ColoAssist vs. MEI
Primary Purpose
Colorectal Cancer, Screening
Status
Completed
Phase
Not Applicable
Locations
Norway
Study Type
Interventional
Intervention
ColoAssist
MEI
Sponsored by
About this trial
This is an interventional diagnostic trial for Colorectal Cancer focused on measuring Colonoscopy, Colorectal cancer, Adenoma
Eligibility Criteria
Inclusion Criteria:
- Inclusion in an ongoing colorectal cancer screening trial (NCT 00883792)
Exclusion Criteria:
- Excluded from the ongoing screening trial (NCT 00883792)
- Inability or unwilling to provide informed consent
Sites / Locations
- SSHF Arendal
- SSHF Kristiansand
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
ColoAssist
MEI
Arm Description
Screening colonoscopy with a new colonoscope with gradual stiffness
Screening colonoscopy with colonoscopes compatible with and guided by MEI
Outcomes
Primary Outcome Measures
Cecal intubation rate
The ability to reach the cecum during colonoscopy
Secondary Outcome Measures
Cecal intubation time
Time to reach the cecum during colonoscopy
Adenoma detection rate
The proportion of participants in whom at least one adenoma is detected
Polyp detection rate
The proportion of participants in whom at least one polyp i detected
Pain
Participants will be asked to score discomfort or pain during and after colonoscopy
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT01895504
Brief Title
ColoAssist vs. MEI
Official Title
ColoAssist vs. Magnetic Guided Colonoscopy - a Randomized Controlled Trial
Study Type
Interventional
2. Study Status
Record Verification Date
March 2015
Overall Recruitment Status
Completed
Study Start Date
April 2013 (undefined)
Primary Completion Date
June 2014 (Actual)
Study Completion Date
July 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Sorlandet Hospital HF
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Colonoscopy aims to investigate the entire colon by advancing the colonoscope tip from the rectum to the cecum, a process called cecal intubation. Cecal intubation may be difficult for different reasons, and features of the colonoscope and the use of imaging devices may influence the success rate. We want to compare the performance of a new colonoscope with novel features including gradual stiffness with that of a colonoscope supplied with a magnetic endoscope imaging (MEI) device. The hypothesis is that the performance of the new instrument is non-inferior to the MEI system.
Detailed Description
The recommended cecal intubation rate in colorectal cancer (CRC) screening is 95%. The MEI system allows real time monitoring of the colonoscope position within the colon and is considered to be a useful supplement to achieve cecal intubation. However, the MEI system is costly, and trial results are equivocal regarding the actual benefits. A newly designed colonoscope (ColoAssist) with gradual stiffness throughout the colonoscope shaft has been developed to improve insertability. We want to investigate if we can achieve equal performance results with the ColoAssist instrument as with the MEI system in CRC screening. The study is designed as a two-center, single-blinded, randomized, controlled non-inferiority trial.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Colorectal Cancer, Screening
Keywords
Colonoscopy, Colorectal cancer, Adenoma
7. Study Design
Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
Participant
Allocation
Randomized
Enrollment
475 (Actual)
8. Arms, Groups, and Interventions
Arm Title
ColoAssist
Arm Type
Experimental
Arm Description
Screening colonoscopy with a new colonoscope with gradual stiffness
Arm Title
MEI
Arm Type
Active Comparator
Arm Description
Screening colonoscopy with colonoscopes compatible with and guided by MEI
Intervention Type
Device
Intervention Name(s)
ColoAssist
Other Intervention Name(s)
FujiFilm EC-590WI4
Intervention Description
Screening colonoscopy with the test instrument
Intervention Type
Device
Intervention Name(s)
MEI
Other Intervention Name(s)
Olympus ScopeGuide
Intervention Description
Colonoscopy with Olympus colonoscopes and MEI guidance
Primary Outcome Measure Information:
Title
Cecal intubation rate
Description
The ability to reach the cecum during colonoscopy
Time Frame
1 hour
Secondary Outcome Measure Information:
Title
Cecal intubation time
Description
Time to reach the cecum during colonoscopy
Time Frame
1 hour
Title
Adenoma detection rate
Description
The proportion of participants in whom at least one adenoma is detected
Time Frame
1 hour
Title
Polyp detection rate
Description
The proportion of participants in whom at least one polyp i detected
Time Frame
1 hour
Title
Pain
Description
Participants will be asked to score discomfort or pain during and after colonoscopy
Time Frame
24 hours
10. Eligibility
Sex
All
Minimum Age & Unit of Time
55 Years
Maximum Age & Unit of Time
66 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Inclusion in an ongoing colorectal cancer screening trial (NCT 00883792)
Exclusion Criteria:
Excluded from the ongoing screening trial (NCT 00883792)
Inability or unwilling to provide informed consent
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Kjetil K Garborg, MD
Organizational Affiliation
SSHF Kristiansand, Norway
Official's Role
Principal Investigator
First Name & Middle Initial & Last Name & Degree
Michael Bretthauer, PhD
Organizational Affiliation
University of Oslo
Official's Role
Study Chair
Facility Information:
Facility Name
SSHF Arendal
City
Arendal
Country
Norway
Facility Name
SSHF Kristiansand
City
Kristiansand
ZIP/Postal Code
4604
Country
Norway
12. IPD Sharing Statement
Citations:
PubMed Identifier
28405331
Citation
Garborg K, Wiig H, Hasund A, Matre J, Holme O, Noraberg G, Loberg M, Kalager M, Adami HO, Bretthauer M. Gradual stiffness versus magnetic imaging-guided variable stiffness colonoscopes: A randomized noninferiority trial. United European Gastroenterol J. 2017 Feb;5(1):128-133. doi: 10.1177/2050640616639162. Epub 2016 Jun 23.
Results Reference
derived
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ColoAssist vs. MEI
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