Will Preoperative MRI Breast in Women Under 56 Years With Breast Cancer Change Primary Treatment (POMB)

Randomized Multicenter Trial Assessing if Preoperative MRI Breast in Women Under 56 Years With Breast Cancer Will Change Primary Treatment

The study is a prospective randomised multicenter trial assessing the additional value of breast MRI in women under 56 years of age with newly diagnosed breast cancer. Will preoperative breast MRI change treatment regimen? Will preoperative breast MRI reduce the number of primary surgeries? Will preoperative breast MRI increase the rate of mastectomies? Will preoperative breast MRI be cost effective?

Completed: the study has concluded normally; participants are no longer being examined or treated (i.e., last patient's last visit has occurred)

The intervention is that preoperative MRI breast will be performed in women under 56 years with newly diagnosed breast cancer

The arm type description implies that no MRI breast will be performed to women under 56 years with newly diagnosed breast cancer

The intervention is that preoperative MRI breast will be performed in 220 women under 56 years with newly diagnosed breast cancer. Aims are to analyze if the intervention will affect primary management, decrease the number of reoperations and to analyze if the intervention leads to an increasing number of unnecessary mastectomies compared to the non intervention arm.

Did breast magnetic resonance imaging add information about the tumour that changed primary treatment plan

Inclusion Criteria: Women under 56 years of age Newly diagnosed breast cancer Swedish or English speaking Exclusion Criteria: Claustrophobia Pregnancy Renal failure Metal items in patients

Gonzalez V, Arver B, Lofgren L, Bergkvist L, Sandelin K, Eriksson S. Impact of preoperative breast MRI on 10-year survival of patients included in the Swedish randomized multicentre POMB trial. BJS Open. 2021 Sep 6;5(5):zrab088. doi: 10.1093/bjsopen/zrab088.