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Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma (acute asthma)

Primary Purpose

ASTHMA

Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
University of South Florida
About
Eligibility
Locations
Outcomes
Full info

About this trial

This is an observational trial for ASTHMA focused on measuring ASTHMA, ACUTE EXACERBATION OF ASTHMA

Eligibility Criteria

18 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Both genders, age 18-85.
  • Females who are pregnant or lactating are not eligible.
  • Read and comprehend English.
  • Ability to give informed consent.
  • Seen in the outpatient setting at one of the clinic.
  • The subject must have a history of physician diagnosed asthma for at least 1 year and must have an exacerbation of asthma for entry into the study.

Sites / Locations

  • Usf Asthma Allergy and Immunology Cru

Outcomes

Primary Outcome Measures

The measurement of NHPs after treatment of an exacerbation of asthma

Secondary Outcome Measures

Full Information

First Posted
August 5, 2010
Last Updated
May 27, 2015
Sponsor
University of South Florida
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1. Study Identification

Unique Protocol Identification Number
NCT01690793
Brief Title
Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma
Acronym
acute asthma
Official Title
Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma
Study Type
Observational

2. Study Status

Record Verification Date
May 2015
Overall Recruitment Status
Completed
Study Start Date
February 2009 (undefined)
Primary Completion Date
December 2010 (Actual)
Study Completion Date
February 2011 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of South Florida

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The investigators hypothesize that there is a statistically significant decrease of Natriuretic Hormone Peptides (NHPs) in subjects with asthma exacerbation compared to levels following treatment of an exacerbation of asthma.
Detailed Description
Overall Study Design Measurement of Natriuretic Hormone Peptides in individuals suffering from exacerbation of asthma. Measurement of Natriuretic Hormone Peptides 5-7 days after initiation of treatment of exacerbation of asthma. Measurement of Natriuretic Hormone Peptides 10-14 days after initiation of treatment of exacerbation of asthma. 3 comparisons of Natriuretic Hormone Peptides levels will be made: Exacerbation compared to 5-7 days after initiation of treatment Exacerbation compared to 10-14 days after initiation of treatment 5-7 days after initiation of treatment compared to 10-14 days after initiation of treatment. Samples of blood will be secured in the Division of Allergy/Immunology at the University of South Florida, Joy McCann Culverhouse Airways Disease Center. All samples will be appropriately coded to maintain confidentiality. Blood specimens will be held at minus 20 degrees Celsius.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
ASTHMA
Keywords
ASTHMA, ACUTE EXACERBATION OF ASTHMA

7. Study Design

Enrollment
30 (Actual)
Biospecimen Retention
Samples With DNA
Biospecimen Description
Samples of blood will be secured in the Division of Allergy/Immunology at the University of South Florida, Joy McCann Culverhouse Airways Disease Center. All samples will be appropriately coded to maintain confidentiality. Blood specimens will be held at minus 20 degrees Celsius. GENETICS SAMPLES ARE OPTIONAL
Primary Outcome Measure Information:
Title
The measurement of NHPs after treatment of an exacerbation of asthma
Time Frame
14 days

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Both genders, age 18-85. Females who are pregnant or lactating are not eligible. Read and comprehend English. Ability to give informed consent. Seen in the outpatient setting at one of the clinic. The subject must have a history of physician diagnosed asthma for at least 1 year and must have an exacerbation of asthma for entry into the study.
Study Population Description
The Asthma Control Test score of less than 18. Asthma control test consists of five questions, scored 1-5 each.
Sampling Method
Probability Sample
Facility Information:
Facility Name
Usf Asthma Allergy and Immunology Cru
City
Tampa
State/Province
Florida
ZIP/Postal Code
33613
Country
United States

12. IPD Sharing Statement

Learn more about this trial

Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma

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