Evaluating Two Types of Cognitive Training in Veterans With Schizophrenia
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring cognitive training, schizophrenia, mismatch negativity, cognition, functional capacity, EEG
Eligibility Criteria
Inclusion Criteria:
- Veterans with a Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnosis of schizophrenia or schizoaffective disorder
- Between 25 and 65 years of age
- Estimated premorbid inteIligence quotient (IQ) > 70 (based on reading ability)
- Understand spoken English sufficiently to comprehend the consent form
- Clinically stable (i.e., no inpatient hospitalization in the 3 months, no changes in psychiatric medications in the 6 weeks, and no changes in housing in the 2 months, prior to enrollment)
Exclusion Criteria:
- Documented history of mental retardation or severe learning disability
- Clinically significant neurological disease as determined by medical history (e.g., epilepsy, stroke)
- History of serious head injury with loss of consciousness greater than 1 hour and concomitant neuropsychological sequelae
- Meeting DSM-IV criteria for drug or alcohol dependence during the 6 months, or abuse during the month preceding study enrollment
Sites / Locations
- Local Board and Care Facilities
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
Specific Perceptual Training - Brain Fitness Program (BFP)
Broad Cognitive Training - Cognitive Package (Cogpack)
Control Treatment - Commercial Computer Games (Sporcle)
In each session, participants will work on 4 of the 6 BFP exercises (15 min per exercise). Duration of training is 1 hour per day, 3 days per week, for 12 weeks, for a total of 36 hours.
In each session, participants will work on a different subset of 4 to 6 Cogpack exercises. Duration of training is 1 hour per day, 3 days per week, for 12 weeks, for a total of 36 hours.
In each session, participants will play between 8 and 16 games (1 to 15 min per game). Duration of training is 1 hour per day, 3 days per week, for 12 weeks, for a total of 36 hours.