Enhancing Synaptic Plasticity and Cognition in Schizophrenia (EXERCISE-II)
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring schizophrenia, negative symptoms, cognitive deficits, synaptic plasticity
Eligibility Criteria
Inclusion Criteria:
- Male and female patients with the diagnosis of schizophrenia (based on ICD-10 criteria)
- Age between 18 and 55
- Verbal IQ ≥ 85
- Stable psychopathology on constant medication for 2 weeks
- Informed consent.
Exclusion Criteria:
Patients, who are
- not willing or able to participate in the sports program and cognitive training
- reveal a significant worsening of psychopathology (based on an increase over 20% of the PANSS positive score)
- have an organic mental disorder (such as intoxication or neurological disorders of the CNS)
- suffer from instable somatic diseases
- have an active substance abuse
Sites / Locations
- Dept. of Psychiatry and Psychotherapy, University Medical Center Goettingen, Georg-August-University
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Placebo Comparator
Experimental
SZ-Exercise
SZ-TableSoccer
HC-Exercise
Standard treatment and participation in the sports program (cycling) including cognitive training, 3 sessions cycling (30 min. each) per week for 3 months and 2 sessions Cogpack per week for the last 6 weeks.
Standard treatment and participation in an activity without physical improvement as placebo condition (table soccer in groups of 4), but including cognitive training, 3 sessions (30 min. each) per week for 3 months and 2 sessions Cogpack per week for the last 6 weeks.
Standard treatment and participation in an activity without physical improvement as placebo condition (table football in groups of 4), but including cognitive training, 3 sessions (30 min. each) per week for 3 months and 2 sessions Cogpack per week for the last 6 weeks.