Effects of Preoperative Physical Therapy in Patients With Lower Extremity Malignancy
Osteosarcoma, Ewing's Sarcoma, Rhabdomyosarcoma
About this trial
This is an interventional supportive care trial for Osteosarcoma focused on measuring Lower extremity malignancy
Eligibility Criteria
Inclusion Criteria:
- Patient being treated at St. Jude Children's Research Hospital
- Permission from participant's physician
- Participants must be between the ages of 6 and 30 years of age
- Patient is newly diagnosed with LE malignancy as shown by biopsy. Diagnoses include: osteosarcoma, Ewing's sarcoma, rhabdomyosarcoma, synovial sarcoma, malignant peripheral nerve sheath sarcoma, malignant fibrous histiocytoma of the bone and chondrosarcoma of the bone, or any other LE malignancy that requires surgical intervention.
- Patient has Karnofsky score ≥ 50 or WHO/ECOG ≤ 2 if ≥ 16 years of age
- Lansky score ≥ 50 for patients age < 16
- Surgical intervention is planned primary mechanism of local control
- Negative pregnancy test
- All patients and/or their parents or legal guardians must sign a written informed consent
Exclusion Criteria:
- Patients with serious, non-healing wound, ulcer or bone fracture (other than pathologic fracture)
- Pre-morbid condition that prevents patient from ambulating
- Patients who do not have at least 10 weeks before receiving local control
Sites / Locations
- St. Jude Children's Research Hospital
Arms of the Study
Arm 1
Experimental
Physical Therapy
The intervention group will receive PT 3 times per week for 60 minutes each session. The therapy sessions will include endurance, strengthening, and stretching exercises. Exercise time and resistance will be progressed per individual's medical status and per participant's tolerance. All participants will be given a tailored home exercise program (HEP). Participants will participate in PT 10 weeks prior to surgery and 10-12 weeks after surgery. Subjects will be seen by the physical therapist both when inpatient and outpatient. Patients will not be seen for PT if platelet count is less than 20,000mm3 and/or hemoglobin is less than 8g/dL.