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Outcome of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab (CREHA Study) (CREHA)

Primary Purpose

Acquired Haemophilia

Status
Unknown status
Phase
Phase 3
Locations
France
Study Type
Interventional
Intervention
Steroid + cyclophosphamide
Steroid + rituximab
Sponsored by
University Hospital, Rouen
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Acquired Haemophilia focused on measuring Acquired haemophilia, Comparative and randomized study, Cyclophosphamide, Rituximab

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • men or women
  • women post-menpausal or with ongoing contraception
  • 18 years old or more
  • diagnosis of acquired hemophilia
  • patient must be insured
  • patient has provided written informed consent prior to enrolment
  • patient compliant

Exclusion Criteria:

  • constitutional hemophilia
  • chemotherapy
  • ongoing treatment with prednisone > 20mg further more 1 month
  • ongoing treatment with prednisone >0.7 mg/d further more 10 days
  • thrombocytopenia
  • leukopenia
  • chronic disease

Sites / Locations

  • University Hospital AmiensRecruiting
  • Hospital Jean VerdierRecruiting
  • Hospital Ambroise ParéRecruiting
  • University Hospital of Brest - Hospital La cavale BlancheRecruiting
  • Hospital of BéziersRecruiting
  • University Hospital Côte de NacreRecruiting
  • University Hospital G. MontpiedRecruiting
  • Hospital Henri MondorRecruiting
  • University Hospital of Dijon - Hospital GénéralRecruiting
  • University Hospital BocageRecruiting
  • University Hospital MichallonRecruiting
  • Hospital Kremlin-BicêtreRecruiting
  • University Regional Hospital of LilleRecruiting
  • university Hospital of LimogesRecruiting
  • AP-HM, University Hospital La ConceptionRecruiting
  • University Hospital Saint-EloiRecruiting
  • Regional Center of Haemophilia Treatment (CRTH) de Lorraine
  • University Hospital of Nantes, Hospital Hôtel-DieuRecruiting
  • Hospital Archet 1
  • Hospital Saint-Louis
  • Hospital Pitié-SalpêtrièreRecruiting
  • Hospital Cochin
  • Hospital BichatRecruiting
  • Europen Hospital of Georges Pompidou (HEGP)Recruiting
  • University Hospital of Bordeaux - Hospital Haut-LévêqueRecruiting
  • Hospital Lyon SudRecruiting
  • University Hospital of PoitiersRecruiting
  • Hospital Sud / Hospital PontchaillouRecruiting
  • University Hospital of RouenRecruiting
  • Hospital NordRecruiting
  • University Regional Hospital HautepierreRecruiting
  • Hospital PurpanRecruiting
  • Hospital RangueilRecruiting
  • Hopsital BretonneauRecruiting

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Experimental

Arm Label

Bras A

Bras B

Arm Description

Steroid 1mg/kg/d and Cyclophosphamide 2mg/kg/d

Steroid 1mg/kg/d and Rituximab 375 mg/m2 every week during four weeks

Outcomes

Primary Outcome Measures

Primary objective
Demonstrate the inferiority of steroid combined with rituximab as compared to the recommended immunosuppressive approach (steroid combined with cysclophosphamide for 21 to 42 days) as the first-line immunosuppressive therapy for FVIII inhibitor eradication in acquired haemophilia
Primary efficacy outcome
The primary efficacy outcome is the proportion of patients achieving complete remission defined as titer FVII inhibitor lower than 0.4 Bethesda unit and factor VIII level > 50%
Primary safety outcomes
The primary safety outcomes will be the occurrence of major bleeding and infection related immunosuppressive treatment adverse events.

Secondary Outcome Measures

Secondary objective
Secondary objective are time to complete remission, number of relapse at M6, M12, M18, adverse events (especially related to bleeding or to immunosuppressive treatment) and mortality
Other key safety outcome
The other key safety outcome are clinically relevant non major bleeding, diabetes and mortality non-related with acquired haemophilia or immunosuppressive therapy

Full Information

First Posted
October 16, 2012
Last Updated
May 25, 2018
Sponsor
University Hospital, Rouen
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1. Study Identification

Unique Protocol Identification Number
NCT01808911
Brief Title
Outcome of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab (CREHA Study)
Acronym
CREHA
Official Title
Outcome of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab (CREHA Study)
Study Type
Interventional

2. Study Status

Record Verification Date
May 2018
Overall Recruitment Status
Unknown status
Study Start Date
May 2012 (Actual)
Primary Completion Date
June 2020 (Anticipated)
Study Completion Date
June 2020 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Rouen

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
CREHA project is a study comparing steroid combined with cyclophosphamide versus steroid combined with rituximab in patients with acquired haemophilia. The study will test the hypothesis that steroid combined with cyclophosphamide is more effective than steroid plus rituximab for FVIII inhibitor eradication in acquired haemophilia.
Detailed Description
CREHA project is a multicenter, randomized, controlled efficacity and safety study comparing steroid combined with cyclophosphamide versus steroid combined with rituximab in patients with acquired haemophilia. The study will test the hypothesis that steroid combined with cyclophosphamide is more effective than steroid plus rituximab for FVIII inhibitor eradication in acquired haemophilia

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Acquired Haemophilia
Keywords
Acquired haemophilia, Comparative and randomized study, Cyclophosphamide, Rituximab

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
164 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Bras A
Arm Type
Active Comparator
Arm Description
Steroid 1mg/kg/d and Cyclophosphamide 2mg/kg/d
Arm Title
Bras B
Arm Type
Experimental
Arm Description
Steroid 1mg/kg/d and Rituximab 375 mg/m2 every week during four weeks
Intervention Type
Drug
Intervention Name(s)
Steroid + cyclophosphamide
Intervention Type
Drug
Intervention Name(s)
Steroid + rituximab
Primary Outcome Measure Information:
Title
Primary objective
Description
Demonstrate the inferiority of steroid combined with rituximab as compared to the recommended immunosuppressive approach (steroid combined with cysclophosphamide for 21 to 42 days) as the first-line immunosuppressive therapy for FVIII inhibitor eradication in acquired haemophilia
Time Frame
During 18 months
Title
Primary efficacy outcome
Description
The primary efficacy outcome is the proportion of patients achieving complete remission defined as titer FVII inhibitor lower than 0.4 Bethesda unit and factor VIII level > 50%
Time Frame
During 18 months
Title
Primary safety outcomes
Description
The primary safety outcomes will be the occurrence of major bleeding and infection related immunosuppressive treatment adverse events.
Time Frame
During 18 months
Secondary Outcome Measure Information:
Title
Secondary objective
Description
Secondary objective are time to complete remission, number of relapse at M6, M12, M18, adverse events (especially related to bleeding or to immunosuppressive treatment) and mortality
Time Frame
6 months, 12 months and 18 months
Title
Other key safety outcome
Description
The other key safety outcome are clinically relevant non major bleeding, diabetes and mortality non-related with acquired haemophilia or immunosuppressive therapy
Time Frame
During 18 months

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: men or women women post-menpausal or with ongoing contraception 18 years old or more diagnosis of acquired hemophilia patient must be insured patient has provided written informed consent prior to enrolment patient compliant Exclusion Criteria: constitutional hemophilia chemotherapy ongoing treatment with prednisone > 20mg further more 1 month ongoing treatment with prednisone >0.7 mg/d further more 10 days thrombocytopenia leukopenia chronic disease
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Hervé LEVESQUE, MD, PhD
Phone
(0)2 32 88 90 01
Ext
+33
Email
herve.levesque@chu-rouen.fr
Facility Information:
Facility Name
University Hospital Amiens
City
Amiens
ZIP/Postal Code
80054
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jean SCHMIDT, MD
Phone
(0)3 22 66 82 30
Ext
+33
Email
schmidt.jean@chu-amiens.fr
First Name & Middle Initial & Last Name & Degree
Jean SCHMIDT, MD
Facility Name
Hospital Jean Verdier
City
Bondy
ZIP/Postal Code
93140
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olivier FAIN, MD, PhD
Phone
(0)1 48 02 63 96
Ext
+33
Email
olivier.fain@jvr.aphp.fr
First Name & Middle Initial & Last Name & Degree
Olivier FAIN, MD, PhD
First Name & Middle Initial & Last Name & Degree
Yves LAURIAN, MD
Facility Name
Hospital Ambroise Paré
City
Boulogne-Billancourt
ZIP/Postal Code
92104
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thomas HANSLIK, MD, PhD
Phone
(0)1 49 09 56 38
Ext
+33
Email
thomas.hanslik@apr.aphp.fr
First Name & Middle Initial & Last Name & Degree
Thomas HANSLIK, MD, PhD
Facility Name
University Hospital of Brest - Hospital La cavale Blanche
City
Brest
ZIP/Postal Code
29609
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Aurélien DELLUC, MD
Phone
(0)2 98 34 73 36
Ext
+33
Email
aurelien.delluc@chu-brest.fr
First Name & Middle Initial & Last Name & Degree
Aurélien DELLUC, MD
First Name & Middle Initial & Last Name & Degree
Brigitte PAN-PETESCH, MD
Facility Name
Hospital of Béziers
City
Béziers
ZIP/Postal Code
34525
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Eric OZIOL, MD
Phone
(0)4 67 35 70 56
Ext
+33
Email
eric.oziol@ch-beziers.fr
First Name & Middle Initial & Last Name & Degree
Eric OZIOL, MD
Facility Name
University Hospital Côte de Nacre
City
Caen
ZIP/Postal Code
14033
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Boris BIENVENU, MD, PhD
Phone
(0)2 31 06 45 84
Ext
+33
Email
bienvenu-b@chu-caen.fr
First Name & Middle Initial & Last Name & Degree
Boris BIENVENU, MD, PhD
Facility Name
University Hospital G. Montpied
City
Clermont-Ferrand
ZIP/Postal Code
63003
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc ANDRE, MD,PhD
Phone
(0)4 73 75 14 35
Ext
+33
Email
mandre@chu-clermontferrand.fr
First Name & Middle Initial & Last Name & Degree
Marc ANDRE, MD, PhD
Facility Name
Hospital Henri Mondor
City
Créteil
ZIP/Postal Code
94010
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc MICHEL, MD, PhD
Phone
(0)1 49 81 20 76
Ext
+33
Email
marc.michel@hmn.aphp.fr
First Name & Middle Initial & Last Name & Degree
Marc MICHEL, MD, PhD
Facility Name
University Hospital of Dijon - Hospital Général
City
Dijon
ZIP/Postal Code
21033
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jean-François BESANCENOT, MD, PhD
Phone
(0)3 80 29 37 73
Ext
+33
Email
jean-francois.besancenot@chu-dijon.fr
First Name & Middle Initial & Last Name & Degree
Jean-François BESANCENOT, MD, PhD
Facility Name
University Hospital Bocage
City
Dijon
ZIP/Postal Code
21079
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Bernard BONNOTTE, MD, PhD
Phone
(0)3 80 29 34 32
Ext
+33
Email
bernard.bonnotte@chu-dijon.fr
First Name & Middle Initial & Last Name & Degree
Bernard BONNOTTE, MD, PhD
Facility Name
University Hospital Michallon
City
Grenoble
ZIP/Postal Code
38043
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laurence BOUILLET, MD
Phone
(0)4 76 7655 20
Ext
+33
Email
Lbouillet@chu-grenoble.fr
First Name & Middle Initial & Last Name & Degree
Laurence BOUILLET, MD
Facility Name
Hospital Kremlin-Bicêtre
City
Le Kremlin-bicetre
ZIP/Postal Code
94270
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Olivier LAMBOTTE, MD, PhD
Phone
(0)1 45 21 27 83
Ext
+33
Email
olivier.lambotte@bct.aphp.fr
First Name & Middle Initial & Last Name & Degree
Olivier LAMBOTTE, MD, PhD
Facility Name
University Regional Hospital of Lille
City
Lille
ZIP/Postal Code
59037
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Marc LAMBERT, MD
Phone
(0)3 20 44 42 96
Ext
+33
Email
marc.lambert@chru-lille.fr
First Name & Middle Initial & Last Name & Degree
Marc LAMBERT, MD
First Name & Middle Initial & Last Name & Degree
Jenny GOUDEMAND, MD, PhD
Facility Name
university Hospital of Limoges
City
Limoges
ZIP/Postal Code
87042
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Elizabeth VIDAL-CATHALA, MD,PhD
Phone
(0)5 55 05 66 41
Ext
+33
Email
elisabeth.vidal@unilim.fr
First Name & Middle Initial & Last Name & Degree
Elizabeth VIDAL-CATHALA, MD, PhD
Facility Name
AP-HM, University Hospital La Conception
City
Marseille
ZIP/Postal Code
13385
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Nicolas SCHLEINITZ, MD, PhD
Phone
(0)4 91 38 35 01
Ext
+33
Email
nicolas.schleinitz@ap-hm.fr
First Name & Middle Initial & Last Name & Degree
Nicolas SCHLEINITZ, MD, PhD
Facility Name
University Hospital Saint-Eloi
City
Montpellier
ZIP/Postal Code
34295
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Alain LE QUELLEC, MD, PhD
Phone
(0)4 67 33 70 17
Ext
+33
Email
a-lequellec@chu-montpellier.fr
First Name & Middle Initial & Last Name & Degree
Alain LE QUELLEC, MD, PhD
Facility Name
Regional Center of Haemophilia Treatment (CRTH) de Lorraine
City
Nancy
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Brigit FROTSCHER, MD
Phone
(0) 03 83 15 37 84
Ext
+33
Email
b.frotscher@chu-nancy.fr
First Name & Middle Initial & Last Name & Degree
Brigit FROTSCHER, MD
Facility Name
University Hospital of Nantes, Hospital Hôtel-Dieu
City
Nantes
ZIP/Postal Code
44093
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Mohamed HAMIDOU, MD, PhD
Phone
(0)2 40 08 31 46
Ext
+33
Email
mohamed.hamidou@chu-nantes.fr
First Name & Middle Initial & Last Name & Degree
Mohamed HAMIDOU, MD, PhD
First Name & Middle Initial & Last Name & Degree
Marc TROSSAËRT, MD
Facility Name
Hospital Archet 1
City
Nice
ZIP/Postal Code
06202
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pierre-Yves JEANDEL, MD
Phone
(0)4 92 03 58 23
Ext
+33
Email
jeandel.p@chu-nice.fr
First Name & Middle Initial & Last Name & Degree
Pierre-Yves JEANDEL, MD
Facility Name
Hospital Saint-Louis
City
Paris 10e
ZIP/Postal Code
75475
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dominique FARGE-BANCEL, MD, PhD
Phone
(0)1 42 49 97 67
Ext
+33
Email
dominique.farge-bancel@sls.aphp.fr
First Name & Middle Initial & Last Name & Degree
Dominique FARGE-BANCEL, MD, PhD
Facility Name
Hospital Pitié-Salpêtrière
City
Paris 13e
ZIP/Postal Code
75651
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zahir AMOURA, MD, PhD
Phone
(0)1 42 17 80 01
Ext
+33
Email
zahir.amoura@psl.aphp.fr
First Name & Middle Initial & Last Name & Degree
Zahir AMOURA, MD, PhD
Facility Name
Hospital Cochin
City
Paris 14e
ZIP/Postal Code
75679
Country
France
Individual Site Status
Not yet recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Philippe BLANCHE, MD
Phone
(0)1 58 41 21 26
Ext
+33
Email
philippe.blanche@cch.aphp.fr
First Name & Middle Initial & Last Name & Degree
Philippe BLANCHE, MD
Facility Name
Hospital Bichat
City
Paris 18e
ZIP/Postal Code
75018
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Thomas PAPO, MD, PhD
Phone
(0)1 40 25 87 05
Ext
+33
Email
thomas.papo@bch.aphp.fr
First Name & Middle Initial & Last Name & Degree
Thomas PAPO, MD, PhD
Facility Name
Europen Hospital of Georges Pompidou (HEGP)
City
Paris
ZIP/Postal Code
75908
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jacques POUCHOT, MD, PhD
Phone
(0)1 56 09 33 32
Ext
+33
Email
jacques.pouchot@egp.aphp.fr
First Name & Middle Initial & Last Name & Degree
Jacques POUCHOT, MD, PhD
Facility Name
University Hospital of Bordeaux - Hospital Haut-Lévêque
City
Pessac
ZIP/Postal Code
33604
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Jean-François VIALLARD, MD, PhD
Phone
(0)5 57 65 64 83
Ext
+33
Email
jean-francois.viallard@chu-bordeaux.fr
First Name & Middle Initial & Last Name & Degree
Jean-François VIALLARD, MD, PhD
Facility Name
Hospital Lyon Sud
City
Pierre-Benite
ZIP/Postal Code
69495
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Isabelle DURIEU, MD, PhD
Phone
(0)4 78 86 14 65
Ext
+33
Email
Isabelle.durieu@chu-lyon.fr
First Name & Middle Initial & Last Name & Degree
Isabelle DURIEU, MD, PhD
Facility Name
University Hospital of Poitiers
City
Poitiers
ZIP/Postal Code
86021
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pascal ROBLOT, MD, PhD
Phone
(0) 5 49 44 44 22
Ext
+33
Email
p.roblot@chu-poitiers.fr
First Name & Middle Initial & Last Name & Degree
Pascal ROBLOT, MD, PhD
Facility Name
Hospital Sud / Hospital Pontchaillou
City
Rennes
ZIP/Postal Code
35000
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Patrick JEGO, MD, PhD
Phone
(0)2 99 26 71 28
Ext
+33
Email
patrick.jego@chu-rennes.fr
First Name & Middle Initial & Last Name & Degree
Patrick JEGO, MD, PhD
First Name & Middle Initial & Last Name & Degree
Benoît GUILLET, MD
Facility Name
University Hospital of Rouen
City
Rouen
ZIP/Postal Code
76031
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Hervé LEVESQUE, MD, PhD
Phone
(0) 2 32 88 90 01
Ext
+33
Email
herve.levesque@chu-rouen.fr
First Name & Middle Initial & Last Name & Degree
Ygal BENHAMOU, MD
Phone
(0)2 32 88 90 14
Ext
+33
Email
ygal.benhamou@chu-rouen.fr
First Name & Middle Initial & Last Name & Degree
Hervé LEVESQUE, MD, PhD
First Name & Middle Initial & Last Name & Degree
Ygal BENHAMOU, MD
First Name & Middle Initial & Last Name & Degree
Loïc BEGARIN, MD
First Name & Middle Initial & Last Name & Degree
Cyrielle ASSIE-CHAUVIER, MD
First Name & Middle Initial & Last Name & Degree
Nicolas GIRSZYN, MD
First Name & Middle Initial & Last Name & Degree
Alice PROUX, MD
First Name & Middle Initial & Last Name & Degree
Severine JOSSE, MD
First Name & Middle Initial & Last Name & Degree
Isabelle MARIE, MD, PhD
First Name & Middle Initial & Last Name & Degree
Jeanne-Yvonne BORG, MD, PhD
First Name & Middle Initial & Last Name & Degree
Véronique LE CAM-DUCHEZ, Md
Facility Name
Hospital Nord
City
Saint-Etienne
ZIP/Postal Code
42055
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Pascal CATHEBRAS, MD, PhD
Phone
(0)4 77 82 83 42
Ext
+33
Email
pascal.cathebras@chu-st-etienne.fr
First Name & Middle Initial & Last Name & Degree
Pascal CATHEBRAS, MD, PhD
Facility Name
University Regional Hospital Hautepierre
City
Strasbourg
ZIP/Postal Code
67098
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Anne BOUGARIT, MD, PhD
Phone
(0)3 88 12 75 94
Ext
+33
Email
anne.bourgarit-durand@chur-strasbourg.fr
First Name & Middle Initial & Last Name & Degree
Anne BOURGARIT, MD, PhD
First Name & Middle Initial & Last Name & Degree
Bernard GOICHOT, MD, PhD
First Name & Middle Initial & Last Name & Degree
Lélia GRUNEBAUM-HIMY, MD
First Name & Middle Initial & Last Name & Degree
Dominique DESPREZ, MD
Facility Name
Hospital Purpan
City
Toulouse
ZIP/Postal Code
31059
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Laurent SAILLER, MD, PhD
Phone
(0)5 61 77 96 78
Ext
+33
Email
sailler.l@chu-toulouse.fr
First Name & Middle Initial & Last Name & Degree
Laurent SAILLER, MD, PhD
First Name & Middle Initial & Last Name & Degree
Marie-France THIERCELIN-LEGRAND, MD
First Name & Middle Initial & Last Name & Degree
Daniel ADOUE, MD, PhD
Facility Name
Hospital Rangueil
City
Toulouse
ZIP/Postal Code
31059
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Dominique CHAUVEAU, MD, PhD
Phone
(0)5 61 32 32 79
Ext
+33
Email
chauveau.d@chu-toulouse.fr
First Name & Middle Initial & Last Name & Degree
Dominique CHAUVEAU, MD, PhD
First Name & Middle Initial & Last Name & Degree
Pierre SIE, MD, PhD
First Name & Middle Initial & Last Name & Degree
Sophie VOISIN, MD
Facility Name
Hopsital Bretonneau
City
Tours
ZIP/Postal Code
37044
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
François MAILLOT, MD, PhD
Phone
(0)2 47 47 47 27
Ext
+33
Email
maillot@med.univ-tours.fr
First Name & Middle Initial & Last Name & Degree
Francois MAILLOT, MD, PhD
First Name & Middle Initial & Last Name & Degree
Yves GRUEL, MD

12. IPD Sharing Statement

Learn more about this trial

Outcome of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab (CREHA Study)

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