Back to resultsOpt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity (Opt-IN)
Primary Purpose
Weight Loss
Status
Completed
Phase
Phase 2
Locations
United States
Study Type
Interventional
Intervention
12 Telephone Coaching Sessions
24 Telephone Coaching Sessions
Report to Primary Care Physician
Text Messages
Recommendations to use meal replacements
Buddy Training
Sponsored by
About this trial
This is an interventional treatment trial for Weight Loss
Eligibility Criteria
Inclusion Criteria:
- 18 and 60 years old
- BMI 25-40 kg/m2
- Weight stable (no loss or gain >25 lbs for the past 6 months)
- Not enrolled in any formal weight loss program or taking anti-obesity medications, but interested in losing weight.
- Own a Smartphone and be willing to install the Opt-IN app
- Able to use the app to record dietary intake and weight onto the Smartphone
"Buddy" participants must:
- 18 years of age or older
- Have access to a computer and internet
- Be willing to undergo "Buddy Training" and participate in 4 webinars
- Be willing to provide support and encouragement to the participant
Exclusion Criteria:
- Unstable medical conditions (uncontrolled hypertension, diabetes, unstable angina pectoris, myocardial infarction, transient ischemic attack, cancer undergoing active treatment, or cerebrovascular accident within the past six months)
- History of diabetes requiring insulin supplementation, Crohn's Disease, or a diagnosis of obstructive sleep apnea requiring intervention (i.e. CPAP)
- Use an assistive device for mobility (e.g., wheelchair, walker, cane)
- Plantar fasciitis
- Hospitalization for a psychiatric disorder within the past 5 years
- At risk for adverse cardiovascular (CVD) events with moderate intensity activity
- Cannot read the study questionnaires
- Committed to following an incompatible dietary regimen
- Not be pregnant, trying to get pregnant, or lactating
- Bulimia, binge eating disorder, current substance abuse or dependence (besides nicotine dependence) or report active suicidal ideation
- Low motivation to change
- Cannot live with a current or past Opt-IN participant
Sites / Locations
- Northwestern University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Arm 9
Arm 10
Arm 11
Arm 12
Arm 13
Arm 14
Arm 15
Arm 16
Arm 17
Arm 18
Arm 19
Arm 20
Arm 21
Arm 22
Arm 23
Arm 24
Arm 25
Arm 26
Arm 27
Arm 28
Arm 29
Arm 30
Arm 31
Arm 32
Arm Type
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Arm Label
Condition 1
Condition 2
Condition 3
Condition 4
Condition 5
Condition 6
Condition 7
Condition 8
Condition 9
Condition 10
Condition 11
Condition 12
Condition 13
Condition 14
Condition 15
Condition 16
Condition 17
Condition 18
Condition 19
Condition 20
Condition 21
Condition 22
Condition 23
Condition 24
Condition 25
Condition 26
Condition 27
Condition 28
Condition 29
Condition 30
Condition 31
Condition 32
Arm Description
1) Lifestyle Core; 2) 12 Telephone Coaching Sessions; 3) Report to Primary Care Physician
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendations to use meal replacements; 5) Buddy training via webinars
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages; 5) Buddy training via webinars
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages
1) Lifestyle Core; 2) 12 telephone sessions; 3) Buddy training via webinars
1) Lifestyle Core; 2) 12 telephone coaching sessions; 3) Recommendations to use meal replacements
1) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages
1) Lifestyle Core; 2) 12 telephone sessions; 3) Recommendation to use meal replacements; 4) Regular text messages, 5) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Report to Primary Care Physician
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages; 5) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages
1) Lifestyle Core; 2) 24 telephone sessions; 3) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Recommendation to use meal replacements
1) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages
1) Lifestyle Core; 2) 24 telephone sessions; 3) Recommendation to use meal replacements; 4) Regular text messages, 5) Buddy training via webinars
1) Lifestyle Core; 2) 12 Telephone Coaching Sessions
1) Lifestyle Core; 2) 12 telephone sessions; 3) Recommendations to use meal replacements; 4) Buddy training via webinars
1) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages; 4) Buddy training via webinars
1) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages; 4) Recommendation to use meal replacements
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Buddy training via webinars
1) Lifestyle Core; 2) 12 telephone coaching sessions; 3) Report to Primary Care Physician; 4) Recommendations to use meal replacements
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages, 6) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone coaching sessions
1) Lifestyle Core; 2) 24 telephone sessions; 3) Recommendation to use meal replacements; 4) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages; 4) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages; 4) Recommendation to use meal replacements
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Buddy training via webinars
1) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages, 6) Buddy training via webinars
Outcomes
Primary Outcome Measures
Weight Change (kg) From Baseline to Month 6, Main Effect of Time
Estimated mean change from Baseline to Month 6 were obtained from a linear mixed models analysis of variance to account for missing data. All randomized participants were utilized in the model (ITT analysis).
Weight Change (kg) From Baseline to Month 6, Time by Factor Interaction
Estimated mean change from Baseline to Month 6 were obtained from a linear mixed models analysis of variance to account for missing data. All randomized participants were utilized in the model (ITT analysis).
This outcome measure is reported as an additional effect beyond that of Outcome Measure 1 (each component has it's own weight loss effect that is above and beyond the weight change calculated in the Outcome Measure 1 analyses).
Secondary Outcome Measures
Intervention for <$500
Using the results from primary aim 1, an intervention with only active treatment components with the largest treatment effect that can be obtained for implementation costs of $500 or less was identified and built.
Full Information
NCT ID
NCT01814072
First Posted
March 15, 2013
Last Updated
January 12, 2023
Sponsor
Northwestern University
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Penn State University
1. Study Identification
Unique Protocol Identification Number
NCT01814072
Brief Title
Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity
Acronym
Opt-IN
Official Title
Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity
Study Type
Interventional
2. Study Status
Record Verification Date
January 2023
Overall Recruitment Status
Completed
Study Start Date
September 2013 (undefined)
Primary Completion Date
September 20, 2017 (Actual)
Study Completion Date
September 20, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Northwestern University
Collaborators
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Penn State University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
The overall objective of the proposed research is to use an innovative methodological framework, the Multiphase Optimization Strategy (MOST), to design, for the first time, an optimized, scalable version of a technology-supported intensive lifestyle intervention (INLI) for obesity. MOST involves highly efficient randomized experimentation to assess the effects of individual treatment components, and thereby identify which components and component levels make important contributions to the overall program effect on weight loss. This information then guides assembly of an optimized treatment package that achieves target outcomes with least resource consumption and participant burden. Because the intervention strategies being tested minimize in-person coaching and leverage technology that participants already own, the new optimized intervention, to be called Opt-IN, will be more scalable than traditional INLIs. Opt-IN will thus enjoy greatly increased reach, and enable significant progress in the fight against obesity.
Detailed Description
The goal of the proposed study is to determine the optimal composition of a technology supported intervention for obesity that minimizes expense and burden to participants, while achieving 6 month weight loss outcomes comparable or superior to those achieved by the current full cost, full burden form of INLIs. All intervention components to be examined were selected based on the Opt-IN model's prediction that they enhance behavioral adherence to weight regulation via the designated pathways. The five components to be tested will be: (1) coaching intensity (12 vs. 24 phone sessions), (2) text messaging (No vs. Yes), (3) progress report to participant's primary care provider (No vs. Yes), (4) recommendation to use meal replacements (No vs. Yes), (5) training participants' self-selected buddies to be supportive (No vs. Yes).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Weight Loss
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 2, Phase 3
Interventional Study Model
Factorial Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
562 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Condition 1
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 Telephone Coaching Sessions; 3) Report to Primary Care Physician
Arm Title
Condition 2
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendations to use meal replacements; 5) Buddy training via webinars
Arm Title
Condition 3
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages; 5) Buddy training via webinars
Arm Title
Condition 4
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages
Arm Title
Condition 5
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Buddy training via webinars
Arm Title
Condition 6
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone coaching sessions; 3) Recommendations to use meal replacements
Arm Title
Condition 7
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages
Arm Title
Condition 8
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Recommendation to use meal replacements; 4) Regular text messages, 5) Buddy training via webinars
Arm Title
Condition 9
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Report to Primary Care Physician
Arm Title
Condition 10
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Buddy training via webinars
Arm Title
Condition 11
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages; 5) Buddy training via webinars
Arm Title
Condition 12
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages
Arm Title
Condition 13
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Buddy training via webinars
Arm Title
Condition 14
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Recommendation to use meal replacements
Arm Title
Condition 15
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages
Arm Title
Condition 16
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Recommendation to use meal replacements; 4) Regular text messages, 5) Buddy training via webinars
Arm Title
Condition 17
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 Telephone Coaching Sessions
Arm Title
Condition 18
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Recommendations to use meal replacements; 4) Buddy training via webinars
Arm Title
Condition 19
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages; 4) Buddy training via webinars
Arm Title
Condition 20
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Regular text messages; 4) Recommendation to use meal replacements
Arm Title
Condition 21
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Buddy training via webinars
Arm Title
Condition 22
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone coaching sessions; 3) Report to Primary Care Physician; 4) Recommendations to use meal replacements
Arm Title
Condition 23
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages
Arm Title
Condition 24
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 12 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages, 6) Buddy training via webinars
Arm Title
Condition 25
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone coaching sessions
Arm Title
Condition 26
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Recommendation to use meal replacements; 4) Buddy training via webinars
Arm Title
Condition 27
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages; 4) Buddy training via webinars
Arm Title
Condition 28
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Regular text messages; 4) Recommendation to use meal replacements
Arm Title
Condition 29
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Buddy training via webinars
Arm Title
Condition 30
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone coaching sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements
Arm Title
Condition 31
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Regular text messages
Arm Title
Condition 32
Arm Type
Experimental
Arm Description
1) Lifestyle Core; 2) 24 telephone sessions; 3) Report to Primary Care Physician; 4) Recommendation to use meal replacements; 5) Regular text messages, 6) Buddy training via webinars
Intervention Type
Behavioral
Intervention Name(s)
12 Telephone Coaching Sessions
Intervention Description
Participants will receive 12 telephone coaching sessions
Intervention Type
Behavioral
Intervention Name(s)
24 Telephone Coaching Sessions
Intervention Description
Participants will receive 24 telephone coaching sessions
Intervention Type
Behavioral
Intervention Name(s)
Report to Primary Care Physician
Intervention Description
Participants will have a report detailing their weight loss progress sent to their primary care physician
Intervention Type
Behavioral
Intervention Name(s)
Text Messages
Intervention Description
Participants will receive regular text messages
Intervention Type
Behavioral
Intervention Name(s)
Recommendations to use meal replacements
Intervention Description
Participants will receive recommendations from their coach to use meal replacements
Intervention Type
Behavioral
Intervention Name(s)
Buddy Training
Intervention Description
Participants will have a buddy that will be trained via webinars to be a supportive buddy
Primary Outcome Measure Information:
Title
Weight Change (kg) From Baseline to Month 6, Main Effect of Time
Description
Estimated mean change from Baseline to Month 6 were obtained from a linear mixed models analysis of variance to account for missing data. All randomized participants were utilized in the model (ITT analysis).
Time Frame
From Baseline to Month 6
Title
Weight Change (kg) From Baseline to Month 6, Time by Factor Interaction
Description
Estimated mean change from Baseline to Month 6 were obtained from a linear mixed models analysis of variance to account for missing data. All randomized participants were utilized in the model (ITT analysis).
This outcome measure is reported as an additional effect beyond that of Outcome Measure 1 (each component has it's own weight loss effect that is above and beyond the weight change calculated in the Outcome Measure 1 analyses).
Time Frame
From Baseline to Month 6
Secondary Outcome Measure Information:
Title
Intervention for <$500
Description
Using the results from primary aim 1, an intervention with only active treatment components with the largest treatment effect that can be obtained for implementation costs of $500 or less was identified and built.
Time Frame
6 months
Other Pre-specified Outcome Measures:
Title
Treatment Adherence
Description
Treatment adherence is a hypothesized mediator that will be operationalized as the number of treatment sessions completed divided by the number of treatment sessions offered (12 or 24)
Time Frame
6 months
Title
Self-monitoring Adherence
Description
Self-monitoring is a hypothesized mediator that will be operationalized as the number of days recording weight, dietary intake, and physical activity
Time Frame
6 months
Title
Self-efficacy
Description
Self-efficacy is an exploratory mediator that will be assessed to examine treatment effects on confidence about performing two categories of behaviors associated with weight loss: diet and physical activity
Time Frame
6 months
Title
Self-Regulation
Description
Self-regulation is an exploratory mediator that will be assessed using the Three Factor Eating Questionnaire and Treatment Self-Regulation Questionnaire
Time Frame
6 months
Title
Supportive Accountability
Description
Supportive accountability is an exploratory mediator that will be measured by assessing two constructs that define supportive accountability: therapeutic alliance and perceived autonomy support
Time Frame
6 months
Title
Facilitation
Description
Facilitation is an exploratory mediator that will be measured by rating how much the tools provided by the study have changed their environment and by the Weight Management Support Inventory
Time Frame
6 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
18 and 60 years old
BMI 25-40 kg/m2
Weight stable (no loss or gain >25 lbs for the past 6 months)
Not enrolled in any formal weight loss program or taking anti-obesity medications, but interested in losing weight.
Own a Smartphone and be willing to install the Opt-IN app
Able to use the app to record dietary intake and weight onto the Smartphone
"Buddy" participants must:
18 years of age or older
Have access to a computer and internet
Be willing to undergo "Buddy Training" and participate in 4 webinars
Be willing to provide support and encouragement to the participant
Exclusion Criteria:
Unstable medical conditions (uncontrolled hypertension, diabetes, unstable angina pectoris, myocardial infarction, transient ischemic attack, cancer undergoing active treatment, or cerebrovascular accident within the past six months)
History of diabetes requiring insulin supplementation, Crohn's Disease, or a diagnosis of obstructive sleep apnea requiring intervention (i.e. CPAP)
Use an assistive device for mobility (e.g., wheelchair, walker, cane)
Plantar fasciitis
Hospitalization for a psychiatric disorder within the past 5 years
At risk for adverse cardiovascular (CVD) events with moderate intensity activity
Cannot read the study questionnaires
Committed to following an incompatible dietary regimen
Not be pregnant, trying to get pregnant, or lactating
Bulimia, binge eating disorder, current substance abuse or dependence (besides nicotine dependence) or report active suicidal ideation
Low motivation to change
Cannot live with a current or past Opt-IN participant
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Bonnie Spring, PhD
Organizational Affiliation
Northwestern University
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Linda Collins, PhD
Organizational Affiliation
Penn State University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Northwestern University
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60611
Country
United States
12. IPD Sharing Statement
Citations:
PubMed Identifier
17466815
Citation
Collins LM, Murphy SA, Strecher V. The multiphase optimization strategy (MOST) and the sequential multiple assignment randomized trial (SMART): new methods for more potent eHealth interventions. Am J Prev Med. 2007 May;32(5 Suppl):S112-8. doi: 10.1016/j.amepre.2007.01.022.
Results Reference
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PubMed Identifier
27663578
Citation
Nahum-Shani I, Smith SN, Spring BJ, Collins LM, Witkiewitz K, Tewari A, Murphy SA. Just-in-Time Adaptive Interventions (JITAIs) in Mobile Health: Key Components and Design Principles for Ongoing Health Behavior Support. Ann Behav Med. 2018 May 18;52(6):446-462. doi: 10.1007/s12160-016-9830-8.
Results Reference
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PubMed Identifier
28577591
Citation
Baker TB, Smith SS, Bolt DM, Loh WY, Mermelstein R, Fiore MC, Piper ME, Collins LM. Implementing Clinical Research Using Factorial Designs: A Primer. Behav Ther. 2017 Jul;48(4):567-580. doi: 10.1016/j.beth.2016.12.005. Epub 2017 Jan 7.
Results Reference
background
PubMed Identifier
31129369
Citation
Pfammatter AF, Nahum-Shani I, DeZelar M, Scanlan L, McFadden HG, Siddique J, Hedeker D, Spring B. SMART: Study protocol for a sequential multiple assignment randomized controlled trial to optimize weight loss management. Contemp Clin Trials. 2019 Jul;82:36-45. doi: 10.1016/j.cct.2019.05.007. Epub 2019 May 23.
Results Reference
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PubMed Identifier
28383950
Citation
Nahum-Shani I, Dziak JJ, Collins LM. Multilevel factorial designs with experiment-induced clustering. Psychol Methods. 2018 Sep;23(3):458-479. doi: 10.1037/met0000128. Epub 2017 Apr 6.
Results Reference
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PubMed Identifier
27670659
Citation
Terry PE, Brown N, Arnett DK, Cushman M, Spring B, Halpern SD, Burke LE, Grossmeier J, Goetzel R, Lang J, Calitz C, Terry PE, Sanchez E. The Art of Health Promotion ideas for improving health outcomes. Am J Health Promot. 2016 Sep;30(7):563-82. doi: 10.1177/0890117116668866. No abstract available.
Results Reference
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PubMed Identifier
29325663
Citation
Pellegrini CA, Conroy DE, Phillips SM, Pfammatter AF, McFadden HG, Spring B. Daily and Seasonal Influences on Dietary Self-monitoring Using a Smartphone Application. J Nutr Educ Behav. 2018 Jan;50(1):56-61.e1. doi: 10.1016/j.jneb.2016.12.004.
Results Reference
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PubMed Identifier
29551330
Citation
Welch WA, Spring B, Phillips SM, Siddique J. Moderating Effects of Weather-Related Factors on a Physical Activity Intervention. Am J Prev Med. 2018 May;54(5):e83-e89. doi: 10.1016/j.amepre.2018.01.025. Epub 2018 Mar 15.
Results Reference
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PubMed Identifier
26271892
Citation
Burke LE, Ma J, Azar KM, Bennett GG, Peterson ED, Zheng Y, Riley W, Stephens J, Shah SH, Suffoletto B, Turan TN, Spring B, Steinberger J, Quinn CC; American Heart Association Publications Committee of the Council on Epidemiology and Prevention, Behavior Change Committee of the Council on Cardiometabolic Health, Council on Cardiovascular and Stroke Nursing, Council on Functional Genomics and Translational Biology, Council on Quality of Care and Outcomes Research, and Stroke Council. Current Science on Consumer Use of Mobile Health for Cardiovascular Disease Prevention: A Scientific Statement From the American Heart Association. Circulation. 2015 Sep 22;132(12):1157-213. doi: 10.1161/CIR.0000000000000232. Epub 2015 Aug 13. No abstract available. Erratum In: Circulation. 2015 Nov 10;132(19):e233.
Results Reference
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PubMed Identifier
30212849
Citation
Piper ME, Cook JW, Schlam TR, Jorenby DE, Smith SS, Collins LM, Mermelstein R, Fraser D, Fiore MC, Baker TB. A Randomized Controlled Trial of an Optimized Smoking Treatment Delivered in Primary Care. Ann Behav Med. 2018 Sep 13;52(10):854-864. doi: 10.1093/abm/kax059.
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PubMed Identifier
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Citation
Booth JN 3rd, Allen NB, Calhoun D, Carson AP, Deng L, Goff DC Jr, Redden DT, Reis JP, Shimbo D, Shikany JM, Sidney S, Spring B, Lewis CE, Muntner P. Racial Differences in Maintaining Optimal Health Behaviors Into Middle Age. Am J Prev Med. 2019 Mar;56(3):368-375. doi: 10.1016/j.amepre.2018.10.020.
Results Reference
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27973672
Citation
Spring B, Pfammatter A, Alshurafa N. First Steps Into the Brave New Transdiscipline of Mobile Health. JAMA Cardiol. 2017 Jan 1;2(1):76-78. doi: 10.1001/jamacardio.2016.4440. No abstract available.
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PubMed Identifier
30461097
Citation
Hoffman SA, Ledford G, Cameron KA, Phillips SM, Pellegrini CA. A qualitative exploration of social and environmental factors affecting diet and activity in knee replacement patients. J Clin Nurs. 2019 Apr;28(7-8):1156-1163. doi: 10.1111/jocn.14719. Epub 2018 Dec 10.
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Hekler EB, Michie S, Pavel M, Rivera DE, Collins LM, Jimison HB, Garnett C, Parral S, Spruijt-Metz D. Advancing Models and Theories for Digital Behavior Change Interventions. Am J Prev Med. 2016 Nov;51(5):825-832. doi: 10.1016/j.amepre.2016.06.013.
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Piper ME, Schlam TR, Cook JW, Smith SS, Bolt DM, Loh WY, Mermelstein R, Collins LM, Fiore MC, Baker TB. Toward precision smoking cessation treatment I: Moderator results from a factorial experiment. Drug Alcohol Depend. 2017 Feb 1;171:59-65. doi: 10.1016/j.drugalcdep.2016.11.025. Epub 2016 Nov 25.
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Spring B, Pellegrini CA, Pfammatter A, Duncan JM, Pictor A, McFadden HG, Siddique J, Hedeker D. Effects of an abbreviated obesity intervention supported by mobile technology: The ENGAGED randomized clinical trial. Obesity (Silver Spring). 2017 Jul;25(7):1191-1198. doi: 10.1002/oby.21842. Epub 2017 May 11.
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26236766
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Pellegrini CA, Pfammatter AF, Conroy DE, Spring B. Smartphone applications to support weight loss: current perspectives. Adv Health Care Technol. 2015 Jul;1:13-22. doi: 10.2147/AHCT.S57844.
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Spring B, Ockene JK, Gidding SS, Mozaffarian D, Moore S, Rosal MC, Brown MD, Vafiadis DK, Cohen DL, Burke LE, Lloyd-Jones D; American Heart Association Behavior Change Committee of the Council on Epidemiology and Prevention, Council on Lifestyle and Cardiometabolic Health, Council for High Blood Pressure Research, and Council on Cardiovascular and Stroke Nursing. Better population health through behavior change in adults: a call to action. Circulation. 2013 Nov 5;128(19):2169-76. doi: 10.1161/01.cir.0000435173.25936.e1. Epub 2013 Oct 7. No abstract available.
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Baker TB, Collins LM, Mermelstein R, Piper ME, Schlam TR, Cook JW, Bolt DM, Smith SS, Jorenby DE, Fraser D, Loh WY, Theobald WE, Fiore MC. Enhancing the effectiveness of smoking treatment research: conceptual bases and progress. Addiction. 2016 Jan;111(1):107-16. doi: 10.1111/add.13154. Epub 2015 Nov 19.
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26327936
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Pellegrini CA, Hoffman SA, Daly ER, Murillo M, Iakovlev G, Spring B. Acceptability of smartphone technology to interrupt sedentary time in adults with diabetes. Transl Behav Med. 2015 Sep;5(3):307-14. doi: 10.1007/s13142-015-0314-3.
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Piper ME, Cook JW, Schlam TR, Smith SS, Bolt DM, Collins LM, Mermelstein R, Fiore MC, Baker TB. Toward precision smoking cessation treatment II: Proximal effects of smoking cessation intervention components on putative mechanisms of action. Drug Alcohol Depend. 2017 Feb 1;171:50-58. doi: 10.1016/j.drugalcdep.2016.11.027. Epub 2016 Nov 24.
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Schlam TR, Fiore MC, Smith SS, Fraser D, Bolt DM, Collins LM, Mermelstein R, Piper ME, Cook JW, Jorenby DE, Loh WY, Baker TB. Comparative effectiveness of intervention components for producing long-term abstinence from smoking: a factorial screening experiment. Addiction. 2016 Jan;111(1):142-55. doi: 10.1111/add.13153. Epub 2015 Nov 19.
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Watkins E, Newbold A, Tester-Jones M, Javaid M, Cadman J, Collins LM, Graham J, Mostazir M. Implementing multifactorial psychotherapy research in online virtual environments (IMPROVE-2): study protocol for a phase III trial of the MOST randomized component selection method for internet cognitive-behavioural therapy for depression. BMC Psychiatry. 2016 Oct 6;16(1):345. doi: 10.1186/s12888-016-1054-8.
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Collins LM, Nahum-Shani I, Almirall D. Optimization of behavioral dynamic treatment regimens based on the sequential, multiple assignment, randomized trial (SMART). Clin Trials. 2014 Aug;11(4):426-434. doi: 10.1177/1740774514536795. Epub 2014 Jun 5.
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Cook JW, Collins LM, Fiore MC, Smith SS, Fraser D, Bolt DM, Baker TB, Piper ME, Schlam TR, Jorenby D, Loh WY, Mermelstein R. Comparative effectiveness of motivation phase intervention components for use with smokers unwilling to quit: a factorial screening experiment. Addiction. 2016 Jan;111(1):117-28. doi: 10.1111/add.13161. Epub 2015 Nov 19.
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24846621
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Pellegrini CA, Hoffman SA, Collins LM, Spring B. Optimization of remotely delivered intensive lifestyle treatment for obesity using the Multiphase Optimization Strategy: Opt-IN study protocol. Contemp Clin Trials. 2014 Jul;38(2):251-9. doi: 10.1016/j.cct.2014.05.007. Epub 2014 May 17. Erratum In: Contemp Clin Trials. 2015 Nov;45(Pt B):468-469.
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28802730
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Pellegrini CA, Hoffman SA, Collins LM, Spring B. Corrigendum to "Optimization of remotely delivered intensive lifestyle treatment for obesity using the Multiphase Optimization Strategy: Opt-IN study protocol" [Contemp. Clin. Trials 38 (2014) 251-259]. Contemp Clin Trials. 2015 Nov;45(Pt B):468-469. doi: 10.1016/j.cct.2015.09.001. Epub 2015 Nov 29. No abstract available.
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32656994
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Spring B, Pfammatter AF, Marchese SH, Stump T, Pellegrini C, McFadden HG, Hedeker D, Siddique J, Jordan N, Collins LM. A Factorial Experiment to Optimize Remotely Delivered Behavioral Treatment for Obesity: Results of the Opt-IN Study. Obesity (Silver Spring). 2020 Sep;28(9):1652-1662. doi: 10.1002/oby.22915. Epub 2020 Jul 12.
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PubMed Identifier
32347804
Citation
Pfammatter AF, Marchese SH, Pellegrini C, Daly E, Davidson M, Spring B. Using the Preparation Phase of the Multiphase Optimization Strategy to Develop a Messaging Component for Weight Loss: Formative and Pilot Research. JMIR Form Res. 2020 May 13;4(5):e16297. doi: 10.2196/16297.
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Opt-IN: Optimization of Remotely Delivered Intensive Lifestyle Treatment for Obesity
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