Effect of Corticotomy on the Orthodontic Tooth Movement
Primary Purpose
Tooth Crowding
Status
Completed
Phase
Not Applicable
Locations
Colombia
Study Type
Interventional
Intervention
Corticotomy
Conventional orthodontics
Sponsored by
About this trial
This is an interventional treatment trial for Tooth Crowding focused on measuring Tooth crowding, Teeth malpositions, corticotomy, orthodontics, tooth movement, periodontal parameters
Eligibility Criteria
Inclusion Criteria:
- Voluntary participation
- Legally adult age (>18 years old)
- Full permanent dentition (28 teeth excluding third molars)
- Severe anterior teeth crowding
- Thick periodontal biotype
Exclusion Criteria:
- Systemic diseases (i.e. diabetes, HIV)
- cigarette smoking
- Under medications: bisphosphonates, anti-epileptic drugs, contraceptives, corticosteroids, estrogen, antihistamine drugs, calcitonin, vitamin D
- Previous orthodontic treatment
- Periodontal disease
- Severe gingival recessions
- Pregnancy
- Previous root resorption
Sites / Locations
- Faculty of Dentistry, Universidad de Antioquia
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Corticotomy-assisted orthodontics
Conventional orthodontics
Arm Description
This group of patients will receive corticotomy surgical procedure at day 0. Orthodontic activation will start immediately after surgery.
This group of patients will receive conventional orthodontics starting at day 0.
Outcomes
Primary Outcome Measures
Changes in tooth position
Secondary Outcome Measures
Periodontal Clinical Parameters
Full Information
NCT ID
NCT01630473
First Posted
June 24, 2012
Last Updated
August 13, 2014
Sponsor
Universidad de Antioquia
1. Study Identification
Unique Protocol Identification Number
NCT01630473
Brief Title
Effect of Corticotomy on the Orthodontic Tooth Movement
Official Title
Clinical Comparison Between the Corticotomy-assisted Orthodontics and Conventional Orthodontics
Study Type
Interventional
2. Study Status
Record Verification Date
August 2014
Overall Recruitment Status
Completed
Study Start Date
August 2011 (undefined)
Primary Completion Date
January 2013 (Actual)
Study Completion Date
August 2013 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Universidad de Antioquia
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
Orthodontic therapy allows for the treatment of dental malpositions in order to produce an adequate relationship between teeth during occlusion. Conventional orthodontic therapy applies slight forces and moves teeth slowly. It is generally performed during a 2 year minimum of time. Recent studies seem to suggest that orthodontic therapy time can be shortened by surgical assistance (corticotomy). This investigation is aimed to determine the velocity of tooth movement and changes in periodontal clinical parameters between corticotomy-assisted orthodontic therapy and conventional orthodontic therapy.
Detailed Description
The use of surgical techniques to accelerate orthodontic tooth movement has been developed. By means of surgical burs, vertical grooves in the cortical plate (corticotomy) are produced mesial and distal to the roots of teeth that are being moved 3 mm below the marginal crest and extending beyond the apex. Animal studies showed that the rapid orthodontic tooth movement was due to increased cellular activity in the surrounding periodontal tissues, a regional acceleratory phenomenon (RAP). A high osteoclastic activity is observed in the compression side although is also observed in the tension side to a less degree. Histological analysis indicates that at day 21 the remodeling tissues are replaced by a fibrous tissue and later (60 days) by bone. Furthermore, the tissues immediately adjacent to the corticotomy are characterized by an increased width of the periodontal ligament, less calcified spongiosa bone surface and higher counts of osteoclasts. But not only the catabolic activity is increased (osteoclasts) but also the anabolic activity (osteoblasts) is increased 3-fold as well. This balances the rate of bone resorption and bone apposition. An interesting finding was the reduced rate of hyalinization at the compression site, which may be due to increased width of the periodontal ligament and thus facilitating tooth movement.
As opposed to conventional osteotomy used in alveolar distraction, the preservation of the medullar vasculature during a corticotomy procedure provides and adequate blood supply and nutrition. This accelerates the rate of tissue healing and remodeling and hence orthodontic movement can start immediately after surgery. It has been calculated that the rate of tooth movement is doubled (2.5mm to 3mm at day 25) in comparison to standard orthodontics without any detrimental effects on periodontal tissues. This surgically assisted approach for improved tooth movement is beneficial for molar intrusion, space closure, de-crowding and open bite management.
This investigation is aimed to determine the velocity of tooth movement and changes in periodontal clinical parameters between corticotomy-assisted orthodontic therapy and conventional orthodontic therapy. Periodontally and systemically healthy subjects in need of orthodontic therapy for the treatment of teeth crowding in the anterior segment. The rate of tooth movement will be assessed by radiographs and cast models and periodontal clinical parameters will be recorded at each visit during the 4 month follow-up.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Tooth Crowding
Keywords
Tooth crowding, Teeth malpositions, corticotomy, orthodontics, tooth movement, periodontal parameters
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
10 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Corticotomy-assisted orthodontics
Arm Type
Experimental
Arm Description
This group of patients will receive corticotomy surgical procedure at day 0. Orthodontic activation will start immediately after surgery.
Arm Title
Conventional orthodontics
Arm Type
Active Comparator
Arm Description
This group of patients will receive conventional orthodontics starting at day 0.
Intervention Type
Procedure
Intervention Name(s)
Corticotomy
Other Intervention Name(s)
Osteotomy
Intervention Description
After a periodontal full flap is dissected, by using small round burs, vertical lines (2 mm depth corticotomy) parallel to each root of the teeth in the anterior segment (canines and incisors) are created 5 mm beyond the apex in the maxillary bones and interconnecting the lines at the apex by horizontal corticotomies. Marginal bone crest is not touched by the surgical procedure.
Intervention Type
Procedure
Intervention Name(s)
Conventional orthodontics
Other Intervention Name(s)
Orthodontic treatment
Intervention Description
Conventional orthodontic treatment
Primary Outcome Measure Information:
Title
Changes in tooth position
Time Frame
0 days, 7 days, 15 days, 1st month, 2nd month, 3rd month and 4th month after surgery and conventional orthodontic
Secondary Outcome Measure Information:
Title
Periodontal Clinical Parameters
Time Frame
0 days, 7 days, 15 days, 1st month, 2nd month, 3rd month and 4th month after surgery and conventional orthodontic
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
40 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Voluntary participation
Legally adult age (>18 years old)
Full permanent dentition (28 teeth excluding third molars)
Severe anterior teeth crowding
Thick periodontal biotype
Exclusion Criteria:
Systemic diseases (i.e. diabetes, HIV)
cigarette smoking
Under medications: bisphosphonates, anti-epileptic drugs, contraceptives, corticosteroids, estrogen, antihistamine drugs, calcitonin, vitamin D
Previous orthodontic treatment
Periodontal disease
Severe gingival recessions
Pregnancy
Previous root resorption
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Juan D Arango, DDS
Organizational Affiliation
Faculty of Dentistry, Universidad de Antioquia
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Javier E Botero, PhD
Organizational Affiliation
Faculty of Dentistry, Universidad de Antioquia
Official's Role
Study Director
Facility Information:
Facility Name
Faculty of Dentistry, Universidad de Antioquia
City
Medellin
State/Province
Antioquia
ZIP/Postal Code
00000
Country
Colombia
12. IPD Sharing Statement
Citations:
PubMed Identifier
18533317
Citation
Nowzari H, Yorita FK, Chang HC. Periodontally accelerated osteogenic orthodontics combined with autogenous bone grafting. Compend Contin Educ Dent. 2008 May;29(4):200-6; quiz 207, 218.
Results Reference
background
PubMed Identifier
11829041
Citation
Wilcko WM, Wilcko T, Bouquot JE, Ferguson DJ. Rapid orthodontics with alveolar reshaping: two case reports of decrowding. Int J Periodontics Restorative Dent. 2001 Feb;21(1):9-19.
Results Reference
background
PubMed Identifier
12628599
Citation
Ozturk M, Doruk C, Ozec I, Polat S, Babacan H, Bicakci AA. Pulpal blood flow: effects of corticotomy and midline osteotomy in surgically assisted rapid palatal expansion. J Craniomaxillofac Surg. 2003 Apr;31(2):97-100. doi: 10.1016/s1010-5182(02)00188-9.
Results Reference
background
PubMed Identifier
19278832
Citation
Koudstaal MJ, Wolvius EB, Schulten AJ, Hop WC, van der Wal KG. Stability, tipping and relapse of bone-borne versus tooth-borne surgically assisted rapid maxillary expansion; a prospective randomized patient trial. Int J Oral Maxillofac Surg. 2009 Apr;38(4):308-15. doi: 10.1016/j.ijom.2009.02.012. Epub 2009 Mar 10.
Results Reference
background
PubMed Identifier
19231781
Citation
Akay MC, Aras A, Gunbay T, Akyalcin S, Koyuncue BO. Enhanced effect of combined treatment with corticotomy and skeletal anchorage in open bite correction. J Oral Maxillofac Surg. 2009 Mar;67(3):563-9. doi: 10.1016/j.joms.2008.06.091.
Results Reference
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Effect of Corticotomy on the Orthodontic Tooth Movement
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