Comparison of Surgical Approach to Endoscopic Pituitary Adenoma Resection
Pituitary Adenoma, Posterior Septectomy, Stamm Approach
About this trial
This is an interventional treatment trial for Pituitary Adenoma
Eligibility Criteria
Inclusion Criteria:
- Age > 18 years old
Diagnosis of a pituitary adenoma requiring resection defined as pituitary lesion with any of the following:
- Neuroimaging or clinical evidence of apoplexy
- Decline in central visual acuity worse than (best-corrected) Snellen equivalent of 20/25 in either eye
- clinically significant visual field loss as determined by Humphrey or Goldmann perimetry
- Clinically significant cranial nerve deficit
- Clinically relevant neuroendocrine deficit
- Intolerance of optimal medical management
- Patient electing endoscopic resection approach
Exclusion Criteria:
- Concurrent chronic rhinosinusitis
- Revision pituitary adenoma resections
- Severe medical co-morbidities with the inability to undergo general anesthesia
Sites / Locations
- University of Calgary
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Posterior Septectomy
Stamm Approach
Patient will be randomized to a study arm. The patient will be blinded to the approach. The surgeon will have performed at least 10 procedures previous for each approach. The surgeon will maintain the following surgical practives: preservation of both middle turbinates, preservation of one superior turbinate (to minimize olfactory injury), elevation of a nasoseptal flap, the use of a combination of gelform, surgicel and nasapore dissolvable spacer placed within the surgical defect. These practices are all standard of care. Patient will start Neilmed high volume low pressure saline irrigation three times daily starting on post operative day five. Patients will receive prophylactic antibiotics for fourteen days post operatively.
Patient will be randomized a study arm. The patient will be blinded to the approach. The surgeon will have performed at least 10 procedures previous for each approach. The surgeon will maintain the following surgical practives: preservation of both middle turbinates, preservation of one superior turbinate (to minimize olfactory injury), elevation of a nasoseptal flap, the use of a combination of gelform, surgicel and nasapore dissolvable spacer placed within the surgical defect. These practices are all standard of care. Patient will start Neilmed high volume low pressure saline irrigation three times daily starting on post operative day five. Patients will receive prophylactic antibiotics for fourteen days post operatively.