Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) Over the Brain on the Neurotransmitter Binding
Stroke, Hemiplegia
About this trial
This is an interventional basic science trial for Stroke focused on measuring Neuronal plasticity, Neurotransmitter agents, Receptors, neurotransmitter, Transcranial magnetic stimulation, Stroke, gamma-Aminobutyric Acid
Eligibility Criteria
Inclusion Criteria:
- Healthy people
- 18-50 yrs old
- Right handedness
- Written informed consent
Exclusion Criteria:
- Previous medical diseases such as seizure, stroke, diabetes, hypertension.
- Taking any drugs
- Smoker
- Pregnancy
- Contraindication of PET or MRI
- Stroke or any tumor in MRI
- Metals objects in the head or eyes
- Cardiac pacemaker or cochlear implant
Sites / Locations
- Seoul National University Bundang Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Sham Comparator
High frequency (10Hz) rTMS
Low frequency (1Hz) rTMS
Sham rTMS
<high frequency rTMS parameters> Intensity: 120% of resting motor threshold; Location: Motor hotspot in primary motor cortex for the dominant hand; Frequency: 10Hz; Number of total stimuli: 750; Coil orientation: tangential to scalp
<low frequency rTMS parameters> Intensity: 120% of resting motor threshold; Location: Motor hotspot in primary motor cortex for the dominant hand; Frequency: 1Hz; Number of total stimuli: 1200; Coil orientation: tangential to the scalp
<Sham rTMS parameters> Intensity: 120% of resting motor threshold; Location: Motor hotspot in primary motor cortex for the dominant hand; Frequency: 1Hz; Number of total stimuli: 1200; Coil orientation: perpendicular to scalp