Cognitive Remediation and Sheltered Employment in Schizophrenia (RemedRehab)
Chronic Schizophrenia
About this trial
This is an interventional treatment trial for Chronic Schizophrenia focused on measuring Schizophrenia, Cognitive Remediation, Working abilities and social functioning
Eligibility Criteria
Inclusion Criteria:
- Age from 18 to 50 years.
- Schizophrenia according to the criteria of the DSM-IV-TR.
- Project of entry to ESAT or to EA in the 6 weeks which follow.
- IQ > 70 (F-NART).
- Stable symptomatology during the month preceding the inclusion.
- Psychotropic treatment unchanged during the month preceding the inclusion (change no more than 25 % posology).
- Overdrawn performances in at least one of the 6 functions estimated by the kit of neuropsychological tests.
- French mother tongue.
- Informed and signed consent by the patient.
- Agreement of the guardian (for protected adults).
- Membership in a national insurance scheme.
Exclusion Criteria:
- Dependence and recent abuses of cannabis (> 2 / week) or in any other substance (according to the criteria of the DSM-IV-TR), except tobacco.
- Neurological disorders of vascular, infectious or neurodegenerative origin; dyschromatopsie.
- Taking of medicine with somatic tropism having a cerebral or psychic impact (eg: corticoids).
- Simultaneous participation to any other program of remediation targeting the neurocognitive deficits.
- Resistance to neuroleptic.
- Reading and writing not acquired.
Sites / Locations
- Hôpital Le Vinatier Pôle Centre
- Hôpital Le Vinatier Pôle Est
- Mental Health Center (MGEN)
- Hôpital Ste Marguerite
- Nantes University Hospital
- Centre Hospitalier de Niort
- Hôpital Ste Anne
- Centre Hospitalier Henri Laborit
- Mental Health Center (MGEN)
- Saint-Cyr Hospital
- Centre Hospitalier de St-Egrève
- Centre de Santé Mentale Angevin (CESAME)
- Tours University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
RECOS
TAU (Treatment as Usual)
The RECOS program (COgnitive REmediation for Schizophrenia) was designed by SBT Company and adapted by Vianin et al (2007) for specific use in schizophrenia. It includes computer based and paper and pencil exercises that target 6 main cognitive functions (selective attention; verbal memory; visuo-spatiale attention and memory, working memory, reasoning, and speed of execution) which have been recommended by the MATRICS consensus. Each exercise has 10 difficulty levels. Allocation of the training modules in RECOS is determined according to the standard scores obtained in the comprehensive neuropsychological assessment. Each patient participates in the module corresponding to his/her most altered cognitive area.
The treatment of the group TAU (Treatment As Usual) will consist of the usual care proposed by every service of the various inquiring centers involved. No additional session will be proposed.