Cardiac Allograft Remodeling and Effects of Sirolimus (CAR)
Cardiac Hypertrophy, Immunosuppression
About this trial
This is an interventional treatment trial for Cardiac Hypertrophy focused on measuring Heart transplantation, Cardiac allograft remodeling, Immunosuppression, Cardiac MRI, M-TOR inhibitor
Eligibility Criteria
Inclusion Criteria:
- All adult cardiac transplant recipients undergoing heart transplantation at UNMC/TNMC.
Exclusion Criteria:
- Adult cardiac transplant recipients with acute rejection (ISHLT R> grade 2) or acute infection.
Sites / Locations
- University of Nebraska Medical Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Active Comparator
Experimental
Active Comparator
Active Comparator
Active Comparator
Experimental
Experimental
Cardiac biopsy C4D stain
Genetic Mechanism of M-TOR
Cardiac MRI
Coronary Angiography with IVUS
Cardiopulmonary Exercise Test (CPET)
MTor Immunosuppression
Cardiac Allograft Remodeling
A procedure that removes a very small sample of your heart muscle so that it can be evaluated in the lab. This procedure may be done to determine the cause of cardiac myopathy (a weakened heart muscle) or to check for rejection after a heart transplant.
To identify the molecular and genetic mechanisms associated with development of early post-transplant CAR, and to evaluate the impact of mTOR-inhibitor Sirolimus on this process. Sirolimus dosage is based on blood levels.
Cardiac Magnetic Resonance Imaging (MRI) produces no side effects from the magnetic fields and radio waves and doesn't carry a risk of cancer or birth defects. Serious reactions to the special contrast dyes used for MRI are very rare. The MRI examination poses almost no risk to the average patient when appropriate safety guidelines are followed, however side effects are possible and include headache, nausea, dizziness, change in taste and allergic reaction. Such reactions usually are mild and easily controlled by medication.
Coronary angiography is a test that uses dye and special x rays to show the insides of your coronary arteries. The coronary arteries supply oxygen-rich blood to your heart. Intravascular ultrasound is a test that uses sound waves to see inside blood vessels. This article discusses intravascular ultrasound to see inside the coronary arteries, the blood vessels that supply the heart.
Is a highly sensitive, non-invasive stress test. It is considered a stress test because the exercise stresses your body's systems by making them work faster and harder. A disease or condition that affects the heart, lungs or muscles will limit how much faster and harder these systems can work. A CPET assesses how well the heart, lungs, and muscles are working individually, and how these systems are working in unison. Your heart and lungs work together to deliver oxygen to your muscles, where it is used to make energy, and to remove carbon dioxide from your body.
Sirolimus Sirolimus dosage is based on blood levels. To assess the potential of mTOR immunosuppressant Sirolimus in attenuation of CAR in HTx recipients and therefore, improve pre-existing cardiac allograft function, vasculopathy, and exercise capacity.
A surgical procedure in wich a diseased heart is replaced with a healthy heart from a deceased person.