hemi paralysis Exclusion Criteria: a condition requiring prolonged anticoagulation or anti-platelets active bleeding or at high risk of bleeding contraindication to anticoagulant therapy general conditions in which subjects are not suitable to participate in the study
Facility Information:
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
City
Bakersfield
State/Province
California
ZIP/Postal Code
93308
Country
United States
City
Fresno
State/Province
California
ZIP/Postal Code
93701
Country
United States
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
City
Long Beach
State/Province
California
ZIP/Postal Code
90822
Country
United States
City
Los Angeles
State/Province
California
ZIP/Postal Code
90073
Country
United States
City
Modesto
State/Province
California
ZIP/Postal Code
95350
Country
United States
City
San Diego
State/Province
California
ZIP/Postal Code
92120
Country
United States
City
Stanford
State/Province
California
ZIP/Postal Code
94305
Country
United States
City
Torrance
State/Province
California
ZIP/Postal Code
90509
Country
United States
City
Englewood
State/Province
Colorado
ZIP/Postal Code
80113
Country
United States
City
Bay Pines
State/Province
Florida
ZIP/Postal Code
33744
Country
United States
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
City
Miami
State/Province
Florida
ZIP/Postal Code
33143
Country
United States
City
Pensacola
State/Province
Florida
ZIP/Postal Code
32504
Country
United States
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34232
Country
United States
City
Vero Beach
State/Province
Florida
ZIP/Postal Code
32960
Country
United States
City
Columbus
State/Province
Georgia
ZIP/Postal Code
31904
Country
United States
City
Decatur
State/Province
Georgia
ZIP/Postal Code
30030
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United States
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
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United States
City
Oak Park
State/Province
Illinois
ZIP/Postal Code
60302
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United States
City
Carmel
State/Province
Indiana
ZIP/Postal Code
46032
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United States
City
Davenport
State/Province
Iowa
ZIP/Postal Code
52803
Country
United States
City
Windsor Heights
State/Province
Iowa
ZIP/Postal Code
50324
Country
United States
City
Topeka
State/Province
Kansas
ZIP/Postal Code
66604
Country
United States
City
Hazard
State/Province
Kentucky
ZIP/Postal Code
41701
Country
United States
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Annapolis
State/Province
Maryland
ZIP/Postal Code
21401
Country
United States
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21287
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United States
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Detroit
State/Province
Michigan
ZIP/Postal Code
48202
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United States
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Grand Blanc
State/Province
Michigan
ZIP/Postal Code
48439
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United States
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Royal Oak
State/Province
Michigan
ZIP/Postal Code
48073
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United States
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Troy
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Michigan
ZIP/Postal Code
48085
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United States
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Duluth
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Minnesota
ZIP/Postal Code
55805
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United States
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Picayune
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Mississippi
ZIP/Postal Code
39466
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United States
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Kansas City
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Missouri
ZIP/Postal Code
64111
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United States
City
Saint Louis
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Missouri
ZIP/Postal Code
63110
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United States
City
Butte
State/Province
Montana
ZIP/Postal Code
59701
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United States
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68131
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United States
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89109
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United States
City
Reno
State/Province
Nevada
ZIP/Postal Code
89502
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United States
City
Atlantic City
State/Province
New Jersey
ZIP/Postal Code
08401
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United States
City
Pomona
State/Province
New Jersey
ZIP/Postal Code
08240
Country
United States
City
Somerville
State/Province
New Jersey
ZIP/Postal Code
08876
Country
United States
City
Summit
State/Province
New Jersey
ZIP/Postal Code
07901
Country
United States
City
Buffalo
State/Province
New York
ZIP/Postal Code
14209
Country
United States
City
Manhasset
State/Province
New York
ZIP/Postal Code
11030
Country
United States
City
Staten Island
State/Province
New York
ZIP/Postal Code
10305
Country
United States
City
Valhalla
State/Province
New York
ZIP/Postal Code
10595
Country
United States
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710
Country
United States
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106-5072
Country
United States
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
City
Camp Hill
State/Province
Pennsylvania
ZIP/Postal Code
17011
Country
United States
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
City
Orangeburg
State/Province
South Carolina
ZIP/Postal Code
29118
Country
United States
City
Austin
State/Province
Texas
ZIP/Postal Code
78705
Country
United States
City
Austin
State/Province
Texas
ZIP/Postal Code
78752
Country
United States
City
Bellaire
State/Province
Texas
ZIP/Postal Code
77401
Country
United States
City
Corsicana
State/Province
Texas
ZIP/Postal Code
75110
Country
United States
City
Dallas
State/Province
Texas
ZIP/Postal Code
75216
Country
United States
City
Fort Worth
State/Province
Texas
ZIP/Postal Code
76104
Country
United States
City
Houston
State/Province
Texas
ZIP/Postal Code
77024
Country
United States
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
City
McAllen
State/Province
Texas
ZIP/Postal Code
78501
Country
United States
City
Mission
State/Province
Texas
ZIP/Postal Code
78572
Country
United States
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78205
Country
United States
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78258
Country
United States
City
Victoria
State/Province
Texas
ZIP/Postal Code
77901
Country
United States
City
Colchester
State/Province
Vermont
ZIP/Postal Code
05401
Country
United States
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
City
Richmond
State/Province
Virginia
ZIP/Postal Code
23249
Country
United States
City
Everett
State/Province
Washington
ZIP/Postal Code
98201
Country
United States
City
Huntington
State/Province
West Virginia
ZIP/Postal Code
25701
Country
United States
City
Buenos Aires
ZIP/Postal Code
1280
Country
Argentina
City
Ciudad Autónoma de Buenos Aires
ZIP/Postal Code
C1181ACH
Country
Argentina
City
Cordoba
ZIP/Postal Code
5000
Country
Argentina
City
Coronel Suarez, Buenos Aires
ZIP/Postal Code
B7540DOL
Country
Argentina
City
Corrientes
ZIP/Postal Code
W3400AMZ
Country
Argentina
City
Córdoba
ZIP/Postal Code
5000
Country
Argentina
City
El Talar
ZIP/Postal Code
1618
Country
Argentina
City
Rosario, Santa Fe
ZIP/Postal Code
S2000DSV
Country
Argentina
City
San Miguel de Tucumán
ZIP/Postal Code
T4000JCU
Country
Argentina
City
Redcliffe
State/Province
Queensland
ZIP/Postal Code
4020
Country
Australia
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
City
Milton
ZIP/Postal Code
Qld 4064
Country
Australia
City
Parkville
ZIP/Postal Code
Vic 3050
Country
Australia
City
Randwick
Country
Australia
City
Richmond
ZIP/Postal Code
Vic 3121
Country
Australia
City
Feldkirch
ZIP/Postal Code
6800
Country
Austria
City
Gratwein
ZIP/Postal Code
8112
Country
Austria
City
Graz
ZIP/Postal Code
8036
Country
Austria
City
Hartberg
ZIP/Postal Code
8230
Country
Austria
City
Linz
ZIP/Postal Code
4020
Country
Austria
City
Wien
ZIP/Postal Code
1100
Country
Austria
City
Wien
ZIP/Postal Code
1160
Country
Austria
City
Zams
ZIP/Postal Code
6511
Country
Austria
City
Bruxelles
ZIP/Postal Code
1070
Country
Belgium
City
Huy
ZIP/Postal Code
4500
Country
Belgium
City
Leper
ZIP/Postal Code
8900
Country
Belgium
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
City
Yvoir
ZIP/Postal Code
5530
Country
Belgium
City
Belo Horizonte - MG
ZIP/Postal Code
30150-221
Country
Brazil
City
Botucatu
ZIP/Postal Code
18618-970
Country
Brazil
City
Brasilia/DF
ZIP/Postal Code
70710-905
Country
Brazil
City
Brasilia
ZIP/Postal Code
70710
Country
Brazil
City
Campinas, Sao Paulo
ZIP/Postal Code
13059-740
Country
Brazil
City
Campinas
ZIP/Postal Code
13083-970
Country
Brazil
City
Curitiba - PR
ZIP/Postal Code
80030-001
Country
Brazil
City
Porto Alegre/RS
ZIP/Postal Code
90620-001
Country
Brazil
City
Porto Alegre
ZIP/Postal Code
90620-001
Country
Brazil
City
Porto Alegre
ZIP/Postal Code
90880-480
Country
Brazil
City
Salvador/BA
ZIP/Postal Code
40140-110
Country
Brazil
City
Salvador/BA
ZIP/Postal Code
41810-011
Country
Brazil
City
Salvador
ZIP/Postal Code
41810-011
Country
Brazil
City
Sao Paulo
ZIP/Postal Code
04012-909
Country
Brazil
City
São José Do Rio Preto- SP
ZIP/Postal Code
15090-000
Country
Brazil
City
São Paulo
ZIP/Postal Code
01308-050
Country
Brazil
City
SãO Paulo
ZIP/Postal Code
01323-903
Country
Brazil
City
Gabrovo
ZIP/Postal Code
5300
Country
Bulgaria
City
Pleven
ZIP/Postal Code
5800
Country
Bulgaria
City
Plovdiv
ZIP/Postal Code
4002
Country
Bulgaria
City
Sandanski
ZIP/Postal Code
2800
Country
Bulgaria
City
Sliven
ZIP/Postal Code
8800
Country
Bulgaria
City
Sofia
ZIP/Postal Code
1202
Country
Bulgaria
City
Sofia
ZIP/Postal Code
1233
Country
Bulgaria
City
Sofia
ZIP/Postal Code
1407
Country
Bulgaria
City
Sofia
ZIP/Postal Code
1606
Country
Bulgaria
City
Sofia
ZIP/Postal Code
1784
Country
Bulgaria
City
Sofia
Country
Bulgaria
City
Yambol
ZIP/Postal Code
8600
Country
Bulgaria
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6K4B3
Country
Canada
City
Halifax
State/Province
Nova Scotia
ZIP/Postal Code
B3H 3A7
Country
Canada
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8L 2X2
Country
Canada
City
Hamilton
State/Province
Ontario
ZIP/Postal Code
L8N 4A6
Country
Canada
City
Kitchener
State/Province
Ontario
ZIP/Postal Code
N2M1B2
Country
Canada
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
City
Thunder Bay
State/Province
Ontario
ZIP/Postal Code
P7B 6R4
Country
Canada
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H1T2M4
Country
Canada
City
Ontario
ZIP/Postal Code
N8X 5A6
Country
Canada
City
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
City
La Serena
ZIP/Postal Code
170000
Country
Chile
City
Osorno
Country
Chile
City
Santiago
ZIP/Postal Code
7650568
Country
Chile
City
Santiago
Country
Chile
City
Temuco
ZIP/Postal Code
4781173
Country
Chile
City
Viña del Mar
ZIP/Postal Code
2570017
Country
Chile
City
Krapinske Toplice
ZIP/Postal Code
49217
Country
Croatia
City
Pula
ZIP/Postal Code
52100
Country
Croatia
City
Rijeka
ZIP/Postal Code
51000
Country
Croatia
City
Varazdin
ZIP/Postal Code
42000
Country
Croatia
City
Zadar
ZIP/Postal Code
23000
Country
Croatia
City
Zagreb
ZIP/Postal Code
10000
Country
Croatia
City
Zagreb
ZIP/Postal Code
1000
Country
Croatia
City
Caslav
ZIP/Postal Code
286 01
Country
Czechia
City
Chrudim
ZIP/Postal Code
537 27
Country
Czechia
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
City
Kladno
ZIP/Postal Code
272 01
Country
Czechia
City
Kromeriz
ZIP/Postal Code
76701
Country
Czechia
City
Kyjov
ZIP/Postal Code
697 33
Country
Czechia
City
Liberec
ZIP/Postal Code
460 63
Country
Czechia
City
Litomysl
ZIP/Postal Code
570 14
Country
Czechia
City
Olomouc
ZIP/Postal Code
771 11
Country
Czechia
City
Ostrava
ZIP/Postal Code
703 84
Country
Czechia
City
Plzen - Bory
ZIP/Postal Code
305 99
Country
Czechia
City
Praha 10
ZIP/Postal Code
100 34
Country
Czechia
City
Praha 1
ZIP/Postal Code
110 00
Country
Czechia
City
Praha 1
ZIP/Postal Code
118 00
Country
Czechia
City
Praha 5
ZIP/Postal Code
150 06
Country
Czechia
City
Praha
ZIP/Postal Code
128 08
Country
Czechia
City
Slany
ZIP/Postal Code
274 01
Country
Czechia
City
Strakonice
ZIP/Postal Code
386 29
Country
Czechia
City
Teplice
ZIP/Postal Code
415 29
Country
Czechia
City
Usti nad Labem
ZIP/Postal Code
401 13
Country
Czechia
City
Zlin
ZIP/Postal Code
762 75
Country
Czechia
City
Znojmo
ZIP/Postal Code
669 02
Country
Czechia
City
Aarhus N
ZIP/Postal Code
DK-8200
Country
Denmark
City
Frederiksberg
ZIP/Postal Code
DK-2000
Country
Denmark
City
Glostrup
ZIP/Postal Code
DK-2600
Country
Denmark
City
Haderslev
ZIP/Postal Code
DK-6100
Country
Denmark
City
Hellerup
ZIP/Postal Code
DK-2900
Country
Denmark
City
Hillerod
ZIP/Postal Code
DK-3400
Country
Denmark
City
Hvidovre
ZIP/Postal Code
DK-2650
Country
Denmark
City
Kobenhavn NV
ZIP/Postal Code
DK-2400
Country
Denmark
City
Silkeborg
ZIP/Postal Code
DK-8600
Country
Denmark
City
Slagelse
ZIP/Postal Code
DK-4200
Country
Denmark
City
Tallinn
ZIP/Postal Code
EE-10138
Country
Estonia
City
Tallinn
ZIP/Postal Code
EE-13419
Country
Estonia
City
Tartu
ZIP/Postal Code
EE-51014
Country
Estonia
City
Helsinki
ZIP/Postal Code
FI-00290
Country
Finland
City
Jyväskylä
ZIP/Postal Code
FI-40620
Country
Finland
City
Kouvola
ZIP/Postal Code
FI-45750
Country
Finland
City
Mikkeli
ZIP/Postal Code
FI-50100
Country
Finland
City
Pori
ZIP/Postal Code
FI-28500
Country
Finland
City
Tampere
Country
Finland
City
Turku
ZIP/Postal Code
FI-20520
Country
Finland
City
Angers
ZIP/Postal Code
49100
Country
France
City
Arras
ZIP/Postal Code
62022
Country
France
City
Avignon
ZIP/Postal Code
84918
Country
France
City
Bois-Guillaume
ZIP/Postal Code
76230
Country
France
City
Bordeaux
ZIP/Postal Code
33075
Country
France
City
Brest
ZIP/Postal Code
29200
Country
France
City
Brest
ZIP/Postal Code
29609
Country
France
City
Cambrai
ZIP/Postal Code
59400
Country
France
City
Castelnau-le-Lez
ZIP/Postal Code
34170
Country
France
City
Clermont-Ferrand
ZIP/Postal Code
63003
Country
France
City
Colombes
ZIP/Postal Code
92700
Country
France
City
Dijon
ZIP/Postal Code
21079
Country
France
City
La Tronche
ZIP/Postal Code
38043
Country
France
City
Le Mans
ZIP/Postal Code
72037
Country
France
City
Lille
ZIP/Postal Code
59020
Country
France
City
Limoges
ZIP/Postal Code
87 042
Country
France
City
Montpellier
ZIP/Postal Code
34295
Country
France
City
Nantes
ZIP/Postal Code
44093
Country
France
City
Nimes
ZIP/Postal Code
30029 cedex 9
Country
France
City
Paris
ZIP/Postal Code
75004
Country
France
City
Paris
ZIP/Postal Code
75010
Country
France
City
Paris
ZIP/Postal Code
75908
Country
France
City
Pierre Benite
ZIP/Postal Code
69495
Country
France
City
Quimper
ZIP/Postal Code
29107
Country
France
City
Rennes
ZIP/Postal Code
35203
Country
France
City
Saint-Priest En Jarrez
ZIP/Postal Code
42055
Country
France
City
Tourcoing
ZIP/Postal Code
59200
Country
France
City
Valenciennes
ZIP/Postal Code
59300
Country
France
City
Vernon
ZIP/Postal Code
27207
Country
France
City
Tbilisi
ZIP/Postal Code
0144
Country
Georgia
City
Tbilisi
ZIP/Postal Code
0159
Country
Georgia
City
Tbilisi
ZIP/Postal Code
0183
Country
Georgia
City
Altenburg
ZIP/Postal Code
04600
Country
Germany
City
Bad Friedrichshall
ZIP/Postal Code
74173
Country
Germany
City
Berlin
ZIP/Postal Code
10787
Country
Germany
City
Bonn
ZIP/Postal Code
53115
Country
Germany
City
Dresden
ZIP/Postal Code
01067
Country
Germany
City
Dresden
ZIP/Postal Code
01307
Country
Germany
City
Essen
ZIP/Postal Code
45147
Country
Germany
City
Hamburg
ZIP/Postal Code
22559
Country
Germany
City
Heidelberg
ZIP/Postal Code
69120
Country
Germany
City
Karlbad
ZIP/Postal Code
76307
Country
Germany
City
Ludwigshafen
ZIP/Postal Code
67063
Country
Germany
City
Magdeburg
ZIP/Postal Code
39120
Country
Germany
City
Mainz
ZIP/Postal Code
55131
Country
Germany
City
Minden
ZIP/Postal Code
32429
Country
Germany
City
Möchengladbach
ZIP/Postal Code
41063
Country
Germany
City
Neuss
ZIP/Postal Code
41464
Country
Germany
City
Oberhausen
ZIP/Postal Code
46045
Country
Germany
City
Paderborn
ZIP/Postal Code
33098
Country
Germany
City
Rüsselsheim
ZIP/Postal Code
65428
Country
Germany
City
Troisdorf
Country
Germany
City
Weiden
ZIP/Postal Code
92637
Country
Germany
City
Wesel
ZIP/Postal Code
46483
Country
Germany
City
Wiesbaden
ZIP/Postal Code
65199
Country
Germany
City
Witten
ZIP/Postal Code
58455
Country
Germany
City
Baja
ZIP/Postal Code
6500
Country
Hungary
City
Balassagyarmat
ZIP/Postal Code
2660
Country
Hungary
City
Balatonfüred
ZIP/Postal Code
8231
Country
Hungary
City
Berettyóújfalu
ZIP/Postal Code
4100
Country
Hungary
City
Budapest,
ZIP/Postal Code
1134
Country
Hungary
City
Budapest
ZIP/Postal Code
1097
Country
Hungary
City
Budapest
ZIP/Postal Code
1122
Country
Hungary
City
Budapest
ZIP/Postal Code
1125
Country
Hungary
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
City
Cegléd
ZIP/Postal Code
2700
Country
Hungary
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
City
Debrecen
ZIP/Postal Code
H-4012
Country
Hungary
City
Eger
ZIP/Postal Code
3300
Country
Hungary
City
Gyula
ZIP/Postal Code
5700
Country
Hungary
City
Hódmezövásárhely
ZIP/Postal Code
6800
Country
Hungary
City
Kistarcsa
ZIP/Postal Code
2143
Country
Hungary
City
Mohács
ZIP/Postal Code
7700
Country
Hungary
City
Nagykanizsa
ZIP/Postal Code
8800
Country
Hungary
City
Szekszárd
ZIP/Postal Code
7100
Country
Hungary
City
Szolnok
ZIP/Postal Code
5000
Country
Hungary
City
Veszprém
ZIP/Postal Code
8200
Country
Hungary
City
Zalaegerszeg
ZIP/Postal Code
8900
Country
Hungary
City
Afula
ZIP/Postal Code
18101
Country
Israel
City
Ashkelon
ZIP/Postal Code
78278
Country
Israel
City
Haifa
ZIP/Postal Code
31048
Country
Israel
City
Haifa
ZIP/Postal Code
31096
Country
Israel
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
City
Kfar Saba
ZIP/Postal Code
44281
Country
Israel
City
Petach Tikva
ZIP/Postal Code
49100
Country
Israel
City
Safed
ZIP/Postal Code
13100
Country
Israel
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
City
Zerifin
ZIP/Postal Code
70300
Country
Israel
City
Castelfranco Veneto
State/Province
Treviso
ZIP/Postal Code
31033
Country
Italy
City
Bollate
ZIP/Postal Code
20021
Country
Italy
City
Frenze
ZIP/Postal Code
50134
Country
Italy
City
Genova
ZIP/Postal Code
16128
Country
Italy
City
Milano
ZIP/Postal Code
20085
Country
Italy
City
Milano
ZIP/Postal Code
20132
Country
Italy
City
Napoli
ZIP/Postal Code
80131
Country
Italy
City
Parma
ZIP/Postal Code
43100
Country
Italy
City
Pavia
ZIP/Postal Code
27100
Country
Italy
City
Piacenza
ZIP/Postal Code
29121
Country
Italy
City
Reggio Emilia
ZIP/Postal Code
42100
Country
Italy
City
Roma
ZIP/Postal Code
00168
Country
Italy
City
Varese
ZIP/Postal Code
21100
Country
Italy
City
Venezia
ZIP/Postal Code
30122
Country
Italy
City
Vittorio Veneto TV
ZIP/Postal Code
31029
Country
Italy
City
Daugavpils
ZIP/Postal Code
LV-5417
Country
Latvia
City
Liepaja
ZIP/Postal Code
LV-3414
Country
Latvia
City
Riga
ZIP/Postal Code
LV-1002
Country
Latvia
City
Riga
ZIP/Postal Code
LV-1038
Country
Latvia
City
Valmiera
ZIP/Postal Code
LV-4201
Country
Latvia
City
Alytus
ZIP/Postal Code
LT-62114
Country
Lithuania
City
Kaunas
ZIP/Postal Code
LT-44320
Country
Lithuania
City
Kaunas
ZIP/Postal Code
LT-45130
Country
Lithuania
City
Kaunas
ZIP/Postal Code
LT-47144
Country
Lithuania
City
Klaipeda
ZIP/Postal Code
LT-92231
Country
Lithuania
City
Klaipeda
ZIP/Postal Code
LT-92288
Country
Lithuania
City
Siauliai
ZIP/Postal Code
LT-76231
Country
Lithuania
City
Utena
ZIP/Postal Code
28151
Country
Lithuania
City
Vilnius
ZIP/Postal Code
LT-04130
Country
Lithuania
City
Vilnius
ZIP/Postal Code
LT-08411
Country
Lithuania
City
Vilnius
ZIP/Postal Code
LT-10207
Country
Lithuania
City
Picayune
State/Province
MS
ZIP/Postal Code
39466
Country
Montserrat
City
Arequipa
ZIP/Postal Code
05154
Country
Peru
City
Callao
ZIP/Postal Code
CALLAO 2
Country
Peru
City
Lima
ZIP/Postal Code
01
Country
Peru
City
Lima
ZIP/Postal Code
18
Country
Peru
City
Lima
ZIP/Postal Code
Lima 11
Country
Peru
City
Lima
ZIP/Postal Code
LIMA 13
Country
Peru
City
Bialystok
ZIP/Postal Code
15-276
Country
Poland
City
Bydgoszcz
ZIP/Postal Code
85-168
Country
Poland
City
Bydgoszcz
ZIP/Postal Code
85-681
Country
Poland
City
Czeladz
ZIP/Postal Code
41-250
Country
Poland
City
Gdansk
ZIP/Postal Code
80-803
Country
Poland
City
Krakow
ZIP/Postal Code
31-121
Country
Poland
City
Krakow
ZIP/Postal Code
31-913
Country
Poland
City
Skierniewice
ZIP/Postal Code
96-100
Country
Poland
City
Tarnobrzeg
ZIP/Postal Code
39-400
Country
Poland
City
Warszawa
ZIP/Postal Code
01-138
Country
Poland
City
Warszawa
ZIP/Postal Code
02-097
Country
Poland
City
Wloclawek
ZIP/Postal Code
87-800
Country
Poland
City
Baia
ZIP/Postal Code
430031
Country
Romania
City
Bucharest
ZIP/Postal Code
020475
Country
Romania
City
Bucharest
ZIP/Postal Code
021659
Country
Romania
City
Bucharest
ZIP/Postal Code
022328
Country
Romania
City
Bucharest
ZIP/Postal Code
041915
Country
Romania
City
Cluj Napoca
ZIP/Postal Code
400006
Country
Romania
City
Cluj-Napoca
ZIP/Postal Code
40001
Country
Romania
City
Craiova
ZIP/Postal Code
200642
Country
Romania
City
Iasi
ZIP/Postal Code
700620
Country
Romania
City
Oradea
ZIP/Postal Code
410169
Country
Romania
City
Pitesti
ZIP/Postal Code
110884
Country
Romania
City
Targu Mures
ZIP/Postal Code
540136
Country
Romania
City
Timisoara
ZIP/Postal Code
300736
Country
Romania
City
Arkhangelsk
ZIP/Postal Code
163045
Country
Russian Federation
City
Barnaul
ZIP/Postal Code
656024
Country
Russian Federation
City
Barnaul
ZIP/Postal Code
656045
Country
Russian Federation
City
Belgorod
ZIP/Postal Code
308007
Country
Russian Federation
City
Chelyabinsk
ZIP/Postal Code
454048
Country
Russian Federation
City
Chelyabinsk
ZIP/Postal Code
454091
Country
Russian Federation
City
Ekaterinburg
ZIP/Postal Code
620039
Country
Russian Federation
City
Ekaterinburg
ZIP/Postal Code
620219
Country
Russian Federation
City
Irkutsk
ZIP/Postal Code
664049
Country
Russian Federation
City
Kaluga
ZIP/Postal Code
428007
Country
Russian Federation
City
Kazan
ZIP/Postal Code
420012
Country
Russian Federation
City
Kazan
ZIP/Postal Code
420043
Country
Russian Federation
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
City
Kirov
ZIP/Postal Code
610014
Country
Russian Federation
City
Krasnodar
ZIP/Postal Code
350086
Country
Russian Federation
City
Lubertsy
ZIP/Postal Code
140006
Country
Russian Federation
City
Moscow
ZIP/Postal Code
111539
Country
Russian Federation
City
Moscow
ZIP/Postal Code
117292
Country
Russian Federation
City
Moscow
ZIP/Postal Code
119881
Country
Russian Federation
City
Moscow
ZIP/Postal Code
119992
Country
Russian Federation
City
Moscow
ZIP/Postal Code
121552
Country
Russian Federation
City
Moscow
ZIP/Postal Code
127473
Country
Russian Federation
City
Murmansk
ZIP/Postal Code
183047
Country
Russian Federation
City
Novosibirsk
ZIP/Postal Code
630007
Country
Russian Federation
City
Novosibirsk
ZIP/Postal Code
630051
Country
Russian Federation
City
Novosibirsk
ZIP/Postal Code
630054
Country
Russian Federation
City
Rostov-on-Don
ZIP/Postal Code
344022
Country
Russian Federation
City
Samara
ZIP/Postal Code
443070
Country
Russian Federation
City
Saratov
ZIP/Postal Code
410028
Country
Russian Federation
City
Saratov
ZIP/Postal Code
410053
Country
Russian Federation
City
Saratov
ZIP/Postal Code
410054
Country
Russian Federation
City
Smolensk
ZIP/Postal Code
214018
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
192242
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
195067
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
196247
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
198205
Country
Russian Federation
City
St. Petersburg
ZIP/Postal Code
199106
Country
Russian Federation
City
St.Petersburg
ZIP/Postal Code
191025
Country
Russian Federation
City
Tomsk
ZIP/Postal Code
643012
Country
Russian Federation
City
Yaroslavl
ZIP/Postal Code
150003
Country
Russian Federation
City
Yaroslavl
ZIP/Postal Code
150030
Country
Russian Federation
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
City
Kragujevac
ZIP/Postal Code
34000
Country
Serbia
City
Niska Banja
ZIP/Postal Code
18205
Country
Serbia
City
Nis
ZIP/Postal Code
18000
Country
Serbia
City
Pancevo
ZIP/Postal Code
26000
Country
Serbia
City
Sremska Kamenica
ZIP/Postal Code
21204
Country
Serbia
City
Singapore
ZIP/Postal Code
119074
Country
Singapore
City
Singapore
ZIP/Postal Code
169608
Country
Singapore
City
Singapore
ZIP/Postal Code
169609
Country
Singapore
City
Bratislava
ZIP/Postal Code
83305
Country
Slovakia
City
Nitra
ZIP/Postal Code
949 01
Country
Slovakia
City
Nitra
ZIP/Postal Code
94901
Country
Slovakia
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2021
Country
South Africa
City
Johannesburg
State/Province
Gauteng
ZIP/Postal Code
2193
Country
South Africa
City
Cape Town
State/Province
Western Cape
ZIP/Postal Code
7530
Country
South Africa
City
Pretoria
ZIP/Postal Code
Gauteng 0084
Country
South Africa
City
Worcester
ZIP/Postal Code
6850
Country
South Africa
City
Barcelona
State/Province
Cataluña
ZIP/Postal Code
08003
Country
Spain
City
Barcelona
State/Province
Cataluña
ZIP/Postal Code
08036
Country
Spain
City
L'Hospitalet de Llobregat
State/Province
Cataluña
ZIP/Postal Code
08907
Country
Spain
City
Sabadell
State/Province
Cataluña
ZIP/Postal Code
08208
Country
Spain
City
Sant Boi de Llobregat
State/Province
Cataluña
ZIP/Postal Code
'08830
Country
Spain
City
Tarragona
State/Province
Cataluña
ZIP/Postal Code
43007
Country
Spain
City
Madrid
State/Province
Communidad De
ZIP/Postal Code
28007
Country
Spain
City
Orihuela
State/Province
Comunidad Valenciana
ZIP/Postal Code
03314
Country
Spain
City
Vigo
State/Province
Galicia
ZIP/Postal Code
36204
Country
Spain
City
Madrid
State/Province
Madrid, Communidad De
ZIP/Postal Code
28034
Country
Spain
City
Majadahonda
State/Province
Madrid, Communidad De
ZIP/Postal Code
28222
Country
Spain
City
San Sebastián de los Reyes
State/Province
Madrid, Communidad De
ZIP/Postal Code
28702
Country
Spain
City
Barcelona
ZIP/Postal Code
08023
Country
Spain
City
Barcelona
ZIP/Postal Code
08041
Country
Spain
City
Cartagena
ZIP/Postal Code
30202
Country
Spain
City
Girona
ZIP/Postal Code
17007
Country
Spain
City
Olot
ZIP/Postal Code
17800
Country
Spain
City
Pontevedra
ZIP/Postal Code
36001
Country
Spain
City
Salamanca
ZIP/Postal Code
37007
Country
Spain
City
Terrassa
ZIP/Postal Code
08221
Country
Spain
City
Donetsk
ZIP/Postal Code
83045
Country
Ukraine
City
Donetsk
ZIP/Postal Code
83114
Country
Ukraine
City
Ivano-Frankivsk
ZIP/Postal Code
76008
Country
Ukraine
City
Ivano-Frankivsk
Country
Ukraine
City
Kharkiv,
ZIP/Postal Code
61058
Country
Ukraine
City
Kharkiv
ZIP/Postal Code
61018
Country
Ukraine
City
Kharkiv
ZIP/Postal Code
61039
Country
Ukraine
City
Kharkiv
ZIP/Postal Code
61176
Country
Ukraine
City
Kherson
ZIP/Postal Code
73039
Country
Ukraine
City
Kirovograd
ZIP/Postal Code
25006
Country
Ukraine
City
Kyiv
ZIP/Postal Code
01023
Country
Ukraine
City
Kyiv
ZIP/Postal Code
02091
Country
Ukraine
City
Kyiv
ZIP/Postal Code
02660
Country
Ukraine
City
Kyiv
ZIP/Postal Code
03680
Country
Ukraine
City
Kyiv
ZIP/Postal Code
04060
Country
Ukraine
City
Lugansk
ZIP/Postal Code
91011
Country
Ukraine
City
Lutsk
ZIP/Postal Code
43024
Country
Ukraine
City
Lviv
ZIP/Postal Code
79010
Country
Ukraine
City
Odesa
ZIP/Postal Code
65009
Country
Ukraine
City
Odesa
ZIP/Postal Code
65014
Country
Ukraine
City
Odesa
ZIP/Postal Code
65025
Country
Ukraine
City
Rivne
ZIP/Postal Code
33001
Country
Ukraine
City
Simferopol
ZIP/Postal Code
95026
Country
Ukraine
City
Uzhgorod
ZIP/Postal Code
88000
Country
Ukraine
City
Vinnytsya
ZIP/Postal Code
21005
Country
Ukraine
City
Yevpatoriya
ZIP/Postal Code
97400
Country
Ukraine
City
Zaporizhzhya
ZIP/Postal Code
69000
Country
Ukraine
City
Zaporizhzhya
ZIP/Postal Code
69065
Country
Ukraine
City
London
ZIP/Postal Code
EC1M 6BQ
Country
United Kingdom
City
London
ZIP/Postal Code
SE5 9RS
Country
United Kingdom
City
London
ZIP/Postal Code
WC1E 6HX
Country
United Kingdom
City
Manchester
ZIP/Postal Code
M23 9LT
Country
United Kingdom
City
Newcastle Upon Tyne
ZIP/Postal Code
NE7 7DN
Country
United Kingdom
City
Romford
ZIP/Postal Code
RM7 0AG
Country
United Kingdom
City
Southall
ZIP/Postal Code
UB1 3HW
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
32657973
Citation
Jamil A, Jamil U, Singh K, Khan F, Chi G. Extended Thromboprophylaxis With Betrixaban or Rivaroxaban for Acutely Ill Hospitalized Medical Patients: Meta-Analysis of Prespecified Subgroups. Crit Pathw Cardiol. 2021 Mar 1;20(1):16-24. doi: 10.1097/HPC.0000000000000232.
Results Reference
derived
PubMed Identifier
31249989
Citation
Yee MK, Gibson CM, Nafee T, Kerneis M, Daaboul Y, Korjian S, Chi G, AlKhalfan F, Hernandez AF, Hull RD, Cohen AT, Goldhaber SZ. Characterization of Major and Clinically Relevant Non-Major Bleeds in the APEX Trial. TH Open. 2019 Apr 17;3(2):e103-e108. doi: 10.1055/s-0039-1685496. eCollection 2019 Apr.
Results Reference
derived
PubMed Identifier
31215264
Citation
Guy H, Laskier V, Fisher M, Bucior I, Deitelzweig S, Cohen AT. Budget impact analysis of betrixaban for venous thromboembolism prophylaxis in nonsurgical patients with acute medical illness in the United Kingdom. Expert Rev Pharmacoecon Outcomes Res. 2020 Jun;20(3):259-267. doi: 10.1080/14737167.2019.1629905. Epub 2019 Jun 19.
Results Reference
derived
PubMed Identifier
30778649
Citation
Chi G, Gibson CM, Kalayci A, Cohen AT, Hernandez AF, Hull RD, Kahe F, Jafarizade M, Sharfaei S, Liu Y, Harrington RA, Goldhaber SZ. Extended-duration betrixaban versus shorter-duration enoxaparin for venous thromboembolism prophylaxis in critically ill medical patients: an APEX trial substudy. Intensive Care Med. 2019 Apr;45(4):477-487. doi: 10.1007/s00134-019-05565-6. Epub 2019 Feb 18.
Results Reference
derived
PubMed Identifier
30419597
Citation
Kalayci A, Gibson CM, Chi G, Yee MK, Korjian S, Datta S, Nafee T, Gurin M, Haroian N, Qamar I, Hull RD, Hernandez AF, Cohen AT, Harrington RA, Goldhaber SZ. Asymptomatic Deep Vein Thrombosis is Associated with an Increased Risk of Death: Insights from the APEX Trial. Thromb Haemost. 2018 Dec;118(12):2046-2052. doi: 10.1055/s-0038-1675606. Epub 2018 Nov 12.
Results Reference
derived
PubMed Identifier
30252149
Citation
Chi G, Gibson CM, Liu Y, Hernandez AF, Hull RD, Cohen AT, Harrington RA, Goldhaber SZ. Inverse relationship of serum albumin to the risk of venous thromboembolism among acutely ill hospitalized patients: Analysis from the APEX trial. Am J Hematol. 2019 Jan;94(1):21-28. doi: 10.1002/ajh.25296. Epub 2018 Oct 17.
Results Reference
derived
PubMed Identifier
29212126
Citation
Chi G, Goldhaber SZ, Hull RD, Hernandez AF, Kerneis M, Al Khalfan F, Cohen AT, Harrington RA, Gibson CM. Thrombus Burden of Deep Vein Thrombosis and Its Association with Thromboprophylaxis and D-Dimer Measurement: Insights from the APEX Trial. Thromb Haemost. 2017 Dec;117(12):2389-2395. doi: 10.1160/TH17-08-0538. Epub 2017 Dec 6.
Results Reference
derived
PubMed Identifier
29188425
Citation
Yee MK, Nafee T, Daaboul Y, Korjian S, AlKhalfan F, Kerneis M, Wiest C, Goldhaber SZ, Hernandez AF, Hull RD, Cohen AT, Harrington RA, Gibson CM. Increased benefit of betrixaban among patients with a history of venous thromboembolism: a post-hoc analysis of the APEX trial. J Thromb Thrombolysis. 2018 Jan;45(1):1-8. doi: 10.1007/s11239-017-1583-0.
Results Reference
derived
PubMed Identifier
28905172
Citation
Chi G, Januzzi JL, Korjian S, Daaboul Y, Goldhaber SZ, Hernandez AF, Hull RD, Gold A, Cohen AT, Harrington RA, Gibson CM. N-terminal pro-B-type natriuretic peptide and the risk of stroke among patients hospitalized with acute heart failure: an APEX trial substudy. J Thromb Thrombolysis. 2017 Nov;44(4):457-465. doi: 10.1007/s11239-017-1552-7.
Results Reference
derived
PubMed Identifier
28840662
Citation
Arbetter DF, Jain P, Yee MK, Michalak N, Hernandez AF, Hull RD, Goldhaber SZ, Harrington RA, Gold A, Cohen AT, Gibson CM. Competing risk analysis in a large cardiovascular clinical trial: An APEX substudy. Pharm Stat. 2017 Nov;16(6):445-450. doi: 10.1002/pst.1823. Epub 2017 Aug 24.
Results Reference
derived
PubMed Identifier
28762617
Citation
Chi G, Goldhaber SZ, Kittelson JM, Turpie AGG, Hernandez AF, Hull RD, Gold A, Curnutte JT, Cohen AT, Harrington RA, Gibson CM. Effect of extended-duration thromboprophylaxis on venous thromboembolism and major bleeding among acutely ill hospitalized medical patients: a bivariate analysis. J Thromb Haemost. 2017 Oct;15(10):1913-1922. doi: 10.1111/jth.13783. Epub 2017 Sep 4.
Results Reference
derived
PubMed Identifier
28698258
Citation
Gibson CM, Korjian S, Chi G, Daaboul Y, Jain P, Arbetter D, Goldhaber SZ, Hull R, Hernandez AF, Lopes RD, Gold A, Cohen AT, Harrington RA; APEX Investigators. Comparison of Fatal or Irreversible Events With Extended-Duration Betrixaban Versus Standard Dose Enoxaparin in Acutely Ill Medical Patients: An APEX Trial Substudy. J Am Heart Assoc. 2017 Jul 11;6(7):e006015. doi: 10.1161/JAHA.117.006015.
Results Reference
derived
PubMed Identifier
28625365
Citation
Gibson CM, Goldhaber SZ, Cohen AT, Nafee T, Hernandez AF, Hull R, Korjian S, Daaboul Y, Chi G, Yee M, Harrington RA. When academic research organizations and clinical research organizations disagree: Processes to minimize discrepancies prior to unblinding of randomized trials. Am Heart J. 2017 Jul;189:1-8. doi: 10.1016/j.ahj.2017.03.018. Epub 2017 Mar 31. No abstract available.
Results Reference
derived
PubMed Identifier
28617144
Citation
Marszalek J, Mehrsefat S, Chi G. The risk of stroke among acutely ill hospitalized medical patients: lessons from recent trials on extended-duration thromboprophylaxis. Expert Rev Hematol. 2017 Aug;10(8):679-684. doi: 10.1080/17474086.2017.1343662. Epub 2017 Jun 21.
Results Reference
derived
PubMed Identifier
27881569
Citation
Gibson CM, Chi G, Halaby R, Korjian S, Daaboul Y, Jain P, Arbetter D, Goldhaber SZ, Hull R, Hernandez AF, Gold A, Bandman O, Harrington RA, Cohen AT; APEX Investigators. Extended-Duration Betrixaban Reduces the Risk of Stroke Versus Standard-Dose Enoxaparin Among Hospitalized Medically Ill Patients: An APEX Trial Substudy (Acute Medically Ill Venous Thromboembolism Prevention With Extended Duration Betrixaban). Circulation. 2017 Feb 14;135(7):648-655. doi: 10.1161/CIRCULATIONAHA.116.025427. Epub 2016 Nov 14.
Results Reference
derived
PubMed Identifier
27232649
Citation
Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, Hernandez AF, Gibson CM; APEX Investigators. Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients. N Engl J Med. 2016 Aug 11;375(6):534-44. doi: 10.1056/NEJMoa1601747. Epub 2016 May 27.
Results Reference
derived
PubMed Identifier
24576517
Citation
Cohen AT, Harrington R, Goldhaber SZ, Hull R, Gibson CM, Hernandez AF, Kitt MM, Lorenz TJ. The design and rationale for the Acute Medically Ill Venous Thromboembolism Prevention with Extended Duration Betrixaban (APEX) study. Am Heart J. 2014 Mar;167(3):335-41. doi: 10.1016/j.ahj.2013.11.006. Epub 2013 Dec 10.
Results Reference
derived

Learn more about this trial

Acute Medically Ill VTE Prevention With Extended Duration Betrixaban Study (The APEX Study)

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