Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone
Post Operative Pain, Hyperalgesia
About this trial
This is an interventional treatment trial for Post Operative Pain focused on measuring hyperalgesia, Patient controlled analgesia, morphine, methadone, ketamine
Eligibility Criteria
Inclusion Criteria:
- patients undergoing open colo-rectal surgery
Exclusion Criteria:
- ASA status more than II, history of chronic pain, ischemic heart disease or chronic pulmonary disease, allergy to any drugs used in the protocol. Body Max Index more than 35.
Sites / Locations
- Fondazione IRCCS Istituto Nazionale dei Tumori
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
No Intervention
Experimental
Experimental
Experimental
zero/morphine
ketamine/morphine
zero/metadone
ketamine/methadone
Patient received a standard balance anaesthesia and morphine for post operative pain.
Ketamine infusion scheme: 5mcg/Kg/min from induction od anaesthesia for 10 min, than 2,5mcg/Kg/min for 20 min and than 2 mcg/Kg/min to the end of surgery.
Methadone PCA
Ketamine infusion scheme: 5mcg/Kg/min from induction od anaesthesia for 10 min, than 2,5mcg/Kg/min for 20 min and than 2 mcg/Kg/min to the end of surgery. Methadone administered by a PCA system (dose 2 mg, lock-out 12min.).