The Role of Surgery of the Primary Tumour in Patients With Synchronous Unresectable Metastases of Colorectal Cancer (CAIRO4)
Colon Cancer, Primary Tumour, Rectal Cancer
About this trial
This is an interventional treatment trial for Colon Cancer focused on measuring Surgery, Chemotherapy
Eligibility Criteria
Inclusion Criteria:
- Histological proof of colorectal cancer
- Resectable primary tumour in situ with unresectable distant metastases
- No indication for neo-adjuvant (chemo)radiation
- No severe signs or symptoms related to the primary tumour (i.e. severe bleeding, obstruction, severe abdominal pain) that require immediate surgery or other symptomatic treatment (e.g. stenting)
- No prior systemic treatment for advanced disease
- Age ≥ 18 years
- WHO performance status 0-2
- Laboratory values obtained ≤ 4 weeks prior to randomization: Adequate bone marrow function (Hb ≥ 6.0 mmol/L, absolute neutrophil count ≥ 1.5 x 109/L, platelets ≥ 100 x 109/L), renal function (serum creatinine ≤ 1.5x ULN and creatinine clearance, Cockroft formula, ≥ 30 ml/min), liver function (serum bilirubin ≤ 2 x ULN, serum transaminases ≤ 3 x ULN without presence of liver metastases or ≤ 5x ULN with presence of liver metastases)
- Expected adequacy of follow-up
- Written informed consent
- CT scan abdomen and CT thorax/X-thorax performed ≤ 4 weeks prior to randomization
Exclusion Criteria:
- Pregnancy, lactation
- Unresectable primary tumour (i.e. neurovascular encasement, substantial ingrowth in pancreatic head), or any condition preventing the safety or feasibility of resection of the primary tumour, i.e. massive ascites or extensive peritoneal disease
- Requirement of neoadjuvant (chmo)radiation therapy
- Second primary malignancy within the past 5 years with the exception of adequately treated in situ carcinoma of any organ or basal cell carcinoma of the skin
- Any medical condition that prevents the safe administration of systemic treatment
- Previous intolerance of fluoropyrimidines, known dihydropyrimidine dehydrogenase (DPD) deficiency
- Planned radical resection of all metastatic disease
- Uncontrolled hypertension, i.e. values consistently > 150/100 mmHg
- Use of ≥ 3 antihypertensive drugs
- Significant cardiovascular disease < 1 yr before randomization (symptomatic congestive heart failure, myocardial infarction, unstable angina pectoris, serious uncontrolled cardiac arrhythmia, cerebro vascular event)
- Chronic active infection
- Concurrent treatment with any other anti-cancer therapy as described per protocol
Sites / Locations
- University Hospital Aalborg
- Rigshospitalet
- Herlev Hospital
- Regionshospital Herning
- Roskilde hospital
- Medisch Centrum Alkmaar
- Ziekenhuisgroep Twente
- Flevoziekenhuis
- Ziekenhuis Amstelland
- Academic Medical Centre
- OLVG
- VUMC
- Gelre Ziekenhuis
- Wilhelmina Ziekenhuis
- Rode Kruis Ziekenhuis
- Amphia Ziekenhuis
- Jeroen Bosch
- MC Haaglanden en Bronovo Nebo
- Slingeland Ziekenhuis
- Albert Schweitzer Ziekenhuis
- Catharina Ziekenhuis
- Maxima Medisch Centrum
- St Annaziekenhuis
- Groene Hart Ziekenhuis
- Martini Ziekenhuis
- UMCG
- Spaarne Gasthuis
- St Jansdal
- Elkerliek Ziekenhuis
- Spaarne Gasthuis
- St Antonius Ziekenhuis
- Radboudumc
- Waterland Ziekenhuis
- Laurentius Ziekenhuis
- Maasstad Ziekenhuis
- Erasmus MC
- Fransicus Gastuis & Vlietland
- Antonius Ziekenhuis
- Ziekenhuis Rivierenland
- Elisabeth-Tweesteden
- Bernhoven Ziekenhuis
- University Medical Centre Utrecht
- Bernhoven Ziekenhuis
- VieCuri Medisch Centrum
- Zaans Medisch Centrum
- Isala Klinieken
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Systemic treatment
Surgery followed by systemic treatment
First-line fluoropyrimidine-based chemotherapy with bevacizumab initiated within 4 weeks of randomization, followed by salvage therapy upon progression at the discretion of the local investigator. Surgery of primary tumour will be performed only when indicated by local signs or symptoms.
Surgery within 4 weeks of randomization followed by fluoropyrimidine-based chemotherapy with bevacizumab until progression or unacceptable toxicity, followed by salvage therapy upon progression at the discretion of the local investigator