Investigation Into the Role of GTN & RIPC in Cardiac Surgery (ERIC-GTN)
Myocardial Reperfusion Injury
About this trial
This is an interventional treatment trial for Myocardial Reperfusion Injury
Eligibility Criteria
Inclusion Criteria:
- Age > 18 years all patients admitted for on- pump CABG and/or valve surgery
- Able to give consent
Exclusion Criteria:
- Allergies to excipients of IMP and placebo
- Chronic Renal failure (eGFR<30 ml/min/kg)
- Severe liver disease
- Peripheral arterial disease
- Pregnant or lactating women
Sites / Locations
- The Heart Hospital, UCL Hospitals NHS Trust
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Sham Comparator
Active Comparator
Experimental
Experimental
Group 1 Control (65 patients)
Group 2 (65 patients)
Group 3 GTN (65 patients):
• Group 4 RIPC+GTN (65 patients):
Sham Remote ischaemic preconditioning with IV normal saline 2-5ml/hour.
Patients administered a Remote Ischaemic preconditioning protocol (three-5 min cycles of simultaneous inflation to cuffs placed on upper arm and thigh) prior to surgery and IV normal saline 2-5 mL/h during surgery.
Patients administered sham simulated Remote Ischaemic Preconditioning protocol prior to surgery and IV Glyceryl Trinitrate 2-5ml/h during surgery.
Patients administered Remote Ischaemic Preconditioning protocol and IV Glyceryl Trinitrate during surgery