Back to resultsInfluence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease
Primary Purpose
Pulmonary Gas Exchange, Carbon Dioxide
Status
Completed
Phase
Not Applicable
Locations
Sweden
Study Type
Interventional
Intervention
Altered breath
Sponsored by
About this trial
This is an interventional basic science trial for Pulmonary Gas Exchange
Eligibility Criteria
Inclusion Criteria:
- No known primary lung disease
Exclusion Criteria:
- Primary lung disease
Sites / Locations
- Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Altered breath
Arm Description
The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.
Outcomes
Primary Outcome Measures
Carbon dioxide elimination in a ventilator assisted breath.
Secondary Outcome Measures
Blood CO2 concentration.
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT01686984
Brief Title
Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease
Official Title
Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease
Study Type
Interventional
2. Study Status
Record Verification Date
May 2015
Overall Recruitment Status
Completed
Study Start Date
September 2012 (undefined)
Primary Completion Date
May 2015 (Actual)
Study Completion Date
May 2015 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Region Skane
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.
The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pulmonary Gas Exchange, Carbon Dioxide
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
8 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Altered breath
Arm Type
Experimental
Arm Description
The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.
Intervention Type
Other
Intervention Name(s)
Altered breath
Primary Outcome Measure Information:
Title
Carbon dioxide elimination in a ventilator assisted breath.
Time Frame
30 minutes
Secondary Outcome Measure Information:
Title
Blood CO2 concentration.
Time Frame
30 minutes
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
No known primary lung disease
Exclusion Criteria:
Primary lung disease
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Mikael Bodelsson, Professor
Organizational Affiliation
Division of Anesthesia, Skane University Hospital, Lund, Sweden
Official's Role
Principal Investigator
Facility Information:
Facility Name
Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund
City
Lund
State/Province
Skane
ZIP/Postal Code
22185
Country
Sweden
12. IPD Sharing Statement
Citations:
PubMed Identifier
27440637
Citation
Sturesson LW, Malmkvist G, Allvin S, Collryd M, Bodelsson M, Jonson B. An appropriate inspiratory flow pattern can enhance CO2 exchange, facilitating protective ventilation of healthy lungs. Br J Anaesth. 2016 Aug;117(2):243-9. doi: 10.1093/bja/aew194.
Results Reference
derived
Learn more about this trial
Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease
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