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Grass Sensitisation and Allergic Rhinitis in Thai Patients

Primary Purpose

Allergy to Grass Pollen, Allergic Rhinitis Due to Weed Pollens

Status
Completed
Phase
Locations
Thailand
Study Type
Observational
Intervention
Immunoblot
Sponsored by
Mahidol University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an observational trial for Allergy to Grass Pollen focused on measuring Grass, Major allergen, cross-reactivity

Eligibility Criteria

10 Years - 50 Years (Child, Adult)All SexesAccepts Healthy Volunteers

Inclusion Criteria:

  • Allergic rhinitis patients age 10-50 years old
  • Control: healthy volunteer age 18-50 years old

Exclusion Criteria:

  • Chronic illness such as cardiovascular diseases, liver diseases
  • History of anaphylaxis
  • Pregnancy

Sites / Locations

  • Siriraj Hospital

Arms of the Study

Arm 1

Arm Type

Arm Label

Pollen Allergy

Arm Description

Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

First Posted
September 12, 2012
Last Updated
September 13, 2016
Sponsor
Mahidol University
Collaborators
National Research Council of Thailand
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1. Study Identification

Unique Protocol Identification Number
NCT01686022
Brief Title
Grass Sensitisation and Allergic Rhinitis in Thai Patients
Official Title
The Study of Allergens From Grass and Weed Which Are Causes of Allergic Rhinitis in Thai Patients
Study Type
Observational

2. Study Status

Record Verification Date
September 2016
Overall Recruitment Status
Completed
Study Start Date
October 2012 (undefined)
Primary Completion Date
October 2015 (Actual)
Study Completion Date
October 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Mahidol University
Collaborators
National Research Council of Thailand

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
Allergic rhinitis patients are the patients who have nasal symptoms when triggered by indoor or outdoor allergens. Outdoor allergen can be divided into grass, tree, or weed. The type of grass or weed are different in various part of the world. The allergens from grass and weed has never been studied in Thailand. This study will find the major allergen from Bermuda grass, Johnson grass, Para grass, sedge, and ragweed, which are very common in Thailand. In addition, the investigators will study about the cross-reactivity among these group of allergen.
Detailed Description
To find the major allergen of grass and weed, the serum of patients will be used to bind with the allergen extract by immunoblot study. The ELISA-inhibition will be used to study about cross-reactivity among various kinds of grass and weed.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Allergy to Grass Pollen, Allergic Rhinitis Due to Weed Pollens
Keywords
Grass, Major allergen, cross-reactivity

7. Study Design

Enrollment
40 (Actual)
Biospecimen Retention
Samples Without DNA
Biospecimen Description
Serum

8. Arms, Groups, and Interventions

Arm Title
Pollen Allergy
Arm Description
Pollen allergy and control will have the same intervention, ie. Skin prick test and collect serum samples.Then measure the specificIgE, immunoblot, and ELISA inhibition
Intervention Type
Other
Intervention Name(s)
Immunoblot
Intervention Description
serum specific IgE binds to grass extract by immunoblot

10. Eligibility

Sex
All
Minimum Age & Unit of Time
10 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria: Allergic rhinitis patients age 10-50 years old Control: healthy volunteer age 18-50 years old Exclusion Criteria: Chronic illness such as cardiovascular diseases, liver diseases History of anaphylaxis Pregnancy
Study Population Description
Allergy Clinic
Sampling Method
Non-Probability Sample
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Punchama Pacharn, MD
Organizational Affiliation
Mahidol University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Siriraj Hospital
City
Bangkoknoi
State/Province
Bangkok
ZIP/Postal Code
10700
Country
Thailand

12. IPD Sharing Statement

Plan to Share IPD
Undecided

Learn more about this trial

Grass Sensitisation and Allergic Rhinitis in Thai Patients

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