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An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate (RA-COMPARE)

Primary Purpose

Rheumatoid Arthritis

Status
Terminated
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Sarilumab
Etanercept
Methotrexate
Placebo (for sarilumab)
Placebo (for etanercept)
Adalimumab
Sponsored by
Sanofi
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Rheumatoid Arthritis

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion criteria:

  • Diagnosis of RA >/= 3 months duration.
  • Continuous treatment of MTX 10 - 25 mg/week (or per local labeling requirements if the dose range differs) for at least 12 weeks before screening visit and on a stable dose for 8 weeks before screening visit.
  • Active disease defined as: at least 6/66 swollen and 8/68 tender joints and high sensitivity C-reactive protein > 10 mg/L.

Exclusion criteria:

  • Age < 18 years.
  • Use of parenteral corticosteroids or intra-articular corticosteroids within 4 weeks of the screening visit.
  • Use of oral corticosteroids in a dose higher than prednisone 10 mg or equivalent per day, or a change in dosage within 4 weeks of the screening visit.
  • Prior treatment with a tumor necrosis factor (TNF)-alpha inhibitor, or other biological disease modifying anti-rheumatoid drug (DMARD) or Janus Kinase inhibitor.
  • New treatment with or dose-adjustment of on-going nonsteroidal anti-inflammatory drugs (NSAIDs) or cyclo-oxygenase-2 (COX-2) inhibitors within 4 weeks of the screening visit.
  • Treatment with traditional oral DMARD /immunosuppressive agents other than MTX within 4 weeks or 12 weeks before the screening visit, depending on DMARD.

The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.

Sites / Locations

  • Investigational Site Number 840004
  • Investigational Site Number 840212
  • Investigational Site Number 840211
  • Investigational Site Number 840049
  • Investigational Site Number 840205
  • Investigational Site Number 840201
  • Investigational Site Number 840209
  • Investigational Site Number 840203
  • Investigational Site Number 840210
  • Investigational Site Number 840128
  • Investigational Site Number 840063
  • Investigational Site Number 840060
  • Investigational Site Number 840207
  • Investigational Site Number 840018
  • Investigational Site Number 840213
  • Investigational Site Number 840109
  • Investigational Site Number 840073
  • Investigational Site Number 840202
  • Investigational Site Number 840204
  • Investigational Site Number 840150
  • Investigational Site Number 840200
  • Investigational Site Number 840037
  • Investigational Site Number 840112
  • Investigational Site Number 840056
  • Investigational Site Number 840117
  • Investigational Site Number 840016
  • Investigational Site Number 840025
  • Investigational Site Number 840074
  • Investigational Site Number 840061
  • Investigational Site Number 840124
  • Investigational Site Number 032052
  • Investigational Site Number 032050
  • Investigational Site Number 032053
  • Investigational Site Number 032013
  • Investigational Site Number 032051
  • Investigational Site Number 032005
  • Investigational Site Number 032009
  • Investigational Site Number 036020
  • Investigational Site Number 036004
  • Investigational Site Number 036014
  • Investigational Site Number 036007
  • Investigational Site Number 076001
  • Investigational Site Number 076016
  • Investigational Site Number 076006
  • Investigational Site Number 076010
  • Investigational Site Number 076005
  • Investigational Site Number 076013
  • Investigational Site Number 152005
  • Investigational Site Number 152018
  • Investigational Site Number 152001
  • Investigational Site Number 152002
  • Investigational Site Number 152011
  • Investigational Site Number 152015
  • Investigational Site Number 170016
  • Investigational Site Number 170001
  • Investigational Site Number 170040
  • Investigational Site Number 170007
  • Investigational Site Number 170009
  • Investigational Site Number 170041
  • Investigational Site Number 203004
  • Investigational Site Number 203001
  • Investigational Site Number 203031
  • Investigational Site Number 203033
  • Investigational Site Number 203030
  • Investigational Site Number 203032
  • Investigational Site Number 203002
  • Investigational Site Number 203006
  • Investigational Site Number 218003
  • Investigational Site Number 218001
  • Investigational Site Number 218002
  • Investigational Site Number 246001
  • Investigational Site Number 246002
  • Investigational Site Number 246030
  • Investigational Site Number 246003
  • Investigational Site Number 246032
  • Investigational Site Number 250003
  • Investigational Site Number 250007
  • Investigational Site Number 250001
  • Investigational Site Number 250002
  • Investigational Site Number 250004
  • Investigational Site Number 250005
  • Investigational Site Number 250006
  • Investigational Site Number 250008
  • Investigational Site Number 276007
  • Investigational Site Number 276057
  • Investigational Site Number 276056
  • Investigational Site Number 276055
  • Investigational Site Number 276051
  • Investigational Site Number 276013
  • Investigational Site Number 276001
  • Investigational Site Number 276058
  • Investigational Site Number 276053
  • Investigational Site Number 276050
  • Investigational Site Number 300010
  • Investigational Site Number 300002
  • Investigational Site Number 300014
  • Investigational Site Number 300012
  • Investigational Site Number 348001
  • Investigational Site Number 348010
  • Investigational Site Number 348021
  • Investigational Site Number 348013
  • Investigational Site Number 348008
  • Investigational Site Number 376032
  • Investigational Site Number 376001
  • Investigational Site Number 376010
  • Investigational Site Number 376031
  • Investigational Site Number 376035
  • Investigational Site Number 376030
  • Investigational Site Number 376011
  • Investigational Site Number 376034
  • Investigational Site Number 380002
  • Investigational Site Number 380004
  • Investigational Site Number 380005
  • Investigational Site Number 380041
  • Investigational Site Number 380042
  • Investigational Site Number 410020
  • Investigational Site Number 410006
  • Investigational Site Number 410013
  • Investigational Site Number 410005
  • Investigational Site Number 410011
  • Investigational Site Number 410016
  • Investigational Site Number 410015
  • Investigational Site Number 410022
  • Investigational Site Number 410023
  • Investigational Site Number 410021
  • Investigational Site Number 410008
  • Investigational Site Number 428002
  • Investigational Site Number 428001
  • Investigational Site Number 428003
  • Investigational Site Number 440005
  • Investigational Site Number 440006
  • Investigational Site Number 440010
  • Investigational Site Number 440011
  • Investigational Site Number 458012
  • Investigational Site Number 458014
  • Investigational Site Number 458001
  • Investigational Site Number 458013
  • Investigational Site Number 458002
  • Investigational Site Number 458010
  • Investigational Site Number 458011
  • Investigational Site Number 484027
  • Investigational Site Number 484023
  • Investigational Site Number 484029
  • Investigational Site Number 484013
  • Investigational Site Number 484018
  • Investigational Site Number 484004
  • Investigational Site Number 484010
  • Investigational Site Number 484026
  • Investigational Site Number 484052
  • Investigational Site Number 484017
  • Investigational Site Number 484025
  • Investigational Site Number 484051
  • Investigational Site Number 554007
  • Investigational Site Number 554010
  • Investigational Site Number 554005
  • Investigational Site Number 554011
  • Investigational Site Number 604001
  • Investigational Site Number 604010
  • Investigational Site Number 604009
  • Investigational Site Number 604012
  • Investigational Site Number 604007
  • Investigational Site Number 604005
  • Investigational Site Number 604020
  • Investigational Site Number 616019
  • Investigational Site Number 616054
  • Investigational Site Number 616052
  • Investigational Site Number 616015
  • Investigational Site Number 616057
  • Investigational Site Number 616059
  • Investigational Site Number 616061
  • Investigational Site Number 616005
  • Investigational Site Number 616063
  • Investigational Site Number 616018
  • Investigational Site Number 616013
  • Investigational Site Number 616056
  • Investigational Site Number 616016
  • Investigational Site Number 616058
  • Investigational Site Number 616051
  • Investigational Site Number 616053
  • Investigational Site Number 642041
  • Investigational Site Number 642012
  • Investigational Site Number 642004
  • Investigational Site Number 642023
  • Investigational Site Number 642001
  • Investigational Site Number 642040
  • Investigational Site Number 642002
  • Investigational Site Number 642042
  • Investigational Site Number 642005
  • Investigational Site Number 642013
  • Investigational Site Number 642014
  • Investigational Site Number 642022
  • Investigational Site Number 643006
  • Investigational Site Number 643056
  • Investigational Site Number 643052
  • Investigational Site Number 643021
  • Investigational Site Number 643031
  • Investigational Site Number 643030
  • Investigational Site Number 643022
  • Investigational Site Number 643010
  • Investigational Site Number 643011
  • Investigational Site Number 643059
  • Investigational Site Number 643008
  • Investigational Site Number 643058
  • Investigational Site Number 643013
  • Investigational Site Number 643050
  • Investigational Site Number 643057
  • Investigational Site Number 643051
  • Investigational Site Number 710011
  • Investigational Site Number 710007
  • Investigational Site Number 710008
  • Investigational Site Number 710006
  • Investigational Site Number 710010
  • Investigational Site Number 724043
  • Investigational Site Number 724009
  • Investigational Site Number 724042
  • Investigational Site Number 724041
  • Investigational Site Number 724040
  • Investigational Site Number 724001
  • Investigational Site Number 724011
  • Investigational Site Number 724012
  • Investigational Site Number 158010
  • Investigational Site Number 158004
  • Investigational Site Number 158012
  • Investigational Site Number 158011
  • Investigational Site Number 158006
  • Investigational Site Number 764003
  • Investigational Site Number 764002
  • Investigational Site Number 764010
  • Investigational Site Number 764011
  • Investigational Site Number 804003
  • Investigational Site Number 804002
  • Investigational Site Number 804024
  • Investigational Site Number 804029
  • Investigational Site Number 804010
  • Investigational Site Number 804001
  • Investigational Site Number 804025
  • Investigational Site Number 804023
  • Investigational Site Number 804014
  • Investigational Site Number 804027
  • Investigational Site Number 804011
  • Investigational Site Number 804030
  • Investigational Site Number 804005
  • Investigational Site Number 804033
  • Investigational Site Number 804020
  • Investigational Site Number 804032
  • Investigational Site Number 804022
  • Investigational Site Number 804012
  • Investigational Site Number 804021
  • Investigational Site Number 804028
  • Investigational Site Number 804031
  • Investigational Site Number 826023
  • Investigational Site Number 826022
  • Investigational Site Number 826021
  • Investigational Site Number 826026
  • Investigational Site Number 826027
  • Investigational Site Number 826020
  • Investigational Site Number 826025

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm Type

Experimental

Active Comparator

Experimental

Experimental

Experimental

Arm Label

Adalimumab Open Label run-in

Etanercept + MTX (Randomized)

Sarilumab 150 mg + MTX (Randomized)

Sarilumab 200 mg + MTX (Randomized)

Sarilumab 150 mg + MTX Open Label Sub-study

Arm Description

Adalimumab 40 mg every 2 weeks (Q2W) for 16 weeks added to stable dose of MTX.

Etanercept 50 mg in combination with Placebo for sarilumab Q2W and etanercept 50 mg on alternating weeks for 24 weeks added to stable dose of MTX.

Sarilumab 150 mg in combination with placebo for etanercept Q2W and placebo for etanercept on alternating weeks for 24 weeks added to stable dose of MTX.

Sarilumab 200 mg in combination with placebo for etanercept Q2W and placebo for etanercept on alternating weeks for 24 weeks added to stable dose of MTX.

Sarilumab 150 mg Q2W for 52 weeks added to stable dose of MTX.

Outcomes

Primary Outcome Measures

Change From Baseline in Disease Activity Score for 28 Joints - C-Reactive Protein (DAS28-CRP) Score at Week 24

Secondary Outcome Measures

Number of Participants With at Least 20% Improvement in American College of Rheumatology (ACR20), at Least 50% Improvement in ACR (ACR50) and at Least 70% Improvement in ACR (ACR70) Efficacy Response Rates at Week 12 and Week 24
Percentage of Participants Achieving Clinical Remission Score (DAS28-CRP) <2.6 at Week 12 and Week 24
Change From Baseline in DAS28-CRP Score at Week 12

Full Information

First Posted
January 8, 2013
Last Updated
June 28, 2017
Sponsor
Sanofi
Collaborators
Regeneron Pharmaceuticals
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1. Study Identification

Unique Protocol Identification Number
NCT01764997
Brief Title
An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate
Acronym
RA-COMPARE
Official Title
A Randomized, Controlled Study of Sarilumab and Methotrexate (MTX) Versus Etanercept and MTX in Patients With Rheumatoid Arthritis (RA) and an Inadequate Response to 4 Months of Treatment With Adalimumab and MTX
Study Type
Interventional

2. Study Status

Record Verification Date
June 2017
Overall Recruitment Status
Terminated
Why Stopped
Due to small number of participants entering randomization. Not a safety issue.
Study Start Date
April 2013 (undefined)
Primary Completion Date
January 2015 (Actual)
Study Completion Date
January 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Sanofi
Collaborators
Regeneron Pharmaceuticals

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Primary Objective: To demonstrate the treatment effect of sarilumab and methotrexate (MTX) compared to etanercept and MTX in participants with rheumatoid arthritis (RA) and an inadequate response to adalimumab and MTX by evaluation of the Disease Activity Score for 28 joints (DAS28). Secondary Objectives: To assess the signs and symptoms of RA in participants taking sarilumab in combination with MTX. To assess the quality of life of participants with RA taking sarilumab in combination with MTX. To assess the safety and tolerability of sarilumab in combination with MTX in participants with RA.
Detailed Description
The maximum study duration per participant enrolled in the open label run-in phase and was eligible to enroll in the randomized phase of main study was 54 weeks: open label screening period of up to 4 weeks open-label treatment period of 16 weeks randomized screening period of 2 to 4 weeks randomized treatment post-treatment safety follow-up period of 6 weeks. The maximum study duration per participant enrolled only in the open label run-in phase and was not eligible to enroll in the randomized phase of main study was 26 weeks: open label screening period of up to 4 weeks open-label treatment period of 16 weeks open label treatment post-treatment safety follow-up period of 6 weeks. The maximum study duration per participant enrolled in the open label run-in phase and was eligible to enroll in the sarilumab sub-study was 82 weeks: open label screening period of up to 4 weeks open-label treatment period of 16 weeks screening period of 2 to 4 weeks sarilumab treatment period of 52 weeks sub-study post-treatment safety follow-up period of 6 weeks.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Rheumatoid Arthritis

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
776 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Adalimumab Open Label run-in
Arm Type
Experimental
Arm Description
Adalimumab 40 mg every 2 weeks (Q2W) for 16 weeks added to stable dose of MTX.
Arm Title
Etanercept + MTX (Randomized)
Arm Type
Active Comparator
Arm Description
Etanercept 50 mg in combination with Placebo for sarilumab Q2W and etanercept 50 mg on alternating weeks for 24 weeks added to stable dose of MTX.
Arm Title
Sarilumab 150 mg + MTX (Randomized)
Arm Type
Experimental
Arm Description
Sarilumab 150 mg in combination with placebo for etanercept Q2W and placebo for etanercept on alternating weeks for 24 weeks added to stable dose of MTX.
Arm Title
Sarilumab 200 mg + MTX (Randomized)
Arm Type
Experimental
Arm Description
Sarilumab 200 mg in combination with placebo for etanercept Q2W and placebo for etanercept on alternating weeks for 24 weeks added to stable dose of MTX.
Arm Title
Sarilumab 150 mg + MTX Open Label Sub-study
Arm Type
Experimental
Arm Description
Sarilumab 150 mg Q2W for 52 weeks added to stable dose of MTX.
Intervention Type
Drug
Intervention Name(s)
Sarilumab
Other Intervention Name(s)
SAR153191, REGN88
Intervention Description
Pharmaceutical form: Solution for injection in pre-filled syringe; Route of administration: Subcutaneous
Intervention Type
Drug
Intervention Name(s)
Etanercept
Other Intervention Name(s)
Enbrel
Intervention Description
Pharmaceutical form: Solution for injection in pre-filled syringe; Route of administration: Subcutaneous
Intervention Type
Drug
Intervention Name(s)
Methotrexate
Intervention Description
Dispensed according to local practice.
Intervention Type
Drug
Intervention Name(s)
Placebo (for sarilumab)
Intervention Type
Drug
Intervention Name(s)
Placebo (for etanercept)
Intervention Type
Drug
Intervention Name(s)
Adalimumab
Intervention Description
Pharmaceutical form: Solution for injection in pre-filled syringe; Route of administration: Subcutaneous
Primary Outcome Measure Information:
Title
Change From Baseline in Disease Activity Score for 28 Joints - C-Reactive Protein (DAS28-CRP) Score at Week 24
Time Frame
Baseline, Week 24
Secondary Outcome Measure Information:
Title
Number of Participants With at Least 20% Improvement in American College of Rheumatology (ACR20), at Least 50% Improvement in ACR (ACR50) and at Least 70% Improvement in ACR (ACR70) Efficacy Response Rates at Week 12 and Week 24
Time Frame
Week 12 and Week 24
Title
Percentage of Participants Achieving Clinical Remission Score (DAS28-CRP) <2.6 at Week 12 and Week 24
Time Frame
Week 12 and Week 24
Title
Change From Baseline in DAS28-CRP Score at Week 12
Time Frame
Baseline, Week 12

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion criteria: Diagnosis of RA >/= 3 months duration. Continuous treatment of MTX 10 - 25 mg/week (or per local labeling requirements if the dose range differs) for at least 12 weeks before screening visit and on a stable dose for 8 weeks before screening visit. Active disease defined as: at least 6/66 swollen and 8/68 tender joints and high sensitivity C-reactive protein > 10 mg/L. Exclusion criteria: Age < 18 years. Use of parenteral corticosteroids or intra-articular corticosteroids within 4 weeks of the screening visit. Use of oral corticosteroids in a dose higher than prednisone 10 mg or equivalent per day, or a change in dosage within 4 weeks of the screening visit. Prior treatment with a tumor necrosis factor (TNF)-alpha inhibitor, or other biological disease modifying anti-rheumatoid drug (DMARD) or Janus Kinase inhibitor. New treatment with or dose-adjustment of on-going nonsteroidal anti-inflammatory drugs (NSAIDs) or cyclo-oxygenase-2 (COX-2) inhibitors within 4 weeks of the screening visit. Treatment with traditional oral DMARD /immunosuppressive agents other than MTX within 4 weeks or 12 weeks before the screening visit, depending on DMARD. The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Sciences & Operations
Organizational Affiliation
Sanofi
Official's Role
Study Director
Facility Information:
Facility Name
Investigational Site Number 840004
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35205
Country
United States
Facility Name
Investigational Site Number 840212
City
Glendale
State/Province
California
ZIP/Postal Code
91205
Country
United States
Facility Name
Investigational Site Number 840211
City
Thousand Oaks
State/Province
California
ZIP/Postal Code
91360
Country
United States
Facility Name
Investigational Site Number 840049
City
Upland
State/Province
California
ZIP/Postal Code
91786
Country
United States
Facility Name
Investigational Site Number 840205
City
Victorville
State/Province
California
ZIP/Postal Code
92395
Country
United States
Facility Name
Investigational Site Number 840201
City
Denver
State/Province
Colorado
ZIP/Postal Code
80230
Country
United States
Facility Name
Investigational Site Number 840209
City
Danbury
State/Province
Connecticut
ZIP/Postal Code
06810
Country
United States
Facility Name
Investigational Site Number 840203
City
Washington, D.C.
State/Province
District of Columbia
ZIP/Postal Code
20003
Country
United States
Facility Name
Investigational Site Number 840210
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33756
Country
United States
Facility Name
Investigational Site Number 840128
City
Ormond Beach
State/Province
Florida
ZIP/Postal Code
32174
Country
United States
Facility Name
Investigational Site Number 840063
City
Palm Harbor
State/Province
Florida
ZIP/Postal Code
34684
Country
United States
Facility Name
Investigational Site Number 840060
City
Sarasota
State/Province
Florida
ZIP/Postal Code
34239
Country
United States
Facility Name
Investigational Site Number 840207
City
Tampa
State/Province
Florida
ZIP/Postal Code
33612
Country
United States
Facility Name
Investigational Site Number 840018
City
Idaho Falls
State/Province
Idaho
ZIP/Postal Code
83404
Country
United States
Facility Name
Investigational Site Number 840213
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46250
Country
United States
Facility Name
Investigational Site Number 840109
City
Lake Charles
State/Province
Louisiana
ZIP/Postal Code
70601
Country
United States
Facility Name
Investigational Site Number 840073
City
Cumberland
State/Province
Maryland
ZIP/Postal Code
21502
Country
United States
Facility Name
Investigational Site Number 840202
City
Hagerstown
State/Province
Maryland
ZIP/Postal Code
21740
Country
United States
Facility Name
Investigational Site Number 840204
City
Battle Creek
State/Province
Michigan
ZIP/Postal Code
49015
Country
United States
Facility Name
Investigational Site Number 840150
City
Lansing
State/Province
Michigan
ZIP/Postal Code
48910
Country
United States
Facility Name
Investigational Site Number 840200
City
Jackson
State/Province
Mississippi
ZIP/Postal Code
39216
Country
United States
Facility Name
Investigational Site Number 840037
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
Facility Name
Investigational Site Number 840112
City
Lincoln
State/Province
Nebraska
ZIP/Postal Code
68516
Country
United States
Facility Name
Investigational Site Number 840056
City
New York
State/Province
New York
ZIP/Postal Code
10016
Country
United States
Facility Name
Investigational Site Number 840117
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15261
Country
United States
Facility Name
Investigational Site Number 840016
City
North Charleston
State/Province
South Carolina
ZIP/Postal Code
29406
Country
United States
Facility Name
Investigational Site Number 840025
City
Jackson
State/Province
Tennessee
ZIP/Postal Code
38305
Country
United States
Facility Name
Investigational Site Number 840074
City
Mesquite
State/Province
Texas
ZIP/Postal Code
75150
Country
United States
Facility Name
Investigational Site Number 840061
City
Tacoma
State/Province
Washington
ZIP/Postal Code
98405
Country
United States
Facility Name
Investigational Site Number 840124
City
Clarksburg
State/Province
West Virginia
ZIP/Postal Code
26301
Country
United States
Facility Name
Investigational Site Number 032052
City
Buenos Aires
ZIP/Postal Code
C1015ABO
Country
Argentina
Facility Name
Investigational Site Number 032050
City
Buenos Aires
ZIP/Postal Code
C1426AAL
Country
Argentina
Facility Name
Investigational Site Number 032053
City
La Plata
Country
Argentina
Facility Name
Investigational Site Number 032013
City
Rosario
ZIP/Postal Code
S200PBJ
Country
Argentina
Facility Name
Investigational Site Number 032051
City
San Miguel De Tucumán
Country
Argentina
Facility Name
Investigational Site Number 032005
City
Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Investigational Site Number 032009
City
Zarate
ZIP/Postal Code
B2800DGH
Country
Argentina
Facility Name
Investigational Site Number 036020
City
Camperdown
ZIP/Postal Code
2050
Country
Australia
Facility Name
Investigational Site Number 036004
City
Heidelberg West
ZIP/Postal Code
3081
Country
Australia
Facility Name
Investigational Site Number 036014
City
Victoria Park
ZIP/Postal Code
6100
Country
Australia
Facility Name
Investigational Site Number 036007
City
Woodville
ZIP/Postal Code
5011
Country
Australia
Facility Name
Investigational Site Number 076001
City
Curitiba
ZIP/Postal Code
80060-240
Country
Brazil
Facility Name
Investigational Site Number 076016
City
Curitiba
Country
Brazil
Facility Name
Investigational Site Number 076006
City
Goiania
ZIP/Postal Code
74110-120
Country
Brazil
Facility Name
Investigational Site Number 076010
City
Juiz De Fora
ZIP/Postal Code
36010-570
Country
Brazil
Facility Name
Investigational Site Number 076005
City
Rio De Janeiro
ZIP/Postal Code
20551-030
Country
Brazil
Facility Name
Investigational Site Number 076013
City
Vitoria
ZIP/Postal Code
29055 450
Country
Brazil
Facility Name
Investigational Site Number 152005
City
Osorno
ZIP/Postal Code
5311092
Country
Chile
Facility Name
Investigational Site Number 152018
City
Santiago
ZIP/Postal Code
7510047
Country
Chile
Facility Name
Investigational Site Number 152001
City
Santiago
Country
Chile
Facility Name
Investigational Site Number 152002
City
Santiago
Country
Chile
Facility Name
Investigational Site Number 152011
City
Santiago
Country
Chile
Facility Name
Investigational Site Number 152015
City
Temuco
Country
Chile
Facility Name
Investigational Site Number 170016
City
Bogota
ZIP/Postal Code
0
Country
Colombia
Facility Name
Investigational Site Number 170001
City
Bogota
Country
Colombia
Facility Name
Investigational Site Number 170040
City
Bogotá
ZIP/Postal Code
NAP
Country
Colombia
Facility Name
Investigational Site Number 170007
City
Bucaramanga
Country
Colombia
Facility Name
Investigational Site Number 170009
City
Bucaramanga
Country
Colombia
Facility Name
Investigational Site Number 170041
City
Medellin
Country
Colombia
Facility Name
Investigational Site Number 203004
City
Ostrava
ZIP/Postal Code
702 00
Country
Czechia
Facility Name
Investigational Site Number 203001
City
Praha 2
ZIP/Postal Code
12850
Country
Czechia
Facility Name
Investigational Site Number 203031
City
Praha 4
ZIP/Postal Code
14059
Country
Czechia
Facility Name
Investigational Site Number 203033
City
Praha 4
ZIP/Postal Code
14800
Country
Czechia
Facility Name
Investigational Site Number 203030
City
Praha 4
Country
Czechia
Facility Name
Investigational Site Number 203032
City
Praha
ZIP/Postal Code
11000
Country
Czechia
Facility Name
Investigational Site Number 203002
City
Uherske Hradiste
ZIP/Postal Code
686 01
Country
Czechia
Facility Name
Investigational Site Number 203006
City
Zlin
ZIP/Postal Code
76001
Country
Czechia
Facility Name
Investigational Site Number 218003
City
Cuenca
Country
Ecuador
Facility Name
Investigational Site Number 218001
City
Guayaquil
ZIP/Postal Code
0593
Country
Ecuador
Facility Name
Investigational Site Number 218002
City
Quito
ZIP/Postal Code
0593
Country
Ecuador
Facility Name
Investigational Site Number 246001
City
Helsinki
ZIP/Postal Code
00290
Country
Finland
Facility Name
Investigational Site Number 246002
City
Hyvinkää
ZIP/Postal Code
05800
Country
Finland
Facility Name
Investigational Site Number 246030
City
Oulu
ZIP/Postal Code
90100
Country
Finland
Facility Name
Investigational Site Number 246003
City
Pori
ZIP/Postal Code
28100
Country
Finland
Facility Name
Investigational Site Number 246032
City
Tampere
Country
Finland
Facility Name
Investigational Site Number 250003
City
Amiens Cedex 1
ZIP/Postal Code
80054
Country
France
Facility Name
Investigational Site Number 250007
City
Bobigny
Country
France
Facility Name
Investigational Site Number 250001
City
La Roche Sur Yon Cedex 9
ZIP/Postal Code
85925
Country
France
Facility Name
Investigational Site Number 250002
City
Montpellier
ZIP/Postal Code
34295
Country
France
Facility Name
Investigational Site Number 250004
City
Paris Cedex 4
ZIP/Postal Code
75181
Country
France
Facility Name
Investigational Site Number 250005
City
Paris
ZIP/Postal Code
74014
Country
France
Facility Name
Investigational Site Number 250006
City
Strasbourg
Country
France
Facility Name
Investigational Site Number 250008
City
Toulouse
ZIP/Postal Code
31000
Country
France
Facility Name
Investigational Site Number 276007
City
Berlin
ZIP/Postal Code
12161
Country
Germany
Facility Name
Investigational Site Number 276057
City
Berlin
ZIP/Postal Code
12161
Country
Germany
Facility Name
Investigational Site Number 276056
City
Dresden
ZIP/Postal Code
01109
Country
Germany
Facility Name
Investigational Site Number 276055
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Investigational Site Number 276051
City
Erlangen
ZIP/Postal Code
91056
Country
Germany
Facility Name
Investigational Site Number 276013
City
Hamburg
ZIP/Postal Code
22147
Country
Germany
Facility Name
Investigational Site Number 276001
City
Herne
ZIP/Postal Code
44649
Country
Germany
Facility Name
Investigational Site Number 276058
City
Koeln
Country
Germany
Facility Name
Investigational Site Number 276053
City
Ludwigsfelde
ZIP/Postal Code
14974
Country
Germany
Facility Name
Investigational Site Number 276050
City
Rostock
Country
Germany
Facility Name
Investigational Site Number 300010
City
Athens
ZIP/Postal Code
11527
Country
Greece
Facility Name
Investigational Site Number 300002
City
Heraklion
ZIP/Postal Code
71110
Country
Greece
Facility Name
Investigational Site Number 300014
City
N. Efkarpia
ZIP/Postal Code
56429
Country
Greece
Facility Name
Investigational Site Number 300012
City
Patras
Country
Greece
Facility Name
Investigational Site Number 348001
City
Budapest
ZIP/Postal Code
1023
Country
Hungary
Facility Name
Investigational Site Number 348010
City
Debrecen
ZIP/Postal Code
4031
Country
Hungary
Facility Name
Investigational Site Number 348021
City
Esztergom
ZIP/Postal Code
2500
Country
Hungary
Facility Name
Investigational Site Number 348013
City
Gy?r
ZIP/Postal Code
9025
Country
Hungary
Facility Name
Investigational Site Number 348008
City
Gyula
ZIP/Postal Code
5700
Country
Hungary
Facility Name
Investigational Site Number 376032
City
Ashkelon
ZIP/Postal Code
78278
Country
Israel
Facility Name
Investigational Site Number 376001
City
Haifa
ZIP/Postal Code
31048
Country
Israel
Facility Name
Investigational Site Number 376010
City
Haifa
ZIP/Postal Code
31096
Country
Israel
Facility Name
Investigational Site Number 376031
City
Haifa
ZIP/Postal Code
34362
Country
Israel
Facility Name
Investigational Site Number 376035
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
Investigational Site Number 376030
City
Ramat Gan
ZIP/Postal Code
52621
Country
Israel
Facility Name
Investigational Site Number 376011
City
Tel Aviv
ZIP/Postal Code
64239
Country
Israel
Facility Name
Investigational Site Number 376034
City
Tel Hashomer
ZIP/Postal Code
52621
Country
Israel
Facility Name
Investigational Site Number 380002
City
Firenze
ZIP/Postal Code
50141
Country
Italy
Facility Name
Investigational Site Number 380004
City
Genova
ZIP/Postal Code
16011
Country
Italy
Facility Name
Investigational Site Number 380005
City
Genova
ZIP/Postal Code
16132
Country
Italy
Facility Name
Investigational Site Number 380041
City
L'Aquila
ZIP/Postal Code
67010
Country
Italy
Facility Name
Investigational Site Number 380042
City
Valeggio Sul Mincio
ZIP/Postal Code
37064
Country
Italy
Facility Name
Investigational Site Number 410020
City
Busan
ZIP/Postal Code
602-715
Country
Korea, Republic of
Facility Name
Investigational Site Number 410006
City
Busan
ZIP/Postal Code
602-739
Country
Korea, Republic of
Facility Name
Investigational Site Number 410013
City
Daegu
ZIP/Postal Code
561-712
Country
Korea, Republic of
Facility Name
Investigational Site Number 410005
City
Daejeon
ZIP/Postal Code
301-721
Country
Korea, Republic of
Facility Name
Investigational Site Number 410011
City
Jeonju
ZIP/Postal Code
561-712
Country
Korea, Republic of
Facility Name
Investigational Site Number 410016
City
Seoul
ZIP/Postal Code
120-752
Country
Korea, Republic of
Facility Name
Investigational Site Number 410015
City
Seoul
ZIP/Postal Code
133-792
Country
Korea, Republic of
Facility Name
Investigational Site Number 410022
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
Investigational Site Number 410023
City
Seoul
ZIP/Postal Code
138-736
Country
Korea, Republic of
Facility Name
Investigational Site Number 410021
City
Seoul
ZIP/Postal Code
158-710
Country
Korea, Republic of
Facility Name
Investigational Site Number 410008
City
Suwon
ZIP/Postal Code
443-721
Country
Korea, Republic of
Facility Name
Investigational Site Number 428002
City
Liepaja
ZIP/Postal Code
LV-3401
Country
Latvia
Facility Name
Investigational Site Number 428001
City
Riga
ZIP/Postal Code
LV-1038
Country
Latvia
Facility Name
Investigational Site Number 428003
City
Ventspils
ZIP/Postal Code
LV 3601
Country
Latvia
Facility Name
Investigational Site Number 440005
City
Kaunas
ZIP/Postal Code
LT-50009
Country
Lithuania
Facility Name
Investigational Site Number 440006
City
Klaipeda
ZIP/Postal Code
LT-92288
Country
Lithuania
Facility Name
Investigational Site Number 440010
City
Panevezys
ZIP/Postal Code
LT- 35144
Country
Lithuania
Facility Name
Investigational Site Number 440011
City
Vilnius
ZIP/Postal Code
08661
Country
Lithuania
Facility Name
Investigational Site Number 458012
City
Batu Caves
ZIP/Postal Code
68100
Country
Malaysia
Facility Name
Investigational Site Number 458014
City
Georgetown
ZIP/Postal Code
10990
Country
Malaysia
Facility Name
Investigational Site Number 458001
City
Ipoh
ZIP/Postal Code
30990
Country
Malaysia
Facility Name
Investigational Site Number 458013
City
Kota Bharu
ZIP/Postal Code
15586
Country
Malaysia
Facility Name
Investigational Site Number 458002
City
Kuching
ZIP/Postal Code
93586
Country
Malaysia
Facility Name
Investigational Site Number 458010
City
Melaka
ZIP/Postal Code
75400
Country
Malaysia
Facility Name
Investigational Site Number 458011
City
Seremban
ZIP/Postal Code
70300
Country
Malaysia
Facility Name
Investigational Site Number 484027
City
Cd. Obregon
Country
Mexico
Facility Name
Investigational Site Number 484023
City
Chihuahua
ZIP/Postal Code
31020
Country
Mexico
Facility Name
Investigational Site Number 484029
City
Deleg. Benito Juárez
ZIP/Postal Code
3100
Country
Mexico
Facility Name
Investigational Site Number 484013
City
Guadalajara
ZIP/Postal Code
44158
Country
Mexico
Facility Name
Investigational Site Number 484018
City
Guadalajara
ZIP/Postal Code
44620
Country
Mexico
Facility Name
Investigational Site Number 484004
City
Merida
ZIP/Postal Code
97000
Country
Mexico
Facility Name
Investigational Site Number 484010
City
Mexicali
ZIP/Postal Code
21200
Country
Mexico
Facility Name
Investigational Site Number 484026
City
Mexicali
ZIP/Postal Code
21200
Country
Mexico
Facility Name
Investigational Site Number 484052
City
Mexico City
ZIP/Postal Code
6726
Country
Mexico
Facility Name
Investigational Site Number 484017
City
México
ZIP/Postal Code
06700
Country
Mexico
Facility Name
Investigational Site Number 484025
City
San Luis
ZIP/Postal Code
78220
Country
Mexico
Facility Name
Investigational Site Number 484051
City
Tijuana
ZIP/Postal Code
22010
Country
Mexico
Facility Name
Investigational Site Number 554007
City
Auckland
ZIP/Postal Code
1023
Country
New Zealand
Facility Name
Investigational Site Number 554010
City
Dunedin
ZIP/Postal Code
9016
Country
New Zealand
Facility Name
Investigational Site Number 554005
City
Hamilton
ZIP/Postal Code
3204
Country
New Zealand
Facility Name
Investigational Site Number 554011
City
Nelson
ZIP/Postal Code
1023
Country
New Zealand
Facility Name
Investigational Site Number 604001
City
Lima
ZIP/Postal Code
021
Country
Peru
Facility Name
Investigational Site Number 604010
City
Lima
ZIP/Postal Code
14
Country
Peru
Facility Name
Investigational Site Number 604009
City
Lima
ZIP/Postal Code
LIMA 01
Country
Peru
Facility Name
Investigational Site Number 604012
City
Lima
ZIP/Postal Code
LIMA 11
Country
Peru
Facility Name
Investigational Site Number 604007
City
Lima
ZIP/Postal Code
Lima 33
Country
Peru
Facility Name
Investigational Site Number 604005
City
Lima
ZIP/Postal Code
LIMA 41
Country
Peru
Facility Name
Investigational Site Number 604020
City
Lima
ZIP/Postal Code
Lima36
Country
Peru
Facility Name
Investigational Site Number 616019
City
Bydgoszcz
ZIP/Postal Code
85-168
Country
Poland
Facility Name
Investigational Site Number 616054
City
Bytom
ZIP/Postal Code
41-902
Country
Poland
Facility Name
Investigational Site Number 616052
City
Dzialdowo
ZIP/Postal Code
13-200
Country
Poland
Facility Name
Investigational Site Number 616015
City
Elblag
Country
Poland
Facility Name
Investigational Site Number 616057
City
Krakow
ZIP/Postal Code
31-121
Country
Poland
Facility Name
Investigational Site Number 616059
City
Krakow
ZIP/Postal Code
31-209
Country
Poland
Facility Name
Investigational Site Number 616061
City
Krakow
Country
Poland
Facility Name
Investigational Site Number 616005
City
Lublin
ZIP/Postal Code
20-607
Country
Poland
Facility Name
Investigational Site Number 616063
City
Myslenice
ZIP/Postal Code
32-400
Country
Poland
Facility Name
Investigational Site Number 616018
City
Poznan
ZIP/Postal Code
61-397
Country
Poland
Facility Name
Investigational Site Number 616013
City
Sosnowiec
ZIP/Postal Code
41-200
Country
Poland
Facility Name
Investigational Site Number 616056
City
Starachowice
ZIP/Postal Code
27-200
Country
Poland
Facility Name
Investigational Site Number 616016
City
Szczecin
ZIP/Postal Code
71-252
Country
Poland
Facility Name
Investigational Site Number 616058
City
Ustron
ZIP/Postal Code
43-450
Country
Poland
Facility Name
Investigational Site Number 616051
City
Warszawa
ZIP/Postal Code
02-653
Country
Poland
Facility Name
Investigational Site Number 616053
City
Zyrardow
ZIP/Postal Code
96-300
Country
Poland
Facility Name
Investigational Site Number 642041
City
Bacau
Country
Romania
Facility Name
Investigational Site Number 642012
City
Bucharest
ZIP/Postal Code
400006
Country
Romania
Facility Name
Investigational Site Number 642004
City
Bucharest
Country
Romania
Facility Name
Investigational Site Number 642023
City
Bucharest
Country
Romania
Facility Name
Investigational Site Number 642001
City
Bucuresti
ZIP/Postal Code
010976
Country
Romania
Facility Name
Investigational Site Number 642040
City
Bucuresti
ZIP/Postal Code
020125
Country
Romania
Facility Name
Investigational Site Number 642002
City
Bucuresti
ZIP/Postal Code
020983
Country
Romania
Facility Name
Investigational Site Number 642042
City
Bucuresti
Country
Romania
Facility Name
Investigational Site Number 642005
City
Galati
ZIP/Postal Code
800578
Country
Romania
Facility Name
Investigational Site Number 642013
City
Iasi
ZIP/Postal Code
700127
Country
Romania
Facility Name
Investigational Site Number 642014
City
Iasi
ZIP/Postal Code
700656
Country
Romania
Facility Name
Investigational Site Number 642022
City
Targoviste
ZIP/Postal Code
130083
Country
Romania
Facility Name
Investigational Site Number 643006
City
Kemerovo
ZIP/Postal Code
650099
Country
Russian Federation
Facility Name
Investigational Site Number 643056
City
Krasnoyarsk
ZIP/Postal Code
660022
Country
Russian Federation
Facility Name
Investigational Site Number 643052
City
Moscow
ZIP/Postal Code
117556
Country
Russian Federation
Facility Name
Investigational Site Number 643021
City
Moscow
ZIP/Postal Code
119049
Country
Russian Federation
Facility Name
Investigational Site Number 643031
City
Moscow
ZIP/Postal Code
121374
Country
Russian Federation
Facility Name
Investigational Site Number 643030
City
Moscow
ZIP/Postal Code
125284
Country
Russian Federation
Facility Name
Investigational Site Number 643022
City
Novosibirsk
ZIP/Postal Code
630091
Country
Russian Federation
Facility Name
Investigational Site Number 643010
City
Samara
ZIP/Postal Code
443095
Country
Russian Federation
Facility Name
Investigational Site Number 643011
City
Saratov
ZIP/Postal Code
410012
Country
Russian Federation
Facility Name
Investigational Site Number 643059
City
Smolensk
ZIP/Postal Code
214019
Country
Russian Federation
Facility Name
Investigational Site Number 643008
City
St-Petersburg
ZIP/Postal Code
192242
Country
Russian Federation
Facility Name
Investigational Site Number 643058
City
St. Peterburg
Country
Russian Federation
Facility Name
Investigational Site Number 643013
City
Ufa
ZIP/Postal Code
450005
Country
Russian Federation
Facility Name
Investigational Site Number 643050
City
Voronezh
Country
Russian Federation
Facility Name
Investigational Site Number 643057
City
Yaroslavl
ZIP/Postal Code
150003
Country
Russian Federation
Facility Name
Investigational Site Number 643051
City
Yaroslavl
Country
Russian Federation
Facility Name
Investigational Site Number 710011
City
Cape Town
ZIP/Postal Code
7405
Country
South Africa
Facility Name
Investigational Site Number 710007
City
Cape Town
ZIP/Postal Code
7500
Country
South Africa
Facility Name
Investigational Site Number 710008
City
Pretoria
ZIP/Postal Code
0002
Country
South Africa
Facility Name
Investigational Site Number 710006
City
Pretoria
ZIP/Postal Code
0182
Country
South Africa
Facility Name
Investigational Site Number 710010
City
Stellenbsoch
ZIP/Postal Code
7600
Country
South Africa
Facility Name
Investigational Site Number 724043
City
Córdoba
ZIP/Postal Code
14004
Country
Spain
Facility Name
Investigational Site Number 724009
City
La Coruña
ZIP/Postal Code
15006
Country
Spain
Facility Name
Investigational Site Number 724042
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Investigational Site Number 724041
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Investigational Site Number 724040
City
Madrid
ZIP/Postal Code
28850
Country
Spain
Facility Name
Investigational Site Number 724001
City
Málaga
ZIP/Postal Code
29009
Country
Spain
Facility Name
Investigational Site Number 724011
City
Sabadell
ZIP/Postal Code
08208
Country
Spain
Facility Name
Investigational Site Number 724012
City
Santiago De Compostela
ZIP/Postal Code
15705
Country
Spain
Facility Name
Investigational Site Number 158010
City
Changhua
ZIP/Postal Code
500
Country
Taiwan
Facility Name
Investigational Site Number 158004
City
Chia-Yi
ZIP/Postal Code
622
Country
Taiwan
Facility Name
Investigational Site Number 158012
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Facility Name
Investigational Site Number 158011
City
Kaohsiung
ZIP/Postal Code
833
Country
Taiwan
Facility Name
Investigational Site Number 158006
City
Taipei
ZIP/Postal Code
402
Country
Taiwan
Facility Name
Investigational Site Number 764003
City
Bangkok-Noi
Country
Thailand
Facility Name
Investigational Site Number 764002
City
Bangkok
ZIP/Postal Code
10330
Country
Thailand
Facility Name
Investigational Site Number 764010
City
Bangkok
ZIP/Postal Code
10400
Country
Thailand
Facility Name
Investigational Site Number 764011
City
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Facility Name
Investigational Site Number 804003
City
Dnipropetrovsk
ZIP/Postal Code
49008
Country
Ukraine
Facility Name
Investigational Site Number 804002
City
Donetsk
ZIP/Postal Code
83114
Country
Ukraine
Facility Name
Investigational Site Number 804024
City
Donetsk
Country
Ukraine
Facility Name
Investigational Site Number 804029
City
Ivano-Frankivsk
ZIP/Postal Code
76018
Country
Ukraine
Facility Name
Investigational Site Number 804010
City
Kharkiv
ZIP/Postal Code
61022
Country
Ukraine
Facility Name
Investigational Site Number 804001
City
Kharkov
ZIP/Postal Code
61057
Country
Ukraine
Facility Name
Investigational Site Number 804025
City
Kiev
ZIP/Postal Code
04114
Country
Ukraine
Facility Name
Investigational Site Number 804023
City
Kyiv
ZIP/Postal Code
01023
Country
Ukraine
Facility Name
Investigational Site Number 804014
City
Kyiv
ZIP/Postal Code
01103
Country
Ukraine
Facility Name
Investigational Site Number 804027
City
Kyiv
ZIP/Postal Code
03680
Country
Ukraine
Facility Name
Investigational Site Number 804011
City
Kyiv
Country
Ukraine
Facility Name
Investigational Site Number 804030
City
Lutsk
ZIP/Postal Code
43024
Country
Ukraine
Facility Name
Investigational Site Number 804005
City
Lviv
ZIP/Postal Code
79005
Country
Ukraine
Facility Name
Investigational Site Number 804033
City
Lviv
ZIP/Postal Code
79010
Country
Ukraine
Facility Name
Investigational Site Number 804020
City
Lviv
ZIP/Postal Code
79013
Country
Ukraine
Facility Name
Investigational Site Number 804032
City
Odesa
ZIP/Postal Code
65025
Country
Ukraine
Facility Name
Investigational Site Number 804022
City
Odesa
ZIP/Postal Code
65026
Country
Ukraine
Facility Name
Investigational Site Number 804012
City
Odessa
ZIP/Postal Code
65117
Country
Ukraine
Facility Name
Investigational Site Number 804021
City
Simferopol
ZIP/Postal Code
95017
Country
Ukraine
Facility Name
Investigational Site Number 804028
City
Zaporozhye
ZIP/Postal Code
69118
Country
Ukraine
Facility Name
Investigational Site Number 804031
City
Zhytomyr
Country
Ukraine
Facility Name
Investigational Site Number 826023
City
Barnsley
Country
United Kingdom
Facility Name
Investigational Site Number 826022
City
Birmingham
ZIP/Postal Code
B15 2TH
Country
United Kingdom
Facility Name
Investigational Site Number 826021
City
Dudley
ZIP/Postal Code
DY1 2HQ
Country
United Kingdom
Facility Name
Investigational Site Number 826026
City
Durham
Country
United Kingdom
Facility Name
Investigational Site Number 826027
City
Durham
Country
United Kingdom
Facility Name
Investigational Site Number 826020
City
Harlow
ZIP/Postal Code
CM20 1QX
Country
United Kingdom
Facility Name
Investigational Site Number 826025
City
Wigan
ZIP/Postal Code
WN6 9EP
Country
United Kingdom

12. IPD Sharing Statement

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An Evaluation of Sarilumab Plus Methotrexate Compared to Etanercept Plus Methotrexate in RA Patients Not Responding to Adalimumab Plus Methotrexate

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