Back to resultsA Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
Primary Purpose
Asthma
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Lebrikizumab
Placebo
Sponsored by
About this trial
This is an interventional treatment trial for Asthma
Eligibility Criteria
Inclusion Criteria:
- Asthma diagnosis for greater than equal to (>/=) 12 months prior to Visit 1
- Bronchodilator response at Visit 1, 2, or 3
- Pre-bronchodilator FEV1 of 40 percent (%) - 80% predicted at both Visits 2 and 3
- On ICS therapy at a total daily dose of 500-2000 micrograms (mcg) of fluticasone propionate dry powder inhaler (DPI) or equivalent for >/=6 months prior to Visit 1
- On an eligible second controller medication (long-acting beta-agonist [LABA], leukotriene receptor antagonist [LTRA], long-acting muscarinic antagonist [LAMA], or theophylline) for 6 months prior to Visit 1
- Uncontrolled asthma at Visit 1 and/or Visit 2, and at Visit 3
- Chest X-ray or computed tomography (CT) scan within 3 months prior to Visit 1 or chest X-ray during the screening period (prior to Visit 3) confirming the absence of other clinically significant lung disease
- Demonstrated adherence with controller medication during the screening period
Exclusion Criteria:
- History of severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the lebrikizumab injection
- Maintenance oral corticosteroid therapy within 3 months of Visit 1
- Treatment with systemic (oral, intravenous [IV], or intramuscular [IM]) corticosteroids within 4 weeks prior to Visit 1 or during the screening period
- Treatment with intra-articular corticosteroids within 4 weeks prior to Visit 1 or during the screening period or anticipated need for intra-articular corticosteroids during the course of the study
- Infection requiring hospital admission for >/=24 hours or requiring treatment with IV or IM antibiotics within 4 weeks prior to Visit 1 or during screening; Upper or lower respiratory tract infection within 4 weeks prior to Visit 1 or during screening; Active infection that required treatment with oral antibiotics within 2 weeks prior to Visit 1 or during screening; Active parasitic infection or Listeria monocytogenes infection within 6 months prior to Visit 1 or during screening
- Active tuberculosis requiring treatment within 12 months prior to Visit 1
- Known immunodeficiency, including, but not limited to, human immunodeficiency virus (HIV) infection
- Evidence of acute or chronic hepatitis or known liver cirrhosis
- History of interstitial lung disease, chronic obstructive pulmonary disease (COPD), or other clinically significant lung disease other than asthma
- Known current malignancy or current evaluation for potential malignancy
- Current smoker or former smoker with a history of greater than (>) 10 pack-years
- History of alcohol or drug abuse
- Past and/or current use of any anti-interleukin (IL)-13 or anti-IL-4/IL-13 therapy, including lebrikizumab
- Use of other monoclonal antibody therapy, including omalizumab, within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) or during screening
- Initiation of or change in allergen immunotherapy within 3 months prior to Visit 1 or during screening
Sites / Locations
- Alabama Clinical Research Associates
- Clinical Trial Connection
- Desert Sun Clinical Research LLC
- Allianz Medical and Research Center
- Allergy & Asthma Medical Group & Research Center, Pc
- Alliance Research LLC
- Allergy Medical Clinic
- CA Allergy & Asthma Med Grp
- North Bay Clinical Trials
- Choc Psf, Amc
- Advances in Medicine
- Allergy Assoc Medical Group
- UCSF School of Medicine
- Bensch Research Associates
- IMMUNOe International Research Centers
- Waterbury Pulmonary Associates
- St. Francis Sleep; Allergy & Lung Institute
- Creekside Medical Research
- Suncoast Research Group LLC
- South Florida Research Phase I-IV, Inc
- Allergy & Asthma Care of FL; Clinical Research
- Emerald Coast Research Associates
- Allergy & Asthma Diagnostic; Treatment Center
- Florida Pulmonary Research Institute, LLC
- Southeastern Lung Care
- Atlanta Allergy & Asthma Clini
- Laporte County Institute For Clinical Research
- Iowa Clinical Research Corporation
- Northeast Medical Research Associates, Inc
- Infusion Associates
- Midwest Clinical Research LLC
- Washington Univ. School of Med
- Montana Medical Research LLC
- Heartland Clinical Research Inc.
- Asthma & Allergy Center, P.C.
- Allergy & Asthma Associates
- Allergy & Asthma Research of Nj, Inc
- Atlantic Research Center, LLC
- Princeton Center For Clinical Research
- North Shore University Hosp
- Montefiore Medical Center
- Allergy & Asthma Center of NC
- PMG Research of Wilmington
- Asthma & Allergy Center
- Cor Clinical Research
- Lynn Health Science Institute
- Allergy & Asthma Research Grp
- Clinical Research Inst. of Southern Oregon, Pc
- Allergy Associates Research Center
- Central PA Asth & Allergy Care; Research Division
- Asthma Allergy Pulm Associates
- Grand View Hospital; Clinical Research Department
- Asthma Allergy Phys of RI
- ADAC Research PA
- Spartanburg Medical Research
- Tekton Research Inc
- TTS Research
- Pharmaceutical Research & Consulting, Inc.
- Allergy & Asthma Research Center of El Paso
- Pioneer Research Solutions
- Metroplex Pulmonology & Sleep Center
- Quality Assurance Research Ctr
- O & O Alpan, LLC
- Clinical Research Partners, LLC
- Manassas Clinical Research Center
- Bellingham Asthma, Allergy & Immunology
- ASTHMA, Inc
- Marycliff Allergy Specialists
- Dean Clinic
- Fundación Faicep
- Centro Médico Dra de Salvo
- Instituto Ave Pulmo
- Centro Respiratorio Quilmes
- Investigaciones en Patologias Respiratorias
- Liverpool Hospital
- St. Vincent's Hospital Melbourne
- Box Hill Hospital; Eastern Clinical Research Unit
- Western Hospital
- The Lung Institute of Western Australia; Sir Charles Gairdner Hospital
- Cliniques Universitaires St-Luc
- UZ Gent
- Alberta Health Services
- Dr. E. Amer
- Inspiration Research Limited
- Albion Finch Medical Centre
- Centre d'investigation Clinique Mauricie
- Centro de Investigaciones Medicas Respiratorias
- Schonffeldt y Guerrero Limitada
- Hospital Carlos Van Buren
- Fundacion Neumologica Colombiana
- Alergopraktik s.r.o.
- Interni A Pneumologicka Ambulance
- MephaCentrum, a.s.
- Alergologie Teplice, s.r.o.
- Hopital Calmette; Pneumologie
- Hopital Nord; CIC
- Hôpital Arnaud de Villeneuve
- CHU Nantes - Hôpital Laennec; Service de Pneumologie
- Nouvel Hôpital Civil; Pôle de Pathologie Thoracique
- Lungenarztpraxis Tegel
- Pneumologisches Zentrum Wiesloch
- Kenezy Korhaz Rendelointezet
- Petz Aladar Megyei Oktato Korhaz
- C.C.C. Hospital Chest Diseases
- Barzilai Medical Center; Pulmonary Inst.
- Lady Davis Carmel Medical Center; Cardiovascular Medicine
- Shaare Zedek Medical Center
- Meir Medical Center; Pulmonary Dept
- Kaplan Medical Center
- University of Catanzaro
- Azienda Ospedaliero Universitaria di Parma
- Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi Di Ancona
- Fondazione Salvatore Maugeri. IRCCS - Divisione di Pneumologia
- A.o. Universitaria Pisana; Dipartimento Cardio Toracico
- Azienda Ospedaliera di Padova
- Tosei General Hospital; Respiratory and Allergy Medicine
- Ofuji Clinic
- Kyushu Central Hospital
- National Hospital Organization Mito Medical Center
- Hiroshima University Hospital
- Oji General Hospital
- National Hospital Organization Asahikawa Medical Center
- Iwate Medical University Hospital
- Yokohama City Minato Red Cross Hospital
- National Hospital Organization Tokyo National Hospital
- Kochi Medical School Hospital
- Oki Clinic
- Takahashi Clinic
- Dokkyo Medical University Koshigaya Hospital
- Tono Chuo Clinic
- Nagaoka Red Cross Hospital
- Niigata City General Hospital
- Osaka City University Hospital
- Touda Clinic
- Kinki-Chuo Chest Medical Center
- Senzoku Kokyuuki and Allergy Clinic
- Japan Community Health Care Organization Hokkaido Hospital
- Fukuwa Clinic
- Tokyo Center Clinic; Internal Medicine
- Sano Toranomon Clinic
- Showa University Hospital
- Teikyo University Hospital
- Sekino Hospital
- University of Fukui Hospital
- Seoul National University Bundang Hospital
- Asan Medical Center
- Samsung Medical Center
- Korea University Guro Hospital
- St. Paul's Hospital, The Catholic University of Korea, College of Medicine
- Wonju Christian Hospital
- Instituto Jalisciense de Investigacion Clinica S.A. de C.V.
- Hospital Dr Angel Leaño universidad Autonoma de Guadalajara AC
- NZ Respiratory & Sleep Institute
- Dunedin Hospital
- RMC Medical Research Ltd
- P3 Research
- Centrum Medycyny Oddechowej Robert M. Mróz
- Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny
- Grazyna Pulka Specjalistyczny Ośrodek ALL-MED
- Specjalistyczne Centrum Medyczne NOWOMED
- Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.
- Poradnia Pulmonologiczna dla Doroslych
- Centrum Alergologii Teresa Hofman
- SPZOZ Proszowice
- Niepubliczny Specjalistyczny ZOZ Puls-Med s.c.
- Medica Pro Familia Sp. z o.o. S.K.A.
- Klinika Chorób Wewnetrznych i Alergologii MSW
- ALL-MED Specjalistyczna Opieka Medyczna
- Colentina Clinical Hospital
- Prof.Dr.Octavian Fodor Emergency Clinical Hospital
- Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Victor Babes Craiova
- Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital
- SIH Kemerovo Regional Clinical Hospital
- Russian Uni of People'S Friendship, Med. Faculty; City Clinical Hospital No 64, Internal Diseases
- Central Clinical Hospital #1 of RZhD JCS
- Novosibirsk Municipal Clinical Hospital For Emergency Medicine #2
- Ryazan Regional Clinical Hosp
- St. George the Martyr City Hospital
- St.-Petersburg SMU n. a. Academician I.P.Pavlov; Therapy Department
- Smolensk State Medical Academy
- City Outpatient Dept #94
- St-Petersburg Diagnostic Ctr#1; Pulmonology
- SHI Ctr Occupational Pathology
- St. Petersburg State Budget Medical Institution Pokrovskaya City Hospital
- Tomsk Regional Clinical Hospital
- Clinical Center of Serbia
- Clinical Hospital Center Zvezdara
- Clinical Hospital Center ''Bezanijska Kosa''; Department of Pulmology
- Alian s.r.o.
- Tehelná Clinic, Inc; IMUNO-ALERGO, s. r.o.
- Plucna ambulancia
- Melomed Hospital Gatesville
- Uni of Cape Town Lung Inst.
- Vawda Z.Fa Practice
- Gatesville Medical Centre
- Deepak Lakha MBCHB Private Practice
- Botho ke Bontle Health Services
- Dr Johannes Breedt; Emmed Research
- Hospital Universitario Araba
- Hospital de la Santa Creu; i Sant Pau
- Hospital Germans Trias i Pujol
- Hosp Univ Fundacion Alcorcon
- Hospital Virgen del Rocio
- Hospital Universitario Doctor Peset
- Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi
- Turgut Ozal Universitesi Tip Fakultesi Bestepe Hastanesi
- Uludag University; Pulmonology and Allergy Department
- Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi
- Ege University Medical Faculty
- Izmir Dr. Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi
- Kirikkale Universitesi Tip Fakultesi Hastanesi
- Mersin University Medical Faculty
- Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board
- Educational Scientific Medical Centre of Donetsk National Medical University;
- Regional Phthisiology and Pulmonology Center
- City Clinical Hospital #27
- Medical and Sanitary Unit of OJSC "Kharkiv Tractor Plant n.a. Ordzhonikidze"; Department of Therapy
- Central Outpatient Hospital of Desnyansky District
- Yanovskyy Inst of Phth. & Pulm; Clinical-functional
- Municipal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital
- Kyiv City Clinical Hospital #8
- Danylo Halytskyy National Medical University; Lviv
- Small Business Private Enterprise Medical Centre Pulse
- Municipal Institution of Health Care "Yevpatoriya City Hospital №1
- SI Dept. Clin. Hospital of Zaporizhzhia-2 Railway Station of SE Prydniprovska Zaliznytsia
- St Peters Hospital
- Castle Hill Hospital; Respiratory Medicine
- Ninewells Hospital; Asthma and Allergy Research Group
- St James University Hospital; Respiratory Department
- University North Tees
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Experimental
Experimental
Placebo Comparator
Arm Label
Lebrikizumab (125 mg)
Lebrikizumab (37.5 mg)
Placebo
Arm Description
Participants will receive SC injection of lebrikizumab (125 milligrams [mg]) every 4 weeks for 104 weeks.
Participants will receive SC injection of lebrikizumab (37.5 mg) every 4 weeks for 104 weeks.
Participants will receive SC injection of lebrikizumab matching placebo every 4 weeks for 52 weeks during placebo-controlled period and then SC injection of lebrikizumab at 125 or 37.5 mg for 52 weeks during active treatment extension period.
Outcomes
Primary Outcome Measures
Rate of Asthma Exacerbations During the 52-Week Placebo-Controlled Period
Secondary Outcome Measures
Absolute Change From Baseline in Pre-Bronchodilator Forced Expiratory Volume in 1 Second (FEV1)
Time to First Asthma Exacerbation
Change From Baseline in Standardized Asthma Quality of Life Questionnaire (AQLQ) Score
Change from Baseline In Asthma Rescue Medication (Number of Puffs or Nebulized Treatments)
Rate of Urgent Asthma-Related Urgent Health Care Utilization
Percentage of Participants With Anti-Therapeutic Antibodies to Lebrikizumab
Change From Baseline in Asthma Control Questionnaire-5 (ACQ-5) Score
Percentage of Participants With Adverse Events
Minimum Serum Concentration (Cmin) of Lebrikizumab
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT01867125
Brief Title
A Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
Official Title
A Phase III, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Lebrikizumab in Patients With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
Study Type
Interventional
2. Study Status
Record Verification Date
May 2017
Overall Recruitment Status
Completed
Study Start Date
July 31, 2013 (Actual)
Primary Completion Date
January 2, 2017 (Actual)
Study Completion Date
January 2, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hoffmann-La Roche
4. Oversight
5. Study Description
Brief Summary
This randomized, multicenter, double-blind, placebo-controlled, parallel-group study will evaluate the efficacy and safety of lebrikizumab in participants with asthma whose disease remains uncontrolled despite daily treatment with inhaled corticosteroid (ICS) therapy and at least one second controller medication. Participants will be randomized in 1:1:1 ratio to receive double-blind treatment with either lebrikizumab ("high" or "low") or placebo, administered subcutaneously (SC) every 4 weeks for 52 weeks, in addition to their standard-of-care therapy. This will be followed by a 52-week double-blind active treatment extension. During double-blind active treatment extension period, all participants will receive SC injection of lebrikizumab from Week 53 to Week 104. The anticipated time on study treatment is 104 weeks. After study treatment, all participants will complete a 20-week safety follow-up.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Asthma
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
1081 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Lebrikizumab (125 mg)
Arm Type
Experimental
Arm Description
Participants will receive SC injection of lebrikizumab (125 milligrams [mg]) every 4 weeks for 104 weeks.
Arm Title
Lebrikizumab (37.5 mg)
Arm Type
Experimental
Arm Description
Participants will receive SC injection of lebrikizumab (37.5 mg) every 4 weeks for 104 weeks.
Arm Title
Placebo
Arm Type
Placebo Comparator
Arm Description
Participants will receive SC injection of lebrikizumab matching placebo every 4 weeks for 52 weeks during placebo-controlled period and then SC injection of lebrikizumab at 125 or 37.5 mg for 52 weeks during active treatment extension period.
Intervention Type
Drug
Intervention Name(s)
Lebrikizumab
Other Intervention Name(s)
RO5490255
Intervention Description
Lebrikizumab will be administered as SC injection at 125 or 37.5 mg every 4 weeks, for 104 weeks.
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Lebrikizumab matching placebo will be administered as SC injection every 4 weeks for 52 weeks.
Primary Outcome Measure Information:
Title
Rate of Asthma Exacerbations During the 52-Week Placebo-Controlled Period
Time Frame
Baseline up to 52 weeks
Secondary Outcome Measure Information:
Title
Absolute Change From Baseline in Pre-Bronchodilator Forced Expiratory Volume in 1 Second (FEV1)
Time Frame
Baseline, Week 52
Title
Time to First Asthma Exacerbation
Time Frame
Baseline up to 52 weeks
Title
Change From Baseline in Standardized Asthma Quality of Life Questionnaire (AQLQ) Score
Time Frame
Baseline, Week 52
Title
Change from Baseline In Asthma Rescue Medication (Number of Puffs or Nebulized Treatments)
Time Frame
Baseline, Week 52
Title
Rate of Urgent Asthma-Related Urgent Health Care Utilization
Time Frame
Baseline up to Week 52
Title
Percentage of Participants With Anti-Therapeutic Antibodies to Lebrikizumab
Time Frame
Baseline up to Week 124 (assessed at Baseline, Weeks 4, 12, 24, 36, 52, 64, 76, 92, 104, 112, and 124)
Title
Change From Baseline in Asthma Control Questionnaire-5 (ACQ-5) Score
Time Frame
Baseline, Week 52
Title
Percentage of Participants With Adverse Events
Time Frame
Baseline, Week 124
Title
Minimum Serum Concentration (Cmin) of Lebrikizumab
Time Frame
Predose (0 hour) on Weeks 4, 12, 24, 36, and 52
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Asthma diagnosis for greater than equal to (>/=) 12 months prior to Visit 1
Bronchodilator response at Visit 1, 2, or 3
Pre-bronchodilator FEV1 of 40 percent (%) - 80% predicted at both Visits 2 and 3
On ICS therapy at a total daily dose of 500-2000 micrograms (mcg) of fluticasone propionate dry powder inhaler (DPI) or equivalent for >/=6 months prior to Visit 1
On an eligible second controller medication (long-acting beta-agonist [LABA], leukotriene receptor antagonist [LTRA], long-acting muscarinic antagonist [LAMA], or theophylline) for 6 months prior to Visit 1
Uncontrolled asthma at Visit 1 and/or Visit 2, and at Visit 3
Chest X-ray or computed tomography (CT) scan within 3 months prior to Visit 1 or chest X-ray during the screening period (prior to Visit 3) confirming the absence of other clinically significant lung disease
Demonstrated adherence with controller medication during the screening period
Exclusion Criteria:
History of severe allergic reaction or anaphylactic reaction to a biologic agent or known hypersensitivity to any component of the lebrikizumab injection
Maintenance oral corticosteroid therapy within 3 months of Visit 1
Treatment with systemic (oral, intravenous [IV], or intramuscular [IM]) corticosteroids within 4 weeks prior to Visit 1 or during the screening period
Treatment with intra-articular corticosteroids within 4 weeks prior to Visit 1 or during the screening period or anticipated need for intra-articular corticosteroids during the course of the study
Infection requiring hospital admission for >/=24 hours or requiring treatment with IV or IM antibiotics within 4 weeks prior to Visit 1 or during screening; Upper or lower respiratory tract infection within 4 weeks prior to Visit 1 or during screening; Active infection that required treatment with oral antibiotics within 2 weeks prior to Visit 1 or during screening; Active parasitic infection or Listeria monocytogenes infection within 6 months prior to Visit 1 or during screening
Active tuberculosis requiring treatment within 12 months prior to Visit 1
Known immunodeficiency, including, but not limited to, human immunodeficiency virus (HIV) infection
Evidence of acute or chronic hepatitis or known liver cirrhosis
History of interstitial lung disease, chronic obstructive pulmonary disease (COPD), or other clinically significant lung disease other than asthma
Known current malignancy or current evaluation for potential malignancy
Current smoker or former smoker with a history of greater than (>) 10 pack-years
History of alcohol or drug abuse
Past and/or current use of any anti-interleukin (IL)-13 or anti-IL-4/IL-13 therapy, including lebrikizumab
Use of other monoclonal antibody therapy, including omalizumab, within 6 months or 5 drug half-lives prior to Visit 1 (whichever is longer) or during screening
Initiation of or change in allergen immunotherapy within 3 months prior to Visit 1 or during screening
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Clinical Trials
Organizational Affiliation
Hoffmann-La Roche
Official's Role
Study Director
Facility Information:
Facility Name
Alabama Clinical Research Associates
City
Pell City
State/Province
Alabama
ZIP/Postal Code
35128
Country
United States
Facility Name
Clinical Trial Connection
City
Flagstaff
State/Province
Arizona
ZIP/Postal Code
86001
Country
United States
Facility Name
Desert Sun Clinical Research LLC
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85710
Country
United States
Facility Name
Allianz Medical and Research Center
City
Fountain Valley
State/Province
California
ZIP/Postal Code
92708
Country
United States
Facility Name
Allergy & Asthma Medical Group & Research Center, Pc
City
Long Beach
State/Province
California
ZIP/Postal Code
90808
Country
United States
Facility Name
Alliance Research LLC
City
Long Beach
State/Province
California
ZIP/Postal Code
90813
Country
United States
Facility Name
Allergy Medical Clinic
City
Los Angeles
State/Province
California
ZIP/Postal Code
90025
Country
United States
Facility Name
CA Allergy & Asthma Med Grp
City
Los Angeles
State/Province
California
ZIP/Postal Code
90025
Country
United States
Facility Name
North Bay Clinical Trials
City
Napa
State/Province
California
ZIP/Postal Code
94558
Country
United States
Facility Name
Choc Psf, Amc
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Facility Name
Advances in Medicine
City
Rancho Mirage
State/Province
California
ZIP/Postal Code
92270
Country
United States
Facility Name
Allergy Assoc Medical Group
City
San Diego
State/Province
California
ZIP/Postal Code
92108
Country
United States
Facility Name
UCSF School of Medicine
City
San Francisco
State/Province
California
Country
United States
Facility Name
Bensch Research Associates
City
Stockton
State/Province
California
ZIP/Postal Code
95207
Country
United States
Facility Name
IMMUNOe International Research Centers
City
Centennial
State/Province
Colorado
ZIP/Postal Code
80112
Country
United States
Facility Name
Waterbury Pulmonary Associates
City
Waterbury
State/Province
Connecticut
ZIP/Postal Code
06708
Country
United States
Facility Name
St. Francis Sleep; Allergy & Lung Institute
City
Clearwater
State/Province
Florida
ZIP/Postal Code
33765
Country
United States
Facility Name
Creekside Medical Research
City
DeLand
State/Province
Florida
ZIP/Postal Code
32720
Country
United States
Facility Name
Suncoast Research Group LLC
City
Miami
State/Province
Florida
ZIP/Postal Code
33135
Country
United States
Facility Name
South Florida Research Phase I-IV, Inc
City
Miami
State/Province
Florida
ZIP/Postal Code
33165
Country
United States
Facility Name
Allergy & Asthma Care of FL; Clinical Research
City
Ocala
State/Province
Florida
ZIP/Postal Code
34471
Country
United States
Facility Name
Emerald Coast Research Associates
City
Panama City
State/Province
Florida
ZIP/Postal Code
32405
Country
United States
Facility Name
Allergy & Asthma Diagnostic; Treatment Center
City
Tallahassee
State/Province
Florida
ZIP/Postal Code
32308
Country
United States
Facility Name
Florida Pulmonary Research Institute, LLC
City
Winter Park
State/Province
Florida
ZIP/Postal Code
32789
Country
United States
Facility Name
Southeastern Lung Care
City
Decatur
State/Province
Georgia
ZIP/Postal Code
30033
Country
United States
Facility Name
Atlanta Allergy & Asthma Clini
City
Woodstock
State/Province
Georgia
ZIP/Postal Code
30188
Country
United States
Facility Name
Laporte County Institute For Clinical Research
City
Michigan City
State/Province
Indiana
ZIP/Postal Code
46360
Country
United States
Facility Name
Iowa Clinical Research Corporation
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52240
Country
United States
Facility Name
Northeast Medical Research Associates, Inc
City
North Dartmouth
State/Province
Massachusetts
ZIP/Postal Code
02747
Country
United States
Facility Name
Infusion Associates
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49525
Country
United States
Facility Name
Midwest Clinical Research LLC
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
Washington Univ. School of Med
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
Montana Medical Research LLC
City
Missoula
State/Province
Montana
ZIP/Postal Code
59808
Country
United States
Facility Name
Heartland Clinical Research Inc.
City
Omaha
State/Province
Nebraska
ZIP/Postal Code
68134
Country
United States
Facility Name
Asthma & Allergy Center, P.C.
City
Papillion
State/Province
Nebraska
ZIP/Postal Code
68046
Country
United States
Facility Name
Allergy & Asthma Associates
City
Las Vegas
State/Province
Nevada
ZIP/Postal Code
89104
Country
United States
Facility Name
Allergy & Asthma Research of Nj, Inc
City
Mount Laurel
State/Province
New Jersey
ZIP/Postal Code
08054
Country
United States
Facility Name
Atlantic Research Center, LLC
City
Ocean City
State/Province
New Jersey
ZIP/Postal Code
07712
Country
United States
Facility Name
Princeton Center For Clinical Research
City
Skillman
State/Province
New Jersey
ZIP/Postal Code
08558
Country
United States
Facility Name
North Shore University Hosp
City
New Hyde Park
State/Province
New York
ZIP/Postal Code
11042
Country
United States
Facility Name
Montefiore Medical Center
City
The Bronx
State/Province
New York
ZIP/Postal Code
10461
Country
United States
Facility Name
Allergy & Asthma Center of NC
City
High Point
State/Province
North Carolina
ZIP/Postal Code
27262
Country
United States
Facility Name
PMG Research of Wilmington
City
Wilmington
State/Province
North Carolina
ZIP/Postal Code
28401
Country
United States
Facility Name
Asthma & Allergy Center
City
Toledo
State/Province
Ohio
ZIP/Postal Code
43617
Country
United States
Facility Name
Cor Clinical Research
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73103
Country
United States
Facility Name
Lynn Health Science Institute
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73112
Country
United States
Facility Name
Allergy & Asthma Research Grp
City
Eugene
State/Province
Oregon
ZIP/Postal Code
97401-7721
Country
United States
Facility Name
Clinical Research Inst. of Southern Oregon, Pc
City
Medford
State/Province
Oregon
ZIP/Postal Code
97504
Country
United States
Facility Name
Allergy Associates Research Center
City
Portland
State/Province
Oregon
ZIP/Postal Code
97202
Country
United States
Facility Name
Central PA Asth & Allergy Care; Research Division
City
Altoona
State/Province
Pennsylvania
ZIP/Postal Code
16601
Country
United States
Facility Name
Asthma Allergy Pulm Associates
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Grand View Hospital; Clinical Research Department
City
Sellersville
State/Province
Pennsylvania
ZIP/Postal Code
18960
Country
United States
Facility Name
Asthma Allergy Phys of RI
City
Lincoln
State/Province
Rhode Island
ZIP/Postal Code
02865
Country
United States
Facility Name
ADAC Research PA
City
Greenville
State/Province
South Carolina
ZIP/Postal Code
29607
Country
United States
Facility Name
Spartanburg Medical Research
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29303
Country
United States
Facility Name
Tekton Research Inc
City
Austin
State/Province
Texas
ZIP/Postal Code
78717
Country
United States
Facility Name
TTS Research
City
Boerne
State/Province
Texas
ZIP/Postal Code
78006
Country
United States
Facility Name
Pharmaceutical Research & Consulting, Inc.
City
Dallas
State/Province
Texas
ZIP/Postal Code
75231
Country
United States
Facility Name
Allergy & Asthma Research Center of El Paso
City
El Paso
State/Province
Texas
ZIP/Postal Code
79925
Country
United States
Facility Name
Pioneer Research Solutions
City
Houston
State/Province
Texas
ZIP/Postal Code
77008
Country
United States
Facility Name
Metroplex Pulmonology & Sleep Center
City
McKinney
State/Province
Texas
ZIP/Postal Code
75069
Country
United States
Facility Name
Quality Assurance Research Ctr
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78205
Country
United States
Facility Name
O & O Alpan, LLC
City
Fairfax
State/Province
Virginia
ZIP/Postal Code
22030
Country
United States
Facility Name
Clinical Research Partners, LLC
City
Henrico
State/Province
Virginia
ZIP/Postal Code
23233
Country
United States
Facility Name
Manassas Clinical Research Center
City
Manassas
State/Province
Virginia
ZIP/Postal Code
20110
Country
United States
Facility Name
Bellingham Asthma, Allergy & Immunology
City
Bellingham
State/Province
Washington
ZIP/Postal Code
98225
Country
United States
Facility Name
ASTHMA, Inc
City
Seattle
State/Province
Washington
ZIP/Postal Code
98105
Country
United States
Facility Name
Marycliff Allergy Specialists
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Dean Clinic
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53715
Country
United States
Facility Name
Fundación Faicep
City
Buenos Aires
ZIP/Postal Code
C1122AAK
Country
Argentina
Facility Name
Centro Médico Dra de Salvo
City
Buenos Aires
ZIP/Postal Code
C1426ABP
Country
Argentina
Facility Name
Instituto Ave Pulmo
City
Mar Del Plata
ZIP/Postal Code
CP 7600
Country
Argentina
Facility Name
Centro Respiratorio Quilmes
City
Quilmes
ZIP/Postal Code
1878
Country
Argentina
Facility Name
Investigaciones en Patologias Respiratorias
City
San Miguel de Tucuman
ZIP/Postal Code
4000
Country
Argentina
Facility Name
Liverpool Hospital
City
Liverpool BC
State/Province
New South Wales
ZIP/Postal Code
1871
Country
Australia
Facility Name
St. Vincent's Hospital Melbourne
City
Fitzroy
State/Province
South Australia
ZIP/Postal Code
3065
Country
Australia
Facility Name
Box Hill Hospital; Eastern Clinical Research Unit
City
Box Hill
State/Province
Victoria
ZIP/Postal Code
3128
Country
Australia
Facility Name
Western Hospital
City
Footscray
State/Province
Victoria
ZIP/Postal Code
3011
Country
Australia
Facility Name
The Lung Institute of Western Australia; Sir Charles Gairdner Hospital
City
Nedlands
State/Province
Western Australia
ZIP/Postal Code
6009
Country
Australia
Facility Name
Cliniques Universitaires St-Luc
City
Bruxelles
ZIP/Postal Code
1200
Country
Belgium
Facility Name
UZ Gent
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
Alberta Health Services
City
Calgary
State/Province
Alberta
ZIP/Postal Code
T2N 4N2
Country
Canada
Facility Name
Dr. E. Amer
City
Mississauga
State/Province
Ontario
ZIP/Postal Code
L5M 2V8
Country
Canada
Facility Name
Inspiration Research Limited
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5T 3A9
Country
Canada
Facility Name
Albion Finch Medical Centre
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M9V4B4
Country
Canada
Facility Name
Centre d'investigation Clinique Mauricie
City
Trois-Rivières
State/Province
Quebec
ZIP/Postal Code
G8T 7A1
Country
Canada
Facility Name
Centro de Investigaciones Medicas Respiratorias
City
Santiago
ZIP/Postal Code
7500692
Country
Chile
Facility Name
Schonffeldt y Guerrero Limitada
City
Santiago
ZIP/Postal Code
7500698
Country
Chile
Facility Name
Hospital Carlos Van Buren
City
Valparaiso
ZIP/Postal Code
2340000
Country
Chile
Facility Name
Fundacion Neumologica Colombiana
City
Bogota DC
ZIP/Postal Code
11001
Country
Colombia
Facility Name
Alergopraktik s.r.o.
City
Jablonec Nad Nisou
ZIP/Postal Code
466 01
Country
Czechia
Facility Name
Interni A Pneumologicka Ambulance
City
Jindrichuv Hradec
ZIP/Postal Code
377 38
Country
Czechia
Facility Name
MephaCentrum, a.s.
City
Ostrava - Poruba
ZIP/Postal Code
708 68
Country
Czechia
Facility Name
Alergologie Teplice, s.r.o.
City
Teplice
ZIP/Postal Code
415 01
Country
Czechia
Facility Name
Hopital Calmette; Pneumologie
City
Lille
ZIP/Postal Code
59037
Country
France
Facility Name
Hopital Nord; CIC
City
Marseille
ZIP/Postal Code
13015
Country
France
Facility Name
Hôpital Arnaud de Villeneuve
City
Montpellier
ZIP/Postal Code
34295
Country
France
Facility Name
CHU Nantes - Hôpital Laennec; Service de Pneumologie
City
Nantes
ZIP/Postal Code
44093
Country
France
Facility Name
Nouvel Hôpital Civil; Pôle de Pathologie Thoracique
City
Strabourg
ZIP/Postal Code
67091
Country
France
Facility Name
Lungenarztpraxis Tegel
City
Berlin
ZIP/Postal Code
13507
Country
Germany
Facility Name
Pneumologisches Zentrum Wiesloch
City
Wiesloch
ZIP/Postal Code
69168
Country
Germany
Facility Name
Kenezy Korhaz Rendelointezet
City
Debrecen
ZIP/Postal Code
4031
Country
Hungary
Facility Name
Petz Aladar Megyei Oktato Korhaz
City
Gyor
ZIP/Postal Code
9024
Country
Hungary
Facility Name
C.C.C. Hospital Chest Diseases
City
Szeged
ZIP/Postal Code
6722
Country
Hungary
Facility Name
Barzilai Medical Center; Pulmonary Inst.
City
Ashkelon
ZIP/Postal Code
78306
Country
Israel
Facility Name
Lady Davis Carmel Medical Center; Cardiovascular Medicine
City
Haifa
ZIP/Postal Code
34362
Country
Israel
Facility Name
Shaare Zedek Medical Center
City
Jerusalem
ZIP/Postal Code
91031
Country
Israel
Facility Name
Meir Medical Center; Pulmonary Dept
City
Kfar Saba
ZIP/Postal Code
44281
Country
Israel
Facility Name
Kaplan Medical Center
City
Rehovot
ZIP/Postal Code
7661041
Country
Israel
Facility Name
University of Catanzaro
City
Catanzaro
State/Province
Calabria
ZIP/Postal Code
88100
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria di Parma
City
Parma
State/Province
Emilia-Romagna
ZIP/Postal Code
43100
Country
Italy
Facility Name
Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I-G.M. Lancisi-G. Salesi Di Ancona
City
Torrette - Ancona
State/Province
Marche
ZIP/Postal Code
60100
Country
Italy
Facility Name
Fondazione Salvatore Maugeri. IRCCS - Divisione di Pneumologia
City
Cassano Murge (BA)
State/Province
Puglia
ZIP/Postal Code
70020
Country
Italy
Facility Name
A.o. Universitaria Pisana; Dipartimento Cardio Toracico
City
Pisa
State/Province
Toscana
ZIP/Postal Code
56100
Country
Italy
Facility Name
Azienda Ospedaliera di Padova
City
Padova
State/Province
Veneto
ZIP/Postal Code
35128
Country
Italy
Facility Name
Tosei General Hospital; Respiratory and Allergy Medicine
City
Aichi
ZIP/Postal Code
489-8642
Country
Japan
Facility Name
Ofuji Clinic
City
Amagasaki-shi
ZIP/Postal Code
660-0862
Country
Japan
Facility Name
Kyushu Central Hospital
City
Fukuoka-shi
ZIP/Postal Code
815-8588
Country
Japan
Facility Name
National Hospital Organization Mito Medical Center
City
Higashiibaraki-gun
ZIP/Postal Code
311-3193
Country
Japan
Facility Name
Hiroshima University Hospital
City
Hiroshima
ZIP/Postal Code
734-8551
Country
Japan
Facility Name
Oji General Hospital
City
Hokkaido
ZIP/Postal Code
053-8506
Country
Japan
Facility Name
National Hospital Organization Asahikawa Medical Center
City
Hokkaido
ZIP/Postal Code
070-8644
Country
Japan
Facility Name
Iwate Medical University Hospital
City
Iwate
ZIP/Postal Code
020-8505
Country
Japan
Facility Name
Yokohama City Minato Red Cross Hospital
City
Kanagawa
ZIP/Postal Code
231-8682
Country
Japan
Facility Name
National Hospital Organization Tokyo National Hospital
City
Kiyose-shi
ZIP/Postal Code
204-8585
Country
Japan
Facility Name
Kochi Medical School Hospital
City
Kochi
ZIP/Postal Code
783-8505
Country
Japan
Facility Name
Oki Clinic
City
Kodaira-shi
ZIP/Postal Code
187-0024
Country
Japan
Facility Name
Takahashi Clinic
City
Kokubunji-shi
ZIP/Postal Code
185-0014
Country
Japan
Facility Name
Dokkyo Medical University Koshigaya Hospital
City
Koshigaya-shi
ZIP/Postal Code
343-0845
Country
Japan
Facility Name
Tono Chuo Clinic
City
Mizunami-shi
ZIP/Postal Code
509-6134
Country
Japan
Facility Name
Nagaoka Red Cross Hospital
City
Nagaoka-shi
ZIP/Postal Code
940-2085
Country
Japan
Facility Name
Niigata City General Hospital
City
Niigata-shi
ZIP/Postal Code
950-11977
Country
Japan
Facility Name
Osaka City University Hospital
City
Osaka
ZIP/Postal Code
545-8586
Country
Japan
Facility Name
Touda Clinic
City
Osaka
ZIP/Postal Code
589-0022
Country
Japan
Facility Name
Kinki-Chuo Chest Medical Center
City
Osaka
ZIP/Postal Code
591-8555
Country
Japan
Facility Name
Senzoku Kokyuuki and Allergy Clinic
City
Ota-ku
ZIP/Postal Code
145-0063
Country
Japan
Facility Name
Japan Community Health Care Organization Hokkaido Hospital
City
Sapporo-shi
ZIP/Postal Code
062-8618
Country
Japan
Facility Name
Fukuwa Clinic
City
Tokyo
ZIP/Postal Code
103-0027
Country
Japan
Facility Name
Tokyo Center Clinic; Internal Medicine
City
Tokyo
ZIP/Postal Code
103-0028
Country
Japan
Facility Name
Sano Toranomon Clinic
City
Tokyo
ZIP/Postal Code
105-0003
Country
Japan
Facility Name
Showa University Hospital
City
Tokyo
ZIP/Postal Code
142-8666
Country
Japan
Facility Name
Teikyo University Hospital
City
Tokyo
ZIP/Postal Code
173-8605
Country
Japan
Facility Name
Sekino Hospital
City
Toshima
ZIP/Postal Code
171-0014
Country
Japan
Facility Name
University of Fukui Hospital
City
Yoshida-gun
ZIP/Postal Code
910-1193
Country
Japan
Facility Name
Seoul National University Bundang Hospital
City
Gyeonggi-do
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
Korea University Guro Hospital
City
Seoul
ZIP/Postal Code
08308
Country
Korea, Republic of
Facility Name
St. Paul's Hospital, The Catholic University of Korea, College of Medicine
City
Seoul
ZIP/Postal Code
130-709
Country
Korea, Republic of
Facility Name
Wonju Christian Hospital
City
Wonju
ZIP/Postal Code
220-701
Country
Korea, Republic of
Facility Name
Instituto Jalisciense de Investigacion Clinica S.A. de C.V.
City
Guadalajara
ZIP/Postal Code
44100
Country
Mexico
Facility Name
Hospital Dr Angel Leaño universidad Autonoma de Guadalajara AC
City
Zapopan
ZIP/Postal Code
45200
Country
Mexico
Facility Name
NZ Respiratory & Sleep Institute
City
Auckland
ZIP/Postal Code
1051
Country
New Zealand
Facility Name
Dunedin Hospital
City
Dunedin
Country
New Zealand
Facility Name
RMC Medical Research Ltd
City
Dunedin
Country
New Zealand
Facility Name
P3 Research
City
Tauranga
ZIP/Postal Code
3110
Country
New Zealand
Facility Name
Centrum Medycyny Oddechowej Robert M. Mróz
City
Bialystok
ZIP/Postal Code
15-003
Country
Poland
Facility Name
Prywatna Praktyka Lekarska Gabinet Pediatryczno-Alergologiczny
City
Bialystok
ZIP/Postal Code
15-430
Country
Poland
Facility Name
Grazyna Pulka Specjalistyczny Ośrodek ALL-MED
City
Krakow
ZIP/Postal Code
31-023
Country
Poland
Facility Name
Specjalistyczne Centrum Medyczne NOWOMED
City
Kraków
ZIP/Postal Code
30-349
Country
Poland
Facility Name
Niepubliczny Zaklad Opieki Zdrowotnej Centrum Medyczne ProMiMed sp z o.o. sp.k.
City
Kraków
ZIP/Postal Code
31-637
Country
Poland
Facility Name
Poradnia Pulmonologiczna dla Doroslych
City
Lódz
ZIP/Postal Code
90-153
Country
Poland
Facility Name
Centrum Alergologii Teresa Hofman
City
Poznan
ZIP/Postal Code
60-214
Country
Poland
Facility Name
SPZOZ Proszowice
City
Proszowice
ZIP/Postal Code
32-100
Country
Poland
Facility Name
Niepubliczny Specjalistyczny ZOZ Puls-Med s.c.
City
Skarżysko-Kamienna
ZIP/Postal Code
26-110
Country
Poland
Facility Name
Medica Pro Familia Sp. z o.o. S.K.A.
City
Warszawa
ZIP/Postal Code
01-868
Country
Poland
Facility Name
Klinika Chorób Wewnetrznych i Alergologii MSW
City
Warszawa
ZIP/Postal Code
02-507
Country
Poland
Facility Name
ALL-MED Specjalistyczna Opieka Medyczna
City
Wroclaw
ZIP/Postal Code
50-445
Country
Poland
Facility Name
Colentina Clinical Hospital
City
Bucharest
ZIP/Postal Code
020125
Country
Romania
Facility Name
Prof.Dr.Octavian Fodor Emergency Clinical Hospital
City
Cluj-Napoca
ZIP/Postal Code
400162
Country
Romania
Facility Name
Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Victor Babes Craiova
City
Craiova
ZIP/Postal Code
200515
Country
Romania
Facility Name
Dr. Victor Babes Pneumology and Infectious Diseases Clinical Hospital
City
Timisoara
ZIP/Postal Code
300310
Country
Romania
Facility Name
SIH Kemerovo Regional Clinical Hospital
City
Kemerovo
ZIP/Postal Code
650002
Country
Russian Federation
Facility Name
Russian Uni of People'S Friendship, Med. Faculty; City Clinical Hospital No 64, Internal Diseases
City
Moscow
ZIP/Postal Code
117292
Country
Russian Federation
Facility Name
Central Clinical Hospital #1 of RZhD JCS
City
Moscow
ZIP/Postal Code
125367
Country
Russian Federation
Facility Name
Novosibirsk Municipal Clinical Hospital For Emergency Medicine #2
City
Novosibirsk
ZIP/Postal Code
630008
Country
Russian Federation
Facility Name
Ryazan Regional Clinical Hosp
City
Ryazan
ZIP/Postal Code
390039
Country
Russian Federation
Facility Name
St. George the Martyr City Hospital
City
Saint Petersburg
Country
Russian Federation
Facility Name
St.-Petersburg SMU n. a. Academician I.P.Pavlov; Therapy Department
City
Saint-Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
Facility Name
Smolensk State Medical Academy
City
Smolensk
ZIP/Postal Code
4812
Country
Russian Federation
Facility Name
City Outpatient Dept #94
City
St Petersburg
ZIP/Postal Code
193231
Country
Russian Federation
Facility Name
St-Petersburg Diagnostic Ctr#1; Pulmonology
City
St. Petersburg
ZIP/Postal Code
194354
Country
Russian Federation
Facility Name
SHI Ctr Occupational Pathology
City
St. Petersburg
ZIP/Postal Code
195271
Country
Russian Federation
Facility Name
St. Petersburg State Budget Medical Institution Pokrovskaya City Hospital
City
St. Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
Facility Name
Tomsk Regional Clinical Hospital
City
Tomsk
ZIP/Postal Code
634063
Country
Russian Federation
Facility Name
Clinical Center of Serbia
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clinical Hospital Center Zvezdara
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
Clinical Hospital Center ''Bezanijska Kosa''; Department of Pulmology
City
Belgrade
ZIP/Postal Code
11080
Country
Serbia
Facility Name
Alian s.r.o.
City
Bardejov
ZIP/Postal Code
08501
Country
Slovakia
Facility Name
Tehelná Clinic, Inc; IMUNO-ALERGO, s. r.o.
City
Bratislava
ZIP/Postal Code
831 03
Country
Slovakia
Facility Name
Plucna ambulancia
City
Spisska Nova Ves
ZIP/Postal Code
052 01
Country
Slovakia
Facility Name
Melomed Hospital Gatesville
City
Cape Town
ZIP/Postal Code
7764
Country
South Africa
Facility Name
Uni of Cape Town Lung Inst.
City
Cape Town
ZIP/Postal Code
7925
Country
South Africa
Facility Name
Vawda Z.Fa Practice
City
Durban
ZIP/Postal Code
4091
Country
South Africa
Facility Name
Gatesville Medical Centre
City
Gatesville
ZIP/Postal Code
7746
Country
South Africa
Facility Name
Deepak Lakha MBCHB Private Practice
City
Johannesburg
ZIP/Postal Code
1820
Country
South Africa
Facility Name
Botho ke Bontle Health Services
City
Pretoria
ZIP/Postal Code
0101
Country
South Africa
Facility Name
Dr Johannes Breedt; Emmed Research
City
Pretoria
ZIP/Postal Code
84
Country
South Africa
Facility Name
Hospital Universitario Araba
City
Vitoria
State/Province
Alava
ZIP/Postal Code
01004
Country
Spain
Facility Name
Hospital de la Santa Creu; i Sant Pau
City
Barcelona
ZIP/Postal Code
08025
Country
Spain
Facility Name
Hospital Germans Trias i Pujol
City
Barcelona
ZIP/Postal Code
08916
Country
Spain
Facility Name
Hosp Univ Fundacion Alcorcon
City
Madrid
ZIP/Postal Code
28922
Country
Spain
Facility Name
Hospital Virgen del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Hospital Universitario Doctor Peset
City
Valencia
ZIP/Postal Code
46017
Country
Spain
Facility Name
Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi
City
Ankara
ZIP/Postal Code
06290
Country
Turkey
Facility Name
Turgut Ozal Universitesi Tip Fakultesi Bestepe Hastanesi
City
Ankara
ZIP/Postal Code
06510
Country
Turkey
Facility Name
Uludag University; Pulmonology and Allergy Department
City
Bursa
ZIP/Postal Code
16059
Country
Turkey
Facility Name
Canakkale Onsekiz Mart Universitesi Tip Fakultesi Hastanesi
City
Canakkale
ZIP/Postal Code
17110
Country
Turkey
Facility Name
Ege University Medical Faculty
City
Izmir
ZIP/Postal Code
35100
Country
Turkey
Facility Name
Izmir Dr. Suat Seren Gogus Hastaliklari ve Cerrahisi Egitim ve Arastirma Hastanesi
City
Izmir
ZIP/Postal Code
35110
Country
Turkey
Facility Name
Kirikkale Universitesi Tip Fakultesi Hastanesi
City
Kirikkale
ZIP/Postal Code
71100
Country
Turkey
Facility Name
Mersin University Medical Faculty
City
Mersin
ZIP/Postal Code
33169
Country
Turkey
Facility Name
Public Institution City Clinical Hospital # 6 of Dnipropetrovsk Regional Board
City
Dnepropetrovsk
ZIP/Postal Code
49000
Country
Ukraine
Facility Name
Educational Scientific Medical Centre of Donetsk National Medical University;
City
Donetsk
ZIP/Postal Code
83003
Country
Ukraine
Facility Name
Regional Phthisiology and Pulmonology Center
City
Ivano-Frankivsk
ZIP/Postal Code
76018
Country
Ukraine
Facility Name
City Clinical Hospital #27
City
Kharkiv
ZIP/Postal Code
61002
Country
Ukraine
Facility Name
Medical and Sanitary Unit of OJSC "Kharkiv Tractor Plant n.a. Ordzhonikidze"; Department of Therapy
City
Kharkiv
ZIP/Postal Code
61007
Country
Ukraine
Facility Name
Central Outpatient Hospital of Desnyansky District
City
Kyiv
ZIP/Postal Code
02232
Country
Ukraine
Facility Name
Yanovskyy Inst of Phth. & Pulm; Clinical-functional
City
Kyiv
ZIP/Postal Code
03680
Country
Ukraine
Facility Name
Municipal Institution of Kyiv Regional Council Kyiv Regional Clinical Hospital
City
Kyiv
ZIP/Postal Code
04107
Country
Ukraine
Facility Name
Kyiv City Clinical Hospital #8
City
Kyiv
ZIP/Postal Code
04201
Country
Ukraine
Facility Name
Danylo Halytskyy National Medical University; Lviv
City
Lviv
ZIP/Postal Code
79010
Country
Ukraine
Facility Name
Small Business Private Enterprise Medical Centre Pulse
City
Vinnytsya
ZIP/Postal Code
21001
Country
Ukraine
Facility Name
Municipal Institution of Health Care "Yevpatoriya City Hospital №1
City
Yevpatoriya
ZIP/Postal Code
97403
Country
Ukraine
Facility Name
SI Dept. Clin. Hospital of Zaporizhzhia-2 Railway Station of SE Prydniprovska Zaliznytsia
City
Zaporizhzhia
ZIP/Postal Code
69104
Country
Ukraine
Facility Name
St Peters Hospital
City
Chertsey
ZIP/Postal Code
KT16 0PZ
Country
United Kingdom
Facility Name
Castle Hill Hospital; Respiratory Medicine
City
Cottingham
ZIP/Postal Code
HU16 5JQ
Country
United Kingdom
Facility Name
Ninewells Hospital; Asthma and Allergy Research Group
City
Dundee
ZIP/Postal Code
DD1 9SY
Country
United Kingdom
Facility Name
St James University Hospital; Respiratory Department
City
Leeds
ZIP/Postal Code
LS9 7TF
Country
United Kingdom
Facility Name
University North Tees
City
Teesside
ZIP/Postal Code
TS27
Country
United Kingdom
12. IPD Sharing Statement
Citations:
PubMed Identifier
33217063
Citation
Chen M, Shepard K 2nd, Yang M, Raut P, Pazwash H, Holweg CTJ, Choo E. Overlap of allergic, eosinophilic and type 2 inflammatory subtypes in moderate-to-severe asthma. Clin Exp Allergy. 2021 Apr;51(4):546-555. doi: 10.1111/cea.13790. Epub 2021 Jan 7.
Results Reference
derived
PubMed Identifier
31803473
Citation
N Bauer R, Yang X, L Staton T, Olsson J, Holweg CTJ, R Arron J, Matthews JG, Choy DF. Seasonal variability of lung function and Asthma Quality of Life Questionnaire Scores in adults with uncontrolled asthma. BMJ Open Respir Res. 2019 Nov 11;6(1):e000406. doi: 10.1136/bmjresp-2019-000406. eCollection 2019.
Results Reference
derived
PubMed Identifier
27616196
Citation
Hanania NA, Korenblat P, Chapman KR, Bateman ED, Kopecky P, Paggiaro P, Yokoyama A, Olsson J, Gray S, Holweg CT, Eisner M, Asare C, Fischer SK, Peng K, Putnam WS, Matthews JG. Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med. 2016 Oct;4(10):781-796. doi: 10.1016/S2213-2600(16)30265-X. Epub 2016 Sep 5.
Results Reference
derived
Learn more about this trial
A Study of Lebrikizumab in Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
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