Effect of Nitroglycerin Ointment on Mastectomy Flap Necrosis

This is an interventional treatment trial for Mastectomy Flap Necrosis Read More

Inclusion Criteria:

• Patients who undergo SSM or NSM with immediate alloplastic or autologous breast reconstruction
• Unilateral and bilateral cases (in bilateral cases only the mastectomy performed by the general surgeon will be included. This will avoid the potential effect of absorption of nitroglycerin from one breast to the other)
• Patients older than 21 and less than 65

Exclusion Criteria:

• Patient declining inclusion in the study

• Patient with medical history that precludes the administration of nitroglycerin, i.e. a medical history significant for

  • Acute circulatory failure accompanied by clear hypotension
  • Myocardial insufficiency related to obstruction
  • Use of sildenafil, vardenafil & tadalafil
  • Use of beta-blockers, calcium channel blockers, diuretics or phenothiazides
  • Salicylates (ASA)
  • Alteplase
  • Recent history of MI or cardiac insufficiency
  • Anemia, severe
  • Cerebral hemorrhage or recent head trauma
  • Glaucoma
  • Hepatic function impairment, severe
  • Hyperthyroidism
  • Hypertrophic cardiomyopathy
  • Hypotension
  • Sensitivity to nitrites
• Patient with a history of mantle radiation
• Patient with an allergy to polysporin or any of its ingredients