Safety and Feasibility Study of Enhanced Recovery in Pancreaticoduodenectomy
Pancreatic Neoplasms
About this trial
This is an interventional treatment trial for Pancreatic Neoplasms
Eligibility Criteria
Inclusion Criteria:
- All patients undergoing elective pancreaticoduodenectomy
Exclusion Criteria:
- Intraoperative detection of metastatic disease (non-operability)
Sites / Locations
- San Raffaele Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Enhanced Recovery After Surgery (ERAS)
Standard perioperative care (Control)
Patients treated with enhanced recovery after surgery protocol: preadmission counselling, preoperative immunonutrition, no preoperative bowel preparation, epidural analgesia with naropin + sufentanil, no pre-anesthetic medication, intraoperative iv fluid restriction, PONV prophylaxis with ondansetron + dexamethasone, hypothermia prophylaxis, removal of nasogastric tube (NGT) at the end of surgery, postoperative mobilization program, solid food diet from POD 2, early stop of iv infusions and removal of urinary catheter.
Patients treated with standard care perioperative protocol: epidural analgesia with naropin + sufentanil, pre-anesthetic medication with diazepam, Preoperative bowel preparation with sodium phosphate, removal of nasogastric tube on POD 1, solid food diet from POD 4