Prospective Trial of Two Hypofractionated Radiotherapy Regimens Versus Conventional Radiotherapy in Diffuse Brainstem Glioma in Children
Pediatric Brain Stem Glioma
About this trial
This is an interventional treatment trial for Pediatric Brain Stem Glioma focused on measuring Diffuse Intrinsic Pontine Glioma (DIPG), Hypofractionated Radiotherapy, Radiotherapy, Median survival
Eligibility Criteria
Inclusion Criteria:
- Newly diagnosed patients with a diffuse intrinsic brainstem glioma
- Aged 2-18years,
- Have symptoms for less than 3 months and at least two findings of the neurologic triad: cranial nerve deficits, ataxia, or long tract signs.
- No performance criteria were required for entry onto the study.
Exclusion Criteria:
- Children were not eligible if they had received any prior therapy other than steroids Treatment
Sites / Locations
- Children's Cancer Hospital Egypt 57357
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Other
Hypofractionated Arm (1)
Hypofractionated Arm (2)
Conventional Arm (3)
A total dose of 39 Gy in daily fractions of 3 Gy, 5 Fractions per week , by conformal radiotherapy sparing of the supratentorial brain. The planning target volume included the tumor as defined by the T2-weighted MRI images with a margin of 1.5-2.0 cm. Margins were adjusted for bony structures and tentorium. With exception of steroids, no neoadjuvant, concomitant, or adjuvant systemic treatment was allowed
The same planning and treatment procedures will be performed. The total dose will be 4500 cGy in 15 fractions in 3 weeks; giving 300 cGy per fraction.
The same planning and treatment procedures will be performed with 54.0 Gy in 30 fractions giving 1.8 Gy per fraction.