DEDICA (Dose of HEparin During Coronary Angioplasty) Trial (DEDICA)
Primary Purpose
Stable Angina, Angina, Unstable, Non-ST Elevation (NSTEMI) Myocardial Infarction
Status
Unknown status
Phase
Phase 4
Locations
Italy
Study Type
Interventional
Intervention
Low-dose heparin
Standard dose heparin
Sponsored by
About this trial
This is an interventional treatment trial for Stable Angina focused on measuring angioplasty, heparin, trial
Eligibility Criteria
Inclusion Criteria:
- Stable angina, unstable angina or Non-ST elevation myocardial infarction undergoing coronary angioplasty.
- Mandatory pretreatment with aspirin and clopidogrel
Exclusion Criteria:
- ST elevation myocardial infarction
- Coronary interventions with rotational atherectomy
- Coronary interventions on chronic total occlusions (CTO)
Sites / Locations
- University of Rome La SapienzaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Experimental
Arm Label
Standard dose heparin
Low-dose heparin
Arm Description
Bolus of 100 UI/Kg of heparin. Activated clotting time (ACT) > 300 sec. during the procedure
Bolus of 50 UI/Kg heparin with a target ACT during the procedure of >200 sec.
Outcomes
Primary Outcome Measures
MACE + stent thrombosis + major bleeding (TIMI definition)
MACE (death, myocardial infarction, target vessel revascularization) + stent thrombosis + major bleeding (TIMI definition)
Secondary Outcome Measures
MACE
MACE = death, myocardial infarction, target vessel revascularization
Major Bleeding
Major bleeding according to TIMI criteria
Stent thrombosis
Stent thrombosis (definite or probable according to ARC criteria)
CK-MB increase
Any CK MB increase >3 times upper limit of normal or >50% baseline levels (if baseline levels already >then upper limit of normal)
Full Information
NCT ID
NCT01694459
First Posted
September 23, 2012
Last Updated
September 26, 2012
Sponsor
San Filippo Neri General Hospital
Collaborators
University of Roma La Sapienza
1. Study Identification
Unique Protocol Identification Number
NCT01694459
Brief Title
DEDICA (Dose of HEparin During Coronary Angioplasty) Trial
Acronym
DEDICA
Official Title
Comparison of Low-dose Heparin Versus Standard Dose Heparin During Coronary Interventions (DEDICA Trial)
Study Type
Interventional
2. Study Status
Record Verification Date
September 2012
Overall Recruitment Status
Unknown status
Study Start Date
January 2010 (undefined)
Primary Completion Date
December 2012 (Anticipated)
Study Completion Date
December 2012 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
San Filippo Neri General Hospital
Collaborators
University of Roma La Sapienza
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
International guidelines support the use of a full-dose heparin (anticoagulants) during coronary intervention. However, a lower dose of heparin may be adequate, thanks to advances in angioplasty techniques and the widespread use of pretreatment with two antiplatelet agents.
Thus the investigators designed a study comparing safety and efficacy of standard dose heparin (100 UI/Kg) versus low-dose (50 UI/Kg) in patients undergoing coronary angioplasty who are on aspirin and clopidogrel at the time of the procedure.
Detailed Description
Patients undergoing coronary angioplasty will be randomised to standard vs. low-dose heparin. the study will include "all-comers" (patients with either stable angina or acute coronary syndromes); only patients with ST-elevation myocardial infarction will be excluded.
An ACT (activated clotting time) will be performed after the initial bolus of heparin: for the standard dose group the target ACT will be > 300 sec. (as recommended by guidelines) while for the low-dose the target ACT will be > 180 sec.
Aim of the study is to show equivalence in ischemic events between the two doses of heparin, in order to confirm the safety of lower dose of heparin in contemporary coronary interventions.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Stable Angina, Angina, Unstable, Non-ST Elevation (NSTEMI) Myocardial Infarction
Keywords
angioplasty, heparin, trial
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 4
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
1000 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Standard dose heparin
Arm Type
Active Comparator
Arm Description
Bolus of 100 UI/Kg of heparin. Activated clotting time (ACT) > 300 sec. during the procedure
Arm Title
Low-dose heparin
Arm Type
Experimental
Arm Description
Bolus of 50 UI/Kg heparin with a target ACT during the procedure of >200 sec.
Intervention Type
Drug
Intervention Name(s)
Low-dose heparin
Other Intervention Name(s)
50 UI/Kg bolus heparin
Intervention Description
Bolus of 50 UI/Kg of heparin at the beginning of coronary interventions
Intervention Type
Drug
Intervention Name(s)
Standard dose heparin
Other Intervention Name(s)
100 Ui/Kg bolus heparin
Intervention Description
Bolus of 100 UI/Kg of heparin at the beginning of coronary interventional procedure.
Primary Outcome Measure Information:
Title
MACE + stent thrombosis + major bleeding (TIMI definition)
Description
MACE (death, myocardial infarction, target vessel revascularization) + stent thrombosis + major bleeding (TIMI definition)
Time Frame
30 days
Secondary Outcome Measure Information:
Title
MACE
Description
MACE = death, myocardial infarction, target vessel revascularization
Time Frame
30 days
Title
Major Bleeding
Description
Major bleeding according to TIMI criteria
Time Frame
30 days
Title
Stent thrombosis
Description
Stent thrombosis (definite or probable according to ARC criteria)
Time Frame
30 days
Title
CK-MB increase
Description
Any CK MB increase >3 times upper limit of normal or >50% baseline levels (if baseline levels already >then upper limit of normal)
Time Frame
30 days
Other Pre-specified Outcome Measures:
Title
Major bleeding
Description
Major bleeding according to STEEPLE criteria
Time Frame
30 days
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Stable angina, unstable angina or Non-ST elevation myocardial infarction undergoing coronary angioplasty.
Mandatory pretreatment with aspirin and clopidogrel
Exclusion Criteria:
ST elevation myocardial infarction
Coronary interventions with rotational atherectomy
Coronary interventions on chronic total occlusions (CTO)
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Vincenzo Pasceri, MD
Phone
+39063306
Ext
2504
Email
vpasceri@hotmail.com
First Name & Middle Initial & Last Name or Official Title & Degree
Francesco Pelliccia, MD
Phone
+393483392006
Email
md4151@mclink.it
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Vincenzo Pasceri, MD
Organizational Affiliation
San Filippo Neri Hospital
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Francesco Pelliccia, MD
Organizational Affiliation
University of Roma La Sapienza
Official's Role
Study Director
Facility Information:
Facility Name
University of Rome La Sapienza
City
Rome
ZIP/Postal Code
00161
Country
Italy
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Francesco Pelliccia, MD
First Name & Middle Initial & Last Name & Degree
Carlo Gaudio, MD
12. IPD Sharing Statement
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DEDICA (Dose of HEparin During Coronary Angioplasty) Trial
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