Perceptual Decision Making Under Conditions of Visual Uncertainty
Parkinson's Disease, Dystonia, Ataxia
About this trial
This is an interventional basic science trial for Parkinson's Disease
Eligibility Criteria
Inclusion Criteria:
- Group 1 - Age and Sex matched healthy controls:
- Age 18-80 Years
Group 2 - Patients with Parkinson's Disease - No DBS:
- "on meds" and "off meds" (tested in separate sessions) - total of 2 sessions
- Age 45-80 Years
- Unified PD rating scale (UPDRS)
- Mini mental health Status (MMHS)
Group 3 - Patients with Parkinson's Disease already consented for DBS (STN):
- Age 45-80 Years
- Unified PD rating scale (UPDRS)
- Mini mental health Status (MMHS)
Group 4 - Patients with Parkinson's Disease already consented for DBS (GPi):
- Age 45-80 Years
- Unified PD rating scale (UPDRS)
- Mini mental health Status (MMHS)
Group 5 - Patients with Cervical Dystonia - No DBS
- Age 30-80 years
- Fahn-Marsden dystonia rating scale (FMDRS)
- Mini mental health Status (MMHS)
Group 6 - Patients with Generalized Dystonia (Ach) - No DBS:
- Age 30-80 years
- Fahn-Marsden dystonia rating scale (FMDRS)
- Mini mental health Status (MMHS)
Group 7 - Patients with Dystonia already consented for DBS (GPi):
- Age 30-80 years
- Fahn-Marsden dystonia rating scale (FMDRS)
- Mini mental health Status (MMHS)
Group 8 - Patients Cerebellar Stroke
- Age 30-80 Years
- Routine neuro exam
- Mini mental health Status (MMHS)
Group 9 - Patients Cerebellar Ataxia
- Age 30-80 Years
- Routine neuro exam
- Mini mental health Status (MMHS)
Exclusion Criteria:
- Visual impairment or ocular motility disorder Inability to sit for the 30 minute task plus 20-30 minute instruction time, setup, and wait time.
For Group 1 (Age Sex Matched Controls), there will additional exclusion criteria of other neurological disease and drug use
Sites / Locations
- Neuroscience Research BuildingRecruiting
Arms of the Study
Arm 1
Other
Deep Brain Stimulator
Some of our subjects that participate to the study have Deep Brain Stimulation implanted. They will perform the behavioral task twice, with the stimulation ON or OFF.