Safety and Efficacy of Aripiprazole and Ziprasidone Among Schizophrenic Patients With Metabolic Syndrome
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring Randomized, Controlled, Trial, Safety, Efficacy, Aripiprazole, Ziprasidone, Metabolic Syndrome
Eligibility Criteria
Inclusion Criteria:
- Schizophrenic patients
- Patients with metabolic syndrome
- Able to provide written informed consent and to comply with all study procedures
Exclusion Criteria:
- Patient with history of diabetes mellitus prior to the treatment of schizophrenia
- Neurological or psychiatric disorders, such as depression, bipolar illness, organic brain disease, dementia, or any diseases that require psychotropic medications
- Serious medical illnesses, including but not limited to; uncontrolled hypertension, significant heart disease (including a history of myocardial infarction, angina, mitral valve prolapse, left ventricular hypertrophy, palpitations, and arrhythmia), hepatic disease, renal disease, or any serious, potentially life-threatening or progressive medical illness that may compromise patient safety or study conduct
Sites / Locations
- University Malaya Medical Centre
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
Ziprasidone
Aripiprazole
Ziprasidone is a psychotropic agent with chemical name: 5-[2-[4-(1,2-benzisothiazole-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one.Ziprasidone is a potent antagonist of both serotonin 5-HT2A and dopamine D2 receptors, although its affinity for 5-HT2A receptors is about 10 times higher than for D2 receptors.
Aripiprazole is a psychotropic drug that is available as tablets for oral administration. Aripiprazole is 7-[ 4-[ 4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3-4-dihydrocarbostyril. Aripiprazole exhibits high affinity for dopamine D2 and D3, serotonin 5-HT1A and 5-HT2A receptors, moderate affinity for dopamine D4, serotonin 5-HT2C and 5-HT7, alpha 1-adrenergic and histamine H1 receptors and moderate affinity for serotonin reuptake site (Ki = 98nM).